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Bipolar Disorder Clinical Trials
A listing of 48 Bipolar Disorder clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 48
There are currently 48 active clinical trials seeking participants for Bipolar Disorder research studies. The states with the highest number of trials for Bipolar Disorder participants are California, Florida, Texas and Ohio.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Chronic Cough Study
Recruiting
Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.
Conditions:
Chronic Cough
Refractory or Unexplained Chronic Cough
Cough
Asthma
Allergic Asthma
Featured Trial
Bipolar Study for Patients Aged 10 to 17
Recruiting
A new short-term study is enrolling children and teens (ages 10-17) with bipolar depression. To pre-qualify, participants must meet the following criteria:
- Male or female patients 10 to 17 years of age
- Have primary diagnosis of Bipolar I or Bipolar II Disorder
- Have a history of at least one manic or hypomanic episode
- Current major depressive episode is ≥ 4 weeks and less than 12 months in duration
- Male or female patients 10 to 17 years of age
- Have primary diagnosis of Bipolar I or Bipolar II Disorder
- Have a history of at least one manic or hypomanic episode
- Current major depressive episode is ≥ 4 weeks and less than 12 months in duration
Conditions:
Bipolar Disorder
Bipolar Depression
Bipolar I Disorder
Depression
Bipolar
Featured Trial
Type 2 Diabetes Clinical Trial
Recruiting
Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.
Conditions:
Type 2 Diabetes
Diabetes Mellitus Type 2 in Obese
Diabetes Type Two
Type 2 Diabetes Mellitus
Diabete Type 2
Effectiveness RCT of Customized Adherence Enhancement
Recruiting
Approximately one in two individuals with bipolar disorder (BD) are non-adherent with medication, often leading to severe and negative consequences. Unfortunately, there is no widely used evidence-based approach to target poor adherence among individuals with BD. Building upon positive efficacy trial results, the proposed project will test the effectiveness of technology-facilitated Customized Adherence Enhancement (CAE) vs. enhanced treatment as usual (eTAU) using a prospective randomized contr... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
02/13/2025
Locations: W.O. Walker Center, Cleveland, Ohio +2 locations
Conditions: Bipolar Disorder
Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults with Bipolar Disorder
Recruiting
The purpose of this study is to use eye-tracking technology to study attentional biases, reward sensitivity, and cognitive control in adult patients with bipolar disorder with or without anxiety and/or substance use disorder comorbidity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: University Hospitals Cleveland Medical Center - Mood Disorders Program, Cleveland, Ohio
Conditions: Bipolar Disorder
Using MHealth to Improve Adherence and Reduce Blood Pressure in Individuals with Hypertension and Mood Disorders
Recruiting
This proposed 2-stage randomized controlled trial (RCT) will evaluate a personalized patient-centered adherence intervention iTAB-CV + Self-Monitoring (iTAB-CV + SM) vs. Self-Monitoring (SM) alone in poorly adherent hypertensive persons with BD or MDD. This practical, technology-facilitated intervention has potential to improve adherence to antihypertensive medication and reduce SBP among high-risk individuals. The intervention is suitable for primary care or mental health settings and has poten... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
09/09/2024
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: Bipolar Disorder, Non-Adherence, Medication, Hypertension, Major Depressive Disorder
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Recruiting
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/05/2024
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers
Recruiting
The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety of polysomnographic and high-density EEG recordings. Subjects in this protocol will undergo an evalua... Read More
Gender:
ALL
Ages:
Between 3 years and 99 years
Trial Updated:
05/02/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Evaluation of the Genetics of Bipolar Disorder
Recruiting
This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
04/30/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Bipolar Disorder
Personalized Mobile Cognitive Behavioral Therapy Application
Recruiting
This study aims to compare the effectiveness of a standard mobile iPhone cognitive behavioral therapy program to a personalized mobile iPhone cognitive behavioral therapy program that introduces new skills over a shorter period of time. Participants will use the Maya app for two days per week, at least 20 minutes per day, for six weeks. Assessments will include a weekly check in with a member of the research team, questionnaires, and optional magnetic resonance imaging (MRI) and electroencephalo... Read More
Gender:
ALL
Ages:
Between 18 years and 25 years
Trial Updated:
04/28/2025
Locations: Weill Cornell Medical College, New York, New York
Transcranial Electric Stimulation Therapy (TEST) for Treatment Resistant Depression (TRD)
Recruiting
Background:
People with TRD are often helped by electroconvulsive therapy (ECT). But ECT can affect memory and thinking. Researchers want to study a treatment called TEST that uses less electricity.
Objective:
To study the safety and feasibility of TEST and assess its antidepressant effects.
Eligibility:
Adults aged 25-64 with major depression that has not been relieved by current treatments.
Design:
Participants will be admitted to the NIH Clinical Center for 5 18 weeks over 2 3 treatmen... Read More
Gender:
ALL
Ages:
Between 25 years and 64 years
Trial Updated:
04/24/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Major Depressive Disorder, Bipolar Disorder, Unipolar Major Depression
Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder
Recruiting
The objective of this study protocol is to test whether intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) can strengthen functional connectivity with a key region in emotion regulation (ER) neurocircuitry (anterior insula, AI) and improve performance on ER-related tasks in patients with bipolar disorder. Individual IPL sites for stimulation will be identified through baseline, pre-TMS functional magnetic resonance imaging (fMRI) scans. Pa... Read More
Gender:
ALL
Ages:
Between 24 years and 65 years
Trial Updated:
04/17/2025
Locations: Martinos Center for Biomedical Imaging, Charlestown, Massachusetts +1 locations
Conditions: Bipolar Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Recruiting
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity, this study aims to improve our understanding of how these conditions affect the brain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/10/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
Alexithymia Intervention for Suicide
Recruiting
Suicide rates among Veterans with Serious Mental Illness (SMI) are intractably high, representing a serious public health concern and a critical target for interventions. Yet, at present available treatments offer modest benefits. Thus, there remains an urgent need to identify novel approaches to address suicide risk in this population. Previous reports have linked suicide risk with poor social functioning. Emerging evidence from basic affective neuroscience research has indicated that effective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: James J. Peters VA Medical Center, Bronx, NY, Bronx, New York
Conditions: Suicide, Schizophrenia, Bipolar Disorder, Post Traumatic Stress Disorder, Major Depressive Disorder
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
Recruiting
Future Self-BD is a 6-session virtual intervention that encourages participants to vividly generate personal and positive future events that they anticipate may be benefited by smoking cessation. Each session will be conducted on HIPAA-compliant Zoom and led by the PI (Dr. Gold).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Bipolar Disorder, Tobacco Use Disorder
1 - 12 of 48