All Clinical Trials in Canada

A listing of 3905 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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Chronic Cancer Pain Management Program

NCT06101849

Recruiting

The goal of this research study is to evaluate an online inter-professional pain management program for survivors of breast cancer. The main questions it aims to answer: 1. whether this treatment will help address the pain management concerns of patients, 2. whether it is feasible to offer this treatment in the future as multi-centre randomized controlled trial (RCT). Participants will be asked to attend a 6-week online pain management group sessions (1h/week). Participants will also be asked... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/29/2024

Locations: Juravinski Cancer Centre, Hamilton, Ontario

Conditions: Breast Cancer, Cancer, Treatment-Related, Pain Cancer

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Multi-channel Time-resolved Functional Near Infrared Spectroscopy for Prevention of Perioperative Brain Injury

NCT05752981

Recruiting

Covert stroke occurs in one out of fourteen patients during or shortly after surgery, and may result in long-term disability. Fortunately, stroke that occurs during non-cardiac surgery is most commonly caused by inadequate blood flow to the brain and is, therefore, preventable if it can be detected early. Current clinical tools used to monitor the brain during surgery do not have the accuracy nor the spatial coverage - they only monitor one small region of the brain. In this study, the investiga... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/28/2024

Locations: London Health Sciences Centre, London, Ontario

Conditions: Stroke, Cerebral Oxygenation

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Targeting Brain Physiology to Treat Neuropsychiatric Symptoms of Dementia Using TMS-EEG and tDCS

NCT03846492

Recruiting

Agitation and aggression impose a tremendous burden on the individuals living with dementia, their families, caregivers, and healthcare systems. Neuropsychiatric symptoms of dementia (NPS) affect up to 80% of patients with Alzheimer's dementia (AD). The mechanisms of agitation in AD are poorly understood and the current interventions are only modestly effective while having serious adverse effects. In this study, the investigators propose to assess the mechanisms and treatment of neuropsychiatri... Read More

Gender:

ALL

Ages:

50 years and above

Trial Updated:

02/27/2024

Locations: Centre for Addiction and Mental Health, Toronto, Ontario

Conditions: Alzheimer Disease, Dementia, Mixed, Dementia, Behavior Problem, Dementia, Alzheimer Type

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Patient Handling Techniques and New Technology for Health Care Workers

NCT06285786

Recruiting

Patient handling is a major risk-factor for the development of musculoskeletal injuries in healthcare providers. To have a significant impact on injury reduction related to patient handling will require the incorporation of technology. This project is to investigate a piece of technology that has been designed to facilitate in-bed patient handling: The Vendlet. The purpose of this research project is to assess the ability of the Vendlet system outfitted on a Span-America Medical Systems (SAMS)... Read More

Gender:

ALL

Ages:

Between 17 years and 40 years

Trial Updated:

02/27/2024

Locations: Universite de Moncton, Moncton, New Brunswick

Conditions: Work-related Injury

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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

NCT01574053

Recruiting

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/26/2024

Locations: University of Alabama, Birmingham, Alabama +182 locations

University of Alabama, Birmingham, Alabama

St. Joseph's Hospital and Medical Center, Phoenix, Arizona

University of California - Irvine Medical Center, Irvine, California

Loma Linda Medical Center, Loma Linda, California

University of California - Los Angeles, Los Angeles, California

University of California - Davis, Sacramento, California

University of California - San Diego, San Diego, California

University of California - San Francisco, San Francisco, California

Cenexel Rocky Mountain Clinical Research, LLC, Englewood, Colorado

University of Connecticut, Farmington, Connecticut

Georgetown University, Washington, District of Columbia

University of Florida Board of Trustees, Gainesville, Florida

University of Miami, Miami, Florida

University of South Florida, HDSA Center of Excellence at USF, Tampa, Florida

Emory University, Wesley Woods Health Center, Atlanta, Georgia

Georgia Health Sciences University, Augusta, Georgia

Northwestern University, Chicago, Illinois

University of Chicago, Chicago, Illinois

Rush University Medical Center, Chicago, Illinois

University of Illinois College of Medicine at Rockford, Rockford, Illinois

Indiana University, Indianapolis, Indiana

University of Iowa, Iowa City, Iowa

University of Kansas Medical Center, Kansas City, Kansas

Hereditary Neurological Disease Center, Wichita, Kansas

University of Louisville, Louisville, Kentucky

University of Maryland School of Medicine, Baltimore, Maryland

Johns Hopkins University, Baltimore, Maryland

Boston University Medical Center, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Wayne State University, Detroit, Michigan

Hennepin County Medical Center, Minneapolis, Minnesota

Washington University in St. Louis, Saint Louis, Missouri

University of Nebraska Medical Center, Omaha, Nebraska

Cleveland Clinic - Las Vegas, Las Vegas, Nevada

Cooper University Hospital, Camden, New Jersey

Rutgers, the State University of New Jersey, New Brunswick, New Jersey

Albany Medical College, Albany, New York

Columbia University, New York, New York

University of Rochester, Rochester, New York

Duke University, Durham, North Carolina

Wake Forest School of Medicine, Winston-Salem, North Carolina

Sanford Health, Fargo, North Dakota

University of Cincinatti, Cincinnati, Ohio

Cleveland Clinic, Cleveland, Ohio

The Ohio State University, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

University of Pennsylvania, Philadelphia, Pennsylvania

University of Pittsburgh, Pittsburgh, Pennsylvania

University of South Carolina, Columbia, South Carolina

University of Tennessee Health Science Center, Memphis, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Baylor College of Medicine, Houston, Texas

University of Texas Health Science Center, Houston, Texas

University of Utah, Salt Lake City, Utah

University of Vermont, Burlington, Vermont

University of Virginia, Charlottesville, Virginia

Virginia Commonwealth University Parkinson's and Movement Disorders Center, Henrico, Virginia

Virginia Commonwealth University, Richmond, Virginia

Booth Gardner Parkinson's Care Center (Evergreen Health), Kirkland, Washington

University of Washington Medical Center, Seattle, Washington

University of Wisconsin - Madison, Madison, Wisconsin

Instituto de Neurociencias Buenos Aires (INEBA), Buenos Aires, Not set

Westmead Hospital, Westmead, New South Wales

Monash University, Melbourne, Victoria

The Neurosciences Unit - North Metropolitan Hospital, Perth, Western Australia

University of Melbourne, Royal Melbourne Hospital, Parkville, Not set

Universitatsklinik Innsbruck, Innsbruck, Not set

University Hospitals Leuven, Leuven, Vlaams-Brabant

Bruxelles - Erasme, Bruxelles, Not set

Institut de Pathologie et de Génétique (IPG), Charleroi, Not set

Hôpital du Beau Vallon ASBL, Saint-Servais, Not set

University of Calgary, Movement Disorders Program, Calgary, Alberta

University of Alberta (Glenrose), Edmonton, Alberta

University of Alberta Hospital in Edmonton, Edmonton, Alberta

University of British Columbia, Vancouver, British Columbia

Nova Scotia Health Authority, Halifax, Nova Scotia

Centre for Movement Disorders, Markham, Ontario

The Ottawa Hospital, Ottawa, Ontario

North York General Hospital, Toronto, Ontario

CHUM Hospital of Notre Dame, Montreal, Quebec

CETRAM, Santiago, Not set

Universidad de Antioquia, Grupo de Neurociencias, Medellín, Antioquia

Servicios Médicos MS, Clínica de Marly, Bogotá, Cundinamarca

University Hospital of Aarhus, Aarhus, Not set

University Hospital of Copenhagen, Copenhagen, Not set

University Hospital of Odense, Odense, Not set

Hôpitaux Universitaires de Strasbourg Hôpital de Hautepierre-Service de Neurologie, Strasbourg, Alsace Lorraine

CHU Amiens-Picardie, Amiens, Not set

CHU Angers, Centre de Référence Maladies Neurogénétiques, Angers, Not set

Bordeaux - Huntington Disease competencies center, Bordeaux, Not set

CHU Gabriel-Montpied, Clermont-Ferrand, Not set

Hôpital Henri Mondor, Centre d'Investigation Clinique, Créteil, Not set

Lille-Amiens - Huntington Disease Constituent site, LILLE Cedex, Not set

Hôpital La Timone, Marseille, Not set

CHU Montpellier, Montpellier, Not set

Institut du Cerveau et de la Moelle Epinière, Paris, Not set

Hôpital Purpan, Centre d'Investigation Clinique, Toulouse, Not set

University Hospital Aachen, Aachen, Not set

University of Berlin, Berlin, Not set

St. Josef und St. Elisabeth Hospital, Bochum, Not set

University Hospital Carl Gustav Carus Dresden, Dresden, Not set

University Hospital Erlangen, Erlangen, Not set

University Medical Center Freiburg, Freiburg, Not set

Paracelsus Elena Klinik Kassel, Kassel, Not set

University Hospital Schleswig-Holstein, Lübeck, Not set

University Hospital Giessen and Marburg, Marburg, Not set

Technical University of Munich, Munich, Not set

George-Huntington-Institut GmbH, Münster, Not set

kbo-Isar-Amper-Klinikum Taufkirchen (Vils), Taufkirchen, Not set

University Hopsital of Ulm, Ulm, Not set

University Hospital of Wuerzburg, Würzburg, Not set

Beaumont Hospital, Dublin 9, Republic Of Ireland

Fondazione IRCCS Istituto Neurologico Carlo Besta - Genetics, Milan, MI

Bari Policlinico General Hospital, Bari, Not set

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Not set

Università degli Studi di Genova (DINOGMI), Genoa, Not set

Fondazione IRCCS Istituto Neurologico Carlo Besta - Neurology, Milan, Not set

University of Naples, Napoli, Not set

Università Cattolica del Sacro Cuore, Rome, Not set

Lega Italiana Ricerca Huntington (LIRH), Rome, Not set

Azienda Ospedaliera Sant'Andrea, Rome, Not set

University Medical Center Groningen, Groningen, Not set

Leiden University Medical Centre, Leiden, Not set

Clinical Trial Center Maastricht B.V., Maastricht, Not set

Auckland City Hospital, Auckland, Not set

New Zealand Brain Research Institute at University of Otago, Christchurch, Not set

Wellington Hospital, Wellington, Not set

Copernicus Podmiotem Leczniczym sp. z o.o., Gdansk, Not set

Krakowska Akademia Neurologii Sp. z o.o, Katowice, Not set

Krakow - Krakowska Akademia Neurologii, Kraków, Not set

Solumed Centrum Medyczne, Poznan, Not set

Medical University of Warsaw, Warsaw, Not set

Institute of Psychiatry and Neurology, Warsaw, Warsaw, Not set

Hospital Prof Doutor Fernando Fonseca, Amadora, Not set

Hospital Universitário de Coimbra, Coimbra, Not set

Central Lisbon Hospital, Lisbon, Not set

Hospital de Santa Maria / Instituto de Medicina Molecular, Lisbon, Not set

Hospital Universitário de São João, Porto, Not set

Hospital Infanta Cristina, Badajoz, Badajoz, Not set

Hospital de Cruces, Barakaldo, Not set

Hospital Universitari de Bellvitge, Barcelona,, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Hospital Mare de Déu de la Mercè, Barcelona, Not set

Fundacion Clinic per a La Recerca Biomèdica, Barcelona, Not set

Hospital Universitario de Burgos, Burgos, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

Fundación Jiménez Díaz, Madrid, Not set

Hospital Son Espases, Palma De Mallorca, Not set

Complejo Hospitalario de Navarra, Pamplona, Not set

Fundacion Hospital Universitario La Fe, Valencia, Not set

Siloah AG, Gümligen, Not set

University Hospital Zurich, Zürich, Not set

Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon

Leicestershire Partnership, Narborough, Leicestershire

North Bristol NHS Trust, Bristol, UK

Fife Health Board, Kirkcaldy, UK

Betsi Cadwaladr University Health Board, Wrexham, UK

University of Aberdeen, Aberdeen, Not set

Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, Not set

University of Cambridge, Cambridge, Not set

Cardiff University, Cardiff, Not set

Tayside Health Board, Dundee, Not set

Lothian Health Board, Edinburgh, Not set

Greater Glasgow Health Board, Glasgow, Not set

Ayrshire Central Hospital, Kilmarnock, Not set

NHS Forth Valley, Larbert, Not set

Leeds Teaching Hospitals, Leeds, Not set

The Walton Centre, Liverpool, Not set

Guy's and St. Thomas's NHS Foundation Trust, London, Not set

St. George's Hospital, London, Not set

University College of London, London, Not set

Central Manchester University Hospitals NHS Foundation Trust, Manchester, Not set

Northumberland, Tyne & Wear NHS Foundation Trust of St. Nicholas Hospital, Newcastle-upon-Tyne, Not set

St. Andrews Healthcare, Northampton, Not set

Oxford Radcliffe Hospitals, Oxford, Not set

Plymouth Hospitals NHS Trust, Plymouth, Not set

Poole Hospital, Poole, Not set

Royal Berkshire NHS Foundation Trust, Reading, Not set

Sheffield Children's NHS Foundation Trust, Sheffield, Not set

University Hospital Southampton, Southampton, Not set

North Staffordshire Combined Healthcare NHS Trust, Stoke-on-Trent, Not set

Avon and Wiltshire Mental Health Partnership, Swindon, Not set

Conditions: Huntington's Disease

Learn More ›

QoR40 Between Intercostal Block and Intercostal Block and Serratus Plane Catheter During VATS

NCT04990713

Recruiting

Video assisted thoracic surgery (VATS) has emerged as standard of care for majority of thoracic surgeries. It is less invasive compared to thoracotomy and is associated with improved perioperative outcomes \[1-3\]. Good perioperative analgesia after thoracic surgery will enable pulmonary toilet, early chest physiotherapy and mobilisation, \[4,5,6\]. Thirty-day hospital visits and hospital readmissions at London Health Sciences Centre (LHSC) is around 21% and 9% respectively \[7\]. One of the top five determinant for hospital visit and readmission in 30 days, was persistent post operative pain \[7\]. Several options to analgesia are available for patients undergoing VATS procedure. Systemic opioid based multimodal analgesia, central neuraxial blocks like thoracic epidural and peripheral nerve blocks are different available options, and their practise varies across institution \[4,8,9\]. Thoracic epidural or paravertebral blocks can be challenging to perform with high failure rates \[10-12\]. Fascial plane blocks (SAB; ESP) are in vogue in the present era \[13-16\]. They are easy to perform and do not require similar dexterity as needed to perform thoracic epidural or paravertebral blocks. They have minimal side effects and provide the options for continuous infusion for prolonged analgesia. They have become an effective part of multimodal analgesia and have established their roles in ERAS (enhanced recovery after surgery) protocol for VATS procedures. SAB has become a common practise at our institution with proved clinical efficacy. Perioperative Surgical Home is a patient centric team-based approach to improve patient's experiences in the perioperative period and thus improve healthcare \[17\]. Quality of Recovery (QoR) is a key determinant to perioperative surgical home and can be measured using the QoR 40 score \[18\]. This is a well validated score with a minimal important clinical difference (MICD) of 6.3 \[19\]. Quality of recovery combines five dimensions of health: patient support, comfort, emotions, physical independence and pain to achieve a single patient outcome - improved patient care \[18\]. The investigators hypothesize the that patients undergoing VATS lung resections using a combination of intercostal nerve block plus continuous SAB catheter infusion of local anesthetics will have a 20% increase in their QoR-40 score 24hour after the surgery compared to a single shot intercostal nerve block. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/26/2024

Locations: London Health Sciences Centre, London, Ontairo

Conditions: Video Assisted Thoracic Surgery (VATS), Pain Management

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STRIVE - Resilience Curriculum for Novice Physicians-In-Training

NCT05724420

Recruiting

The goal of this trial is to compare self-reported resilience scores in junior physicians-in-training after completion of formal resilience training. The main questions this trial aims to answer are: * Does formal resilience training improve self-reported resilience scores? * Does the timing of resilience training (i.e., first vs second year of residency training) impact the effect of training? All participants will be provided with resources on resilience and learner support as per usual insti... Read More

Gender:

ALL

Ages:

All

Trial Updated:

02/26/2024

Locations: London Health Sciences Centre, London, Ontario

Conditions: Stress, Emotional

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Mpox Prospective Observational Cohort Study

NCT06291259

Recruiting

The goal of this multicentre prospective observational cohort study is to shed light on the following unknowns: 1. The clinical manifestations of Mpox infection since the 2022 outbreak in Canada. 2. The social and psychological impacts of Mpox infection since the 2022 outbreak in Canada 3. The transmissibility of Mpox infection 4. Viral shedding over time in infected individuals The study is divided into Part 1 (corresponding to the acute phase of illness) and Part 2 (corresponding to the conv... Read More

Gender:

ALL

Ages:

All

Trial Updated:

02/26/2024

Locations: BC Centre For Excellence, Vancouver, British Columbia +2 locations

Conditions: Monkeypox

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Vaping Adverse Lung and Heart Events Cohort

NCT06291597

Recruiting

This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/26/2024

Locations: IUCPQ-UL, Québec, Not set

Conditions: Vaping, Electronic Cigarette Use

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rTMS for Depression in Young Adults With Autism

NCT04972136

Recruiting

The current clinical trial is focused on evaluating the efficacy of rTMS for treatment of depression in youth and young adults (hereafter called transition aged youth, TAY) with autism spectrum disorder (ASD). The motivation to undertake the current efficacy study is driven by: (1) the substantial impact of depression on TAY with ASD (based on prevalence and contribution to disability/impairment); (2) lack of evidence-based treatments for depression in autism (there are no current trials rigorou... Read More

Gender:

ALL

Ages:

Between 16 years and 35 years

Trial Updated:

02/25/2024

Locations: Centre for Addiction and Mental Health, Toronto, Ontario

Conditions: Autism Spectrum Disorder, Major Depressive Disorder

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IV Acetaminophen After Cardiac Surgery - PILOT

NCT05246644

Recruiting

Double blind double dummy of Intravenous Acetaminophen and oral acetaminophen placebo versus IV placebo versus oral acetaminophen in patients following cardiac surgery. The primary endpoint is development of Delirium during the post-operative stay.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/25/2024

Locations: McGill University Health Centre, Montreal, Quebec +1 locations

Conditions: Delirium

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Effects of NAC on Symptoms of CHR Patients

NCT05142735

Recruiting

Schizophrenia is a chronic debilitating psychotic disorder. Identifying persons with "clinical high-risk" (CHR) symptoms, which are like those of schizophrenia but less severe, and providing psychiatric care to these individuals has been shown to help prevent psychosis. Current medications used for CHR symptoms, however, are associated with substantial side effect burden. Therefore, practice guidelines do not recommend current medications as routine treatment for the CHR state, and there is a ne... Read More

Gender:

ALL

Ages:

Between 16 years and 35 years

Trial Updated:

02/23/2024

Locations: Centre for Addiction and Mental Health, Toronto, Ontario

Conditions: Prodromal Schizophrenia

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