Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease
NCT03969953
Recruiting
The TRACK trial is an investigator-initiated, multicentre, prospective, randomised, quadruple-blind (participant, healthcare provider, data collector, outcomes assessor), placebo-controlled trial. TRACK is a global trial and will be conducted in renal units that provide comprehensive CKD care. Approximately 2000 participants will be recruited. The TRACK trial will assess a strategy of administering low dose rivaroxaban to reduce the risk of major adverse cardiac event (MACE) in people with Chro... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/26/2023
Locations: Canberra Hospital, Garran, Australian Capital Territory +82 locations
Conditions: Chronic Kidney Diseases, Cardiovascular Disease, Dialysis-dependent Kidney Failure
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Bupivacaine Versus Lidocaine Infiltration for Postoperative Pain in Thyroid Surgery
NCT04427904
Recruiting
The purpose of this study is to compare the efficacy of Bupivicaine and Lidocaine for postoperative pain control in thyroid surgery.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
11/26/2023
Locations: St. Joeseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Postoperative Pain, Thyroid Diseases, Anesthesia, Local
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Behavioural Activation Therapy for Bipolar Disorder
NCT04317859
Recruiting
Mood disorders including bipolar disorder and depression are common disabling disorders with depression affecting 11.2 to 16.0% of the general population and the lifetime prevalence of bipolar disorders at an estimated 4.4%. Although treatment with antidepressants medications is common and effective in some patients, 42.7% of patients show inadequate response to treatment with antidepressants and a large proportion (55.3%) continue to have ongoing depressive symptoms. Psychological and behaviour... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/24/2023
Locations: St. Joseph's Healthcare Hamilton, Hamilton, Ontario
Conditions: Bipolar Disorder
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Auditory MMN EEG in TRD in Response to Ketamine
NCT05464264
Recruiting
To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/24/2023
Locations: St. Michael's Hospital, Toronto, Ontario
Conditions: Treatment-resistant Depression (TRD)
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Anterior Chamber Versus Scleral Fixated Intraocular Lens: Long-term Vision and Safety Outcomes
NCT04072978
Recruiting
This is a prospective comparative non-randomized cohort study to understand the long-term vision outcomes, safety, and stability of anterior chamber intraocular lenses (AC IOLs) vs. scleral-fixated intraocular lenses (SF IOLs).
Gender:
ALL
Ages:
Between 16 years and 99 years
Trial Updated:
11/23/2023
Locations: Sunnybrook Hospital, Toronto, Ontario
Conditions: Corneal Endothelial Cell Loss, Secondary Intraocular Lens
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JoyPop Mobile Mental Health App With Post-Secondary Students
NCT06154369
Recruiting
Students within post-secondary education settings are experiencing increasing stress, distress, and mental health difficulties. Many post-secondary education settings have identified student mental health and wellbeing as a priority and yet are struggling to adequately meet the needs of students. This has led to exploring whether technology can be used to help promote mental health and wellbeing among students. The JoyPop app is one mobile mental health app with a growing evidence base. It was d... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
11/23/2023
Locations: Lakehead University, Thunder Bay, Ontario
Conditions: Emotion Regulation, Depression, Anxiety, Stress, Well-Being, Psychological
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Social Cognition in Youth Who Have a First Degree Relative With Schizophrenia
NCT04681807
Recruiting
Social cognition is an individual's ability to perceive, process, understand, and react to other individuals in a social situation. Social cognition is impaired in individuals with schizophrenia, including difficulty recognizing others' emotions. A promising treatment avenue for emotion recognition problems in individuals with schizophrenia is continued practice with various facial expression recognition training programs. First degree relatives of someone with schizophrenia are considered at fa... Read More
Gender:
ALL
Ages:
Between 15 years and 25 years
Trial Updated:
11/21/2023
Locations: The Royal Ottawa Mental Health Centre, Ottawa, Ontario
Conditions: Schizophrenia
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Alternative Dosing Of Niraparib To Decrease Dose Interruption In First Line Maintenance Treatment For Ovarian Cancer
NCT05961124
Recruiting
The goal of this clinical trial is to test alternative dosing of niraparib in patients with newly diagnosed high-grade, advanced stage ovarian cancer. The main questions it aims to answer are: What is the incidence of hematologic and other adverse events? What is the incidence of dose interruption, dose reduction and discontinuation? What is the length of time of progression-free survival at 24 months?
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/21/2023
Locations: Sunnybrook Research Institute, Toronto, Ontario
Conditions: Ovarian Cancer, Stage III Ovarian Cancer, Stage IV Ovarian Cancer, High Grade Ovarian Serous Adenocarcinoma
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Examining the Efficacy of a Virtual Reality Cognitive Remediation Program for People Living With Psychosis
NCT05973110
Recruiting
Individuals living with a psychotic disorder often experience changes to their thinking and social skills that can lead to challenges with work, school, relationships and living independently. One intervention to target these areas is cognitive remediation therapy, which can be delivered in virtual reality to help apply the skills and strategies learned to day-to-day life. Over the past few years, our team has co-developed a cognitive remediation program in virtual reality with healthcare profes... Read More
Gender:
ALL
Ages:
Between 20 years and 55 years
Trial Updated:
11/21/2023
Locations: Royal Ottawa Mental Health Centre, Ottawa, Ontario
Conditions: Psychotic Disorders, Schizophrenia, Schizo Affective Disorder
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Effect of Sprint Interval Training Frequency on Improvements in Fitness
NCT06142942
Recruiting
The goal of this study is to learn how the number of weekly exercise sessions affects improvements in fitness in healthy university aged students. The main question it aims to answer is how training frequency affects improvements in fitness. Participants will complete a pre-testing sessions to assess fitness level and sprint performance. Following this participants are assigned to one of four groups. A group that exercises 2 days a week, a group that trains 3 days a week, a group that trains 4 d... Read More
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
11/21/2023
Locations: Wilfrid Laurier University, Waterloo, Ontario
Conditions: Cardiorespiratory Fitness
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Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
NCT00680264
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: Rady Children's Hospital, San Diego, California +14 locations
Conditions: Cerebral Palsy, Scoliosis
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Virtual Reality for Port-a-Cath Access
NCT04931745
Recruiting
Children with cancer almost universally receive port-a-catheters (ports) to deliver medication, fluids, blood products, and conduct blood tests. Port access requires a needle inserted through the skin to the subcutaneous tissue. Despite the application of topical anesthetic, port access can be painful and anxiety producing. Virtual reality (VR) interfaces provide a strategy to reduce anxiety and have been employed in other painful procedures in children. This trial will explore the effectiveness... Read More
Gender:
ALL
Ages:
Between 5 years and 17 years
Trial Updated:
11/20/2023
Locations: London Health Sciences Centre, London, Ontario
Conditions: Oncology Pain
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