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All Clinical Trials in Canada
A listing of 3904 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
2221 - 2232 of 3904
Biologic Augment of the Medial Patellofemoral Ligament Following Primary Lateral Patellofemoral Dislocation (BioPPD)
Recruiting
This study aims to determine the ability of medial patellofemoral ligament (MPFL) repair augmented with Biobrace® to decrease the re-dislocation rate after a primary patellofemoral dislocation. First-time patellofemoral dislocation is a significant problem, and the ramifications of recurrence for patients are substantial. Due to the multifactorial nature of the pathoanatomy of patellofemoral instability, it has been difficult to design trials that will show how interventions could affect the nat... Read More
Gender:
ALL
Ages:
Between 13 years and 30 years
Trial Updated:
01/31/2025
Locations: Banff Sport Medicine, Canmore, Alberta
Conditions: Patellofemoral Dislocation
VOICE-Early Response to Vedolizumab and IL-23 Antagonists in Participants With Crohn's Disease: A Prospective Observational Study
Recruiting
The primary aim of this study is to explore the time course of response to Vedolizumab in participants with CD as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference-short form (SF), as well as other PROMIS domain SFs (fatigue, anxiety, depression, sleep disturbance, physical function, and ability to participate in social roles and activities); other PRO measures will also be assessed.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: GI Alliance - Sun City, Sun City, Arizona +19 locations
Conditions: Crohn's Disease
The VICTORY Trial: Virtual, Innovative, Postsurgical Care To Optimize Return Home for Older People With frailtY
Recruiting
Canadian hospitals continue to struggle with severe emergency department and hospital bed capacity shortages. Maximizing bed availability and minimizing emergency department and urgent-centre visits by providing patients with alternative options to care is an important part of the solution. Surgical patients with frailty are at high risk of requiring subsequent acute-hospital care. The VICTORY trial will answer an important question that will inform how to improve care for surgical patients with... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/31/2025
Locations: The Ottawa Hospital, Ottawa, Ontario
Conditions: Surgery, Frailty
Managing Frailty Through Mobilization in Males and Female Inpatients with Cardiovascular Disease
Recruiting
Frailty describes the overall health of a person. Inpatients with cardiovascular problems have a higher risk for frailty - or the sick are more likely to get sicker - causing longer hospital stays, hospital readmission, and death. Females are particularly vulnerable to these problems, generally displaying higher frailty levels than males. In hospital, patients spend almost all their time in bed, and this lack of movement worsens cardiovascular and musculoskeletal health, sometimes lengthening pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2025
Locations: Dr. Georges-L.-Dumont University Hospital CentreDr. Georges-L.-Dumont University Hospital Centre, Moncton, New Brunswick
Conditions: Cardiovascular Diseases, Frailty
Tailored Axillary Surgery With or Without Axillary Lymph Node Dissection Followed by Radiotherapy in Patients With Clinically Node-positive Breast Cancer (TAXIS)
Recruiting
RATIONALE: The use of tailored axillary dissection as a tailored procedure will avoid surgical overtreatment by selectively removing the lymph nodes that are affected by the cancer, thereby sparing many women the unnecessary complications of a radical surgery, providing a better quality of life while keeping the same efficacy.
PURPOSE: The phase III trial is evaluating the optimal treatment for breast cancer patients in terms of surgery and radiotherapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland +66 locations
Conditions: Node-positive Breast Cancer
Genomic Investigation of Unusual Responders
Recruiting
Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic agents in an effort to understand the fundamental genetic basis of this response. The present protocol seeks to retrospectively perform Exome, next-generation (DNA) sequencing and/or other molecular techniques on tumor samples to identify the genetic basis of a patient's e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Cancer, Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer, Genitourinary Cancer, Gynecological Cancer, Upper Aerodigestive Tract Cancer, Pancreatobiliary Gastrointestinal Cancer, Melanoma (Skin), Rare Cancer, Carcinoma of Unknown Primary
Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma
Recruiting
This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival.
After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Mayo Clinic Hospital in Arizona, Phoenix, Arizona +148 locations
Conditions: Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
Low-dose Naltrexone for Post-COVID Fatigue Syndrome
Recruiting
This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e. confirmed SARS-CoV-2 case). LDN refers to naltrexone given in doses of 1-4.5 mg. Overall, studies have found that LDN is safe and well-tolerated. It may help to reduce pain and inflammation and improve well-being and immune function.The trial will be conducted by the Compl... Read More
Gender:
ALL
Ages:
Between 19 years and 69 years
Trial Updated:
01/30/2025
Locations: Women's Health Research Institute, Vancouver, British Columbia
Conditions: Post-Viral Fatigue Syndrome
Optimizing lymphoDepletion to Improve Outcomes In Patients Receiving Cell Therapy With Yescarta
Recruiting
This is a Phase 1b study of participants with Diffuse Large B Cell Lymphoma (DLBCL). The purpose of this study is to identify an optimized lymphodenpletion (LD) regimen by evaluating standard and intermediate doses of Fludarabine (Flu) / Cyclophosphamide (Cy) with or without a fixed dose of total lymphoid irradiation (TLI) in the setting of standard of care CAR T cell therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: DLBCL - Diffuse Large B Cell Lymphoma
Albumin Utilization in Adult Cardiac Surgical Patients : a Multicentre Prospective Cohort Study
Recruiting
The goal of our proposed multicentre prospective cohort study is to characterize perioperative usage patterns of crystalloids and albumin, as well as key patient outcomes, in cardiac surgical patients. Results obtained from this observational study will be combined with the results of other studies to clarify the optimal role of albumin and other blood products in the perioperative management of cardiac surgical patients. This study will also address numerous other knowledge gaps in the area of... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
01/30/2025
Locations: Kingston Health Sciences Centre, Kingston, Ontario +1 locations
Conditions: Antithrombin III Levels, Albumin Levels
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Recruiting
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/30/2025
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Total Knee Anthroplasty, Osteoarthritis(primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host
Recruiting
By obtaining clinical specimens from participants with triple negative breast cancer (TNBC), colorectal cancer (CRC), high grade serous ovarian cancer (HGSOC), and other select tumor types to establish and profile as freshly implanted tumors in mice, the aim of this study is to identify agents with predicted activity in the host patient while also potentially providing them with personalized cancer treatment options
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2025
Locations: Princess Margaret Cancer Centre, Toronto, Ontario
Conditions: Colorectal Neoplasms, Colorectal Cancer, Breast Cancer, Breast Neoplasms, Ovarian Cancer, Ovarian Neoplasm
2221 - 2232 of 3904
