Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan Era
NCT06508567
Recruiting
This is an interventional, single-centre, single-arm, non-randomized, prospective, feasibility trial investigating salvage MR-guided High-Dose-Rate brachytherapy for prostate bed recurrence after postoperative radiotherapy.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
02/06/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Prostate Cancer Recurrent, Prostate Cancer
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Evaluating Myelodysplastic Syndrome Risks in NET Patients Planned for Peptide Radionuclide Therapy
NCT06510868
Recruiting
This is a prospective observational study which aims to identify individuals predisposed to developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) could improve patient outcomes in different ways. First, it will enable improved patient selection for PRRT where alternative treatment options are available. Second, understanding the final pathway and how it is modulated by PRRT could allow the design of strategies to halt this process. Third, while it is unknown whether the deve... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/06/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Myelodysplastic Syndrome, Acute Myeloid Leukemia
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The Supporting Her In Navigating Exercise Program: Examining Peer Support to Promote Exercise Among Undergraduate Women
NCT06823336
Recruiting
The purpose of this randomized controlled pilot trial is to test the effectiveness of a six-week tailored physical activity program with and without peer mentoring on the psychological constructs and exercise behaviour of inactive undergraduate women. The objectives are to: * Quantify the degree to which a peer-mentorship intervention affects exercise motivation determined through three basic psychological needs (i.e., autonomy, competence, and relatedness). * Examine general psychological dist... Read More
Gender:
FEMALE
Ages:
All
Trial Updated:
02/06/2025
Locations: Lakehead University, Thunder Bay, Ontario
Conditions: Social Support (Formal and Informal)
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The T Cell Activator of Cell Killing ("TACK") IT ON" STUDY
NCT06823596
Recruiting
Antiretroviral therapy or ART blocks HIV replication reducing plasma viral loads to undetectable levels but has no effect on persistently infected cells in the body, called the virus reservoir. These cells carry infectious HIV capable of restarting HIV replication if therapy is stopped. The reservoir is so stable forcing people to adhere life-long ART. Over 5% of ART adherent individuals continue to have residual non-suppressive viremia (NSV) detected by clinical assays (40-400 copies/ml). Resid... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/06/2025
Locations: Unity Health Toronto -St. Michael's Hospital, Toronto, Ontario +1 locations
Conditions: Hiv
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Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
NCT04045665
Recruiting
The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying POAF event, who decline randomization, will be offered the option of enrollment in a parallel registry that captures their ba... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: CHI St. Vincent, Arkansas, Little Rock, Arkansas +95 locations
Conditions: Atrial Fibrillation, Stroke, Bleeding
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MyAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
NCT05204888
Recruiting
Parallel-group, prospective, randomized, controlled phase III trial of home High flow Nasal Therapy (HFNT) via myAirvo 3 plus usual COPD medical care vs. usual COPD medical care, for at least 1 year and up to two years in 642 GOLD Grade D, Stages II-IV patients with moderate to very severe COPD at risk for moderate and severe exacerbations with a prior history of severe exacerbation requiring hospitalization within the past 6 weeks.
Gender:
ALL
Ages:
30 years and above
Trial Updated:
02/05/2025
Locations: UAB School of Medicine/Lung Health Center, Birmingham, Alabama +26 locations
Conditions: COPD
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Accuracy of Community General Pediatrician Diagnosis of Autism Compared to a Multidisciplinary Team Assessment
NCT05699928
Recruiting
The goals of this diagnostic study are to determine how accurate general pediatricians are in autism spectrum disorder (ASD) diagnostic assessment and which children might be best suited for this type of assessment. The investigators will also evaluate the use of a new virtual diagnostic tool, the Autism Assessment for Preschoolers with Language Element Sequence (AAPLES). The investigators will recruit twenty general pediatricians from across Ontario, Canada, as well as 200 of their patients (m... Read More
Gender:
ALL
Ages:
Between 0 months and 64 months
Trial Updated:
02/05/2025
Locations: Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario
Conditions: Autism Spectrum Disorder
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Transforming Care for Individuals with Childhood-onset Systemic Lupus Erythematosus
NCT06232304
Recruiting
This study aims to investigate the feasibility and effectiveness of a cognitive behavioral coping skills program, Treatment and Education Approach for Childhood-onset Lupus (TEACH), for youth with cSLE when integrated into medical care. This TEACH program aims to teach participants skills in order to cope with fatigue, pain, and depressive symptoms--symptoms that commonly affect adolescents and young adults with lupus.
Gender:
ALL
Ages:
Between 12 years and 22 years
Trial Updated:
02/05/2025
Locations: University of Alabama Birmingham Hospital, Birmingham, Alabama +6 locations
Conditions: Systemic Lupus Erythematosus of Childhood (Disorder)
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Neuromodulation With Spinal Stimulation Methods
NCT06272279
Recruiting
This is a pilot research study to test the protocols needed for transcutaneous spinal electrical stimulation in persons living with spinal cord injury (SCI). Up to 24 participants will be enrolled. A variety of stimulation parameters and outcome measures will be assessed.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/05/2025
Locations: University of Manitoba, Winnipeg, Manitoba +1 locations
Conditions: Spinal Cord Injuries, Spinal Cord Injury at C5-C7 Level, Paraplegia, Spinal, Paraplegia, Incomplete
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Technology in Play for Children With Physical Disabilities: the Dice Model of Play
NCT06319430
Recruiting
Play is an important activity for children. Almost all children play, but what is play? It is not easy to define play. In the past, people believed that children played to burn their energy. Now, it is known that play is important for children's growth. Some kids with disabilities cannot play. Many experts use play to teach children specific skills. People often forget that play is a child's right. It is important to help all children play. The first step is to define play and find what features... Read More
Gender:
ALL
Ages:
Between 3 years and 8 years
Trial Updated:
02/05/2025
Locations: Rehabilitation Centre for Children, Winnipeg, Manitoba
Conditions: Disability Physical, Disabilities Mental
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Optimization of ITBS for Depression
NCT06464445
Recruiting
Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as cortical excitability. Cortical excitability is important for the induction of brain plasticity, the ability of the brain to reorganize itself and form new connections in response to stimuli. A particular class of rTMS, intermittent theta burst TMS (iTBS), is commonly used... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
02/05/2025
Locations: Centre de recherche du Centre hospitalier universitaire de Sherbrook, Sherbrooke, Quebec
Conditions: Neuromodulation
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Sustained Release Lidocaine for the Treatment of Postoperative Pain
NCT05193227
Recruiting
In this study, the investigators are testing a new formulation of lidocaine for its suitability in managing postoperative pain after pelvic (circumcision, inguinal, scrotal), perineal (hemorrhoidectomy) or perianal (fistulotomy) incisions. The new formulation ST-01 is a sustained release lidocaine formulation and is expected to provide pain relief over multiple days. Currently, the drug lidocaine is not available as an injectable slow-release formulation.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
02/04/2025
Locations: Vancouver Prostate Centre, Vancouver, British Columbia +1 locations
Conditions: Postoperative Pain, Postsurgical Pain
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