A Community-based Program That Supports Physical Activity, Healthy Eating, Social Participation and System Navigation in Older Adults
NCT05008159
Recruiting
Physical mobility and social participation are needed to maintain independence and quality of life for adults over 55 years of age. Despite the known benefits of physical activity and dietary change programs for older adults, the best ways to deliver these interventions are not well understood. The goal of the EMBOLDEN study is to promote physical and community mobility in older adults who experience difficulties taking up community programs and reside in areas of high health inequity. Building... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
05/01/2024
Locations: Community, Hamilton, Ontario(ON) +1 locations
Conditions: Mobility Limitation, Health Related Quality of Life, Healthy Aging, Health Inequity
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Promoting Sustainable Return to Work Among Employees on Sick Leave Due to a Mental Health Condition: Evaluation of the HealthyMinds Online Group Intervention
NCT05963308
Recruiting
The purpose of this clinical trial is to evaluate the impact of an online group intervention called Healthy Minds in facilitating a sustainable return to work for individuals with a mood disorder. The study aims to answer the following key questions : * Does receiving the Healthy Minds online intervention lead to a more sustainable return to work compared to not receiving the intervention? * Are the health outcomes (e.g., depressive symptoms) and work-related outcomes (e.g., work functioning) o... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
05/01/2024
Locations: Université du Québec à Montréal, Montréal, Quebec
Conditions: Depression Anxiety Disorder, Adjustment Disorders, Adjustment Disorder With Anxious Mood, Adjustment Disorder With Depressed Mood
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Study of Navtemadlin as Maintenance Therapy in TP53WT Advanced or Recurrent Endometrial Cancer
NCT05797831
Recruiting
This study evaluates navtemadlin as maintenance treatment for patients with advanced or recurrent endometrial cancer (EC) who have achieved complete response or partial response on chemotherapy. The study will be conducted in 2 parts. Part 1 will evaluate safety and efficacy of two different doses of navtemadlin alongside an observational control arm to determine the Phase 3 navtemadlin dose. Part 2 will evaluate the efficacy and safety of navtemadlin Phase 3 dose compared to placebo.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/30/2024
Locations: Kaiser Permanente Center, Vallejo, California +82 locations
Conditions: Endometrial Cancer
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TSA Techniques in Glenohumeral OA
NCT02966886
Recruiting
Osteoarthritis (OA) of the shoulder is a disease resulting from the wearing down of cartilage over time. OA can produce pain and dysfunction at the affected joint and is a growing occurrence in an aging population. Total shoulder arthroplasty (TSA) is a surgical treatment used to treat patients with shoulder OA which involves replacing the worn-out ball and socket shoulder joint with prosthetic components. TSA is performed today with high success rates, however, complication rates associated wit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: The Ottawa Hospital, Ottawa, Ontario
Conditions: Osteoarthritis, Shoulder
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Remplissage Versus Latarjet Coracoid Transfer for Recurrent Shoulder Instability
NCT03453710
Recruiting
This is a pilot study designed as a prospective, randomized controlled trial comparing arthroscopic Bankart repair and Remplissage with an open Latarjet coracoid transfer for the treatment of recurrent anterior glenohumeral instability with subcritical bone loss.
Gender:
ALL
Ages:
Between 15 years and 60 years
Trial Updated:
04/29/2024
Locations: Pan Am Clinic, Winnipeg, Manitoba +1 locations
Conditions: Shoulder Dislocation
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TSA v RSA in Osteoarthritic Shoulders With Greater Than 15 Degrees of Retroversion
NCT05487274
Recruiting
This study will compare total shoulder arthroplasty (TSA) with an augmented glenoid component and reverse shoulder arthroplasty (RSA) procedures, in participants with advanced glenohumeral osteoarthritis aged 65 years and older, who also present with greater than 15 degrees of glenoid retroversion, in the context of a prospective, randomized controlled trial to determine the optimal treatment in this patient population.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/29/2024
Locations: Ottawa Hospital Research Institute, Ottawa, Ontario
Conditions: Osteoarthritis Shoulder
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A Digital Active Aging Training Program for Older Adults
NCT06270862
Recruiting
The proposed project aims to develop and validate a multi-dimensional digital active aging program integrated with resilience to promote the biopsychosocial functions of older adults aged 60, including Chinese older immigrants in Canada (Study 1) and English-speaking White Canadian older adults (Study 2). The proposed study takes a typical pretest-training-posttest design. Pretest and posttest: a battery of outcome measures on physical, psychological, and social functions will be administered t... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/29/2024
Locations: Cognitive Aging Lab, Toronto, Ontario
Conditions: Healthy Aging, Cognitive Change, Psychological Stress, Loneliness, Social Interaction
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Cyclosporine and Intense Pulsed Light for Dry Eye in Contact Lens Users
NCT06392438
Recruiting
In this study, two treatments typically used for dry eye disease will be tried for contact lens users to see if their symptoms when they use their contact lenses get better. Cyclosporine is a drop that is used for long-term management of the inflammation and Intense pulsed light (IPL) is a treatment done in a clinic to improve the health of the eyelid glands. The main question in this study is: Does the combined treatment of cyclosporine and IPL improve the symptoms and the dry eye signs of con... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2024
Locations: Opto-Réseau Sherbrooke Est, Sherbrooke, Quebec
Conditions: Dry Eye, Contact Lens Complication
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Motor & Autonomic Concomitant Health Improvements With Neuromodulation & Exercise Training: An SCI RCT
NCT04726059
Recruiting
Spinal cord injury (SCI) disrupts many aspects of life, including the loss of volitional movement and involuntary control of bodily functions; both crucial functional recovery priorities for this population. Mobility impairments and secondary complications limit an individual's ability to exercise, a behavior known to have wide-ranging functional and health benefits. This trial will investigate whether activity-based therapy (ABT), using body-weight-supported treadmill training (BWSTT), can chan... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/26/2024
Locations: Blusson Spinal Cord Centre, Vancouver, British Columbia
Conditions: Spinal Cord Injuries, Neurogenic Bladder, Neurogenic Bowel
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Neuromodulation as an Anti-inflammatory Treatment in SCI
NCT05730049
Recruiting
The goal of this single-blinded randomized, controlled trial is to assess the impact of 1-hour of active transcutaneous auricular vagus nerve stimulation (taVNS) vs sham taVNS on serum biomarkers of the inflammatory reflex and inflammation in individuals with spinal cord injury. The main question it aims to answer is: whether taVNS is a safe and effective anti-inflammatory intervention for individuals with SCI. Participants will perform a single 1-hour bout of the respective taVNS treatment wit... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2024
Locations: Parkwood Institute, St Joseph's Health Care London, London, Ontario
Conditions: Spinal Cord Injuries, Inflammation
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Powered Assist Hip Exoskeleton to Improve Ambulation in Severe Lung Disease
NCT05835271
Recruiting
Chronic respiratory disease (CRD) is among the most prevalent and growing diseases worldwide with disabling consequences. Many with a compromised respiratory system cannot support the metabolic energy demands of walking causing them to walk slowly and stop often. Those with CRD could receive substantial benefit from a powered wearable exoskeleton device that assumes part of the energy of walking. Assisting the legs will lower the metabolic energy demands, and therefore the ventilation required f... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/26/2024
Locations: Westpark Health Care Centre, Toronto, Ontario
Conditions: Lung Disease Chronic
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Evaluation of the Transitional and Lifelong Care Program
NCT05849285
Recruiting
The population cared for in the Transitional and Lifelong Care (TLC) clinic is youth and adults with childhood-onset disability, of which the large majority are adults with brain-based, neurodevelopmental conditions such as cerebral palsy, spina bifida and developmental disability. The TLC program was created to address the health inequities that have long existed for this population because of the gaps in care they experience once they transition from pediatric healthcare services to the adult... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
04/26/2024
Locations: Parkwood Institute, London, Ontario
Conditions: Cerebral Palsy, Spina Bifida, Developmental Disability
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