Nonmyeloablative Stem Cell Transplant in Children with Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor
NCT03214354
Recruiting
The aim of this study to evaluate the safety and efficacy of a nonmyeloablative conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in pediatric patients with sickle cell disease (SCD) who have a matched related major ABO-incompatible donor. The nonmyeloablative regimen will use alemtuzumab, total body irradiation (TBI) and sirolimus for immune suppression. This study will expand the access of HSCT for patients with SCD who are currently not eligible because of don... Read More
Gender:
ALL
Ages:
Between 1 year and 19 years
Trial Updated:
12/05/2024
Locations: Alberta Children's Hospital, Calgary, Alberta
Conditions: Sickle Cell Disease, Stem Cell Transplant Complications, Red Blood Cell Disorder, Pure Red Cell Aplasia
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Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI
NCT04007380
Recruiting
This clinical trial will examine the efficacy of continuous positive airway pressure (CPAP) therapy in improving psychosocial, neurocognitive and behavioral consequences of moderate-to-severe sleep-related breathing disorders (SRBDs) in people living with spinal cord injury (SCI).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Lyndhurst Centre, KITE - TRI UHN, Toronto, Ontario
Conditions: Spinal Cord Injuries, Sleep Apnea
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Stroke Thrombectomy and Aneurysm Registry
NCT04994756
Recruiting
This international multi-center registry is used to collect existing information and outcomes for patients undergoing an operation for treatment of injuries to the brain including the blockage of blood flow to an area of the brain, an abnormal ballooning of an artery, abnormal tangling of blood vessels, abnormal formation of blood vessels, tearing of vein, and bleeding in the brain. This information is used to help predict outcomes that undergo an operation for treatment of the above-listed brai... Read More
Gender:
ALL
Ages:
Between 1 year and 120 years
Trial Updated:
12/05/2024
Locations: University of Arizona, Tucson, Arizona +62 locations
Conditions: Stroke, Thromboses, Intracranial, Aneurysm, Brain
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Effect of Colchicine on the Progression of Aortic Valve Stenosis - a Pilot Study
NCT05253794
Recruiting
COPAS pilot is a pilot single center double blinded randomized study to determine the effect of targeted anti-inflammation therapy using colchicine, on valvular calcification activity using imaging, i.e. aortic valvular NaF uptake. The current proposal uses a randomized design to evaluate the effect of colchicine vs. placebo on valvular calcification activity over 6 months measured using NaF PET
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: Aortic Stenosis, Inflammation
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Hypercapnia in Orthostatic Hypotension
NCT05295810
Recruiting
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow. Neurogenic Orthostatic Hypotension (NOH) occurs when our "fight-or-flight" part ("sympathetic") of the ANS fails. BP can drop a lot when upright, reducing blood flow and oxygen delivery to the brain, and this can cause symptoms of light... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
12/05/2024
Locations: University of Calgary, Calgary, Alberta
Conditions: Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
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Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in Clinical Trials
NCT05335876
Recruiting
This is a global, prospective, multi-center study that is designed to assess the long-term safety and efficacy of OAV101 in patients who participated in an OAV101 clinical trial. The assessments of safety and efficacy in Study COAV101A12308 will continue for 5 years after enrollment in this study.
Gender:
ALL
Ages:
Between 0 years and 100 years
Trial Updated:
12/05/2024
Locations: Child Hosp Of The Kings Daughters, Norfolk, Virginia +28 locations
Conditions: Spinal Muscular Atrophy (SMA)
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Canagliflozin Targeting Vascular Inflammation
NCT05427084
Recruiting
CANTOR SING is a pilot single center double blinded randomized study. The investigators will compare the effect of canagliflozin (300 mg daily - intervention arm) vs. placebo (control group) on the FDG aortic uptake in patients with stable CAD (over 60 days post-myocardial infarction) after a 6-month period of treatment. The investigators plan to enroll 8 patients in each arm (total sample size: 16 patients). Primary endpoint is the change in FDG aortic uptake between baseline and 6 months in ea... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: Diabetes Type 2, Coronary Artery Disease
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Outcomes Post Treatment: Impact on Motor Impairment of Sleep Efficiency in SCI (OPTIMISE SCI Trial)
NCT05473689
Recruiting
This randomized clinical trial will compare three groups of individuals with cervical/thoracic, complete or incomplete spinal cord injury (SCI) that will undergo: (i) early CPAP therapy in the management of moderate-to-severe sleep-related breathing disorders (SRBDs) among adults at 6 weeks after SCI; (ii) delayed CPAP therapy in the management of moderate-to-severe SRBDs among adults at 22 weeks after SCI; and (iii) no treatment as they either have mild or no SRBD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: KITE Toronto Research Institute, Toronto, Ontario
Conditions: Spinal Cord Injuries, Spine Disease
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Effectiveness of Digital Cognitive Behavioral Therapy for Insomnia in Frontline Health Care Workers (The HCW-CBTi Study)
NCT05816304
Recruiting
The COVID-19 pandemic has resulted in increased workload and concerns about personal and family safety for frontline healthcare workers (HCWs), which can lead to decreased well-being and worsening mental health. Sleep disruption is particularly prevalent among HCWs providing frontline COVID-19 care. It can have direct consequences on their cognitive and emotional functioning, as well as on patient safety. Cognitive Behavioral Therapy for insomnia (CBTi) is a first-line treatment for insomnia. It... Read More
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2024
Locations: Toronto Western Hospital - UHN, Toronto, Ontario +1 locations
Conditions: Insomnia, Post Traumatic Stress Disorder, Anxiety Disorders, Depression
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The TELENEO Trial: a Multicenter Trial of Telemedicine for Advanced Neonatal Resuscitations in Community Hospitals
NCT06087224
Recruiting
The purpose of this study is to evaluate the impact of real-time audio-video telemedicine consults with a neonatologist (termed teleneonatology) on the early health outcomes of at-risk neonates delivered in community hospitals.
Gender:
ALL
Ages:
0 days and above
Trial Updated:
12/05/2024
Locations: Bartlett Regional Hospital, Juneau, Alaska +33 locations
Conditions: Death; Neonatal, Morbidity;Newborn
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Study of Safety and Efficacy of RGT-61159 in Adults with Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC)
NCT06462183
Recruiting
Phase 1 study to evaluate safety, tolerability and anti-tumor activity of RGT-61159 in patients with ACC or CRC
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Dana-Farber Cancer Institute, Boston, Massachusetts +9 locations
Conditions: Adenoid Cystic Carcinoma, Colorectal Cancer
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COgnitive-somatoSensory-MOtor Training to Improve Arm and Hand Function After Stroke (iCOSMO)
NCT06498011
Recruiting
The iCOSMO study investigates the feasibility and beneficial effects of an intervention combining sensation, motor and cognition to improve arm and hand function after chronic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Toronto Rehabilitation Institute, Toronto, Ontario
Conditions: Stroke, CVA, Cerebrovascular Accident
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