QEEG Brain Signature of Depression & Neuromodulation-induced Recovery
NCT06719427
Recruiting
This study aims to explore how repetitive transcranial magnetic stimulation (rTMS), a treatment for depression, affects brain function. Depression disrupts the brain's complex network or regions that regulate cognition, emotion, and behavior. rTMS targets these disruptions to restore network function. To measure these effects, researchers will use dry quantitative EEG (qEEG), a new technology that records brain electrical activity quickly (15 minutes compared to 1 hour for traditional EEG) witho... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/26/2025
Locations: Sunnybrook Health Sciences Centre, North York, Ontario +1 locations
Conditions: Major Depressive Diorder
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Study Comparing SBS and LRTI for Treatment of CMC Arthritis
NCT05111405
Recruiting
A multi-center, randomized control trial comparing the two standard of care surgical treatments for CMC arthritis ; trapezial excision with or without soft tissue interposition and /or ligament reconstruction (LRTI) versus the suture button suspension arthroplasty (SBS). Patient reported outcomes will be collected at 6 and 6 weeks, 3, 6, and 12 months.
Gender:
ALL
Ages:
50 years and above
Trial Updated:
02/26/2025
Locations: South Campus Research Unit for Bone and Soft Tissue, Calgary, Alberta +1 locations
Conditions: Arthritis
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Strength After Elbow Fractures in the Elderly
NCT05135949
Recruiting
Elderly patients strength and function, specifically the ability to rise from a seat after either operative or non operative treatment of an mayo type 2 olecranon fracture.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/26/2025
Locations: Royal Columbian Hospital, New Westminster, British Columbia
Conditions: Fracture;Elbow
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Exactech Shoulder Post Market Clinical Follow-up Study
NCT05603728
Recruiting
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
02/26/2025
Locations: South County Orthopedic Specialists, Laguna Woods, California +37 locations
Conditions: Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy, Ankylosing Spondylitis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis, Fracture, Infections
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Pharmacogenomics of Stimulant Treatment Response
NCT06221358
Recruiting
The "Pharmacogenomics of Stimulant Treatment Response" (PGx-STaR) study aims to identify genetic profiles related to methylphenidate treatment outcomes in children and adolescents aged 6-24 with Attention deficit/hyperactivity disorder (ADHD).
Gender:
ALL
Ages:
Between 6 years and 24 years
Trial Updated:
02/26/2025
Locations: University of Calgary, Calgary, Alberta
Conditions: Attention-Deficit/ Hyperactivity Disorder (ADHD)
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Study of ATX-01 in Participants with DM1
NCT06300307
Recruiting
The goal of this clinical trial is to test ATX-01 in participants with myotonic dystrophy type 1 (DM1). The main question it aims to answer is if ATX-01 is safe and well tolerated. The trial will compare the safety and tolerability of ATX-01 and a matching placebo. There will be a single-ascending dose part of the trial and a multiple-ascending dose part. In the single-ascending dose, participants will receive one dose of ATX-01 or placebo. In the multiple-ascending dose part, participants will... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
02/26/2025
Locations: University of Florida, Gainesville, Florida +8 locations
Conditions: Myotonic Dystrophy 1
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Early Fixation for Diaphyseal Humeral Shaft Fractures in the Elderly Patients
NCT06605482
Recruiting
The study purpose is to evaluate whether early surgical fixation of upper arm fractures in elderly patients' age 65 years and older improves patient functional and psychological outcome scores compared to the standard of care with non-operative management.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
02/26/2025
Locations: Royal Columbian Hospital, New Westminster, British Columbia
Conditions: Humerus Shaft Fracture, Elderly (people Aged 65 or More)
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eSense-Cancer: Adapting an Online Intervention for Sexual Health Concerns to Gynecologic Cancer
NCT06619769
Recruiting
Sexual health is a vital component of gynecologic cancer treatment and survivorship. Unfortunately, most gynecologic cancer survivors lack sufficient information about the impact of cancer on sexual health and treatment opportunities. This research aims to assess how well an adapted online health intervention meets the sexual health needs of gynecologic cancer survivors and to test the efficacy of the new platform. If successful, eSense-Cancer may increase access to treatment for gynecologic can... Read More
Gender:
FEMALE
Ages:
19 years and above
Trial Updated:
02/26/2025
Locations: University of British Columbia, Vancouver, British Columbia
Conditions: Gynecologic Cancers
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Evaluation of the Achievement of a Pharmacodynamic Target of Piperacillin-Tazobactam for the Population with Obesity
NCT06690905
Recruiting
This study aims to evaluate the feasibility of an open randomized controlled study which would assess the proportion patients with obesity who will have a favorable pharmacodynamic parameter (i.e. fT\> 100% MIC) after 24 hours of piperacillin-tazobactam administered as a prolonged intermittent infusion compared to a standard infusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Hôpital Charles- Le Moyne, Greenfield Park, Quebec
Conditions: Infections, Obesity and Obesity-related Medical Conditions
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Amplatzer Amulet LAAO Vs. NOAC
NCT04226547
Recruiting
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for ischemic stroke and who are recommended for long-term NOAC therapy. The clinical investigation is a prospective, randomized, multicenter active control worldwide trial. Subjects will be randomized in a 1:1 ratio between the Amulet LAA occlusion device ("Device Group") and a commercially available NOAC medication ("Cont... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: University Hospital - Univ. of Alabama at Birmingham (UAB), Birmingham, Alabama +131 locations
Conditions: Atrial Fibrillation, Stroke, Bleeding
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Longitudinal Study for Central Nervous System Vasculitis
NCT05734404
Recruiting
Primary central nervous system vasculitis (CNSV) is a potentially fatal, single-organ vasculitis that often involves a spectrum of neurologic complications, including strokes, cognitive and speech impairment, visual loss, dementia, and encephalopathy. The purpose of this study is to establish a research cohort to investigate the disease process, treatments, and patient outcomes in CNSV.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: Cleveland Clinic, Cleveland, Ohio +4 locations
Conditions: Central Nervous System Vasculitis, CNS Vasculitis, CNSV, Vasculitis
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Behaviour Change for Cancer Survivors Trial
NCT06624930
Recruiting
This study will be a two-arm, multi-site RCT, to examine the effects of an entirely virtual, 6-month supervised PA program plus standard exercise counselling (PA+EC) versus a supervised PA plus motivationally-enhanced behavioral counselling (PA+BC) on moderate to vigorous physical activity (MVPA) in cancer survivors. A 6-month post intervention follow-up (T2) and 1-year post intervention follow-up (T3; 1-year follow-up from post-intervention) will take place after the intervention to address mai... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/25/2025
Locations: University of British Columbia, Vancouver, British Columbia +1 locations
Conditions: Cancer, Exercise
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