Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users
NCT06164678
Recruiting
This study aims to determine if a standardized approach including counselling and Nicotine Replacement Therapy (NRT) can help e-cigarette users quit vaping. Current e-cigarette users will be randomly assigned to either to counselling and NRT or counselling only group. Self-reported rates of vaping cessation will be measured throughout the year in both groups. The use of e-cigarettes has grown substantially among non-smokers, particularly among youth and young adults. These devices deliver high l... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/11/2024
Locations: The University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: Tobacco Smoking, Vaping
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A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult
NCT06363942
Recruiting
This is a randomized interventional clinical trial, whereby 100 participants will be randomized to either follow the SAFE exercise program (experimental group) or not (control group). At the end of the intervention, the experimental group will be encouraged to continue doing the exercises, and the control group will have the opportunity to participate in the SAFE exercises. 12 weeks post-intervention, the investigators will follow up with participants by telephone to follow up whether they are s... Read More
Gender:
ALL
Ages:
70 years and above
Trial Updated:
07/11/2024
Locations: Royal Victoria Hospital - Glen site, Montréal, Quebec
Conditions: Fall Injury, Frailty, Old Age; Atrophy, Age-Related Atrophy, Age-Related Sarcopenia
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Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
NCT02735707
Recruiting
REMAP-CAP is a randomised, embedded, multifactorial, adaptive platform trial for community-acquired pneumonia. The purpose of this study is to evaluate the effect of a range of interventions to improve outcome of patients admitted to intensive care with community-acquired pneumonia. In addition, REMAP-CAP provides and adaptive research platform for evaluation of multiple treatment modalities in the event of a respiratory pandemic such as COVID-19. REMAP-COVID is a sub-platform of REMAP-CAP th... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of Florida, Jacksonville, Florida +407 locations
Conditions: Community-acquired Pneumonia, Influenza, COVID-19
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Epinephrine Dose: Optimal Versus Standard Evaluation Trial
NCT03826524
Recruiting
The objective of this randomized controlled trial is to evaluate the effectiveness of a low cumulative dose of epinephrine compared to a standard cumulative dose of epinephrine during resuscitation from ventricular fibrillation (VF) or ventricular tachycardia (VT) in adult out-of-hospital cardiac arrest (OHCA) patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: British Columbia Emergency Health Services (BCEHS), Victoria, British Columbia +2 locations
Conditions: Cardiac Arrest, Out-Of-Hospital, Sudden Cardiac Arrest, Ventricular Fibrillation, Ventricular Tachycardia-Pulseless
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Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke
NCT04475510
Recruiting
To determine the safety of antithrombotic treatment discontinuation 12 months following successful transcatheter PFO closure.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
07/10/2024
Locations: IUCPQ, Quebec, Not set
Conditions: Patent Foramen Ovale, Ischemic Stroke, Bleeding Ulcer
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Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR
NCT05459233
Recruiting
Data on valve performance following ViV-TAVR has usually been obtained with the use of Doppler-echocardiography. However, some reports have shown significant discordances in the evaluation of mean transvalvular gradient between echocardiography and catheterization, with an overestimation of the real gradient with echo (vs. cath) in most cases. Thus, the incidence of procedural-device failure may be lower than that reported in the ViV-TAVR literature,
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/10/2024
Locations: University of California, San Francisco, California +6 locations
Conditions: Aortic Valve Stenosis, Aortic Valve Regurgitation, Prosthesis Failure
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Comparison Between Chromoendoscopy and Virtual Chromoendoscopy (NBI, I-scan, FICE) for Detection of Neoplasia in Long Standing Ulcerative Colitis
NCT01882205
Recruiting
The risk for colon cancer in patients with longstanding ulcerative colitis exceeding the rectum is increased and therefore patients should be enrolled in a surveillance program eight years after the diagnosis. Until today, official international guidelines for endoscopic screening in patients with ulcerative colitis advise to take 4 biopsies every 10 centimeters (with a minimum of 32) and of each suspected visible lesion. These guidelines are merely based on consensus during expert opinion meeti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/09/2024
Locations: University Hospitals Leuven, Leuven, Not set +4 locations
Conditions: Ulcerative Colitis
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TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence
NCT02621645
Recruiting
Multi-center open-label randomized controlled trial to assess if early intervention (12.0-14.0 weeks) (study group) improves the outcome of TRAP sequence as compared to late intervention (16.0-19.0 weeks) (control group). The investigators will randomly assign women diagnosed with TRAP sequence diagnosed between 12.0 and 13.6 weeks to an early or late intervention group (1:1), using a web-based application and a computer-generated list with random permuted blocks of sizes 2 or 4 (www.sealedenvel... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/09/2024
Locations: Children's Memorial Hermann Hospital, Houston, Texas +13 locations
Conditions: Twin Reversal Arterial Perfusion Syndrome
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ATr Inhibitor in Combination With Olaparib/Durvalumab (MEDI4736) in Gynaecological Cancers With ARId1A Loss or no Loss
NCT04065269
Recruiting
ATARI trial tests the ATR inhibitor drug ceralasertib (AZD6738) alone and in combination with either a PARP inhibitor drug called olaparib, or an anti-PD-L1 immunotherapy called durvalumab (MEDI4736) in patients with relapsed gynaecological cancers to assess the response in groups of patients selected based on their cancer cell subtype and the presence of an abnormality in the ARID1A gene.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
07/09/2024
Locations: The Ottawa Hospital Cancer Centre, Ottawa, Ontario +8 locations
Conditions: Gynaecological Cancers
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IV Ketamine Vs. in Esketamine for MDD TRD
NCT06488586
Recruiting
The goal of this observational study is to learn about the comparative acute effects of ketamine vs esketamine in participants over the age of 18 for the treatment of their severe depression and suicidal ideations. Participants are already taking antidepressants and/or antipsychotics as part of their regular medical care for depression,
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/08/2024
Locations: Providence Care Hospital, KIngston, Ontario
Conditions: Treatment Resistant Depression
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Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)
NCT06472986
Recruiting
The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2024
Locations: Toronto Rehabilitation Institute, Toronto, Ontario
Conditions: Spinal Cord Injuries, Spinal Cord Injury Cervical
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Parathyroid Allotransplant for Severe Refractory Hypoparathyroidism
NCT06499246
Recruiting
Hypoparathyroidism following thyroid surgery presents significant challenges, often leading to debilitating symptoms and reduced quality of life despite conventional treatment. Having now reported the first successful case of a deceased donor fresh tissue parathyroid allotransplant with immunosuppression in a transplant-naive recipient, the purpose of this study is to further assess the safety and efficacy of this procedure in patients with severe intractable post-surgical hypoparathyroidism.
Gender:
ALL
Ages:
19 years and above
Trial Updated:
07/06/2024
Locations: University Health Network, Toronto, Ontario
Conditions: Hypoparathyroidism Postprocedural
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