The state of California currently has 46 active clinical trials seeking participants for Asthma research studies. These trials are conducted in various cities, including Los Angeles, San Francisco, San Diego and Sacramento.
Site and Mechanism(s) of Expiratory Airflow Limitation in COPD, Emphysema and Asthma-COPD Overlap
NCT03263130
Recruiting
The purpose of this cross-sectional, observational study is to evaluate the site and mechanism(s) for expiratory airflow limitation in chronic, treated, current or former smokers (>15 pack years) with COPD, Emphysema, and Asthma-COPD Overlap with mild to severe expiratory airflow limitation. Treatment may include short and long acting inhaled beta2agonists, short and long acting inhaled muscarinic receptor antagonists, inhaled and or oral corticosteroid, oral antibiotic, supplemental oxygen, and... Read More
Gender:
All
Ages:
30 years and above
Trial Updated:
10/25/2023
Locations: Arthur F Gelb MD, Lakewood, California +1 locations
Conditions: COPD, Emphysema, Asthma COPD Overlap, Emphysema
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An Open-Label Extension Study of GSK3511294 (Depemokimab) in Participants Who Were Previously Enrolled in 206713 (NCT04719832) or 213744 (NCT04718103)
NCT05243680
Recruiting
The purpose of this open-label 12-month extension study is to continue to characterize the long-term safety, efficacy and immunogenic profile of GSK3511294 (Depemokimab) in participants with severe asthma with an eosinophilic phenotype following completion of clinical studies 206713 or 213744.
Gender:
All
Ages:
12 years and above
Trial Updated:
10/13/2023
Locations: GSK Investigational Site, Lancaster, California +1 locations
Conditions: Asthma
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Simultaneously Implementing Pathways for Improving Asthma, Pneumonia, and Bronchiolitis Care for Hospitalized Children
NCT05206695
Recruiting
This study's objective is to identify and test pragmatic and sustainable strategies for implementing a multi-condition clinical pathway intervention for children hospitalized with asthma, pneumonia, or bronchiolitis in community hospitals. The hypothesis is that the multi-condition pathway intervention will be associated with significantly greater increases in clinicians' adoption of evidence-based practices compared to control. The study is a pragmatic, cluster-randomized trial in US community... Read More
Gender:
All
Ages:
17 years and below
Trial Updated:
10/12/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Asthma, Pneumonia, Bronchiolitis
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Pulmonary Specialist-Health Coach Consult Model Study
NCT03695276
Recruiting
The Pulmonary Specialist-Health Coach Consultation (PuSHCon) study examines the implementation of health coach-assisted consultations to improve access to specialist care and implementation of specialist recommendations for patients with COPD, asthma, and asthma COPD overlap syndrome (ACOS) for low-income and vulnerable patients seen at public health clinics. Three hundred sixty (360) patients from ten clinics will be enrolled in the study and randomized at the individual level to receive health... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/21/2023
Locations: St. Anthony Medical Clinic, San Francisco, California +10 locations
Conditions: COPD Asthma
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Impact of Metabolic Dysfunction and Mucus Plugging on Asthma Physiology
NCT05757583
Recruiting
This is a single-center study of 80 subjects with asthma including those with obesity and metabolic dysfunction (MD), those with obesity and without metabolic dysfunction, those with severe asthma and mucus plugging and those with severe asthma and without mucus plugging. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in a cardiopulmonary exercise testing (CPET) visit to compare lung function markers and change... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/13/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma
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PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
NCT04129931
Recruiting
The primary objective of this study is to evaluate several interventions given to participants with severe asthma. Interventions are administered in a crossover manner with 16-week treatment periods followed by 8 to 16 week washout.
Gender:
All
Ages:
12 years and above
Trial Updated:
05/16/2023
Locations: University of California Davis, Sacramento, California +3 locations
Conditions: Asthma
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Lung Function Outcomes Following Removal of Airway Mucus Plugs in Patients With Asthma (FOCUS)
NCT05748912
Recruiting
This is a single-center study that will evaluate the safety and tolerability of removal of mucus plugs by bronchoscopy in patients with asthma. This protocol will also plan for the analysis of the features of the mucus plugs removed.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/17/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma
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Blood Lymphocytes in Asthmatics Treated With Therapeutic Proteins
NCT04514926
Recruiting
This is an observational, clinic-based, single center study of 120 subjects. Participants will be comprised of patients seen in the outpatient faculty practice in ambulatory care at the UCSF Parnassus campus. Study investigators will enroll 20 healthy participants with no history of lung disease, 50 asthmatics who are newly prescribed therapeutic proteins for their asthma, and 50 asthmatics already being treated with therapeutic proteins for their asthma. Participants will be seen at 1 to 3 visi... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/09/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Asthma, Therapeutic Proteins
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The Effect of NAC on Lung Function and CT Mucus Score
NCT03822637
Recruiting
This study evaluates 20% n-acetylcysteine (NAC) in the treatment of moderate-to-severe asthma that is complicated by mucus in the airway, as determined by CT imaging. The study is a crossover design, which means that half the study participants will get 20% NAC in the first 14-day treatment period and placebo in the next 14-day treatment period; and the other half will get placebo in the first 14-day treatment period and 20% NAC in the next 14-day treatment period.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/08/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Asthma
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Tissue Immune Interaction in Nasal Polyposis
NCT04628442
Recruiting
This is a cross-sectional study of up to 100 subjects who are undergoing clinically indicated sinus procedures to treat chronic rhinosinusitis. Participants will be asked to donate leftover sino-nasal secretions, sino-nasal tissue and blood as well as undergo partial characterization. As optional extensions of the main study, participants may also undergo a biopsy of extra sino-nasal tissue for additional tissue analysis and/or a more detailed characterization visit performed in the UCSF Airway... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/08/2023
Locations: UCSF Airway Clinical Research Center, San Francisco, California
Conditions: Chronic Rhinosinusitis (Diagnosis), Chronic Rhinosinusitis With Nasal Polyps, Asthma
Register for Updates