All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Patient Reported Experiences and Outcomes Associated with Standard C-Section Wound Closure Versus STRATAFIX/DERMABOND PRINEO Wound Closure (CS-PREO)

NCT06614829

Recruiting

The aim of the study is to compare outcomes between patients receiving standard C-section wound closure compared to a wound closure bundle that includes Stratafix sutures and Dermabond PRINEO.

Gender:

FEMALE

Ages:

18 years and above

Trial Updated:

11/26/2024

Locations: North York General Hospital, North York, Ontario

Conditions: Cesarean Section; Complications, Wound, Infection (Following Delivery)

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NSCLC Liquid Biopsies and Exhaled VOC

NCT06707519

Recruiting

The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for detecting mutations in extracted cell-free DNA in non-small cell lung cancer (NSCLC) patients, before and after surgery, and any recurrence within a 24-month postoperative follow-up period. This is a pilot feasibility study, proposed as a 24-month prospective, single-cente... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

11/26/2024

Locations: St. Joseph's Healthcare Hamilton, Hamilton, Ontario

Conditions: Lung Cancer, Circulating Tumor DNA

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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

NCT03860883

Recruiting

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

11/25/2024

Locations: University of South Alabama Mitchell Cancer Institute, Mobile, Alabama +191 locations

University of South Alabama Mitchell Cancer Institute, Mobile, Alabama

Banner MD Anderson Cancer Center, Gilbert, Arizona

Mayo Clinic Phoenix, Phoenix, Arizona

University of Arkansas for Medical Sciences, Little Rock, Arkansas

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California

Los Angeles General Medical Center, Los Angeles, California

USC Norris Comprehensive Cancer Center, Los Angeles, California

The Angeles (Cedars-Sinai Medical Center and its Affiliates), Los Angeles, California

UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange, California

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Orange, California

Stanford Cancer Institute, Palo Alto, California

Huntington Memorial Hospital, Pasadena, California

Stanford Cancer Center South Bay, San Jose, California

Kaiser Permanente - Vallejo Medical Center, Vallejo, California

Kaiser Permanente - Walnut Creek Medical Center, Walnut Creek, California

Smilow Hospital Care Center, Guilford, Guilford, Connecticut

Yale University, New Haven, Connecticut

MedStar Georgetown University Hospital, Washington, District of Columbia

MedStar Washington Hospital Center, Washington, District of Columbia

University of Miami Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida

University of Miami Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables, Florida

University of Miami Sylvester Cancer Center at Coral Springs, Coral Springs, Florida

University of Miami Sylvester Comprehensive Center at Deerfield Beach, Deerfield Beach, Florida

University of Miami Sylvester Comprehensive Center at Hollywood, Hollywood, Florida

Baptist MD Anderson Cancer Center, Jacksonville, Florida

Mayo Clinic in Florida, Jacksonville, Florida

Lakeland Regional Health Hollis Cancer Center, Lakeland, Florida

University of Miami Miller School of Medicine-Sylvester Cancer Centre, Miami, Florida

University of Miami Comprehensive Cancer Center at Kendall, Miami, Florida

University of Miami Comprehensive Cancer Center at Plantation, Plantation, Florida

Moffitt Cancer Center - McKinley Campus, Tampa, Florida

Moffitt Cancer Center, Magnolia Campus, Tampa, Florida

Emory University Hospital Midtown, Atlanta, Georgia

Emory University, Atlanta, Georgia

Emory Saint Joseph's Hospital, Atlanta, Georgia

Northside Hospital Atlanta, Atlanta, Georgia

Northside Hospital Cancer Institute, Atlanta, Georgia

Nancy N and JC Lewis Cancer & Research Pavilion St. Joseph's/Candler, Savannah, Georgia

Advocate Illinois Masonic Medical Center, Chicago, Illinois

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois

Northwestern University, Evanston, Illinois

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois

Northwestern Medicine Cancer Center Lake Forest Hospital, Lake Forest, Illinois

Advocate Lutheran General Hospital, Park Ridge, Illinois

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois

Indiana University - Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, Indiana

Franciscan Health Indianapolis, Indianapolis, Indiana

University of Kansas Hospital - Indian Creek Campus, Overland Park, Kansas

University of Kansas Hospital- Westwood Cancer Center, Westwood, Kansas

University of Kentucky, Lexington, Kentucky

MedStar Franklin Square Medical Center, Baltimore, Maryland

University of Michigan Medical Center, Ann Arbor, Michigan

University of Michigan - Brighton Center for Specialty Care, Brighton, Michigan

Mercy Health Saint Mary's, Grand Rapids, Michigan

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan

West Michigan Cancer Centre, Kalamazoo, Michigan

Siteman Cancer Centre, Barnes Jewish West County, Creve Coeur, Missouri

University of Kansas Cancer Center, Kansas City, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Cox South Hospital, Springfield, Missouri

Nebraska Medicine - Bellevue, Bellevue, Nebraska

Nebraska Medicine-Village Pointe, Omaha, Nebraska

University of Nebraska Medicine, Omaha, Nebraska

Cooperman Barnabas Medical Center, Livingston, New Jersey

Rutgers Cancer Institute of New Jersey, Piscataway, New Jersey

Lovelace Medical Centre-Saint Joseph Square, Albuquerque, New Mexico

Lovelace Women's Hospital, Albuquerque, New Mexico

Northwell Health Imbert Cancer Center, Bay Shore, New York

Roswell Park Cancer Institute, Buffalo, New York

Northwell Health/Center for Advanced Medicine, Lake Success, New York

NYU Langone Medical Center (Winthrop Hospital), Mineola, New York

Northern Westchester Hospital, Mount Kisco, New York

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Vassar Brothers Medical Center, Poughkeepsie, New York

University of Rochester, Rochester, New York

Phelps Memorial Hospital Center, Sleepy Hollow, New York

State University of New York Upstate Medical University, Syracuse, New York

State University of New York Upstate Medical Center-Community Campus, Syracuse, New York

Wilmont Cancer Institute at Webster, Webster, New York

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Duke University Medical Center, Durham, North Carolina

East Carolina University, Greenville, North Carolina

University of North Carolina Hospitals - Hillsborough Campus, Hillsborough, North Carolina

Sanford Broadway Medical Centre, Fargo, North Dakota

Sanford Roger Maris Cancer Centre, Fargo, North Dakota

University Hospitals Avon Health Center, Avon, Ohio

Miami Valley Hospital South, Centerville, Ohio

University Hospitals Geauga Medical Center, Chardon, Ohio

University of Cincinnati, Cincinnati, Ohio

University Hospitals Cleveland Medical Centre, Cleveland, Ohio

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

University Hospitals Chagrin Highlands Medical Centre, Orange Village, Ohio

West Chester Hospital (OH394), West Chester, Ohio

University Hospitals St. John Medical Center, Westlake, Ohio

OUHSC Stephenson Cancer Center, Oklahoma City, Oklahoma

Mercy Health Center - Oncology Hematology, Oklahoma City, Oklahoma

Kaiser Sunnyside Medical Center, Clackamas, Oregon

Kaiser Permanente Northwest - Oncology Clinic, Portland, Oregon

St. Luke's University Health Network - Allentown Cancer Center, Allentown, Pennsylvania

St Luke's University Health Network, Bethlehem Campus, Bethlehem, Pennsylvania

St Luke's University Health Network, Anderson Campus, Easton, Pennsylvania

Fox Chase Cancer Center, Philadelphia, Pennsylvania

St Luke's University Health Network Quakertown Campus, Quakertown, Pennsylvania

St. Luke's University Health Network - Upper Bucks, Quakertown, Pennsylvania

Guthrie Medical Group PC-Robert Packer Hospital, Sayre, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Sanford Cancer Center Oncology Clinic, Sioux Falls, South Dakota

Sanford USD Medical Center - Sioux Falls, Sioux Falls, South Dakota

The University of Texas MD Anderson Cancer Center, Houston, Texas

University of Texas Health Science Center at San Antonio, San Antonio, Texas

Intermountain Medical Center, Murray, Utah

Huntsman Cancer Institute (The University of Utah), Salt Lake City, Utah

University of Vermont Medical Center, Burlington, Vermont

University of Vermount and Sate Agricultural College, Burlington, Vermont

University of Virginia Health System, Charlottesville, Virginia

VCU Massey Cancer Center Peninsula Cancer Institute, Newport News, Virginia

VCU Massey Cancer Center, Richmond, Virginia

Carilion Roanoke Memorial Hospital, Roanoke, Virginia

VCU Massey Cancer Center Affiliate Valley Health, Winchester, Virginia

University of Winsconsin Carbone Cancer Center-Eastpark medical Center, Madison, Wisconsin

University of Wisconsin Carbone Cancer Center, Madison, Wisconsin

Marshfield Medical Center - Marshfield, Marshfield, Wisconsin

Aurora St Luke's Medical Center, Milwaukee, Wisconsin

Medical College of Wisconsin, Milwaukee, Wisconsin

Marshfield Medical Center- Weston, Weston, Wisconsin

Calvary Public Hospital Bruce, Bruce, Australian Capital Territory

The Canberra Hospital, Garran, Australian Capital Territory

Westmead Hospital, Sydney, New South Wales

Melanoma Institute Australia, Sydney, New South Wales

Royal Prince Alfred Hospital, Sydney, New South Wales

Princess Alexandra Hospital, Brisbane, Queensland

Robina Hospital, Gold Coast, Queensland

Royal Adelaide Hospital, Adelaide, South Australia

Peter MacCallum Cancer Centre, Melbourne, Victoria

The Alfred Hospital, Melbourne, Victoria

Tom Baker Cancer Centre, Calgary, Alberta

BCCA - Cancer Centre for the Southern Interior, Kelowna, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Royal Victoria Regional Health Centre, Barrie, Ontario

Hamilton Health Sciences Centre, Hamilton, Ontario

Oak Valley Health, Markham, Ontario

Ottawa Hospital Research Institute, Ottawa, Ontario

Sunnybrook Health Sciences Centre, Toronto, Ontario

UHN - Princess Margaret Cancer Centre, Toronto, Ontario

Hopital Maisonneuve-Rosemont, Montreal, Quebec

Centre Hospitalier de l'Universite de Montreal (CHUM), Montréal, Quebec

Hotel-Dieu de Quebec, Québec City, Quebec

Cork University Hospital, Cork, Not set

Mater Misericordiae University Hospital, Dublin, Not set

St James Hospital, Dublin, Not set

IOV Istituto Oncologico Veneto IRCCS-Padova, Padova, Not set

Fondazione IRCCS Policlinico San Matteo, Pavia, Not set

AOU Città della Salute e della Scienza di Torino, Torino, Not set

Flevo Hospital, Almere, Flevoland

Ziekenhuis Gelderse Vallei, Ede, Gelderland

Gelre Hospital, Zutphen, Gelderland

Maxima Medical Centre, Eindhoven, Eindhoven, Noord-Brabant

University Medical Centre Groningen, Groningen, Not set

Zuyderland Medical Center, Heerlen, Not set

Maastricht University Medical Center, Maastricht, Not set

Diakonessenhuis, Utrecht, Not set

Maxima Medical Center - Veldhoven, Veldhoven, Not set

Isala Hospital, Zwolle, Not set

North Shore Hospital, Auckland, Not set

Institute of Oncology Ljubljana, Ljubljana, Not set

Sahlgrenska University Hospital, Gothenburg, Not set

Central Hospital Kristianstad, Kristianstad, Not set

University Hospitals Birmingham NHS Foundation Trust, Edgbaston, Birmingham

Royal Cornwall Hospital NHS Trust, Truro, Cornwall

Hull University Teaching Hospitals NHS Trust, Hull, East Yorkshire

MID & South Essex NHS Foundation Trust, Westcliff on Sea, Essex

Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Lancashire

Oxford University Hospitals NHS Foundation Trust, Headington, Oxford

Imperial College Healthcare NHS Trust, London, The Bays

Queen Victoria Hospital NHS Foundation Trust, East Grinstead, West Sussex

North Bristol NHS Trust, Bristol, Not set

Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set

The Leeds Teaching Hospitals NHS Trust, Leeds, Not set

St. Helens & Knowsley Teaching Hospitals NHS Trust, Liverpool, Not set

The Royal Marsden Hospital NHS Foundation Trust, London,, Not set

Royal Free London NHS Foundation Trust, London, Not set

Guy's and St Thomas's NHS Foundation Trust, of St Thomas' Hospital, London, Not set

St George's University Hospitals NHS Foundation Trust, London, Not set

The Christie NHS Foundation Trust, Manchester, Not set

South Tees Hospitals NHS Foundation Trust of The James Cook University Hospital, Middlesbrough, Not set

Norfolk and Norwich University Hospital NHS Trust, Norwich, Not set

Nottingham University Hospitals, NHS Trust, Trust HQ, City Hospital, Nottingham, Not set

Conditions: Cutaneous Melanoma, Stage II

Learn More ›

Mindfulness-Based Interventions for OCD

NCT04914923

Recruiting

Obsessive-compulsive disorder (OCD) is a severe and debilitating anxiety disorder afflicting about 2% of the population. It is characterized by the presence of recurrent obsessions and/or compulsions that are time consuming and cause marked distress and/or impairment. Untreated, OCD runs a chronic and deteriorating course. According to the World Health Organization, OCD is among the top 10 leading causes of disability worldwide. Examination of non-medicinal treatments for OCD has focused on two distinct treatments: exposure and response prevention (ERP) and cognitive therapy (CT), often combined into an integrated cognitive-behavioural treatment (CBT). CBT is considered the first line psychological treatment for OCD, with estimates of response rates of between 70-80%. However, there are a significant number of treatment non-responders and the majority of responders are still left with impairing residual symptoms. One area of investigation that has shown potential benefit for general mood and anxiety disorders has been mindfulness-based interventions (MBIs), yet the potential benefits of MBIs in OCD has been largely unexamined, except for several small preliminary studies that show clinical promise. The purpose of this study is to examine the clinical benefits of a standardized MBI treatment for OCD in a large-scale, multi-site randomized controlled trial. The results of this study will directly determine whether Mindfulness can be considered an effective treatment for OCD. If this study can demonstrate that a short-term mindfulness intervention can significantly reduce the suffering associated with OCD, then the findings could easily be translated into routine clinical care in and out of hospital settings. Results of this study will also potentially add to our understanding of the mechanisms that drive OCD symptoms, improve our knowledge of psychological treatment mechanisms, and elucidate how biological factors influence psychological treatment outcomes. Read Less

Gender:

ALL

Ages:

Between 18 years and 65 years

Trial Updated:

11/25/2024

Locations: St. Joseph's Healthcare Hamilton, Hamilton, Ontario +1 locations

Conditions: Obsessive-Compulsive Disorder

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A Study of SPY002-072 in Healthy Volunteers

NCT06622070

Recruiting

This is a Phase 1, randomized, double-blind, placebo-controlled, single-dose, first in human safety, tolerability, and pharmacokinetic study of SPY002-072 in healthy participants.

Gender:

ALL

Ages:

Between 18 years and 60 years

Trial Updated:

11/25/2024

Locations: Spyre Site 2, Cypress, California +1 locations

Conditions: Healthy

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Respiratory Outbreak Mitigation in Long-Term Care Using Point-of-Care Testing

NCT06660433

Recruiting

Outbreaks of seasonal respiratory viruses can spread rapidly in long-term care homes. Timely results for diagnostic tests remains a challenge for respiratory viruses due to the logistics of using a reference laboratory with delays leading to missed opportunities to implement virus-specific control measures to interrupt transmission resulting in larger outbreaks. Use of a point-of-care testing platform is a potential solution that provides faster results, but it is uncertain whether this translat... Read More

Gender:

ALL

Ages:

All

Trial Updated:

11/25/2024

Locations: Michael Garron Hospital, Toronto, Ontario +1 locations

Conditions: Outbreaks

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Impacts of the VEGA Family Violence Education Resources for Psychology Trainees

NCT06630598

Recruiting

The current research project aims to assess the effectiveness of the ©Violence, Evidence, Guidance, and Action (VEGA) Family Violence Education Resources (VEGA Project, 2019) in improving the knowledge, self-efficacy, and clinical responses of clinical psychology doctoral students to family violence in clinical settings. The VEGA on-line training is a collection of family violence online education resources designed to inform health and social service practitioners about family violence in a Can... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

11/23/2024

Locations: University of Ottawa - Child Wellbeing Lab, Ottawa, Ontario

Conditions: Family Violence

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MDMA-Assisted CBCT for PTSD vs CBCT RCT

NCT06044675

Recruiting

This study aims to evaluate the safety, feasibility, acceptability, and effectiveness of MDMA-assisted Cognitive-Behavioral Conjoint Therapy (CBCT) versus CBCT alone for the treatment of Post-Traumatic Stress Disorder (PTSD). PTSD is a debilitating condition that significantly impacts interpersonal relationships and the functioning of individuals and their loved ones. There is also a well-established reciprocal relationship between interpersonal relationships, PTSD, and recovery. CBCT is a manualized treatment for PTSD that simultaneously addresses PTSD symptoms and relationship satisfaction. It provides dyads with behavioral tools to navigate PTSD-related challenges, as well as the knowledge behind PTSD and how it impacts relationships. Previous research has demonstrated the efficacy of CBCT in improving PTSD symptoms, partner functioning, and relationship satisfaction in both distressed and non-distressed dyads. MDMA is a drug commonly used recreationally that has been increasingly studied because of its ability to reduce the impact of PTSD symptoms. The effects of MDMA are reduced fear, enhanced communication, trust and introspection, and increased empathy and compassion. The effects of MDMA create a state that enhances the positive effects of therapy by increasing the ability to tolerate negative emotions and allowing clients to stay engaged in therapy without being overwhelmed by the intense emotions surrounding the memories of traumatic events. It is believed that MDMA may help promote the effects of CBCT due to its ability to induce empathy and interpersonal openness. This randomized study is the second study designed to explore the efficacy of combining MDMA-assisted therapy with CBCT. This study will enroll 30 dyads, where one individual has symptoms of PTSD. Participants will undergo a 7-week psychotherapy course, in MDMA-assisted CBCT or CBCT alone. In the MDMA-assisted CBCT, participants will go through CBCT sessions, and two doses of MDMA will be used as an adjunct to psychotherapy. Participants assigned to the CBCT-only condition will go through CBCT sessions and will have the opportunity to crossover and receive the two MDMA sessions after follow-up. The primary goal of this research is to contribute to the literature on MDMA-assisted CBCT by investigating its feasibility, safety, acceptability, and effectiveness, and by comparing it to active PTSD treatments. Read Less

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

11/22/2024

Locations: Remedy Institute, Toronto, Ontario

Conditions: Post Traumatic Stress Disorder

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Timing of TAP Blocks in Bariatric Surgery

NCT06270147

Recruiting

This clinical trial aims to determine the optimal timing for administering a Transversus Abdominis Plane (TAP) block in bariatric surgery, specifically investigating whether initiating TAP blocks at the beginning of surgery is more beneficial than at the end, which is the current practice. The study targets obese patients undergoing bariatric surgery, with a focus on reducing postoperative pain and opioid use. Key outcomes include recovery duration, pain levels, opioid consumption, and respirato... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

11/22/2024

Locations: St. Joseph's Healthcare Hamilton - Charlton Campus, Hamilton, Ontario

Conditions: Opioid Use, Pain, Postoperative

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Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD

NCT06704321

Recruiting

This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota among both men and women with MASLD.

Gender:

ALL

Ages:

Between 18 years and 75 years

Trial Updated:

11/22/2024

Locations: Institut sur la nutrition et les aliments fonctionnels (INAF), Québec, Quebec

Conditions: Non-Alcoholic Fatty Liver Disease

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Online Memory Intervention for Individuals with Traumatic Brain Injury

NCT04331392

Recruiting

This study will examine the behavioural and neurophysiological efficacy and feasibility of an online spatial navigation intervention for improving memory and brain health in individuals who have sustained moderate-severe traumatic brain injury.

Gender:

ALL

Ages:

Between 18 years and 55 years

Trial Updated:

11/21/2024

Locations: Toronto Rehabilitation Institute, Toronto, Ontario

Conditions: Brain Injuries, Traumatic, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, Brain Injury, Chronic

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Comparing the Efficacy of Accelerated Vs. Standard FMRI-guided ITBS in Treating Adolescents Depression

NCT06528938

Recruiting

Repetitive transcranial magnetic stimulation (rTMS) is a Health Canada approved treatment for major depression. Theta burst stimulation (TBS), a type of rTMS, is a very promising new treatment for major depression in adults and adolescents. However, very few studies have assessed the efficacy of accelerated, three times a day TBS in comparison with standard once a day TBS in adolescents. The study aims to explore further evidence in hopes to conduct a large-scale, randomized, multisite, placebo-... Read More

Gender:

ALL

Ages:

Between 16 years and 19 years

Trial Updated:

11/21/2024

Locations: The Royal's Institute of Mental Health Research, Ottawa, Ontario

Conditions: Depression, Depressive Disorder, Major

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