PDA Treatment With Ibuprofen and Changes in Tissue Oxygenation.
NCT05325177
Recruiting
Babies who are born very prematurely are often born with murmurs in the heart. In preterm babies, one of the most common causes of murmur is the presence of a PDA. This is the persistence of a connection that normally exists in the baby before it is born, connecting between the major blood vessels that leave the heart. In term babies, this channel closes shortly after birth when normal adult circulation is achieved. However, in preterm babies, the PDA can remain open, which can lead to multiple... Read More
Gender:
ALL
Ages:
29 weeks and below
Trial Updated:
01/29/2024
Locations: The Ottawa General Hospital, Ottawa, Not set
Conditions: Patent Ductus Arteriosus After Premature Birth
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Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness
NCT06193980
Recruiting
This study aims to investigate how sepsis and shock can impair microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/28/2024
Locations: Health Sciences Centre Winnipeg, Winnipeg, Manitoba
Conditions: ICU Acquired Weakness, Microvascular Dysfunction, Sepsis, Shock
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Helping People Adhere to Their Varenicline Treatment by Co-creating a Conversational Agent: A Feasibility Study
NCT05997901
Recruiting
The goal of this feasibility study is to co-create and evaluate a theory informed, evidence-based, patient-centered healthbot aimed at helping people adhere to their varenicline regimen. The main research questions it aims to answer are: 1. What are the challenges to varenicline adherence and strategies to overcome such challenges from the perspective of service users and service providers? 2. What features of a healthbot would help improve adherence to varenicline? 3. Does a healthbot develope... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/26/2024
Locations: Centre for Addiction and Mental Health, Toronto, Ontario
Conditions: Medication Adherence, Smoking Cessation
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Lithium for Fracture Treatment: a Double Blind Randomized Controlled Trial (LiFT)
NCT02999022
Recruiting
This is a study designed to see if a low dose of Lithium treatment, taken for 2 weeks, can improve fracture healing and improve patients' function and productivity.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/25/2024
Locations: Royal Victoria Regional Health Centre, Barrie, Ontario +4 locations
Conditions: Fractures
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An Evaluation of the Talk Test for Exercise Prescription for Home-Based Cardiac Rehabilitation
NCT05157932
Recruiting
The objectives of this pilot RCT are to examine if the Talk Test is an effective and safe tool as compared with CPET for exercise prescription in patients who have undergone CABG or PCI and enrolled in a home-based CR program with virtual exercise training monitoring.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
01/25/2024
Locations: University of Ottawa Heart Institute, Ottawa, Ontario
Conditions: Coronary Artery Disease
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De-escalated Dose SBRT in Localized Prostate Cancer (DESTINATION-MRL)
NCT06177093
Recruiting
This study is a single centre feasibility trial. The trial will recruit men with intermediate risk localised prostate cancer who will all receive targeted dose (escalated/de-escalated dose directed by MRI) 5 fraction SBRT to the prostate. Trial Objectives are: 1. Primary To develop a 5 fraction de-escalated dose SBRT protocol capable of reducing side effects 2. Secondary * To assess levels of acute GU and GI toxicity (CTCAE) * To assess levels of late GU and GI toxicity (CTCAE) * To... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/25/2024
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Prostate Cancer
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A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
NCT04849728
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Pinnacle Research Group, Anniston, Alabama +493 locations
Conditions: NASH - Nonalcoholic Steatohepatitis
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Clinical Outcomes From Enhanced SCREENing Strategies for NASH in Type 2 Diabetes (SCREEN NASH T2D)
NCT05029583
Recruiting
The study is stratified cluster randomized trial. The study population will include adults with T2D and presumed NASH.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/23/2024
Locations: LMC Diabetes & Endocrinology Ltd., Toronto, Ontario
Conditions: Nonalcoholic Steatohepatitis, Type 2 Diabetes
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Sperm Oxidative Stress and Pregnancy Success During IUI and IVF
NCT03539874
Recruiting
Oxidative stress (OS) is characterized by an imbalance between the production of reactive oxygen species (ROS) and the ability of the body to eliminate them. Such an imbalance can lead to lipid peroxidation, DNA damage and cell apoptosis. Studies have suggested that infertile men are more likely to have high concentrations of ROS in their seminal plasma. The investigators hypothesize that a high level of oxidative stress (OS) in patients with abnormal sperm parameters could influence fertilizati... Read More
Gender:
MALE
Ages:
Between 18 years and 40 years
Trial Updated:
01/22/2024
Locations: Fertilys, Laval, Quebec
Conditions: Oxidative Stress
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Effect of Polyphenol Supplementation on Hepatic Steatosis and Vascular Compliance
NCT03994029
Recruiting
The main objective is to study the effect of polyphenol supplementation on hepatic steatosis as measured by hepatic ultrasound, hepatic magnetic resonance imaging and on intima-media thickness and vascular elastography in obese adolescents known for hepatic steatosis as diagnosed by liver biopsy
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
01/22/2024
Locations: CHU Sainte-Justine, Montreal, Quebec
Conditions: Obesity, Childhood, Hepatic Steatosis, Intimal Hyperplasia
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Long Term Oral Appliance Therapy Effectiveness for Obstructive Sleep Apnea Syndrome
NCT02410850
Recruiting
Obstructive sleep apnea (OSA) is a highly prevalent breathing problem that occurs during sleep. OSA have been associated with the obesity epidemic in developing countries; additionally, high OSA prevalence rates are present in populations with cardiovascular and metabolic disorders. Two OSA treatments are currently available, oral appliance (OA) therapy and continuous positive airway pressure (CPAP). OAs are an underutilized non-surgical treatment and few studies have analyzed their long-term ef... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/21/2024
Locations: University of British Columbia, Vancouver, British Columbia
Conditions: Obstructive Sleep Apnea
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The Surgical Safety Checklist Revisited
NCT05700890
Recruiting
The goal of this study is to develop and iteratively improve a toolkit - the "High-Performance Checklist" (HPC) toolkit - that provides clinicians with evidence-informed strategies for improving their Modification, Implementation, Training on, and Evaluation of the Surgical Safety Checklist. The study team will test the toolkit in the operating rooms of Calgary's Peter Lougheed Centre and collect feedback via surveys and questionnaires. This feedback will be used to iteratively improve the tool... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/19/2024
Locations: Karolina Kogut, Calgary, Alberta
Conditions: Surgical Procedure, Unspecified, Communications Personnel, Tool Use Behavior
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