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All Clinical Trials in Canada
A listing of 3913 clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
649 - 660 of 3913
Intensive Cancer Screening After Cryptogenic Stroke
Recruiting
The INCOGNITO Pilot Trial is a single centre pilot prospective randomized open-label blinded endpoint (PROBE) trial to assess the feasibility of a full-scale randomized trial to determine whether an occult cancer screening strategy of FDG PET/CT (F-fluorodeoxyglucose positron emission/computed tomography) in addition to usual care increases the number of occult cancers diagnosed after screening compared to usual care cancer screening alone in patients with cryptogenic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: The Ottawa Hospital, Ottawa, Ontario
Conditions: Occult Cancer
Study of Quemliclustat and Chemotherapy Versus Placebo and Chemotherapy in Patients With Metastatic Pancreatic Ductal Adenocarcinoma
Recruiting
The purpose of this study is to compare overall survival of quemliclustat, nab-paclitaxel and gemcitabine versus placebo, nab-paclitaxel and gemcitabine in all randomized patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Mayo Clinic Arizona - Phoenix Campus, Phoenix, Arizona +132 locations
Conditions: Metastatic Pancreatic Ductal Adenocarcinoma
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
Recruiting
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: Local Institution - 0066, Birmingham, Alabama +46 locations
Conditions: Lung Cancer
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
Recruiting
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/29/2025
Locations: City of Hope, Duarte, California +28 locations
Conditions: Diabetes Mellitus, Type 1, Impaired Hypoglycemic Awareness, Severe Hypoglycemia
A Study to Evaluate the Efficacy and Safety of JCAR017 in Adult Subjects With Relapsed or Refractory Indolent B-cell Non-Hodgkin Lymphoma (NHL)
Recruiting
This is a global Phase 2, open-label, single-arm, multicohort, multicenter study to evaluate efficacy and safety of JCAR017 in adult subjects with r/r FL or MZL.
The study will be conducted in compliance with the International Council on Harmonisation (ICH) of Technical Requirements for Registration of Pharmaceuticals for Human Use/Good Clinical Practice (GCP) and applicable regulatory requirements.
This study is divided into three periods:
* Pretreatment, which consists of screening assessme... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2025
Locations: UCLA Medical Centre-Santa Monica, Santa Monica, California +58 locations
Conditions: Lymphoma, Non-Hodgkin
Trifecta-Heart cfDNA-MMDx Study
Recruiting
Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood transplant recipient and the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from heart transplants.
Gender:
ALL
Ages:
All
Trial Updated:
07/28/2025
Locations: Baptist Health Institute for Research and Innovation, Little Rock, Arkansas +11 locations
Conditions: Heart Transplant Rejection
Methoxyflurane for IUD Insertion and Endometrial Biopsy
Recruiting
The aim of this study is to determine if 3ml of inhaled Methoxyflurane, in the form of a Penthrox inhaler, reduces pain during IUD insertion and/or endometrial biopsy. The proposed study is a double-blind, placebo-controlled RCT.
Each participant will be randomly assigned to one of two arms:
1. Intervention (3ml of Methoxyflurane via a Penthrox inhaler)
2. Placebo (3ml of normal saline via an identical placebo Penthrox inhaler)
The primary outcome is global pain score, which will be patient-r... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
07/28/2025
Locations: OPG, Toronto, Ontario
Conditions: Endometrial Biopsy, Intrauterine Devices
Long-Term, Open-label Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE
Recruiting
This is a Phase 3, multicenter, long-term, open-label study to evaluate the safety and efficacy of once-daily orally administered deucrictibant extended-release tablet for prophylaxis to prevent angioedema attacks in participants aged ≥12 years with Hereditary Angioedema
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/28/2025
Locations: Study Site, Santa Monica, California +16 locations
Conditions: Hereditary Angioedema (HAE)
Pan-Canadian Lung Cancer Observational Study (PALEOS)
Recruiting
A multicenter, ambispective observational study focusing on patients diagnosed with lung cancer in Canada identified after January 1, 2000 inclusive. This data will be combined with that from deceased patients identified.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Milena (Lynn) Vicente, Brampton, Ontario
Conditions: Lung Cancer
ADVENT Post Approval Study
Recruiting
The ADVENT Post Approval Study (PAS) is a prospective, global, multicenter, observational study.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Mobile Infirmary Medical Center, Mobile, Alabama +33 locations
Conditions: Paroxysmal Atrial Fibrillation
Cannabidiol After Multi-Trauma for Pain and Opioid Therapy
Recruiting
The aim of this project is to investigate the therapeutic potential and safety of acute Cannabidiol (CBD) treatment on longitudinal pain symptoms, and to assess potential interactions with pain mediators including opioids and sex on CBD treatment response. To this end, this research protocol proposes a comprehensive translational approach including a placebo-controlled randomized clinical trial comparing two daily doses of CBD treatment administered for one month on pain relief. This study will... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/28/2025
Locations: Hôpital Sacré-Coeur de Montréal, Montréal, Quebec
Conditions: Fracture
A Study to Investigate Efficacy, Safety, and Tolerability of Remibrutinib Compared With Placebo in Adults With CINDU Inadequately Controlled by H1-antihistamines
Recruiting
This is a Phase 3, parallel group, placebo-controlled, double-blind, confirmatory study in patients with CINDU, with an optional Open-label Extension (OLE).
The purpose of the core period (52 weeks of treatment) of this study is to evaluate the efficacy, safety, and tolerability of remibrutinib (LOU064) vs. placebo in adults suffering from CINDU inadequately controlled by H1-antihistamines (H1-AHs).
The purpose of the OLE period is to collect long-term efficacy, safety, and tolerability data o... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/28/2025
Locations: Allervie Clinical Research, Birmingham, Alabama +160 locations
Conditions: Chronic Inducible Urticaria
649 - 660 of 3913