All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

NCT04031677

Recruiting

This is a multicenter, randomized, open label phase lll trial to assess whether preoperative chemotherapy, as an adjunct to curative-intent surgery, improves the prognosis of high risk DDLPS (dedifferentiated Liposarcoma) and LMS (Leiomyosarcoma) patients as measured by disease free survival. After confirmation of eligibility criteria, patients will be randomized to either the standard arm or experimental arm.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/30/2025

Locations: Mayo Clinic Hospital in Arizona, Phoenix, Arizona +148 locations

Mayo Clinic Hospital in Arizona, Phoenix, Arizona

City of Hope Comprehensive Cancer Center, Duarte, California

UC Irvine Health/Chao Family Comprehensive Ca Ctr, Orange, California

UCHealth University of Colorado Hospital, Aurora, Colorado

Smilow Cancer Hospital-Derby Care Center, Derby, Connecticut

Smilow Cancer Hospital Care Center-Fairfield, Fairfield, Connecticut

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury, Connecticut

Smilow Cancer Hospital Care Center at Greenwich, Greenwich, Connecticut

Smilow Cancer Hospital Care Center - Guiford, Guilford, Connecticut

Smilow Cancer Hospital Care Ctr at Saint Francis, Hartford, Connecticut

Yale University, New Haven, Connecticut

Yale-New Haven Hospital North Haven Medical Center, North Haven, Connecticut

Smilow Cancer Hospital Care Center at Long Ridge, Stamford, Connecticut

Smilow Cancer Hospital Care Center-Trumbull, Trumbull, Connecticut

Smilow Cancer Hospital-Waterbury Care Center, Waterbury, Connecticut

Smilow Cancer Hospital Care Center - Waterford, Waterford, Connecticut

Mayo Clinic in Florida, Jacksonville, Florida

Moffitt Cancer Center-International Plaza, Tampa, Florida

Moffitt Cancer Center - McKinley Campus, Tampa, Florida

Moffitt Cancer Center, Tampa, Florida

Emory University Hospital Midtown, Atlanta, Georgia

Northwestern University, Chicago, Illinois

University of Illinois at Chicago MBCCOP, Chicago, Illinois

Indiana Univ/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

University of Kansas Cancer Center, Kansas City, Kansas

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas

University of Kansas Hospital-Westwood Cancer Ctr, Westwood, Kansas

James Graham Brown Ca Ctr at Univ of Louisville, Louisville, Kentucky

LSU Health Baton Rouge-North Clinic, Baton Rouge, Louisiana

Our Lady of The Lake Hospital, Baton Rouge, Louisiana

Our Lady of the Lake Physician Group, Baton Rouge, Louisiana

Johns Hopkins Univ/Sidney Kimmel Cancer Center, Baltimore, Maryland

Dana-Farber/Harvard Cancer Center, Boston, Massachusetts

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota

Mayo Clinic, Rochester, Minnesota

Siteman Cancer Center-West County, Creve Coeur, Missouri

Washington University School of Medicine - Siteman Cancer Center, Saint Louis, Missouri

Siteman Cancer Center-South Country, Saint Louis, Missouri

Nebraska Medicine-Bellevue, Bellevue, Nebraska

Nebraska Medicine-Bellevue, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Dartmouth Hitchcock Med Ctr/Dartmouth Cancer Ctr, Lebanon, New Hampshire

HMH-Hackensack University Medical Center, Hackensack, New Jersey

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Roswell Park Cancer Institute, Buffalo, New York

NYU Langone Hospital - Long Island, Mineola, New York

Laura and Issac Perlmutter Ca Ctr at NYU Langone, New York, New York

University of Rochester, Rochester, New York

Stony Brook University Medical Center, Stony Brook, New York

Duke University Medical Center, Durham, North Carolina

Sanford Bismarck Medical Center, Bismarck, North Dakota

Sanford Broadway Medical Center, Fargo, North Dakota

Sanford Roger Maris Cancer Center, Fargo, North Dakota

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Oregon Health and Science University, Portland, Oregon

Saint Vincent Hospital, Erie, Pennsylvania

Jefferson Hospital, Jefferson Hills, Pennsylvania

Forbes Hospital, Monroeville, Pennsylvania

Allegheny Valley Hospital, Natrona Heights, Pennsylvania

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania

Pennsylvania Hospital, Philadelphia, Pennsylvania

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

Allegheny General Hospital, Pittsburgh, Pennsylvania

West Penn Hospital, Pittsburgh, Pennsylvania

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania

Wexford Health and Wellness Pavilion, Wexford, Pennsylvania

Rhode Island Hospital, Providence, Rhode Island

Smilow Cancer Hospital Care Center - Westerly, Westerly, Rhode Island

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

M D Anderson Cancer Center, Houston, Texas

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

VCU Massey Cancer Center at Hanover Medical Park, Mechanicsville, Virginia

VCU Massey Cancer Center at Stony Point, Richmond, Virginia

Virginia Commonwealth Univ/Massey Cancer Center, Richmond, Virginia

Carilion Roanoke Memorial Hospital, Roanoke, Virginia

VCU Community Memorial Health Center, South Hill, Virginia

FHCC South Lake Union, Seattle, Washington

Fred Hutchinson Cancer Center, Seattle, Washington

University of Washington Medical Center - Montlake, Seattle, Washington

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin

Marshfield Medical Center, Marshfield, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

Marshfield Medical Center, Minocqua, Wisconsin

Marshfield Medical Center, Rice Lake, Wisconsin

Marshfield Med Ctr-River Region at Stevens Point, Stevens Point, Wisconsin

Marshfield Medical Center, Weston, Wisconsin

Princess Alexandra Hospital - University Of Queensland, Woolloongabba, Queensland

Peter Maccallum Cancer Institute, Melbourne, Victoria

Chris O'Brian Life House - Chris O'Brien Lifehouse, Camperdown, Not set

BCCA - Vancouver Cancer Centre, Vancouver, British Columbia

London Regional Cancer Center, London, Ontario

The Ottawa Hospital - General Campus, Ottawa, Ontario

Hopital Maisonneuve Rosemont, Montréal, Quebec

The Research Institute of the McGill University Health Centre, Montréal, Quebec

Mount Sinai Hospital, Toronto, Not set

Bank Of Cyprus Oncology Centre, Stróvolos, Not set

Masaryk Memorial Cancer Institute, Brno, Not set

Herlev Hospital - University Copenhagen, Herlev, Copenhagen

Aarhus University Hospitals - Aarhus University Hospital-Skejby, Aarhus, Not set

Centre Leon Berard, Lyon, Not set

Institut du Cancer de Montpellier, Montpellier, Not set

Institut Curie- Hopital de Paris, Paris, Not set

Hopitaux Universitaires de Strasbourg - Hautepierre, Strasbourg, Not set

Institut Gustave Roussy, Villejuif, Not set

Universitaetsmedizin Goettingen - Georg-August Universitaet, Goettigen, Lower Saxony

Universitaetsklinikum Carl Gustav Carus, Dresden, Not set

UniversitaetsMedizin Mannheim, Mannheim, Not set

Centro Di Riferimento Oncologico, Aviano, Not set

IRCCS - Fondazione Piemonte Inst di Candiolo, Candiolo, Not set

IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Not set

Istituto Clinico Humanitas, Milano, Not set

Istituto Europeo di Oncologia, Milano, Not set

IRCCS - Istituto Nazionale dei Tumori, Milan, Not set

IRCCS - Istituto Oncologico Veneto, Padova, Not set

Policlinico Universitario Campus Bio-Medico- Oncology Center, Roma, Not set

Kyushu University Hospital, Higashi-ku, Fukuoka

Yokohama City University Hospital, Yokohama, Kanagawa

Kanagawa Cancer Center, Yokohama, Kanagawa

Tohoku University Hospital, Sendai, Miyagi

Aichi Cancer Center, Chikusa-ku, Nagoya

Nagoya University Hospital, Showa-ku, Nagoya

Niigata University Medical and Dental Hospital, Niigata City, Niigata

Okayama University Hospital, Kita-ku, Okayama

Osaka International Cancer Institute, Chuo-ku, Osaka

National Cancer Center Hospital, Chuo-ku, Tokyo

Cancer Institute Hospital of JFCR, Koto-ku, Tokyo

Saitama Medical Center, Jichi Medical University, Saitama, Not set

The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis, Amsterdam, Not set

Leiden University Medical Centre, Leiden, Not set

Radboudumc - Radboud University Medical Center Nijmegen, Nijmegen, Not set

Maria Sklodowska-Curie Memorial Cancer Centre - Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Not set

National Cancer Institute, Bratislava, Not set

Hospital De La Santa Creu I Sant Pau, Barcelona, Not set

Institut Catala d'Oncologia - ICO Badalona - Hospital Germans Trias i Pujol, Barcelona, Not set

Hospital General Universitario Gregorio Maranon, Madrid, Not set

Hospital Universitario San Carlos, Madrid, Not set

University Hospitals Birmingham - Queen Elisabeth Medical Centre, Birmingham, Not set

NHS Greater Glasgow and Clyde - Beatson West of Scotland Cancer Centre - Gartnavel General Hospital, Glasgow, Not set

Leeds Teaching Hospitals NHS Trust - St. James's University Hospital, Leeds, Not set

the Royal Marsden Hospital, London, Not set

Newcastle Hospitals - Freeman Hospital, Northern Centre For Cancer Care, Newcastle, Not set

Nottingham University Hospitals NHS Trust - City Hospital, Nottingham, Not set

Oxford University Hospitals NHS Trust - Churchill Hospital, Oxford, Not set

Clatterbridge cancer center, Wirral, Not set

Conditions: Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma

Learn More ›

Low-dose Naltrexone for Post-COVID Fatigue Syndrome

NCT05430152

Recruiting

This study aims to determine if low-dose naltrexone (LDN) reduces fatigue, improves related symptoms, and reduces inflammatory markers in peripheral blood in cases with Post-COVID-19 Fatigue Syndrome (PCFS) from COVID-19 (i.e. confirmed SARS-CoV-2 case). LDN refers to naltrexone given in doses of 1-4.5 mg. Overall, studies have found that LDN is safe and well-tolerated. It may help to reduce pain and inflammation and improve well-being and immune function.The trial will be conducted by the Compl... Read More

Gender:

ALL

Ages:

Between 19 years and 69 years

Trial Updated:

01/30/2025

Locations: Women's Health Research Institute, Vancouver, British Columbia

Conditions: Post-Viral Fatigue Syndrome

Learn More ›

Optimizing lymphoDepletion to Improve Outcomes In Patients Receiving Cell Therapy With Yescarta

NCT05950802

Recruiting

This is a Phase 1b study of participants with Diffuse Large B Cell Lymphoma (DLBCL). The purpose of this study is to identify an optimized lymphodenpletion (LD) regimen by evaluating standard and intermediate doses of Fludarabine (Flu) / Cyclophosphamide (Cy) with or without a fixed dose of total lymphoid irradiation (TLI) in the setting of standard of care CAR T cell therapy.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/30/2025

Locations: Princess Margaret Cancer Centre, Toronto, Ontario

Conditions: DLBCL - Diffuse Large B Cell Lymphoma

Learn More ›

Albumin Utilization in Adult Cardiac Surgical Patients : a Multicentre Prospective Cohort Study

NCT06395480

Recruiting

The goal of our proposed multicentre prospective cohort study is to characterize perioperative usage patterns of crystalloids and albumin, as well as key patient outcomes, in cardiac surgical patients. Results obtained from this observational study will be combined with the results of other studies to clarify the optimal role of albumin and other blood products in the perioperative management of cardiac surgical patients. This study will also address numerous other knowledge gaps in the area of... Read More

Gender:

ALL

Ages:

Between 18 years and 99 years

Trial Updated:

01/30/2025

Locations: Kingston Health Sciences Centre, Kingston, Ontario +1 locations

Conditions: Antithrombin III Levels, Albumin Levels

Learn More ›

COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty

NCT06809998

Recruiting

Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/30/2025

Locations: St. Michael's Hospital, Toronto, Ontario

Conditions: Total Knee Anthroplasty, Osteoarthritis(primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis

Learn More ›

Personalized Patient Derived Xenograft (pPDX) Modeling to Test Drug Response in Matching Host

NCT02732860

Recruiting

By obtaining clinical specimens from participants with triple negative breast cancer (TNBC), colorectal cancer (CRC), high grade serous ovarian cancer (HGSOC), and other select tumor types to establish and profile as freshly implanted tumors in mice, the aim of this study is to identify agents with predicted activity in the host patient while also potentially providing them with personalized cancer treatment options

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/29/2025

Locations: Princess Margaret Cancer Centre, Toronto, Ontario

Conditions: Colorectal Neoplasms, Colorectal Cancer, Breast Cancer, Breast Neoplasms, Ovarian Cancer, Ovarian Neoplasm

Learn More ›

A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients

NCT03127631

Recruiting

RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.

Gender:

MALE

Ages:

45 years and above

Trial Updated:

01/29/2025

Locations: Georgia Cancer Center at Augusta University, Augusta, Georgia +53 locations

Georgia Cancer Center at Augusta University, Augusta, Georgia

University of Kansas Medical Center, Kansas City, Kansas

Westmead Hospital, Westmead, New South Wales

Royal Adelaide Hospital, Adelaide, South Australia

Flinders Medical Center, Adelaide, South Australia

Centro de Pesquisa Clínica do Brasil, Brasilia, DF

Hospital Felício Rocho, Belo Horizonte, Minas Gerais

Universidade Federal do Triângulo Mineiro, Uberaba, Minas Gerais

Sociedade Hospitalar Angelina Caron, Campina Grande Do Sul, Paraná

Nucleo de Pesquisa Clinica Hospital do Rocio, Campo Largo, Paraná

Centro Médico São Francisco, Curitiba, Paraná

Instituto De Medicina Integral Prof. Fernando Figueira - IMIP, Recife, Pernambuco

Hospital de Caridade de Ijuí, Ijuí, Rio Grande do Sul

Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul

Irmandade Da Santa Casa De Misericórdia De Porto Alegre, Porto Alegre, Rio Grande do Sul

Hospital Mae de Deus, Porto Alegre, Rio Grande Do Sul

Hospital Municipal de Barueri, Barueri, Sao Paulo

Faculdade de Medicina da Universidade Estadual Paulista - Campus de Botucatu - UNESP, Botucatu, São Paulo

Hospital Universitário São Francisco na Providência de Deus, Bragança Paulista, São Paulo

Fundacao Doutor Amaral Carvalho, Jaú, São Paulo

Fundação Faculdade Regional de Medicina de São José do Rio Preto, São José Do Rio Preto, São Paulo

Integral Pesquisa e Ensino, Votuporanga, São Paulo

Instituto Nacional de Cardiologia, Rio De Janeiro, Not set

Santa Casa de São Paulo (IPITEC), São Paulo, Not set

Hospital Alemao Oswaldo Cruz, São Paulo, Not set

Beneficência Nipo-Brasileira de São Paulo. Hospital Nipo-Brasileiro, São Paulo, Not set

Marina Leonardo, São Paulo, Not set

Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and Fundação Zerbini (Incor), São Paulo, Not set

Hospital Santa Marcelina, São Paulo, Not set

Instituto D'Or de Pesquisa e Ensino, São Paulo, Not set

Vancouver General Hospital, Vancouver, British Columbia

St. Joseph's Healthcare, Hamilton, Ontario

Juravinski Cancer Centre, Hamilton, Ontario

Queen's University, Kingston, Ontario

Grand River Hospital, Grand River Regional Cancer Centre, Kitchener, Ontario

London Health Sciences Centre, London, Ontario

London Health Sciences, Victoria Hospital, London, Ontario

Niagara Health, St. Catharines Site, Niagara, Ontario

Ottawa Hospital Research Institute, Ottawa, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario

University Hospital of Montreal, Montreal, Quebec

Jewish General Hospital, Montreal, Quebec

Hopital Maisonneuve-Rosemont, Montréal, Quebec

McGill University, Montréal, Quebec

Laval University, Quebec City, Quebec

Centre Universitaire de Sherbrooke, Sherbrooke, Quebec

Hospital Universitario San Ignacio, Bogotá, Cundinamarca

FOSCAL, Floridablanca, Santander

Fundacio Valle de Lili, Cali, Valle del Cauca

Heart Institute - Holon Medical Center, Holon, Not set

Rabin Medical Center, Petach Tikva, Not set

Tel-Aviv Sourasky Medical Centre, Tel Aviv, Not set

Istanbul University, Istanbul, Not set

Conditions: Prostate Cancer, Cardiovascular Disease

Learn More ›

Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation

NCT03433274

Recruiting

Prospective, controlled, multicenter clinical investigation with four trial cohorts: Randomized, Non-repairable, Severe Mitral Annular Calcification (MAC) and Severe Mitral Annular Calcification Continued Access Protocol (MAC CAP). Subjects in the Randomized cohort will be randomized in a 1:1 ratio to the trial device or to the MitraClip system. Subjects in the Non-repairable, Severe MAC, and Severe MAC CAP cohorts will receive the trial device. The objective of the Clinical Trial to Evaluate t... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/29/2025

Locations: Princeton Baptist Medical Center, Birmingham, Alabama +79 locations

Princeton Baptist Medical Center, Birmingham, Alabama

UAB University Hospital, Birmingham, Alabama

Banner-University Medical Center, Phoenix, Arizona

HonorHealth Scottsdale Shea Medical Center, Scottsdale, Arizona

Baptist Health Medical Center, Little Rock, Arkansas

Fresno Heart Hospital, Fresno, California

University of Southern California University Hospital, Los Angeles, California

Cedars-Sinai Medical Center, Los Angeles, California

Sutter Medical Center, Sacramento, Sacramento, California

University of California - Davis Medical Center, Sacramento, California

San Diego Cardiac Center, San Diego, California

University of California at San Francisco, San Francisco, California

Stanford Health Care, Stanford, California

Los Robles Hospital and Medical Center, Thousand Oaks, California

University of Colorado Hospital, Aurora, Colorado

Manatee Memorial Hospital, Bradenton, Florida

Morton Plant Hospital, Clearwater, Florida

Delray Medical Center, Delray Beach, Florida

North Florida Regional Medical Center, Gainesville, Florida

Shands at the University of Florida, Gainesville, Florida

Baptist Hospital of Miami, Miami, Florida

Tallahassee Research Institute, Tallahassee, Florida

Cleveland Clinic Florida, Weston, Florida

Piedmont Heart Institute, Atlanta, Georgia

Emory University Hospital, Atlanta, Georgia

Wellstar Kennestone Hospital, Marietta, Georgia

St. Alphonsus Regional Medical Center, Boise, Idaho

Rush University Medical Center, Chicago, Illinois

Advocate Christ Medical Center, Oak Lawn, Illinois

Prairie Education & Research Cooperative, Springfield, Illinois

St. Vincent Hospital, Indianapolis, Indiana

Cardiovascular Research Institute of Kansas, Wichita, Kansas

MedStar Health Research Institute, Balitmore, Maryland

University of Maryland Medical Center, Baltimore, Maryland

Adventist HealthCare White Oak Medical Center, Silver Spring, Maryland

Beth Israel Deaconess Medical Center, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Henry Ford Hospital, Detroit, Michigan

Beaumont Hospital, Royal Oak, Michigan

Abbott Northwestern Hospital, Minneapolis, Minnesota

Mayo Clinic, Rochester, Minnesota

St. Luke's Hospital, Kansas City, Missouri

St. Louis University Hospital, Saint Louis, Missouri

The International Heart Institute of Montana, Missoula, Montana

Catholic Medical Center, Manchester, New Hampshire

Hackensack University Medical Center, Hackensack, New Jersey

Robert Wood Johnson University Hospital, New Brunswick, New Jersey

Newark Beth Israel Medical Center, Newark, New Jersey

Albany Medical College at Albany Medical Center, Albany, New York

South Shore University Hospital, Bay Shore, New York

Buffalo General Hospital, Buffalo, New York

New York Presbyterian Hospital/ Weill Cornell Medical Center, New York, New York

Lenox Hill Hospital, New York, New York

Mission Health & Hospitals, Asheville, North Carolina

Carolinas Medical Center, Charlotte, North Carolina

Novant Health Heart and Vascular Research Institute, Charlotte, North Carolina

University of Cincinnati Medical Center, Cincinnati, Ohio

The Cleveland Clinic Foundation, Cleveland, Ohio

Oklahoma Heart Institute at Utica, Tulsa, Oklahoma

Providence Heart & Vascular Institute, Portland, Oregon

Allegheny General Hospital - ASRI, Pittsburgh, Pennsylvania

UPMC Shadyside, Pittsburgh, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Baptist Memorial Hospital, Memphis, Tennessee

Centennial Medical Center, Nashville, Tennessee

St. Thomas Hospital, Nashville, Tennessee

Cardiothoracic & Vascular Surgeons, Austin, Texas

Baylor Scott & White Heart and Vascular Hospital, Dallas, Texas

Medical City Dallas Hospital, Dallas, Texas

Memorial Hermann Hospital, Houston, Texas

University of Virginia Medical Center, Charlottesville, Virginia

Inova Fairfax Hospital, Falls Church, Virginia

Swedish Medical Center - Heart & Vascular, Seattle, Washington

West Virginia University Hospital, Morgantown, West Virginia

Medical College of Wisconsin, Milwaukee, Wisconsin

Ottawa Heart Institute, Ottawa, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

St. Michael's Hospital, Toronto, Ontario

The Royal Victoria Hospital, Montreal, Quebec

Institut de Cardiologie de Montreal (Montreal Heart Institute), Montréal, Quebec

Conditions: Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease

Learn More ›

RESTORE - Study of AGN1 LOEP to Prevent Secondary Hip Fractures

NCT04796350

Recruiting

A randomized controlled trial to evaluate AGN1 to prevent secondary hip fractures in osteoporotic women undergoing treatment of index hip fractures. Up to 2400 subjects will be randomized between a treatment group and a control group. Subjects will be followed for a minimum of 5 years after undergoing hip fracture repair surgery.

Gender:

FEMALE

Ages:

65 years and above

Trial Updated:

01/29/2025

Locations: Innsbruck Hospital, Innsbruck, Not set +53 locations

Innsbruck Hospital, Innsbruck, Not set

Health Sciences Centre - Eastern Health, Saint John's, Newfoundland and Labrador

Aarhus University Hospital, Aarhus, Not set

CHU Grenoble-Alpes, Grenoble, Not set

CHU Lyon, Lyon, Not set

CHU Toulouse, Toulouse, Not set

University Hospital of Duesseldorf, Düsseldorf, Not set

Justus Liebig Universitat Gießen, Gießen, Not set

Medizinische Hochschule Hannover, Hannover, Not set

Universitatsklinikum Schleswig-Holstein, Kiel, Not set

Klinikum der Universität München, München, Not set

University Hospital of Münster, Münster, Not set

Universitätsklinikum Regensburg, Regensburg, Not set

BG Klinik Tuebingen, Tuebingen, Not set

Helios Wuppertal, Wuppertal, Not set

Azienda Ospedaliero Universitaria Careggi, Firenze, Not set

ASST Gaetano Pini CTO, Milano, Not set

University Hospital San Raffaele Milano, Milano, Not set

Policlinico Tor Vergata, Rome, Not set

CTO Torino, Torino, Not set

Akita City Hospital, Akita-shi, Akita

Southern Tohoku General Hospital, Kōriyama, Fukushima

Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo

Kagawa Rosai Hospital, Marugame, Kagawa

Kanto Rosai Hospital, Kawasaki City, Kanagawa

Shin-yurigaoka General Hospital, Kawasaki-Shi, Kanagawa

Chikamori Hospital, Kouchi City, Kochi

Okayama Medical Center, Okayama City, Okayama

Jutendo University Shizuoka Hospital, Izunokuni City, Shizuoka

The University of Tokyo Hospital, Bunkyō-Ku, Tokyo

St. Mary's Hospital, Fukuoka, Not set

Iwata City Hospital, Iwata, Not set

Shin-Yurigaoka General Hospital, Kawasaki-shi, Not set

National Hospital Organization Kumamoto Medical Center, Kumamoto, Not set

Saga-Ken Medical Centre Koseikan, Saga, Not set

Japanese Red Cross Shizuoka Hospital, Shizuoka, Not set

Deventer Hospital, Deventer, Not set

Saint Anna Ziekenhuis, Geldrop, Not set

Maastricht UMC, Maastricht, Not set

Isala Hospital, Zwolle, Not set

Vall d'Hebron University Hospital, Barcelona, Not set

Clinic de Barcelona, Barcelona, Not set

Hospital Universitario de Basurto, Bilbao, Not set

Galdakao-Usansolo Hospital, Galdakao, Not set

Hospital Neuro-Traumatológico de Jaén, Jaén, Not set

Hospital Clínico San Carlos, Madrid, Not set

Hospital Universitario 12 de Octubre, Madrid, Not set

PARC Tauli, Sabadell, Not set

Mutua de Terrassa University Hospital, Terrassa, Not set

Valladolid University Clinic Hospital, Valladolid, Not set

Birmingham Heartlands Hospital, Birmingham, England

Leicester Royal Infirmary, Leicester, England

Royal Infirmary of Edinburgh, Edinburgh, Scotland

Nottingham University Hospitals, Queen's Medical Center, Nottingham, Not set

Conditions: Fragility Fracture, Hip Fractures, Osteoporosis

Learn More ›

Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study

NCT04962672

Recruiting

Cancer is a leading cause of death worldwide. It is estimated that approximately 55,000 Canadians are surviving with brain tumors. It is projected that around 3000 persons will be diagnosed with brain and spinal cord tumors, and approximately 75 percent patients will not survive. Out of all brain cancers, high-grade gliomas \[Glioblastoma Multiforme (GBM)\] impose highest morbidity and mortality. Therefore, it is important to explore ways in which Investigators can improve and prolong the lives of patients suffering from brain cancers, particularly high-grade glioma, which is the most common and aggressive primary brain tumor. So far the Investigators know that the surgery, chemotherapy and radiotherapy are the three corner stones management options for these patients, and majority of the research have been conducted on these three major domains. Therefore, it is imperative to explore the other variables those may impact survival characteristics. One of the integral variables of the brain cancer surgery is anesthesia. Interestingly, the role of anesthetics was explored in some other non-brain solid organ tumor surgeries. It is observed that out of the two main types of anesthesia \[one is through intravenous (propofol) and other one is gaseous (sevoflurane)\], intravenous based anesthesia maintenance regime may delay the cancer progression and prolong the recurrence free period. In addition, two very large retrospective studies with approximately 11,000 and 18,000 patients respectively, showed that as compared to gaseous (volatile anesthetics) based, intravenous (propofol) based anesthesia conferred some protection against cancer progression and was also associated with lesser overall mortality. The exact nature of these protective mechanisms is not known but in animal and other laboratory-based experiments, propofol seems to inhibit cancer formation steps, delays inflammation and provide protection from cancer cell growth. This is a feasibility study for knowing various aspects of workflow; recruitment characteristics of participants and various obstacles in implying anesthesia based protocols so that the Investigators can conduct a well-designed multicenter international randomized study. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/29/2025

Locations: Toronto Western Hospital/UHN, Toronto, Ontario

Conditions: Anesthesia, Brain Cancer, Survival

Learn More ›

The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients

NCT05938712

Recruiting

The study aims to determine the short-term efficacy, mechanisms and safety of 12 weeks of dapagliflozin and semaglutide combination therapy in 20 KTR, with and without T2D.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/29/2025

Locations: Toronto General Hospital, Toronto, Ontario

Conditions: Kidney Transplant Recipients

Learn More ›

Minimally Displaced Femoral Neck Fracture Pilot Study

NCT05947058

Recruiting

The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial. Adult patients ages 60 years or older with a low-energy minimally displaced femoral neck fracture (FNF) treated with surgery will be eligible to participate in the study. Patients will be randomized to one of two treatment groups, hip arthroplasty or internal fixation. Participants will be followed for 1 year.

Gender:

ALL

Ages:

60 years and above

Trial Updated:

01/29/2025

Locations: University of Southern California, Los Angeles, California +10 locations

Conditions: Femoral Neck Fractures

Learn More ›