The Feasibility of Implementing Syphilis Point-of-care Testing Into a Prenatal Clinic for People Facing Barriers to Care
NCT06829602
Recruiting
The goal of this clinical trial is to learn if a finger-prick blood test for rapid diagnosis of syphilis infection can be implemented in a low-barrier prenatal clinic for people at risk of syphilis in pregnancy. The test gives results in 5 minutes and also tests for HIV. The main questions the study aims to answer are: * How often do pregnant people at risk of syphilis agree to the rapid test? * How well do healthcare providers perform the rapid test? * Does the rapid test speed up diagnosis a... Read More
Gender:
ALL
Ages:
Between 13 years and 49 years
Trial Updated:
07/03/2025
Locations: Maternity Centre of Hamilton, Hamilton, Ontario
Conditions: Syphilis
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To Assess Safety of Mitapivat and Provide Proof of Concept of the Efficacy of the Drug in Patients With RBC Membranopathies or CDAII.
NCT07055243
Recruiting
This is a prospective exploratory phase 2 study designed to evaluate the safety and efficacy of mitapivat in RBC membranopathies and CDAII, a rare sub type of anemia. Nine patients from Princess Margaret who are diagnosed with CDAII will be enrolled to the study. Patients will be in the trial for 57 weeks treatment weeks and a safety follow up week after 30 days from last dose. First 8 weeks will be dose escalating period followed by 48 weeks of fixed dose period. 57th week will be dose tapering... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: University Health Network (UHN), Toronto, Ontario
Conditions: Anemia
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Nutritional Management of Post COVID-19 Cognitive Symptoms
NCT05705648
Recruiting
The goal of this clinical trial is to learn about in brain "fog" complaints associated with long-COVID in people aged 22-50-years. The main questions it aims to answer are: * the natural course of brain "fog" complaints * the effect, if any of supplemental dietary oil on brain "fog" complaints Participants will be asked to undergo some brain testing (X-rays and questions. Treatments they'll be given will be one of two supplemental oils to consume daily. Researchers will compare outcomes in the... Read More
Gender:
ALL
Ages:
Between 22 years and 50 years
Trial Updated:
07/03/2025
Locations: University of Alberta, Edmonton, Alberta
Conditions: Long COVID
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Effectiveness of the Journey Total Knee Arthroplasty Versus Two Standard of Care Total Knee Arthroplasty Prostheses
NCT03895489
Recruiting
The purpose of the study is to determine if knee replacement performed using Journey II implant is different from two other standard-of-care knee replacements using Stryker and Zimmer in terms of knee movements and forces, walking patterns, pain, and function after surgery.
Gender:
ALL
Ages:
Between 50 years and 75 years
Trial Updated:
07/03/2025
Locations: Edmonton Bone and Joint Centre, Edmonton, Alberta
Conditions: Osteoarthritis, Knee
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Evaluating a Virtual Stepped Care Portal in Youth Awaiting Tertiary Chronic Pain Care: An Implementation-Effectiveness Hybrid Type III Study
NCT05894772
Recruiting
Pain is one of the most common symptoms of extreme stress in youth. Without treatment, short-term pain can last for months to years (called 'chronic pain'; CP), a problem already affecting 1 in 5 Canadian youth. The COVID-19 pandemic is one of the greatest threats to youth mental health seen in generations. CP in childhood can trigger a wave of mental health issues that last well into adulthood. In 2019, we learned that "access to pain care" is poor and a priority for youth with CP and their fam... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/03/2025
Locations: IWK Health Center, Halifax, Nova Scotia +10 locations
Conditions: Chronic Pain
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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes
NCT06399302
Recruiting
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: University of California Los Angeles, Los Angeles, California +16 locations
Conditions: Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure
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iCanCope With Post-Operative Pain (iCanCope PostOp)
NCT05382962
Recruiting
There are few applications available in the community to help teenagers manage pain after surgery. The focus of this study is to better understand the pain experience of children after having surgery and to design a Smartphone app called "iCanCope with Post-Operative Pain" (iCanCope PostOp), to help children and parents to better manage pain at home after surgery. The app will help keep track of pain, provide information about the teenager's surgery and provides "in-the-moment" advice wherever a... Read More
Gender:
ALL
Ages:
Between 12 years and 18 years
Trial Updated:
07/03/2025
Locations: Boston Children's Hospital, Boston, Massachusetts +1 locations
Conditions: Pain, Chronic, Pain, Chronic Post-Surgical
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Optimizing the Management of Staphylococcus Aureus Bacteremia (OPTIMUS-SAB)
NCT06338176
Recruiting
Staphylococcus aureus bacteremia (SAB) is associated with high morbidity and mortality rates with an incidence disproportionately higher in vulnerable populations. Management according to evidence-based care parameters, in particular Infectious Diseases (ID) consultation, is associated with improved mortality. SAB management is suboptimal in Alberta compared to other jurisdictions. An Alberta-based pilot study confirmed that timely recommendations to optimize SAB care, including ID consultation,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Athabasca Healthcare Centre, Athabasca, Alberta +100 locations
Conditions: Staph Aureus Bacteremia
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A Registry Based Randomized-Controlled Trial of an Upper Limb Exergaming Intervention for Children and Adolescents With Spinal Muscular Atrophy
NCT06396325
Recruiting
This is a multisite randomized controlled registry-based trial to evaluate the efficacy of an 8-week home-based exergaming intervention as compared to usual care on occupational satisfaction of children and youth (8-18 years old age) with spinal muscular atrophy (SMA).
Gender:
ALL
Ages:
Between 8 years and 18 years
Trial Updated:
07/03/2025
Locations: Alberta Children's Hospital, Calgary, Alberta +4 locations
Conditions: Spinal Muscular Atrophy
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A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis
NCT06407934
Recruiting
This is a multinational, multicenter, randomized, double-blind, placebo-controlled, parallel, Phase 3 study for treatment of participants aged 12 years and older diagnosed with moderate-to-severe atopic dermatitis (AD). The main objective of this study is to evaluate if those participants who received amlitelimab dose 1 in the parent studies (EFC17559 \[COAST-1\], EFC17560 \[COAST 2\], EFC17561 \[SHORE\]) and were responders can maintain their response either remaining at dose 1 or switching to... Read More
Gender:
ALL
Ages:
12 years and above
Trial Updated:
07/03/2025
Locations: Cahaba Dermatology & Skin Health Center- Site Number : 8401066, Birmingham, Alabama +304 locations
Conditions: Dermatitis Atopic
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Surgery Versus Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer
NCT05183932
Recruiting
The development of stereotactic body radiation therapy (SBRT) for the treatment of stage I non-small cell lung cancer (NSCLC) has inspired a close partnership between thoracic surgery and radiation oncology. In this study, patients with stage I NSCLC will be screened prior to treatment and will be consented after their treatment plan has been determined. Prospectively collected patient-reported outcomes (PROs) will be collected for 3 years or for the duration of the study (whichever is shorter),... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2025
Locations: Emory University, Atlanta, Georgia +7 locations
Conditions: Non Small Cell Lung Cancer, Non-small Cell Lung Cancer
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Eliciting Informed Goals of Care in Elderly Patients
NCT06002113
Recruiting
Patient-centered medical care considers a patient's values and goals for their health and well-being. Healthcare providers use this information to formulate a medical care plan that is aligned with these expectations. This shared-decision making process should occur with every medical decision, but it is especially important whenever decisions about end-of-life care are being considered. Eliciting patient preferences about resuscitation and life-support treatments in the event of life-threatenin... Read More
Gender:
ALL
Ages:
80 years and above
Trial Updated:
07/03/2025
Locations: Royal Victoria Regional Health Centre, Barrie, Ontario
Conditions: Goals of Care, Patient Preference, End of Life
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