Clonal Hematopoiesis is a Risk Factor for Chemotherapy-Related Complications
NCT04053439
Recruiting
'CHIP' stands for Clonal Hematopoiesis of Indeterminate Significance, which are mutations in bone marrow stem cells that give that population of cells a survival or 'clonal' advantage for growth. This study investigates whether CHIP in lymphoma patients aged 60 years and older is a risk factor for chemotherapy-related complications like low blood counts, infections, cardiac events, hospitalizations, dose delays and dose reductions, and failure to recover normal blood counts after chemotherapy fi... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/02/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Lymphoma, Chemotherapeutic Toxicity
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rTMS for Apathy Clinical Trial
NCT05561205
Recruiting
Apathy is a common, early, and disabling symptom in dementias and mild behavioural impairment such as Alzheimer's disease (AD) and is characterized by lack of interest and enthusiasm. Both repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, and methylphenidate, a medication, have been shown to improve apathy. This pilot study will investigate rTMS as a treatment for apathy in neurocognitive disorders and mild behavioural impairment in individuals receiv... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/02/2025
Locations: Sunnybrook Health Sciences Centre, Toronto, Ontario
Conditions: Alzheimer Disease, Apathy in Dementia, Dementia, Mild Behavioural Impairment, Mild Cognitive Impairment, Neurocognitive Disorders
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Feasibility, Accuracy, and Reproducibility of Virtual Reality Visual Field Testing in Patients With Glaucoma
NCT07063537
Recruiting
The goal of this clinical trial is to evaluate the feasibility of using virtual reality based visual field testing to monitor glaucoma in a clinical setting. This will be done through comparison of a virtual reality (VR) based device to the current gold standard Ziess Humphrey Field Analyzer (HFA). The main questions the study aims to answer are: * Can both devices produce similar results in terms of detecting visual field defects and progression? * Does the stage (early, moderate, advanced) of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Eadie Technologies Inc, Halifax, Nova Scotia
Conditions: Glaucoma Open-Angle
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Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users
NCT05854667
Recruiting
The goal of this clinical trial is to learn if administering a high dose stimulant with Contingency Management reduces days of use in adults who use methamphetamine better than the usual treatment provided by the clinic. The main questions the trial aims to answer are: Is a high dose stimulant better than a placebo and usual treatment at helping reduce the number of days they use methamphetamine? Is a high dose stimulant with contingency management better than placebo and usual treatment at he... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
07/02/2025
Locations: Rapid Access Addiction Medicine Clinic, St. Paul's Hospital, Vancouver, British Columbia +3 locations
Conditions: Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance, Addiction
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Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise
NCT07063732
Recruiting
The purpose of this trial is to investigate the effect of acute ketone monoester ingestion (0.6 g KME/kg body weight) on the occurrence of the ventilatory threshold and the subsequent response of blood velocity in cerebral arteries during a maximal exercise test at low altitude and high altitude.
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
07/02/2025
Locations: Barcroft Research Station, Bishop, California +1 locations
Conditions: High Altitude Hypoxia, Exercise
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Improving Pain Disability With the Use of Oral Cannabinoids
NCT05351905
Recruiting
The investigators are conducting a pilot (i.e. a small study) in order to find out the effectiveness and safety of medical cannabis in the management of chronic pain. At the end of this 3 month study, investigators will gather information on how easy it is for patients to enroll and complete the entire study. The results of this pilot study will help the study team design a larger randomized controlled trial.
Gender:
ALL
Ages:
25 years and above
Trial Updated:
07/02/2025
Locations: University Health Network, Toronto, Ontario
Conditions: Chronic Pain, Opioid Use, Cannabis
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Acoustics as a Metric of Airway Pressure in Premature Infants Using Bubble Continuous Positive Airway Pressure
NCT07060833
Recruiting
This is an observational, proof-of-concept, feasibility study where 30 preterm infants on bubble CPAP with gestational age \< 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's Hospital. The study's main goals are: 1. To determine the relationship between ambient bubbling sounds and delivered pressures in preterm infants on bCPAP. 2. To determine the relationship between transmitted bubbling sounds and airway pressures transmitted to the lungs... Read More
Gender:
ALL
Ages:
Between 28 weeks and 32 weeks
Trial Updated:
07/02/2025
Locations: McGill University Health Center, Montreal, Quebec
Conditions: Preterm Infant
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Online Psychology Program for Chronic Pain After Surgery
NCT06455345
Recruiting
This project will evaluate the feasibility of a new fully self-guided online Acceptance and Commitment Therapy (ACT) program entitled Advancing Online Psychology Tools for the Transitional Pain Service (ADOPT-TPS), developed on an online health application platform called Manage My Pain (MMP). The ACT program is designed to teach mindfulness skills and provide psychoeducation about post-surgical pain. The feasibility of the self-guided online program will be compared to a pre-existing psychologi... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/02/2025
Locations: Toronto General Hospital- The Department of Anesthesia and Pain Management, Toronto, Ontario +1 locations
Conditions: Post-surgical Pain, Pain, Acute, Pain, Chronic, Post-Surgical Pain, Chronic
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A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy
NCT05774951
Recruiting
This is a Phase III open-label study to assess if camizestrant improves outcomes compared to standard endocrine therapy in patients with ER+/HER2 - early breast cancer with intermediate or high risk for disease recurrence who completed definitive locoregional therapy (with or without chemotherapy) and standard adjuvant endocrine therapy (ET) for at least 2 years and up to 5 years. The planned duration of treatment in either arm of the study is 60 months.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
07/01/2025
Locations: Research Site, Birmingham, Alabama +723 locations
Conditions: Breast Cancer, Early Breast Cancer
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Study of Tuvusertib (M1774) in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)
NCT05396833
Recruiting
This is an open-label, multicenter, clinical study conducted in multiple parts to establish the safety, tolerability, Pharmacokinetic/Pharmacodynamic (PK/PD) profile, maximum tolerated dose (MTD) combinations (if observed) and recommended dose for expansion (RDE) combination for tuvusertib in combination with lartesertib (in Part A1), food effect on the PK of lartesertib as monotherapy followed by treatment with tuvusertib in combination with lartesertib in participants with specific tumor types... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: Providence Medical Foundation, Santa Rosa, California +19 locations
Conditions: Metastatic or Locally Advanced Unresectable Solid Tumors
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A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475
Recruiting
The purpose of this study is to measure the change in hemoglobin A1c (HbA1c) with LY3457263 compared with placebo in participants with type 2 diabetes who are not at HbA1c goal when treated with a stable dose of semaglutide or tirzepatide. Participation in the study will last about 9 months.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/01/2025
Locations: Helios Clinical Research - Phoenix, Phoenix, Arizona +55 locations
Conditions: Type 2 Diabetes
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BoStOn SCientific Rhythm MAnagemenT REgiStry (SOCRATES)
NCT04823663
Recruiting
SOCRATES is part of Boston Scientific's (BSC) Post-market surveillance system. The implementation of such systems is mandatory per local regulations such as the Regulation '(EU) 2017/745 of the European Parliament and of the Council of 5 April 2017 on medical devices' or short Medical Device Regulation (MDR). The SOCRATES design is therefore based on the BSC's commitment as well as external regulatory requirements to proactively and systematically gather, record and analyze relevant data on the... Read More
Gender:
ALL
Ages:
All
Trial Updated:
07/01/2025
Locations: Universitair Ziekenhuis Brussel, Jette, Not set +23 locations
Conditions: Cardiac Disease
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