American Hepato-Pancreato-Biliary Association (AHPBA) Pancreatic Irreversible Electroporation (IRE) Registry
NCT02674100
Recruiting
The purpose of this study is to create a registry to provide insight into treatment selection and treatment outcome of pancreatic IRE in order to develop an evidence base such that physicians can provide the best possible care to patients with pancreatic cancer requiring surgical interventions. The investigators seek a better understanding of the uses of ablation in the treatment of unresectable soft tissue pancreatic tumors and the limitations, concerns and complications that earlier users hav... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/23/2025
Locations: University of Alabama Birmingham, Birmingham, Alabama +15 locations
Conditions: Pancreatic Cancer
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Dose Efficacy in Adhesive Capsulitis
NCT06848374
Recruiting
The purpose of this study is to find out if the treatment of adhesive capsulitis with 40 mg of methylprednisolone in combination with a hydrodilatation is comparable to 80 mg of methylprednisolone for pain reduction, improving shoulder mobility, and reducing side effects. Researchers will enroll 40 people in this study which is taking place solely at the Toronto Rehabilitation Institute, University Avenue. This study should take approximately 12 months to complete and the results should be know... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/23/2025
Locations: Toronto Rehabilitation Institution, Toronto, Ontario
Conditions: Adhesive Capsulitis of the Shoulder
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The Irrigation or No Irrigation in Simple Lacerations Trials
NCT02976480
Recruiting
The purpose of this study is to determine whether the irrigation or non-irrigation of a simple laceration treated in the emergency department has an effect on the subsequent rate of infection.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: CIUSSS Saguenay-Lac-St-Jean, Hôpital de Chicoutimi, Chicoutimi, Quebec
Conditions: Laceration - Injury, Infection
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Validation of Continuous Monitoring of Vital Signs in Children with a Connected Patch
NCT04627766
Recruiting
Small connected devices monitoring vital signs do not exist in children although they could be very useful to monitor patients once they have left the pediatric intensive care unit (PICU) in order to early identify patients at risk of PICU readmission. The main objective of this study is to assess the accuracy of a connected thoracic patch (VT-Patch) for the continuous monitoring of vital signs in PICU patients. This monitoring device will be used to monitor children in PICU for 8 hours and re... Read More
Gender:
ALL
Ages:
Between 0 years and 18 years
Trial Updated:
02/21/2025
Locations: CHU Sainte Justin Hospital, Montreal, Quebec
Conditions: Vital Signs
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Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
NCT06780917
Recruiting
The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder. The main objectives of this research are: 1. To confirm the feasibility of administering the Creyos cognitive battery to older adults with Mild Cognitive Impairment MCI) or Major Depressive Disorder in remission (rMDD). 2. To determine whether the Creyos battery can detect changes in cognition that are predictiv... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
02/21/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched
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Extended Effects of Cannabis Abstinence on Clinical Symptoms and Cognition in Depression
NCT04935619
Recruiting
The prevalence of major depressive disorder (MDD) is \~5.0%, and rates of co-occurring SUDs in these patients approach 40-50%. Specifically, rates of co-morbid cannabis use disorder (CUD) in patients with MDD are elevated 2-3 fold compared to 2.9% in the general population, and is associated with poorer treatment outcomes and impaired cognitive and psychosocial functioning in comparison to MDD patients without CUD. Most studies of cannabis use in MDD are cross-sectional in design, and therefore... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
02/21/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Cannabis Use, Major Depressive Disorder, Cognitive Impairment
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Combined and Separate Effects of Cannabis and Tobacco: Psychomotor, Subjective and Physiological Outcomes
NCT05526196
Recruiting
Co-administration of cannabis and tobacco is a common practice, but there is little experimental evidence aimed at understanding the reasons for this prevalence. Some preliminary evidence suggests that tobacco may actually counteract the cognitive-impairing effects of cannabis, and may also increase the subjective ('liking') effects of cannabis, but results are inconclusive. Further, there are no studies into the effects of tobacco on other cannabis-related harms such as driving, or on the abili... Read More
Gender:
ALL
Ages:
Between 19 years and 45 years
Trial Updated:
02/21/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Driving Under the Influence
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Appetitive Conditioning in Anorexia Nervosa
NCT05531604
Recruiting
Anorexia nervosa (AN) is characterized by a reduced drive to pursue rewarding experiences and stimuli. Food consumption - which is almost universally experienced as pleasurable - is not described as rewarding by those with AN. This is thought to be underpinned by abnormalities around reward learning. However, the most fundamental question relating to reward in AN - whether those with AN may learn positive associations - remains unaddressed. In this study, the investigators will identify the pat... Read More
Gender:
FEMALE
Ages:
Between 12 years and 22 years
Trial Updated:
02/21/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Anorexia Nervosa
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TMS Visual Modulation in Body Dysmorphic Disorder
NCT05607121
Recruiting
The goal of this observational study is to test the effects of a type of noninvasive brain stimulation called transcranial magnetic stimulation (TMS) on visual processing in adults with body dysmorphic disorder symptoms when combined with modifying visual attention. The main goals are to understand, in people with body dysmorphic disorder and people with subclinical body dysmorphic disorder: * The effects of intermittent and continuous TMS stimulation of parietal brain regions when done right... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
02/21/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Body Dysmorphic Disorders
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A 32-week Trial to Evaluate the Efficacy and Safety of Tralokinumab in Subjects With Moderate-to-severe Atopic Hand Eczema Who Are Candidates for Systemic Therapy
NCT05958407
Recruiting
The purpose of this study is to test if treatment with tralokinumab is safe and effectful to treat moderate-to-severe atopic hand eczema. This will be judged by a range of assessments that rate the severity and extent of atopic hand eczema and its symptoms, as well as general health status and quality of life. The trial will last for up to 40 weeks. There will be up to 15 visits, 3 of which will be conducted by phone. The first part of the trial is called a screening period and will last up to... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/21/2025
Locations: LEO Pharma Investigational Site, Birmingham, Alabama +75 locations
Conditions: Atopic Dermatitis, Atopic Hand Eczema
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Early-life MRI Biomarkers of Longer-term Respiratory Morbidity in Infants Born Extremely Preterm (EMBLEM)
NCT06065215
Recruiting
Bronchopulmonary dysplasia (BPD) is a common, major complication of premature birth, associated with developmental and health consequences that continue into adulthood. Prediction of who will have these problems is challenging using traditional definitions of disease. It is believed that underdevelopment and injury occur in both lung tissue and the blood vessels in the lungs, with a sophisticated interplay between them that contributes to lung disease seen in prematurity. New magnetic resonance... Read More
Gender:
ALL
Ages:
Between 35 weeks and 21 months
Trial Updated:
02/21/2025
Locations: The Children's Hospital of Eastern Ontario, Ottawa, Ontario +3 locations
Conditions: Lung Function, BPD - Bronchopulmonary Dysplasia
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Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
NCT06299319
Recruiting
Psilocybin, the chemical component of "magic mushrooms", has been administered with psychotherapy in several randomized clinical trials (RCTs) showing large and sustained antidepressant effects. There is interest to see if similar effects may be provided in those with obsessive compulsive disorder (OCD). The purpose of this study is to evaluate the safety, feasibility, and clinical effects of psilocybin administration in those with OCD. Ten participants with treatment-resistant OCD will receive... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/21/2025
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Obsessive-Compulsive Disorder
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