Neurocognitive Effects of FMT in MDD Patients With and Without IBS
NCT05174273
Recruiting
This study is a phase 2/3 open-label controlled trial (CT) in which adults with Major Depressive Disorder (MDD) and adults who have MDD plus comorbid Inflammatory Bowel Syndrome (IBS) will be assigned to either receive oral Fecal Microbiota Transplantation (FMT) or to continue with the treatment they are currently receiving in a Treatment As Usual (TAU) arm. An IBS alone group receiving TAU will be recruited as a clinical control group. The primary goals of this study are to determine effective... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
11/27/2023
Locations: University of Calgary, TRW building, Calgary, Alberta
Conditions: Major Depressive Disorder, Irritable Bowel Syndrome
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Risk and Resiliency Factors in the RCMP: A Prospective Investigation
NCT05527509
Recruiting
The Royal Canadian Mounted Police (RCMP), like all public safety personnel (PSP), are frequently exposed to potentially psychologically traumatic events that contribute to posttraumatic stress injuries (PTSI). Addressing PTSI is impeded by the limited available research. The RCMP are working to build evidence-based solutions to PTSI and other mental health challenges facing their members, which by extension will help all PSP, as part of the Canadian Government Federal Framework on Posttraumatic... Read More
Gender:
ALL
Ages:
Between 19 years and 57 years
Trial Updated:
11/27/2023
Locations: University of Regina, Regina, Saskatchewan
Conditions: Posttraumatic Stress Disorder, Major Depressive Disorder, Panic Disorder, Generalized Anxiety Disorder, Trauma, Traumatic Stress Disorder, Trauma and Stress Related Disorders, Vicarious Trauma
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A Clinical Trial of Fecal Microbiota Transplantation in a Population With Obsessive-compulsive Disorder
NCT05720793
Recruiting
Obsessive-compulsive disorder (OCD) is a psychiatric condition marked by recurrent intrusive thoughts (obsessions) and ritualistic behaviors aimed at reducing distress (compulsions). While there exist a number of medications to treat this illness, half of those who need them either do not respond or can not tolerate current medications because of side effects. Therefore, there is an urgent need to develop new ways to treat this illness. One of the areas being explored as a potential option is ba... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/27/2023
Locations: University of Calgary, TRW building, Calgary, Alberta
Conditions: Obsessive-Compulsive Disorder
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Real World Evidence on the Use of Medical Cannabis in Pediatrics
NCT05863910
Recruiting
CAN-RWE is an observational study that is following 500 children who have authorizations for medical cannabis for two years from across Canada.
Gender:
ALL
Ages:
Between 3 years and 17 years
Trial Updated:
11/27/2023
Locations: U Manitoba, Winnipeg, Manitoba
Conditions: Cancer, Epilepsy, Neurodevelopmental Disorders
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Inhaled Nitric Oxide for Cardiac Arrest in Pediatrics and Adults (iNOCAPA)
NCT05868109
Recruiting
This study is a multi-center, double blind, randomized controlled trial of inhaled nitric oxide (iNO) in children and adults with cardiac arrest (CA). The purpose of this pilot study is to test the feasibility of rapidly randomizing patients to iNO or sham treatment during cardiopulmonary resuscitation (CPR) or shortly after return of circulation (ROC) and evaluate blood biomarkers associated with iNO compared to sham. Return of circulation may refer to return of spontaneous circulation (ROSC) o... Read More
Gender:
ALL
Ages:
Between 1 day and 80 years
Trial Updated:
11/27/2023
Locations: St. Michael's Hospital, Toronto, Ontario +3 locations
Conditions: Cardiac Arrest
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Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease
NCT03969953
Recruiting
The TRACK trial is an investigator-initiated, multicentre, prospective, randomised, quadruple-blind (participant, healthcare provider, data collector, outcomes assessor), placebo-controlled trial. TRACK is a global trial and will be conducted in renal units that provide comprehensive CKD care. Approximately 2000 participants will be recruited. The TRACK trial will assess a strategy of administering low dose rivaroxaban to reduce the risk of major adverse cardiac event (MACE) in people with Chro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2023
Locations: Canberra Hospital, Garran, Australian Capital Territory +82 locations
Conditions: Chronic Kidney Diseases, Cardiovascular Disease, Dialysis-dependent Kidney Failure
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Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery
NCT04427904
Recruiting
The purpose of this study is to compare the efficacy of Bupivicaine and Lidocaine for postoperative pain control in thyroid surgery.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/26/2023
Locations: St. Joeseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Postoperative Pain, Thyroid Diseases, Anesthesia, Local
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Behavioural Activation Therapy for Bipolar Disorder
NCT04317859
Recruiting
Mood disorders including bipolar disorder and depression are common disabling disorders with depression affecting 11.2 to 16.0% of the general population and the lifetime prevalence of bipolar disorders at an estimated 4.4%. Although treatment with antidepressants medications is common and effective in some patients, 42.7% of patients show inadequate response to treatment with antidepressants and a large proportion (55.3%) continue to have ongoing depressive symptoms. Psychological and behaviour... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/24/2023
Locations: St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Bipolar Disorder
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Auditory MMN EEG in TRD in Response to Ketamine
NCT05464264
Recruiting
To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/24/2023
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Treatment-resistant Depression (TRD)
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Anterior Chamber Versus Scleral Fixated Intraocular Lens: Long-term Vision and Safety Outcomes
NCT04072978
Recruiting
This is a prospective comparative non-randomized cohort study to understand the long-term vision outcomes, safety, and stability of anterior chamber intraocular lenses (AC IOLs) vs. scleral-fixated intraocular lenses (SF IOLs).
Gender:
ALL
Ages:
Between 16 years and 99 years
Trial Updated:
11/23/2023
Locations: Sunnybrook Hospital, Toronto, Ontario
Conditions: Corneal Endothelial Cell Loss, Secondary Intraocular Lens
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JoyPop Mobile Mental Health App With Post-Secondary Students
NCT06154369
Recruiting
Students within post-secondary education settings are experiencing increasing stress, distress, and mental health difficulties. Many post-secondary education settings have identified student mental health and wellbeing as a priority and yet are struggling to adequately meet the needs of students. This has led to exploring whether technology can be used to help promote mental health and wellbeing among students. The JoyPop app is one mobile mental health app with a growing evidence base. It was d... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
11/23/2023
Locations: Lakehead University, Thunder Bay, Ontario
Conditions: Emotion Regulation, Depression, Anxiety, Stress, Well-Being, Psychological
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Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis
NCT05973110
Recruiting
Individuals living with a psychotic disorder often experience changes to their thinking and social skills that can lead to challenges with work, school, relationships and living independently. One intervention to target these areas is cognitive remediation therapy, which can be delivered in virtual reality to help apply the skills and strategies learned to day-to-day life. Over the past few years, our team has co-developed a cognitive remediation program in virtual reality with healthcare profes... Read More
Gender:
ALL
Ages:
Between 20 years and 55 years
Trial Updated:
11/21/2023
Locations: Royal Ottawa Mental Health Centre, Ottawa, Ontario
Conditions: Psychotic Disorders, Schizophrenia, Schizo Affective Disorder
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