Olorofim Aspergillus Infection Study
NCT05101187
Recruiting
The purpose of this study is to compare treatment with olorofim versus treatment with AmBisome® followed by standard of care (SOC) in patients with IFD caused by proven IA or probable lower respiratory tract disease Aspergillus species (invasive aspergillosis, IA).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +139 locations
Conditions: Invasive Aspergillosis
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Metabolic and Inflammatory Outcomes of the Ketogenic Diet Comparing Saturated and Unsaturated Fat Sources
NCT05681468
Recruiting
The goal of this clinical trial is to compare a healthy KETO diet supplemented with canola oil (KETO-Can) compared to a traditional KETO diet high in saturated fat (KETO-Sat) and low-fat diet (LFD) in adults at high risk of or diagnosed with type 2 diabetes. The main question\[s\] it aims to answer are: * Effects on CVD risk factors (plasma cholesterol, TG, ApoB100, glucose, insulin and HbA1C). * Effects on systemic inflammation and immune function. * Adherence to interventions. Participants w... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
09/26/2024
Locations: University of Alberta, Edmonton, Alberta
Conditions: PreDiabetes, Diabetes Mellitus, Type 2, Overweight and Obesity
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Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer
NCT06185972
Recruiting
The objective of this study is to demonstrate the efficacy and response of novel Magnetic Resonance Imaging (MRI)-guided ultrasound stimulated microbubble treatment to enhance radiation effects in humans receiving external beam radiotherapy delivered using a LINAC (linear accelerator) radiation therapy device.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Breast Cancer
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ACT-GLOBAL THROMBOLYSIS (ACT-WHEN-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632
NCT06320431
Recruiting
This domain has a prospective, randomized, controlled, open-label, parallel group with blinded endpoint assessment (PROBE) design. Up to 4,000 patients with presumed acute ischemic stroke (AIS) will be followed for 90 days (or until death, if prior to 90 days). The end of the trial is defined as the date that all participants have completed their Day 90 assessment. This domain aim is to efficiently, reliably, and simultaneously, determine the comparative effectiveness of intravenous thrombolysi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: The George Institute for Global Health, Sydney, Barangaroo +4 locations
Conditions: Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
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Digital Technology for Sleep and Homelessness
NCT06620601
Recruiting
In Canada, 35,000 people are experiencing homelessness on any night. Compared to the general population, people experiencing homelessness (PEH) sleep less and experience increased daytime fatigue. A common sleep disorder and treatable cause of morbidity and low quality of life is sleep apnea. High prevalence of chronic comorbid disorders of sleep apnea in PEH suggest high prevalence of sleep apnea, but the rate of sleep apnea treatment in PEH is very low. Also, in PEH, individual and systemic ba... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/26/2024
Locations: Dixon Hall, Toronto, Ontario +1 locations
Conditions: Sleep Apnea, Sleep Disorder, Sleep Deprivation, Sleep Disturbance
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Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI
NCT03474029
Recruiting
This study is conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin-based treatment (standard of care, control arm) of latent M. tuberculosis infection (LTBI). This trial is conducted among persons who are at increased risk of progression to tuberculosis (TB) and require treatment of LTBI. The study will be conducted in low, medium and high TB incidence settings that have t... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
09/25/2024
Locations: Denver Health and Hospital Authority, Denver, Colorado +15 locations
Conditions: Latent Tuberculosis
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IKS03 in Patients with Advanced B Cell Non-Hodgkin Lymphomas
NCT05365659
Recruiting
This first-in-human study will evaluate the recommended dose for further clinical development, safety, tolerability, antineoplastic activity, immunogenicity, pharmacokinetics and pharmacodynamics of IKS03, a CD19 targeting antibody-drug conjugate, in patients with advanced B cell non-Hodgkin lymphoma (NHL).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: University of Maryland Baltimore, Baltimore, Maryland +12 locations
Conditions: B-cell Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Mantle Cell Lymphoma, B-cell Lymphoma
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Delayed Cold-Stored Platelets -PLTS-1
NCT06147531
Recruiting
PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada. The study is designed to assess the feasibility of a future, definitive RCT to determine the non-inferiority of cold-stored platelets compared to conventional platelets with respect to hemostatic effectiveness (total number of allogeneic blood products transfused within 24 hours after CPB), as well as safety.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: Kingston Health Sciences Centre, Kingston, Ontario +1 locations
Conditions: Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
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Comparing the Efficacy of FMRI-Guided Vs. Standard ITBS in Treating Depression
NCT06152705
Recruiting
In this triple-blind randomized controlled trial, we ask if targeting intermittent theta burst stimulation (iTBS) based on individual resting state connectivity improves treatment outcomes in major depressive disorder (MDD). For the trial, we will recruit 210 patients with major depressive disorder. Each patient will undergo a 30-40-minute MRI scan, after which they will receive a 6-week standard iTBS treatment. Participants will be randomized to receive iTBS either to the standard neuronavigate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: The Royal's Institute of Mental Health Research, Ottawa, Ontario
Conditions: Depression, Depressive Disorder, Major, Depressive Episode
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Positron Emission Mammography and Liquid Biopsy in Women With High-risk Breast Screenings
NCT06268405
Recruiting
The goal of this research study is to evaluate the performance of two experimental tests, namely Liquid Biopsy and Positron Emission Mammography (PEM) in women at high risk of breast cancer. The plan for this study is to assess whether findings from the combination or each individual test can assist radiologists in visualizing and characterizing beast abnormalities. Liquid Biopsy is a blood test that can detect early tumours in patients with malignancies, while PEM is an imaging tool equipped w... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: University Health Network, Toronto, Ontario
Conditions: Breast Cancer
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Digital Health Pathway for Children With Medical Complexity Requiring Tracheostomy
NCT06375369
Recruiting
The DECIDE-T project is developing a standardized clinical pathway specifically for pediatric patients who require tracheostomy with or without long-term ventilation (tracheostomy/LTV). These patients represent a small portion of Alberta's population but account for over 50% of pediatric patients hospitalized for more than 180 days. The pathway will include a hospital-to-home directive that incorporates digital health solutions to provide support to families, caregivers, and healthcare professio... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
09/25/2024
Locations: Alberta Children's Hospital, Calgary, Alberta +1 locations
Conditions: Tracheostomy
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Evaluation of Intraocular Pressure Following a Vitreoretinal Surgery Using Goldmann Applanation Tonometry, Icare and Accupen
NCT06522867
Recruiting
The goal of this prospective controlled study is to measure the reliability of two intraocular pressure (IOP)-measuring instruments in comparison to the gold standard, Goldmann applanation tonometry (GAT) following vitreo-retinal surgery. The main question the current study aims to answer is: are Icare and Accupen as accurate as GAT in measuring IOP one day post eye surgery? Participants in this study will have their IOP measured by the three different instruments one day post-surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2024
Locations: Hôpital du Saint-Sacrement, CHU de Québec - Université Laval, Québec, Quebec
Conditions: Intraocular Pressure
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