Chronic Lymphocytic Leukemia Clinical Trials

A listing of 66 Chronic Lymphocytic Leukemia clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 66 active clinical trials seeking participants for Chronic Lymphocytic Leukemia research studies. The states with the highest number of trials for Chronic Lymphocytic Leukemia participants are California, Ohio, Illinois and Michigan.

Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Chronic Cough Study

Recruiting

Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.

Conditions:

Chronic Cough

Refractory or Unexplained Chronic Cough

Cough

Asthma

Allergic Asthma

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Featured Trial

Studying an Investigational Virus Vaccine

Recruiting

The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.

Conditions:

Healthy

Interested in vaccine studies

All Conditions

Preventative Trials

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Featured Trial

Type 2 Diabetes Clinical Trial

Recruiting

Can changing your breakfast improve your type 2 diabetes? If you have an HbA1C of 7.0% or higher, you are invited to participate in an online study at the University of Michigan.

Conditions:

Type 2 Diabetes

Diabetes Mellitus Type 2 in Obese

Diabetes Type Two

Type 2 Diabetes Mellitus

Diabete Type 2

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Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients with CLL or SLL Resistant to Covalent BTKi

NCT06466122

Recruiting

This phase II trial tests how well pirtobrutinib (LOXO-305) and venetoclax works in treating patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that remains despite treatment (resistant) with covalent bruton tyrosine kinase inhibitors (BTKi). Pirtobrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the a protein that signals cancer cells to multiply. Venetoclax is in a class of medications called B-cell lymphoma-2 (... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

01/30/2025

Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Learn More ›

Anti-pneumococcal Vaccine Strategy in Patients with Chronic Lymphocytic Leukemia

NCT05417165

Recruiting

This phase II trial compares the effect of initial vaccination (PCV20 followed by PSV23) with yearly vaccinations of PSV23 to the standard 5 year vaccination in patients with chronic lymphocytic leukemia. At present chronic lymphocytic leukemia patients are poorly protected by anti-pneumococcal vaccination. Current vaccination schedule for chronic lymphocytic leukemia patients is based on general recommendations in immunocompromised patients (initial vaccination with PCV13 followed by one dose o... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

12/27/2024

Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

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Acalabrutinib in Combination with Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia

NCT05336812

Recruiting

This phase II trial tests whether acalabrutinib in combination with venetoclax or obinutuzumab works to shrink tumors in patients with treatment-naive chronic lymphocytic leukemia . Acalabrutinib is also an inhibitor that works in the body to block the activation of certain cells that lead to the growth of cancerous B cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer ce... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

09/19/2024

Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Learn More ›

Natural Killer (NK) Cells in Combination with Interleukin-2 (IL-2) and Transforming Growth Factor Beta (TGFbeta) Receptor I Inhibitor Vactosertib in Cancer

NCT05400122

Recruiting

One of the ways that cancer grows and spreads is by avoiding the immune system.NK cells are immune cells that kill cancer cells, but are often malfunctioning in people with colorectal cancer and blood cancers. A safe way to give people with colorectal cancer and blood cancers fresh NK cells from a healthy donor has recently been discovered. The purpose of this study is to show that using two medicines (vactosertib and IL-2) with NK cells will be safe and will activate the donor NK cells. NK cell... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

03/03/2025

Locations: University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center, Cleveland, Ohio

Conditions: Colorectal Cancer, Hematologic Malignancy, Rectum Cancer, Acute Myeloid Leukemia, Myelodysplastic Syndromes, Acute Lymphoblastic Leukemia, Chronic Myeloid Leukemia, Chronic Lymphocytic Leukemia, Hodgkin Lymphoma, Non Hodgkin Lymphoma, Myeloproliferative Syndrome, Plasma Cell Myeloma, Gastric Cancer, Esophageal Cancer, Esophagus Cancer, Gastric Cancer, Metastatic, Unresectable Esophageal Cancer, Metastatic Esophageal Cancer

Learn More ›

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

NCT04269902

Recruiting

This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Immunotherapy with monoclonal antibodies, such as obinutuzumab, may help t... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/17/2025

Locations: University of Alabama at Birmingham Cancer Center, Birmingham, Alabama +612 locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama

Anchorage Associates in Radiation Medicine, Anchorage, Alaska

Anchorage Radiation Therapy Center, Anchorage, Alaska

Alaska Breast Care and Surgery LLC, Anchorage, Alaska

Alaska Oncology and Hematology LLC, Anchorage, Alaska

Alaska Women's Cancer Care, Anchorage, Alaska

Anchorage Oncology Centre, Anchorage, Alaska

Katmai Oncology Group, Anchorage, Alaska

Providence Alaska Medical Center, Anchorage, Alaska

Fairbanks Memorial Hospital, Fairbanks, Alaska

Cancer Center at Saint Joseph's, Phoenix, Arizona

Mercy Hospital Fort Smith, Fort Smith, Arkansas

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas

Kaiser Permanente-Anaheim, Anaheim, California

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande, California

Kaiser Permanente-Baldwin Park, Baldwin Park, California

Kaiser Permanente-Bellflower, Bellflower, California

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank, California

Marshall Cancer Center, Cameron Park, California

Mercy Cancer Center - Carmichael, Carmichael, California

Mercy San Juan Medical Center, Carmichael, California

UC Irvine Health Cancer Center-Newport, Costa Mesa, California

City of Hope Comprehensive Cancer Center, Duarte, California

Mercy Cancer Center - Elk Grove, Elk Grove, California

Kaiser Permanente-Fontana, Fontana, California

Kaiser Permanente South Bay, Harbor City, California

City of Hope Seacliff, Huntington Beach, California

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine, California

City of Hope at Irvine Lennar, Irvine, California

Kaiser Permanente-Irvine, Irvine, California

UCI Health Laguna Hills, Laguna Hills, California

City of Hope Antelope Valley, Lancaster, California

City of Hope at Long Beach Elm, Long Beach, California

Tibor Rubin VA Medical Center, Long Beach, California

Kaiser Permanente Los Angeles Medical Center, Los Angeles, California

Kaiser Permanente West Los Angeles, Los Angeles, California

Fremont - Rideout Cancer Center, Marysville, California

City of Hope Newport Beach, Newport Beach, California

Kaiser Permanente-Ontario, Ontario, California

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange, California

Stanford Cancer Institute Palo Alto, Palo Alto, California

Kaiser Permanente - Panorama City, Panorama City, California

Kaiser Permanente-Riverside, Riverside, California

Mercy Cancer Center - Rocklin, Rocklin, California

Mercy Cancer Center - Sacramento, Sacramento, California

University of California Davis Comprehensive Cancer Center, Sacramento, California

Kaiser Permanente-San Diego Zion, San Diego, California

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo, California

Kaiser Permanente-San Marcos, San Marcos, California

Mission Hope Medical Oncology - Santa Maria, Santa Maria, California

City of Hope South Pasadena, South Pasadena, California

City of Hope South Bay, Torrance, California

City of Hope Upland, Upland, California

Kaiser Permanente-Woodland Hills, Woodland Hills, California

Woodland Memorial Hospital, Woodland, California

Rocky Mountain Cancer Centers-Aurora, Aurora, Colorado

The Medical Center of Aurora, Aurora, Colorado

Boulder Community Foothills Hospital, Boulder, Colorado

Rocky Mountain Cancer Centers-Boulder, Boulder, Colorado

Rocky Mountain Cancer Centers - Centennial, Centennial, Colorado

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado

Rocky Mountain Cancer Centers-Penrose, Colorado Springs, Colorado

Cancer Center of Colorado at Sloan's Lake, Denver, Colorado

National Jewish Health-Main Campus, Denver, Colorado

The Women's Imaging Center, Denver, Colorado

AdventHealth Porter, Denver, Colorado

Colorado Blood Cancer Institute, Denver, Colorado

Presbyterian - Saint Lukes Medical Center - Health One, Denver, Colorado

Rocky Mountain Cancer Centers-Midtown, Denver, Colorado

Saint Joseph Hospital - Cancer Centers of Colorado, Denver, Colorado

Rocky Mountain Cancer Centers-Rose, Denver, Colorado

Rose Medical Center, Denver, Colorado

Western Surgical Care, Denver, Colorado

Mercy Medical Center, Durango, Colorado

Southwest Oncology PC, Durango, Colorado

Mountain Blue Cancer Care Center - Swedish, Englewood, Colorado

Rocky Mountain Cancer Centers - Swedish, Englewood, Colorado

Swedish Medical Center, Englewood, Colorado

The Melanoma and Skin Cancer Institute, Englewood, Colorado

National Jewish Health-Western Hematology Oncology, Golden, Colorado

Saint Mary's Hospital and Regional Medical Center, Grand Junction, Colorado

Grand Valley Oncology, Grand Junction, Colorado

Banner North Colorado Medical Center, Greeley, Colorado

Good Samaritan Hospital - Cancer Centers of Colorado, Lafayette, Colorado

Rocky Mountain Cancer Centers-Lakewood, Lakewood, Colorado

Saint Anthony Hospital, Lakewood, Colorado

Rocky Mountain Cancer Centers-Littleton, Littleton, Colorado

AdventHealth Littleton, Littleton, Colorado

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree, Colorado

Sky Ridge Medical Center, Lone Tree, Colorado

Longmont United Hospital, Longmont, Colorado

Rocky Mountain Cancer Centers-Longmont, Longmont, Colorado

Banner McKee Medical Center, Loveland, Colorado

AdventHealth Parker, Parker, Colorado

Saint Mary Corwin Medical Center, Pueblo, Colorado

National Jewish Health-Northern Hematology Oncology, Thornton, Colorado

Rocky Mountain Cancer Centers-Thornton, Thornton, Colorado

Beebe Medical Center, Lewes, Delaware

Beebe South Coastal Health Campus, Millville, Delaware

Delaware Clinical and Laboratory Physicians PA, Newark, Delaware

Helen F Graham Cancer Center, Newark, Delaware

Medical Oncology Hematology Consultants PA, Newark, Delaware

Christiana Care Health System-Christiana Hospital, Newark, Delaware

Beebe Health Campus, Rehoboth Beach, Delaware

TidalHealth Nanticoke / Allen Cancer Center, Seaford, Delaware

Christiana Care Health System-Wilmington Hospital, Wilmington, Delaware

MedStar Georgetown University Hospital, Washington, District of Columbia

Sibley Memorial Hospital, Washington, District of Columbia

Holy Cross Hospital, Fort Lauderdale, Florida

Sacred Heart Hospital, Pensacola, Florida

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho

Saint Luke's Cancer Institute - Boise, Boise, Idaho

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell, Idaho

Kootenai Health - Coeur d'Alene, Coeur d'Alene, Idaho

Walter Knox Memorial Hospital, Emmett, Idaho

Saint Luke's Cancer Institute - Fruitland, Fruitland, Idaho

Idaho Urologic Institute-Meridian, Meridian, Idaho

Saint Luke's Cancer Institute - Meridian, Meridian, Idaho

Saint Alphonsus Cancer Care Center-Nampa, Nampa, Idaho

Saint Luke's Cancer Institute - Nampa, Nampa, Idaho

Kootenai Clinic Cancer Services - Post Falls, Post Falls, Idaho

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint, Idaho

Saint Luke's Cancer Institute - Twin Falls, Twin Falls, Idaho

OSF Saint Anthony's Health Center, Alton, Illinois

Rush - Copley Medical Center, Aurora, Illinois

Illinois CancerCare-Bloomington, Bloomington, Illinois

Loyola Center for Health at Burr Ridge, Burr Ridge, Illinois

Illinois CancerCare-Canton, Canton, Illinois

Memorial Hospital of Carbondale, Carbondale, Illinois

SIH Cancer Institute, Carterville, Illinois

Illinois CancerCare-Carthage, Carthage, Illinois

Centralia Oncology Clinic, Centralia, Illinois

Northwestern University, Chicago, Illinois

University of Chicago Comprehensive Cancer Center, Chicago, Illinois

Carle at The Riverfront, Danville, Illinois

Cancer Care Specialists of Illinois - Decatur, Decatur, Illinois

Decatur Memorial Hospital, Decatur, Illinois

Northwestern Medicine Cancer Center Kishwaukee, DeKalb, Illinois

Illinois CancerCare-Dixon, Dixon, Illinois

Carle Physician Group-Effingham, Effingham, Illinois

Crossroads Cancer Center, Effingham, Illinois

Elmhurst Memorial Hospital, Elmhurst, Illinois

Illinois CancerCare-Eureka, Eureka, Illinois

NorthShore University HealthSystem-Evanston Hospital, Evanston, Illinois

Illinois CancerCare-Galesburg, Galesburg, Illinois

Western Illinois Cancer Treatment Center, Galesburg, Illinois

Northwestern Medicine Cancer Center Delnor, Geneva, Illinois

NorthShore University HealthSystem-Glenbrook Hospital, Glenview, Illinois

Northwestern Medicine Glenview Outpatient Center, Glenview, Illinois

Northwestern Medicine Grayslake Outpatient Center, Grayslake, Illinois

Ingalls Memorial Hospital, Harvey, Illinois

NorthShore University HealthSystem-Highland Park Hospital, Highland Park, Illinois

Loyola Medicine Homer Glen, Homer Glen, Illinois

Illinois CancerCare-Kewanee Clinic, Kewanee, Illinois

Northwestern Medicine Lake Forest Hospital, Lake Forest, Illinois

Illinois CancerCare-Macomb, Macomb, Illinois

Carle Physician Group-Mattoon/Charleston, Mattoon, Illinois

Loyola University Medical Center, Maywood, Illinois

Marjorie Weinberg Cancer Center at Loyola-Gottlieb, Melrose Park, Illinois

SSM Health Good Samaritan, Mount Vernon, Illinois

Edward Hospital/Cancer Center, Naperville, Illinois

UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois

Cancer Care Center of O'Fallon, O'Fallon, Illinois

University of Chicago Medicine-Orland Park, Orland Park, Illinois

Illinois CancerCare-Ottawa Clinic, Ottawa, Illinois

Illinois CancerCare-Pekin, Pekin, Illinois

Illinois CancerCare-Peoria, Peoria, Illinois

Methodist Medical Center of Illinois, Peoria, Illinois

Illinois CancerCare-Peru, Peru, Illinois

Valley Radiation Oncology, Peru, Illinois

Edward Hospital/Cancer Center?Plainfield, Plainfield, Illinois

Illinois CancerCare-Princeton, Princeton, Illinois

UW Health Carbone Cancer Center Rockford, Rockford, Illinois

Southern Illinois University School of Medicine, Springfield, Illinois

Springfield Clinic, Springfield, Illinois

Springfield Memorial Hospital, Springfield, Illinois

Carle Cancer Center, Urbana, Illinois

The Carle Foundation Hospital, Urbana, Illinois

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois

Illinois CancerCare - Washington, Washington, Illinois

Rush-Copley Healthcare Center, Yorkville, Illinois

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana

Reid Health, Richmond, Indiana

Mary Greeley Medical Center, Ames, Iowa

McFarland Clinic - Ames, Ames, Iowa

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny, Iowa

McFarland Clinic - Boone, Boone, Iowa

Saint Anthony Regional Hospital, Carroll, Iowa

Physicians' Clinic of Iowa PC, Cedar Rapids, Iowa

Mercy Cancer Center-West Lakes, Clive, Iowa

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive, Iowa

Alegent Health Mercy Hospital, Council Bluffs, Iowa

Greater Regional Medical Center, Creston, Iowa

Iowa Methodist Medical Center, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines, Iowa

Broadlawns Medical Center, Des Moines, Iowa

Mercy Medical Center - Des Moines, Des Moines, Iowa

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines, Iowa

Iowa Lutheran Hospital, Des Moines, Iowa

McFarland Clinic - Trinity Cancer Center, Fort Dodge, Iowa

Trinity Regional Medical Center, Fort Dodge, Iowa

McFarland Clinic - Jefferson, Jefferson, Iowa

McFarland Clinic - Marshalltown, Marshalltown, Iowa

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee, Iowa

Methodist West Hospital, West Des Moines, Iowa

Mercy Medical Center-West Lakes, West Des Moines, Iowa

Central Care Cancer Center - Garden City, Garden City, Kansas

Central Care Cancer Center - Great Bend, Great Bend, Kansas

HaysMed, Hays, Kansas

University of Kansas Cancer Center, Kansas City, Kansas

Lawrence Memorial Hospital, Lawrence, Kansas

The University of Kansas Cancer Center - Olathe, Olathe, Kansas

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas

Salina Regional Health Center, Salina, Kansas

University of Kansas Health System Saint Francis Campus, Topeka, Kansas

University of Kansas Hospital-Westwood Cancer Center, Westwood, Kansas

Flaget Memorial Hospital, Bardstown, Kentucky

Commonwealth Cancer Center-Corbin, Corbin, Kentucky

Saint Joseph Radiation Oncology Resource Center, Lexington, Kentucky

Saint Joseph Hospital East, Lexington, Kentucky

Saint Joseph London, London, Kentucky

Jewish Hospital, Louisville, Kentucky

Saints Mary and Elizabeth Hospital, Louisville, Kentucky

UofL Health Medical Center Northeast, Louisville, Kentucky

Jewish Hospital Medical Center South, Shepherdsville, Kentucky

Hematology/Oncology Clinic PLLC, Baton Rouge, Louisiana

Ochsner LSU Health Monroe Medical Center, Monroe, Louisiana

Tulane University School of Medicine, New Orleans, Louisiana

Ochsner LSU Health Saint Mary's Medical Center, Shreveport, Louisiana

LSU Health Sciences Center at Shreveport, Shreveport, Louisiana

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland

Walter Reed National Military Medical Center, Bethesda, Maryland

Tufts Medical Center, Boston, Massachusetts

Dana-Farber Cancer Institute, Boston, Massachusetts

Hickman Cancer Center, Adrian, Michigan

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor, Michigan

Bronson Battle Creek, Battle Creek, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton, Michigan

Trinity Health Medical Center - Brighton, Brighton, Michigan

Henry Ford Cancer Institute-Downriver, Brownstown, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton, Michigan

Trinity Health Medical Center - Canton, Canton, Michigan

Caro Cancer Center, Caro, Michigan

Chelsea Hospital, Chelsea, Michigan

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea, Michigan

Hematology Oncology Consultants-Clarkston, Clarkston, Michigan

Newland Medical Associates-Clarkston, Clarkston, Michigan

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan

Henry Ford Medical Center-Fairlane, Dearborn, Michigan

Henry Ford Hospital, Detroit, Michigan

Henry Ford Health Saint John Hospital, Detroit, Michigan

Henry Ford River District Hospital, East China Township, Michigan

Cancer Hematology Centers - Flint, Flint, Michigan

Genesee Hematology Oncology PC, Flint, Michigan

Genesys Hurley Cancer Institute, Flint, Michigan

Hurley Medical Center, Flint, Michigan

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids, Michigan

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan

Trinity Health Grand Rapids Hospital, Grand Rapids, Michigan

Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods, Michigan

Henry Ford Saint John Hospital - Breast, Grosse Pointe Woods, Michigan

Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods, Michigan

Allegiance Health, Jackson, Michigan

Bronson Methodist Hospital, Kalamazoo, Michigan

West Michigan Cancer Center, Kalamazoo, Michigan

Ascension Borgess Cancer Center, Kalamazoo, Michigan

Ascension Borgess Hospital, Kalamazoo, Michigan

University of Michigan Health - Sparrow Lansing, Lansing, Michigan

Hope Cancer Clinic, Livonia, Michigan

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia, Michigan

Henry Ford Saint John Hospital - Macomb Medical, Macomb, Michigan

Henry Ford Warren Hospital - Breast Macomb, Macomb, Michigan

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette, Michigan

Toledo Clinic Cancer Centers-Monroe, Monroe, Michigan

Trinity Health Muskegon Hospital, Muskegon, Michigan

Corewell Health Lakeland Hospitals - Niles Hospital, Niles, Michigan

Cancer and Hematology Centers of Western Michigan - Norton Shores, Norton Shores, Michigan

Henry Ford Medical Center-Columbus, Novi, Michigan

Hope Cancer Center, Pontiac, Michigan

Michigan Healthcare Professionals Pontiac, Pontiac, Michigan

Newland Medical Associates-Pontiac, Pontiac, Michigan

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac, Michigan

Corewell Health Reed City Hospital, Reed City, Michigan

MyMichigan Medical Center Saginaw, Saginaw, Michigan

Oncology Hematology Associates of Saginaw Valley PC, Saginaw, Michigan

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph, Michigan

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph, Michigan

Henry Ford Macomb Health Center - Shelby Township, Shelby, Michigan

Henry Ford Health Providence Southfield Hospital, Southfield, Michigan

Bhadresh Nayak MD PC-Sterling Heights, Sterling Heights, Michigan

MyMichigan Medical Center Tawas, Tawas City, Michigan

Munson Medical Center, Traverse City, Michigan

Advanced Breast Care Center PLLC, Warren, Michigan

Henry Ford Health Warren Hospital, Warren, Michigan

Henry Ford Madison Heights Hospital - Breast, Warren, Michigan

Henry Ford Warren Hospital - GLCMS, Warren, Michigan

Macomb Hematology Oncology PC, Warren, Michigan

Henry Ford West Bloomfield Hospital, West Bloomfield, Michigan

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch, Michigan

University of Michigan Health - West, Wyoming, Michigan

Huron Gastroenterology PC, Ypsilanti, Michigan

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti, Michigan

Fairview Ridges Hospital, Burnsville, Minnesota

Minnesota Oncology - Burnsville, Burnsville, Minnesota

Cambridge Medical Center, Cambridge, Minnesota

Mercy Hospital, Coon Rapids, Minnesota

Essentia Health - Deer River Clinic, Deer River, Minnesota

Essentia Health Cancer Center, Duluth, Minnesota

Fairview Southdale Hospital, Edina, Minnesota

Unity Hospital, Fridley, Minnesota

Essentia Health Hibbing Clinic, Hibbing, Minnesota

Fairview Clinics and Surgery Center Maple Grove, Maple Grove, Minnesota

Minnesota Oncology Hematology PA-Maplewood, Maplewood, Minnesota

Saint John's Hospital - Healtheast, Maplewood, Minnesota

Abbott-Northwestern Hospital, Minneapolis, Minnesota

Hennepin County Medical Center, Minneapolis, Minnesota

Minneapolis VA Medical Center, Minneapolis, Minnesota

Health Partners Inc, Minneapolis, Minnesota

Monticello Cancer Center, Monticello, Minnesota

New Ulm Medical Center, New Ulm, Minnesota

Fairview Northland Medical Center, Princeton, Minnesota

North Memorial Medical Health Center, Robbinsdale, Minnesota

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park, Minnesota

Regions Hospital, Saint Paul, Minnesota

United Hospital, Saint Paul, Minnesota

Essentia Health Sandstone, Sandstone, Minnesota

Saint Francis Regional Medical Center, Shakopee, Minnesota

Lakeview Hospital, Stillwater, Minnesota

Essentia Health Virginia Clinic, Virginia, Minnesota

Ridgeview Medical Center, Waconia, Minnesota

Rice Memorial Hospital, Willmar, Minnesota

Minnesota Oncology Hematology PA-Woodbury, Woodbury, Minnesota

Fairview Lakes Medical Center, Wyoming, Minnesota

Baptist Memorial Hospital and Cancer Center-Golden Triangle, Columbus, Mississippi

Baptist Cancer Center-Grenada, Grenada, Mississippi

Baptist Memorial Hospital and Cancer Center-Union County, New Albany, Mississippi

Baptist Memorial Hospital and Cancer Center-Desoto, Southhaven, Mississippi

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin, Missouri

Central Care Cancer Center - Bolivar, Bolivar, Missouri

Mercy Cancer Center - Cape Girardeau, Cape Girardeau, Missouri

Saint Francis Medical Center, Cape Girardeau, Missouri

Saint Luke's Hospital, Chesterfield, Missouri

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri

Parkland Health Center - Farmington, Farmington, Missouri

MU Health Care Goldschmidt Cancer Center, Jefferson City, Missouri

Freeman Health System, Joplin, Missouri

Mercy Hospital Joplin, Joplin, Missouri

University Health Truman Medical Center, Kansas City, Missouri

University of Kansas Cancer Center - North, Kansas City, Missouri

University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri

Mercy Clinic-Rolla-Cancer and Hematology, Rolla, Missouri

Phelps Health Delbert Day Cancer Institute, Rolla, Missouri

Heartland Regional Medical Center, Saint Joseph, Missouri

Saint Louis Cancer and Breast Institute-South City, Saint Louis, Missouri

Washington University School of Medicine, Saint Louis, Missouri

Mercy Hospital South, Saint Louis, Missouri

Siteman Cancer Center-South County, Saint Louis, Missouri

Missouri Baptist Medical Center, Saint Louis, Missouri

Siteman Cancer Center at Christian Hospital, Saint Louis, Missouri

Mercy Hospital Saint Louis, Saint Louis, Missouri

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri

Sainte Genevieve County Memorial Hospital, Sainte Genevieve, Missouri

Mercy Hospital Springfield, Springfield, Missouri

CoxHealth South Hospital, Springfield, Missouri

Missouri Baptist Sullivan Hospital, Sullivan, Missouri

BJC Outpatient Center at Sunset Hills, Sunset Hills, Missouri

Mercy Hospital Washington, Washington, Missouri

Community Hospital of Anaconda, Anaconda, Montana

Billings Clinic Cancer Center, Billings, Montana

Saint Vincent Healthcare, Billings, Montana

Saint Vincent Frontier Cancer Center, Billings, Montana

Bozeman Health Deaconess Hospital, Bozeman, Montana

Benefis Sletten Cancer Institute, Great Falls, Montana

Great Falls Clinic, Great Falls, Montana

Logan Health Medical Center, Kalispell, Montana

Saint Patrick Hospital - Community Hospital, Missoula, Montana

Community Medical Center, Missoula, Montana

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island, Nebraska

CHI Health Good Samaritan, Kearney, Nebraska

Saint Elizabeth Regional Medical Center, Lincoln, Nebraska

Cancer Partners of Nebraska, Lincoln, Nebraska

Alegent Health Immanuel Medical Center, Omaha, Nebraska

Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska

Alegent Health Lakeside Hospital, Omaha, Nebraska

Creighton University Medical Center, Omaha, Nebraska

Midlands Community Hospital, Papillion, Nebraska

OptumCare Cancer Care at Seven Hills, Henderson, Nevada

OptumCare Cancer Care at Charleston, Las Vegas, Nevada

OptumCare Cancer Care at Fort Apache, Las Vegas, Nevada

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon, New Hampshire

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey

Cooper Hospital University Medical Center, Camden, New Jersey

Jersey City Medical Center, Jersey City, New Jersey

Monmouth Medical Center Southern Campus, Lakewood, New Jersey

Monmouth Medical Center, Long Branch, New Jersey

Memorial Sloan Kettering Monmouth, Middletown, New Jersey

Memorial Sloan Kettering Bergen, Montvale, New Jersey

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

Community Medical Center, Toms River, New Jersey

MD Anderson Cancer Center at Cooper-Voorhees, Voorhees, New Jersey

University of New Mexico Cancer Center, Albuquerque, New Mexico

Presbyterian Kaseman Hospital, Albuquerque, New Mexico

Memorial Medical Center-Las Cruces, Las Cruces, New Mexico

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho, New Mexico

Hematology Oncology Associates of Central New York-Auburn, Auburn, New York

Hematology Oncology Associates of CNY at Camillus, Camillus, New York

Memorial Sloan Kettering Commack, Commack, New York

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York

Glens Falls Hospital, Glens Falls, New York

Memorial Sloan Kettering Westchester, Harrison, New York

Mount Sinai Hospital, New York, New York

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York

Memorial Sloan Kettering Cancer Center, New York, New York

Upstate Cancer Center at Oswego, Oswego, New York

Rochester General Hospital, Rochester, New York

University of Rochester, Rochester, New York

State University of New York Upstate Medical University, Syracuse, New York

SUNY Upstate Medical Center-Community Campus, Syracuse, New York

Memorial Sloan Kettering Nassau, Uniondale, New York

Upstate Cancer Center at Verona, Verona, New York

Wilmot Cancer Institute at Webster, Webster, New York

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina

Southeastern Medical Oncology Center-Clinton, Clinton, North Carolina

Durham VA Medical Center, Durham, North Carolina

Duke University Medical Center, Durham, North Carolina

Southeastern Medical Oncology Center-Goldsboro, Goldsboro, North Carolina

Margaret R Pardee Memorial Hospital, Hendersonville, North Carolina

University of North Carolina-Hillsborough Campus, Hillsborough, North Carolina

Southeastern Medical Oncology Center-Jacksonville, Jacksonville, North Carolina

ECU Health Oncology Kenansville, Kenansville, North Carolina

ECU Health Oncology Kinston, Kinston, North Carolina

ECU Health Oncology Richlands, Richlands, North Carolina

Indu and Raj Soin Medical Center, Beavercreek, Ohio

Strecker Cancer Center-Belpre, Belpre, Ohio

Saint Elizabeth Boardman Hospital, Boardman, Ohio

Cleveland Clinic Mercy Hospital, Canton, Ohio

Mercy Hematology and Oncology Associates Inc, Canton, Ohio

Dayton Physicians LLC-Miami Valley South, Centerville, Ohio

Miami Valley Hospital South, Centerville, Ohio

Adena Regional Medical Center, Chillicothe, Ohio

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio

Good Samaritan Hospital - Cincinnati, Cincinnati, Ohio

Oncology Hematology Care Inc-Kenwood, Cincinnati, Ohio

Bethesda North Hospital, Cincinnati, Ohio

TriHealth Cancer Institute-Westside, Cincinnati, Ohio

TriHealth Cancer Institute-Anderson, Cincinnati, Ohio

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio

Cleveland Clinic Foundation, Cleveland, Ohio

Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Mount Carmel East Hospital, Columbus, Ohio

Columbus Oncology and Hematology Associates Inc, Columbus, Ohio

Riverside Methodist Hospital, Columbus, Ohio

Grant Medical Center, Columbus, Ohio

The Mark H Zangmeister Center, Columbus, Ohio

Mount Carmel Health Center West, Columbus, Ohio

Doctors Hospital, Columbus, Ohio

Miami Valley Hospital, Dayton, Ohio

Dayton Physician LLC - Englewood, Dayton, Ohio

Miami Valley Hospital North, Dayton, Ohio

Delaware Health Center-Grady Cancer Center, Delaware, Ohio

Grady Memorial Hospital, Delaware, Ohio

Dublin Methodist Hospital, Dublin, Ohio

Armes Family Cancer Center, Findlay, Ohio

Blanchard Valley Hospital, Findlay, Ohio

Orion Cancer Care, Findlay, Ohio

Atrium Medical Center-Middletown Regional Hospital, Franklin, Ohio

Dayton Physicians LLC-Atrium, Franklin, Ohio

Central Ohio Breast and Endocrine Surgery, Gahanna, Ohio

Dayton Physicians LLC-Wayne, Greenville, Ohio

Wayne Hospital, Greenville, Ohio

Mount Carmel Grove City Hospital, Grove City, Ohio

Greater Dayton Cancer Center, Kettering, Ohio

Kettering Medical Center, Kettering, Ohio

Fairfield Medical Center, Lancaster, Ohio

Saint Rita's Medical Center, Lima, Ohio

OhioHealth Mansfield Hospital, Mansfield, Ohio

Marietta Memorial Hospital, Marietta, Ohio

OhioHealth Marion General Hospital, Marion, Ohio

Memorial Hospital, Marysville, Ohio

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio

Knox Community Hospital, Mount Vernon, Ohio

Licking Memorial Hospital, Newark, Ohio

Newark Radiation Oncology, Newark, Ohio

Mercy Health - Perrysburg Hospital, Perrysburg, Ohio

Southern Ohio Medical Center, Portsmouth, Ohio

Springfield Regional Cancer Center, Springfield, Ohio

Springfield Regional Medical Center, Springfield, Ohio

ProMedica Flower Hospital, Sylvania, Ohio

Mercy Health - Saint Vincent Hospital, Toledo, Ohio

Mercy Health - Saint Anne Hospital, Toledo, Ohio

Toledo Clinic Cancer Centers-Toledo, Toledo, Ohio

Dayton Physicians LLC - Troy, Troy, Ohio

Upper Valley Medical Center, Troy, Ohio

Saint Joseph Warren Hospital, Warren, Ohio

University of Cincinnati Cancer Center-West Chester, West Chester, Ohio

Saint Ann's Hospital, Westerville, Ohio

Wright-Patterson Medical Center, Wright-Patterson Air Force Base, Ohio

Saint Elizabeth Youngstown Hospital, Youngstown, Ohio

Genesis Healthcare System Cancer Care Center, Zanesville, Ohio

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma

Mercy Hospital Oklahoma City, Oklahoma City, Oklahoma

Saint Alphonsus Cancer Care Center-Baker City, Baker City, Oregon

Saint Charles Health System, Bend, Oregon

Clackamas Radiation Oncology Center, Clackamas, Oregon

Providence Cancer Institute Clackamas Clinic, Clackamas, Oregon

Bay Area Hospital, Coos Bay, Oregon

Providence Newberg Medical Center, Newberg, Oregon

Saint Alphonsus Cancer Care Center-Ontario, Ontario, Oregon

Providence Willamette Falls Medical Center, Oregon City, Oregon

Providence Portland Medical Center, Portland, Oregon

Providence Saint Vincent Medical Center, Portland, Oregon

Saint Charles Health System-Redmond, Redmond, Oregon

Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania

Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania

Christiana Care Health System-Concord Health Center, Chadds Ford, Pennsylvania

Geisinger Medical Center, Danville, Pennsylvania

Pocono Medical Center, East Stroudsburg, Pennsylvania

Lehigh Valley Hospital-Hazleton, Hazleton, Pennsylvania

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

Jefferson Torresdale Hospital, Philadelphia, Pennsylvania

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre, Pennsylvania

Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina

Ralph H Johnson VA Medical Center, Charleston, South Carolina

Medical University of South Carolina, Charleston, South Carolina

Prisma Health Cancer Institute - Easley, Easley, South Carolina

Prisma Health Cancer Institute - Butternut, Greenville, South Carolina

Prisma Health Cancer Institute - Faris, Greenville, South Carolina

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina

Prisma Health Cancer Institute - Greer, Greer, South Carolina

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina

Bristol Regional Medical Center, Bristol, Tennessee

Ballad Health Cancer Care - Kingsport, Kingsport, Tennessee

Wellmont Holston Valley Hospital and Medical Center, Kingsport, Tennessee

Baptist Memorial Hospital and Cancer Center-Memphis, Memphis, Tennessee

Vanderbilt University/Ingram Cancer Center, Nashville, Tennessee

Saint Joseph Regional Cancer Center, Bryan, Texas

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas

STCC at DHR Health Institute for Research and Development, Edinburg, Texas

UT Southwestern Clinical Center at Richardson/Plano, Richardson, Texas

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah

Ballad Health Cancer Care - Bristol, Bristol, Virginia

Ballad Health Cancer Care - Norton, Norton, Virginia

VCU Massey Cancer Center at Stony Point, Richmond, Virginia

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia

Providence Regional Cancer System-Aberdeen, Aberdeen, Washington

FHCC Overlake, Bellevue, Washington

PeaceHealth Saint Joseph Medical Center, Bellingham, Washington

Highline Medical Center-Main Campus, Burien, Washington

Providence Regional Cancer System-Centralia, Centralia, Washington

Swedish Cancer Institute-Edmonds, Edmonds, Washington

Saint Elizabeth Hospital, Enumclaw, Washington

Providence Regional Cancer Partnership, Everett, Washington

Saint Francis Hospital, Federal Way, Washington

Swedish Cancer Institute-Issaquah, Issaquah, Washington

Kadlec Clinic Hematology and Oncology, Kennewick, Washington

FHCC at EvergreenHealth, Kirkland, Washington

Providence Regional Cancer System-Lacey, Lacey, Washington

Saint Clare Hospital, Lakewood, Washington

PeaceHealth Saint John Medical Center, Longview, Washington

Jefferson Healthcare, Port Townsend, Washington

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo, Washington

Pacific Gynecology Specialists, Seattle, Washington

Swedish Medical Center-Ballard Campus, Seattle, Washington

Fred Hutchinson Cancer Center, Seattle, Washington

Swedish Medical Center-Cherry Hill, Seattle, Washington

Swedish Medical Center-First Hill, Seattle, Washington

FHCC at Northwest Hospital, Seattle, Washington

University of Washington Medical Center - Montlake, Seattle, Washington

PeaceHealth United General Medical Center, Sedro-Woolley, Washington

Providence Regional Cancer System-Shelton, Shelton, Washington

Saint Michael Cancer Center, Silverdale, Washington

Franciscan Research Center-Northwest Medical Plaza, Tacoma, Washington

Northwest Medical Specialties PLLC, Tacoma, Washington

PeaceHealth Southwest Medical Center, Vancouver, Washington

Providence Saint Mary Regional Cancer Center, Walla Walla, Washington

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima, Washington

Providence Regional Cancer System-Yelm, Yelm, Washington

Langlade Hospital and Cancer Center, Antigo, Wisconsin

ThedaCare Regional Cancer Center, Appleton, Wisconsin

Duluth Clinic Ashland, Ashland, Wisconsin

HSHS Sacred Heart Hospital, Eau Claire, Wisconsin

Marshfield Medical Center-EC Cancer Center, Eau Claire, Wisconsin

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin

Gundersen Lutheran Medical Center, La Crosse, Wisconsin

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison, Wisconsin

University of Wisconsin Carbone Cancer Center - University Hospital, Madison, Wisconsin

Marshfield Medical Center-Marshfield, Marshfield, Wisconsin

Aspirus Medford Hospital, Medford, Wisconsin

Marshfield Medical Center - Minocqua, Minocqua, Wisconsin

Cancer Center of Western Wisconsin, New Richmond, Wisconsin

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls, Wisconsin

Aspirus Cancer Care - James Beck Cancer Center, Rhinelander, Wisconsin

Marshfield Medical Center-Rice Lake, Rice Lake, Wisconsin

Saint Vincent Hospital Cancer Center at Sheboygan, Sheboygan, Wisconsin

Aspirus Cancer Care - Stevens Point, Stevens Point, Wisconsin

Marshfield Medical Center-River Region at Stevens Point, Stevens Point, Wisconsin

Aspirus Regional Cancer Center, Wausau, Wisconsin

Marshfield Medical Center - Weston, Weston, Wisconsin

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids, Wisconsin

Cheyenne Regional Medical Center-West, Cheyenne, Wyoming

Billings Clinic-Cody, Cody, Wyoming

Welch Cancer Center, Sheridan, Wyoming

BCCA-Vancouver Cancer Centre, Vancouver, British Columbia

CancerCare Manitoba, Winnipeg, Manitoba

Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John, New Brunswick

QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax, Nova Scotia

Lakeridge Health Oshawa, Oshawa, Ontario

Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario

Jewish General Hospital, Montreal, Quebec

Allan Blair Cancer Centre, Regina, Saskatchewan

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Learn More ›

A Study Assessing Adverse Event and How Oral ABBV-453 Moves Through the Body in Adult Participants With Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

NCT06291220

Recruiting

Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries. The purpose of this study is to assess how well ABBV-453 works adult participants with relapsed/refractory (R/R) untreated CLL/small lymphocytic lymphoma (SLL). Adverse events, pharmacokinetics, and change in disease activity will be assessed. ABBV-453 is an investigational drug for the treatment of CLL and SLL. There are 2 parts to this study. In part A participants will be placed 1 of 5 cohorts with a specific target dose for each cohort and receive obinutuzumab during the debulking period followed escalating doses of ABBV-453, until the appropriate target dose is achieved. In part B participants will be placed in 2 cohorts and receive up to the maximum dose in part A, with cohort 2.1 including a debulking period (obinutuzumab) as in part A. Approximately 80 adult participants with previously R/R CLL/SLL will be enrolled in the study in approximately 40 sites across the world. Participants in part A will placed into 1 of 5 cohorts with a specific target dose for each cohort and will receive intravenous (IV) obinutuzumab as part of the debulking period, followed by escalating doses of oral ABBV-453 until the appropriate target dose is achieved. Participants in part B will be place in one of 2 cohorts. Participants in cohort 2.1 will receive IV obinutuzumab as part of the debulking period, followed by escalating doses of oral ABBV-453 until the maximum target dose from part A is achieved. Participants in cohort 2.2 will receive no treatment during the the debulking period, followed by escalating doses of oral ABBV-453 until the maximum target dose from part A is achieved. The estimated study duration is 5 years. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, and checking for side effects. Read Less

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/17/2025

Locations: City of Hope /ID# 253904, Duarte, California +20 locations

City of Hope /ID# 253904, Duarte, California

City of Hope Orange County Lennar Foundation Cancer Center /ID# 267158, Irvine, California

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana /ID# 264622, Billings, Montana

Atrium Health /ID# 265136, Charlotte, North Carolina

Duke Cancer Center /ID# 258707, Durham, North Carolina

MD Anderson Cancer Center /ID# 253713, Houston, Texas

Royal Prince Alfred Hospital /ID# 263129, Sydney, New South Wales

Gold coast University Hospital /ID# 255785, SouthPort, Queensland

Austin Health /ID# 256776, Heidelberg, Victoria

Royal Perth Hospital /ID# 256464, Perth, Western Australia

Universitaetsklinikum Ulm /ID# 263148, Ulm, Baden-Wuerttemberg

Universitaetsklinikum Schleswig-Holstein - Campus Kiel /ID# 263150, Kiel, Schleswig-Holstein

Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin /ID# 263433, Berlin, Not set

Universitaetsklinikum Halle (Saale) /ID# 263299, Halle (Saale), Not set

Universitaetsklinikum Hamburg-Eppendorf /ID# 263730, Hamburg, Not set

Yitzhak Shamir Medical Center /ID# 257626, Zerifin, HaMerkaz

The Chaim Sheba Medical Center /ID# 254383, Ramat Gan, Tel-Aviv

Hadassah Medical Center-Hebrew University /ID# 254721, Jerusalem, Yerushalayim

IRCCS Ospedale San Raffaele /ID# 263064, Milan, Milano

IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 263065, Bologna, Not set

Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 263062, Perugia, Not set

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Learn More ›

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

NCT06588478

Recruiting

The main purpose of this study is to assess the efficacy and safety of 3 dose levels of Pirtobrutinib in participants with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), who have received 1-3 lines of treatment including a covalent Bruton tyrosine kinase (BTK) inhibitor. The study is expected to last approximately 3 years.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/17/2025

Locations: Ironwood Cancer & Research Centers, Chandler, Arizona +136 locations

Ironwood Cancer & Research Centers, Chandler, Arizona

City of Hope National Medical Center, Duarte, California

City of Hope National Medical Center, Irvine, California

Palo Alto Medical Foundation Research Institute (PAMFRI), Palo Alto, California

Stanford Cancer Center, Palo Alto, California

Rocky Mountain Cancer Center, Aurora, Colorado

University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami, Florida

City of Hope National Medical Center, Atlanta Cancer Center, Newnan, Georgia

Mission Cancer + Blood, Waukee, Iowa

Saint Elizabeth Medical Center Edgewood, Edgewood, Kentucky

American Oncology Partners of Maryland, PA, Bethesda, Maryland

Boston Medical Center, Boston, Massachusetts

Gulfport Memorial Hospital, Gulfport, Mississippi

Clinical Research Alliance, Westbury, New York

East Carolina University, Greenville, North Carolina

Williamette Valley Cancer Institute & Research Center, Eugene, Oregon

Cancer Care Associates Of York, York, Pennsylvania

The West Clinic, PLLC dba West Cancer Center, Germantown, Tennessee

USO-Texas Oncology-Central/South Texas, Austin, Texas

Sarah Cannon Research Institute/SCRI, The Woodlands, Texas

USO-Virginia Oncology Associates, Hampton, Virginia

USO-Northwest Cancer Specialists, PC, Vancouver, Washington

Bankstown-Lidcombe Hospital, Bankstown, New South Wales

Coffs Harbour Health Campus, Coffs Harbour, New South Wales

Calvary Mater Newcastle, Waratah, New South Wales

Princess Alexandra Hospital, Woolloongabba, Queensland

Flinders Medical Centre, Adelaide, South Australia

ICON Cancer Centre - Kurralta Park, Kurralta Park, South Australia

Royal Hobart Hospital, Hobart, Tasmania

Box Hill Hospital, Box Hill, Victoria

Latrobe Regional Health, Traralgon, Victoria

The Perth Blood Institute - West Perth, West Perth, Western Australia

Clinique Saint Pierre, Ottignies, Brabant Wallon

Institut Jules Bordet, Anderlecht, Bruxelles-Capitale, Région De

Groupe Jolimont, La Louvière, Hainaut

CHR Verviers - La Tourelle, Verviers, Liège

UZ Gent, Gent, Oost-Vlaanderen

AZ Nikolaas, Sint-Niklaas, Oost-Vlaanderen

UZ Leuven, Leuven, Vlaams-Brabant

AZ Sint-Jan Brugge-Oostende AV, Brugge, West-Vlaanderen

AZ Delta vzw, Roeselare, West-Vlaanderen

Royal Victoria Regional Health Centre, Barrie, Ontario

CIUSSS- saguenay-Lac-Saint-Jean, Chicoutimi, Quebec

Saskatoon Cancer Centre, Saskatoon, Saskatchewan

Fakultní nemocnice Brno Bohunice, Brno, Brno-město

Fakultni nemocnice Hradec Kralove, Hradec Kralove, Hradec Králové

Fakultni nemocnice Kralovske Vinohrady, PRague, Praha 10

Vseobecna fakultni nemocnice v Praze, Praha 2, Not set

Aarhus Universitetshospital, Skejby, Aarhus, Midtjylland

Odense Universitetshospital, Odense, Syddanmark

Centre Antoine-Lacassagne, Nice, Alpes-Maritimes

Groupe Hospitalier de la Région de Mulhouse et Sud Alsace - Hôpital Emile Muller, Mulhouse, Alsace

Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre, Caen, Calvados

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE, Toulouse, Haute-Garonne

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau, Tours, Indre-et-Loire

Centre Hospitalier du Mans, Le Mans, Sarthe

Centre Hospitalier d'Argenteuil Victor Dupouy, Argenteuil, Val-d'Oise

Klinikum Aschaffenburg-Alzenau, Aschaffenburg, Bayern

Centrum für Hämatologie und Onkologie Bethanien, Frankfurt, Hessen

OSP Göttingen, Goettingen, Niedersachsen

Onkologisches Ambulanzzentrum Hannover, Hannover, Niedersachsen

MV-Zentrum für Onkologie und Hämatologie, Cologne, Nordrhein-Westfalen

InVO Institut für Versorgungsforschung in der Onkologie, Koblenz, Rheinland-Pfalz

Evangelismos General Hospital of Athens, Athens, Attikí

Attikon General University Hospital, Chaidari, Attikí

General Hospital of Athens "Laiko", Αthens, Attikí

G. Papanikolaou General Hospital, Thessaloniki, Thessaloníki

Pécsi Tudományegyetem Klinikai Központ, Pécs, Baranya

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ, Szeged, Csongrád

Semmelweis Egyetem, Budapest, Not set

Dél-Pesti Centrumkórház, Budapest, Not set

Azienda Ospedaliero Universitaria S.Anna, Cona, Emilia-Romagna

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore, Roma, Lazio

ASST Grande Ospedale Metropolitano Niguarda, Milan, Lombardia

A.O.U.C. Policlinico di Bari, Bari, Puglia

Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO, Palermo, Sicilia

Azienda Ospedaliera Universitaria Careggi, Firenze, Toscana

AO Santa Maria della Misericordia, Perugia, Umbria

Azienda Ospedale - Università Padova, Padova, Veneto

Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, Not set

AOU Policlinico Umberto I, Roma, Not set

Chonnam National University Hwasun Hospital, Hwasun-gun, Jeonranamdo

Pusan National University Hospital, Busan, Pusan-Kwangyǒkshi

Seoul National University Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Samsung Medical Center, Seoul, Seoul-teukbyeolsi [Seoul]

The Catholic Univ. of Korea Seoul St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

The Catholic University of Korea, Yeouido St. Mary's Hospital, Seoul, Seoul-teukbyeolsi [Seoul]

Uniwersytecki Szpital Kliniczny im. Jana Mikulicza-Radeckiego we Wrocławiu, Wrocław, Dolnośląskie

IN VIVO, Bydgoszcz, Kujawsko-pomorskie

Pratia MCM Krakow, Kraków, Małopolskie

AIDPORT Sp. z o.o., Skórzewo, Wielkopolskie

Pratia Onkologia Katowice, Katowice, Śląskie

Fundeni Clinical Institute, Bucuresti, București

Ovidius Clinical Hospital OCH, Ovidiu, Constanța

Spitalul Clinic Municipal Filantropia Craiova, Craiova, Dolj

Spitalul Clinic Colțea, București, Not set

Institutul Oncologic Cluj, Cluj, Not set

Institutul Regional de Oncologie, Iași, Not set

Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica, Banska Bystrica, Banskobystrický Kraj

Narodny onkologicky ustav, Bratislava, Bratislavský Kraj

Univerzitna Nemocnica L. Pasteura Kosice, Kosice, Košický Kraj

Univerzitna nemocnica Martin, Martin, Žilinský Kraj

Hospital Universitario Virgen Macarena, Sevilla, Andalucía

Hospital Universitario Central de Asturias, Oviedo, Asturias

Institut Català d'Oncologia (ICO) - Badalona, Badalona, Barcelona [Barcelona]

Hospital Universitari Vall d'Hebron, Barcelona, Barcelona [Barcelona]

Institut Català d'Oncologia - L'Hospitalet, L'Hospitalet Del Llobregat, Barcelona [Barcelona]

Hospital Universitario Marqués de Valdecilla, Santander, Cantabria

Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña]

Clinica Universidad de Navarra, Madrid, Madrid, Comunidad De

Hospital Universitario Infanta Leonor, Madrid, Madrid, Comunidad De

MD Anderson Cancer Center, Madrid, Madrid, Comunidad De

Hospital Universitario Ramón y Cajal, Madrid, Madrid, Comunidad De

Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Comunidad De

Hospital Costa del Sol, Marbella, Málaga

Hospital Universitario 12 de Octubre, Madrid, Not set

Hospital Universitario Quironsalud Madrid, Madrid, Not set

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca, Salamanca, Not set

Hospital Universitario Virgen Del Rocio, Sevilla, Not set

Kocaeli Üniversitesi, Izmit, Kocaeli

Sakarya University School of Medicine, Adapazarı, Sakarya

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi, Ankara, Not set

Ankara University Health Practice and Research Hospitals, Ankara, Not set

Memorial Antalya Hospital, Antalya, Not set

Yeditepe Üniversitesi Koşuyolu Hastanesi, Istanbul, Not set

Ege Universitesi Hastanesi, Izmir, Not set

VM Medical Park Mersin Hastanesi, Mersin, Not set

Ondokuz Mayıs Universitesi, Samsun, Not set

Maidstone Hospital, Maidstone, Kent

Lincoln County Hospital, Lincoln, Lincolnshire

Northwick Park Hospital, Harrow, London, City Of

Hammersmith Hospital, London, London, City Of

Heartlands Hospital, Birmingham, Not set

The Beatson West of Scotland Cancer Centre, Glasgow, Not set

St James's University Hospital, Leeds, Not set

Clatterbridge Cancer Centre - Liverpool, Liverpool, Not set

Singleton Hospital, Swansea, Not set

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Learn More ›

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

NCT05458297

Recruiting

The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter's transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). This study will also evaluate zilovertamab vedotin as monotherapy and in combination with respect to objective response rate. * Cohort A: Participants with relapsed or refractory MCL r... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/16/2025

Locations: Alaska Oncology and Hematology ( Site 0037), Anchorage, Alaska +107 locations

Alaska Oncology and Hematology ( Site 0037), Anchorage, Alaska

Banner MD Anderson Cancer Center ( Site 0040), Gilbert, Arizona

Banner MD Anderson Cancer Center - University Medical Center Phoenix-Medical Oncology ( Site 0036), Phoenix, Arizona

University of Colorado Anschutz Medical Campus-The Center for Cancer and Blood Disorders ( Site 0008, Aurora, Colorado

Cancer Care Specialists of Illinois ( Site 0031), Decatur, Illinois

University of Kansas Medical Center-Division of Hematologic Malignancies and Cellular Therapeutics (, Fairway, Kansas

Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0007), Saint Matthews, Kentucky

Greenebaum Comprehensive Cancer Center-Hematology & Multiple Myeloma ( Site 0010), Baltimore, Maryland

Tufts Medical Center ( Site 0024), Boston, Massachusetts

Massachusetts General Hospital ( Site 0018), Boston, Massachusetts

Dana-Farber Cancer Institute-Lymphoma ( Site 0026), Boston, Massachusetts

University of Michigan ( Site 0009), Ann Arbor, Michigan

Henry Ford Hospital ( Site 0035), Detroit, Michigan

Icahn School of Medicine at Mount Sinai ( Site 0023), New York, New York

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0014), Fargo, North Dakota

The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C, Columbus, Ohio

Avera Cancer Institute- Research ( Site 0011), Sioux Falls, South Dakota

Medical Oncology Associates, PS ( Site 0005), Spokane, Washington

University of Wisconsin Hospitals and Clinics-Carbone Cancer Center ( Site 0030), Madison, Wisconsin

MEDICAL COLLEGE OF WISCONSIN ( Site 0021), Milwaukee, Wisconsin

Liga Norte Riograndense Contra o Câncer-Centro de Pesquisa Clínica ( Site 1807), Natal, Rio Grande Do Norte

Instituto Nacional de Câncer - INCA-Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico HC1 (, Rio de Janeiro, Not set

ICESP - INSTITUTO DO CÂNCER DO ESTADO DE SÃO PAULO ( Site 1808), Sao Paulo, Not set

Hospital Paulistano-Americas Oncologia ( Site 1805), Sao Paulo, Not set

BC Cancer Vancouver-Clinical Trials Unit ( Site 0201), Vancouver, British Columbia

The Moncton Hospital-Oncology ( Site 0211), Moncton, New Brunswick

QEII Health Sciences Centre - Victoria General Site ( Site 0213), Halifax, Nova Scotia

Lawson Health Research Institute - London Health Sciences Ce-London Regional Cancer Program ( Site 0, London, Ontario

Princess Margaret Cancer Centre-Division of Medical Oncology and Hematology ( Site 0200), Toronto, Ontario

Jewish General Hospital ( Site 0202), Montreal, Quebec

Allan Blair Cancer Centre-Care Services ( Site 0208), Regina, Saskatchewan

IC La Serena Research ( Site 1909), La Serena., Coquimbo

Centro de Estudios Clínicos SAGA-CECSAGA ( Site 1907), Santiago, Region M. De Santiago

Clínica Inmunocel ( Site 1910), Santiago, Region M. De Santiago

Clínica Alemana de Santiago ( Site 1903), Santiago, Region M. De Santiago

Beijing Cancer hospital ( Site 1200), Beijing, Beijing

Zhujiang Hospital ( Site 1207), Guangzhou, Guangdong

Southern Medical University Nanfang Hospital ( Site 1202), Guangzhou, Guangdong

Sun Yat-sen University Cancer Center ( Site 1201), Guangzhou, Guangdong

Henan Cancer Hospital-hematology department ( Site 1212), Zhengzhou, Henan

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1210), Wuhan, Hubei

Tongji Hospital Tongji Medical,Science & Technology ( Site 1221), Wuhan, Hubei

The First Affiliated Hospital of Soochow University-hematology department ( Site 1218), Suzhou, Jiangsu

The Affiliated Hospital of Xuzhou Medical College ( Site 1223), Xuzhou, Jiangsu

The First Affiliated Hospital of Nanchang University ( Site 1204), Nanchang, Jiangxi

Jiangxi Provincial Cancer Hospital ( Site 1213), Nanchang, Jiangxi

Jilin Province Tumor Hospital-oncology department ( Site 1220), Chuangchun, Jilin

Fudan University Shanghai Cancer Center ( Site 1208), Shanghai, Shanghai

West China Hospital of Sichuan University-Head and Neck Oncology ( Site 1206), Cheng Du, Sichuan

The First Affiliated Hospital, Zhejiang University ( Site 1211), Hangzhou, Zhejiang

Zhejiang Cancer Hospital ( Site 1214), Hangzhou, Zhejiang

Fakultní nemocnice Brno Bohunice-Interni hematologicka a onkologicka klinika ( Site 0300), Brno, Brno-mesto

Fakultni nemocnice Ostrava-Klinika Hematoonkologie ( Site 0301), Ostrava, Moravskoslezsky Kraj

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Praha 2, Not set

North Estonia Medical Centre Foundation ( Site 0401), Tallinn, Harjumaa

Universitaetsklinikum Ulm ( Site 0502), Ulm, Baden-Wurttemberg

Universitaetsklinikum Koeln ( Site 0506), Köln, Nordrhein-Westfalen

St. James's Hospital ( Site 0600), Dublin, Not set

Emek Medical Center-Hematology Unit ( Site 0705), Afula, Not set

Soroka Medical Center-Hematology Department ( Site 0707), Be'er Sheva, Not set

Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 0706), Haifa, Not set

Carmel Hospital ( Site 0709), Haifa, Not set

Hadassah Medical Center ( Site 0701), Jerusalem, Not set

Galilee Medical Center ( Site 0710), Nahariya, Not set

Sheba Medical Center-Hemato Oncology ( Site 0700), Ramat Gan, Not set

IRCCS - AOU di Bologna-SSD: Diagnosi e terapie dei linfomi e delle sindromi linfoproliferative cron, Bologna, Emilia-Romagna

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 0802), Rozzano, Milano

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare -Azienda Ospedaliera Nazionale SS. Ant, Alessandria, Not set

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -ISTITUTO DI EMATOLOGIA ( Site 0804), Roma, Not set

National Hospital Organization Nagoya Medical Center ( Site 1108), Nagoya, Aichi

Hokkaido University Hospital ( Site 1104), Sapporo, Hokkaido

Tokai University Hospital ( Site 1100), Isehara, Kanagawa

Tohoku University Hospital ( Site 1106), Sendai-shi, Miyagi

Kindai University Hospital ( Site 1102), Sayama, Osaka

National Cancer Center Hospital ( Site 1103), Chuo-ku, Tokyo

The Cancer Institute Hospital of JFCR ( Site 1101), Koto, Tokyo

Kyushu University Hospital ( Site 1105), Fukuoka, Not set

Okayama University Hospital ( Site 1107), Okayama, Not set

Seoul National University Hospital ( Site 1300), Seoul, Not set

Samsung Medical Center ( Site 1301), Seoul, Not set

Centro Medico Monte Carmelo ( Site 1702), Arequipa, Ariqipa

INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 1700), Lima, Not set

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumat-Oddiał Hematologii Ogólnej ( Site 1008), Łódź, Lodzkie

Centrum Onkologii Ziemi Lubelskiej-Oddzial Hematologiczny ( Site 1006), Lublin, Lubelskie

Pratia MCM Krakow ( Site 1001), Krakow, Malopolskie

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworów Układu Chłonnego ( S, Warszawa, Mazowieckie

Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Sit, Olsztyn, Warminsko-mazurskie

Champalimaud Foundation ( Site 2002), Lisbon, Lisboa

Unidade Local de Saude de Braga - Hospital de Braga ( Site 2001), Braga, Not set

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2000), Porto, Not set

National Cancer Centre Singapore ( Site 1500), Singapore, Central Singapore

Instituto Catalan de Oncologia - Hospital Duran i Reynals-Haematology Department ( Site 4003), L'Hospitalet Del Llobregat, Barcelona

Hospital Universitari Vall d'Hebron ( Site 4004), Barcelona, Cataluna

MD Anderson Cancer Center ( Site 4006), Madrid, Madrid, Comunidad De

Clinica Universidad de Navarra ( Site 4005), Pamplona, Navarra

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca-Hematology ( S, Salamanca, Not set

Skånes Universitetssjukhus Lund ( Site 5000), Lund, Skane Lan

Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 5002), Uppsala, Uppsala Lan

Sahlgrenska Universitetssjukhuset ( Site 5003), Gothenburg, Vastra Gotalands Lan

Mega Medipol-Hematology ( Site 6009), Stanbul, Istanbul

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 6001), Ankara, Not set

Trakya University ( Site 6005), Edirne, Not set

Ege Universitesi Hastanesi ( Site 6002), İzmir, Not set

Ondokuz Mayıs Universitesi-Oncology department ( Site 6004), Samsun, Not set

The Royal Cornwall Hospital-Haematology ( Site 7006), Truro, Cornwall

University College London Hospital ( Site 7001), London, London, City Of

The Churchill Hospital ( Site 7002), Oxford, Oxfordshire

The Christie NHS Foundation Trust ( Site 7007), Manchester, Not set

Conditions: Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Follicular Lymphoma, Richter Transformation Lymphoma

Learn More ›

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

NCT03986034

Recruiting

Background: The drug venetoclax treats chronic lymphocytic leukemia (CLL). Researchers want to find better treatments for CLL. To do that, they need to learn how the drug affects CLL cancer cells and the immune system. Objective: To learn about genetic changes that happen during treatment of CLL with venetoclax. Eligibility: Adults ages 18 and older with relapsed or refractory CLL after at least 1 prior therapy Design: Participants will be screened under a separate protocol. In Phase 1,... Read More

Gender:

ALL

Ages:

Between 18 years and 85 years

Trial Updated:

04/15/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Chronic Lymphocytic Leukemia

Learn More ›

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

NCT06136559

Recruiting

The goal of this study is to evaluate nemtabrutinib compared with investigator's choice of ibrutinib or acalabrutinib in participants with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who have not received any prior therapy. The primary hypotheses are that (1) nemtabrutinib is non-inferior to ibrutinib or acalabrutinib with respect to objective response rate (ORR) per International Workshop on Chronic Lymphocytic Leukemia (iwCLL) Criteria 2018 by blinded independent centra... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/15/2025

Locations: USA Mitchell Cancer Institute ( Site 0014), Mobile, Alabama +163 locations

USA Mitchell Cancer Institute ( Site 0014), Mobile, Alabama

Arizona Oncology Associates - NAHOA ( Site 8007), Prescott, Arizona

Alta Bates Summit Medical Center ( Site 0004), Berkeley, California

Moores Cancer Center ( Site 0003), La Jolla, California

Florida Cancer Specialists - South ( Site 7001), Fort Myers, Florida

Florida Cancer Specialists - East ( Site 7002), West Palm Beach, Florida

Parkview Research Center at Parkview Regional Medical Center ( Site 0002), Fort Wayne, Indiana

University of Iowa-Holden Comprehensive Cancer Center ( Site 0017), Iowa City, Iowa

Corewell Health-Lemmon Holton Cancer Pavilion ( Site 0011), Grand Rapids, Michigan

Summit Medical Group Cancer Center ( Site 0007), Florham Park, New Jersey

John Theurer Cancer Center at Hackensack University Medical Center ( Site 0016), Hackensack, New Jersey

Consultants in Medical Oncology and Hematology (CMOH) ( Site 8002), Broomall, Pennsylvania

Cancer Care Associates Of York ( Site 0005), York, Pennsylvania

Texas Oncology - Central/South Texas ( Site 8008), Austin, Texas

Texas Oncology - San Antonio ( Site 8006), San Antonio, Texas

Inova Schar Cancer Institute ( Site 0015), Fairfax, Virginia

Medical Oncology Associates, PS (dba Summit Cancer Centers) ( Site 0010), Spokane, Washington

University Hospital and UW Health Clinics ( Site 0006), Madison, Wisconsin

Royal North Shore Hospital ( Site 2806), St Leonards, New South Wales

AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0205), Mechelen, Antwerpen

UZ Leuven-Hematology ( Site 0200), Leuven, Vlaams-Brabant

Hospital 9 De Julho ( Site 2206), São Paulo, Sao Paulo

Instituto Nacional de Câncer - INCA ( Site 2201), Rio de Janeiro, Not set

Hospital Paulistano-Americas Oncologia ( Site 2202), Sao Paulo, Not set

BC Cancer Victoria ( Site 0109), Victoria, British Columbia

William Osler Health System ( Site 0103), Brampton, Ontario

The Ottawa Hospital - General Campus ( Site 0102), Ottawa, Ontario

McGill University Health Centre ( Site 0106), Montréal, Quebec

Centre intégré de santé et de services sociaux du Bas Saint-Laurent- Hôpital régional de Rimouski (, Rimouski, Quebec

Bradfordhill-Clinical Area ( Site 2310), Santiago., Region M. De Santiago

FALP-UIDO ( Site 2300), Santiago, Region M. De Santiago

Clínica Alemana de Santiago-Unidad de Investigaciones ( Site 2306), Santiago, Region M. De Santiago

Anhui Provincial Cancer Hospital ( Site 2001), Hefei, Anhui

Peking University First Hospital ( Site 2022), Beijing, Beijing

Peking University Third Hospital-Hematology ( Site 2011), Beijing, Beijing

Chongqing University Cancer Hospital ( Site 2041), Chongqing, Chongqing

Southern Medical University Nanfang Hospital-Department of Hematopathology ( Site 2006), Guangzhou, Guangdong

Sun Yat-sen University Cancer Center ( Site 2028), Guangzhou, Guangdong

Liuzhou People's Hospital ( Site 2029), Liuzhou, Guangxi

Guangxi Medical University Affiliated Tumor Hospital ( Site 2004), Nanning, Guangxi

The Affiliated Hospital of Guizhou Medical University ( Site 2024), Guiyang, Guizhou

Hainan General Hospital ( Site 2018), Haikou, Hainan

Henan Cancer Hospital-hematology department ( Site 2025), Zhengzhou, Henan

Tongji Hospital Affiliated to Tongji Medical College of HUST ( Site 2016), Wuhan, Hubei

Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 2015), Wuhan, Hubei

Hunan Cancer Hospital ( Site 2020), Changsha, Hunan

The Second Xiangya Hospital of Central South University ( Site 2010), Changsha, Hunan

Jiangsu Province Hospital ( Site 2000), Nanjing, Jiangsu

The First Affliated Hospital of Suzhou University ( Site 2027), Suzhou, Jiangsu

The Affiliated Hospital of Xuzhou Medical College ( Site 2013), Xuzhou, Jiangsu

The First Affiliated Hospital of Nanchang University ( Site 2023), Nanchang, Jiangxi

Jiangxi Provincial Cancer Hospital ( Site 2009), Nanchang, Jiangxi

The First Hospital of Jilin University-Hematology ( Site 2030), Changchun, Jilin

Shaanxi provincial people's hospital ( Site 2012), Xian, Shaanxi

Shandong Cancer Hospital ( Site 2003), Jinan, Shandong

Shanxi Cancer Hospital ( Site 2033), Taiyuan, Shanxi

West China Hospital, Sichuan University-Head and Neck Oncology ( Site 2026), Cheng Du, Sichuan

Tianjin Medical University Cancer Institute & Hospital-lymphoma ( Site 2019), Tianjin, Tianjin

Institute of hematology&blood disease hospital-Lymphoma ( Site 2005), Tianjin, Tianjin

Xinjiang Medical University Cancer Hospital - Urumqi ( Site 2014), Urumqi, Xinjiang

The first Affiliated Hospital, Zhejiang University School of Medicine-Hematology ( Site 2002), Hangzhou, Zhejiang

Zhejiang Cancer Hospital ( Site 2017), Hangzhou, Zhejiang

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2405), Valledupar, Cesar

Oncomédica S.A.S ( Site 2401), Montería, Cordoba

Fundacion Valle del Lili- CIC-Oncology CIC ( Site 2402), Cali, Valle Del Cauca

Fakultni nemocnice Hradec Kralove-IV. interni hematologicka klinika ( Site 0301), Hradec Kralove, Not set

Fakultni nemocnice Olomouc ( Site 0303), Olomouc, Not set

Vseobecna fakultni nemocnice v Praze-I. Interní klinika - klinika hematologie ( Site 0302), Praha 2, Not set

Aalborg Universitetshospital, Syd ( Site 0403), Aalborg, Nordjylland

Roskilde Sygehus-Department of Hematology ( Site 0402), Roskilde, Sjaelland

Odense Universitetshospital-Department of Hematology ( Site 0401), Odense C, Syddanmark

Universitaetsklinikum Ulm.... ( Site 0601), Ulm, Baden-Wurttemberg

VK&K Studien GbR ( Site 0607), Landshut, Bayern

Kliniken Maria Hilf ( Site 0603), Mönchengladbach, Nordrhein-Westfalen

InVO Institut für Versorgungsforschung in der Onkologie ( Site 0606), Koblenz, Rheinland-Pfalz

Universitätsklinikum Halle ( Site 0604), Halle, Sachsen-Anhalt

Onkologische Schwerpunktpraxis Kurfuerstendamm ( Site 0600), Berlin, Not set

University Hospital of Alexandroupolis ( Site 0701), Alexandroupolis, Anatoliki Makedonia Kai Thraki

Evangelismos General Hospital of Athens ( Site 0700), Athens, Attiki

University Hospital of Ioannina ( Site 0702), Ioannina, Not set

Queen Mary Hospital ( Site 3300), Hong Kong, Not set

Rambam Health Care Campus-Hematology and Bone Marrow Transplantation ( Site 1503), Haifa, Not set

Bnai Zion Medical Center ( Site 1505), Haifa, Not set

Hadassah Medical Center-Hemato-Oncology ( Site 1500), Jerusalem, Not set

Rabin Medical Center ( Site 1504), Petah Tikva, Not set

Sheba Medical Center-Hemato Oncology ( Site 1501), Ramat Gan, Not set

Yitzhak Shamir Medical Center. ( Site 1506), Zerifin, Not set

Nagoya University Hospital ( Site 1907), Nagoya, Aichi

Gunma University Hospital ( Site 1903), Maebashi, Gunma

Hokkaido University Hospital ( Site 1900), Sapporo, Hokkaido

Kobe City Medical Center General Hospital ( Site 1910), Kobe, Hyogo

Tohoku University Hospital ( Site 1901), Sendai, Miyagi

Kindai University Hospital ( Site 1909), Sayama, Osaka

Shimane University Hospital ( Site 1911), Izumo, Shimane

Cancer Institute Hospital of JFCR ( Site 1906), Koto, Tokyo

Chiba Cancer Center ( Site 1905), Chiba, Not set

Kyushu University Hospital ( Site 1914), Fukuoka, Not set

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 1913), Hiroshima, Not set

Okayama University Hospital ( Site 1912), Okayama, Not set

Japanese Red Cross Osaka Hospital ( Site 1908), Osaka, Not set

Yamagata University Hospital ( Site 1902), Yamagata, Not set

University Malaya Medical Centre ( Site 1604), Lembah Pantai, Kuala Lumpur

Hospital Pulau Pinang ( Site 1602), George Town, Pulau Pinang

Queen Elizabeth Hospital ( Site 1603), Kota Kinabalu, Sabah

Centro de Infusion Superare ( Site 2602), Ciudad de México, Distrito Federal

Health Pharma Professional Research S.A. de C.V: ( Site 2608), Ciudad de México, Distrito Federal

Waikato Hospital-Haematology ( Site 3202), Hamilton, Waikato

North Shore Hospital-Department of Haematology ( Site 3200), Auckland, Not set

Aotearoa Clinical Trials ( Site 3201), Auckland, Not set

Akershus Universitetssykehus ( Site 0902), Lørenskog, Akershus

Oslo Universitetssykehus Rikshospitalet-Avdeling for blodsykdommer ( Site 0901), Oslo, Not set

Centro Medico Monte Carmelo-Oncology ( Site 2706), Arequipa, Ariqipa

Clínica Anglo Americana ( Site 2701), Lima, Not set

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii, Transplantacji Szp, Lublin, Lubelskie

Pratia MCM Krakow ( Site 1007), Krakow, Malopolskie

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Kilinka Onkologii I Hematologii ( Site, Warszawa, Mazowieckie

Uniwersyteckie Centrum Kliniczne-Klinika Hematologii i Transplantologii ( Site 1011), Gdansk, Pomorskie

Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku-Oddział Hematologii i Transplantacji (, Słupsk, Pomorskie

Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1000), Gliwice, Slaskie

Pratia Onkologia Katowice ( Site 1009), Katowice, Slaskie

Samodzielny Publiczny Zakład Opieki Zdrowotnej MSWiA w Olsztynie-Oddzial Kliniczny Hematologii ( Sit, Olsztyn, Warminsko-mazurskie

Instituto Português de Oncologia de Lisboa Francisco Gentil ( Site 3103), Lisbon, Lisboa

Champalimaud Foundation ( Site 3102), Lisbon, Lisboa

Unidade Local de Saude Gaia/Espinho - Hospital Eduardo Santos Silva ( Site 3107), Vila Nova de Gaia, Porto

Unidade Local de Saude Lisboa Ocidental - Hospital de São Francisco Xavier ( Site 3104), Lisboa, Not set

Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3106), Lisboa, Not set

Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 3100), Porto, Not set

Netcare Pretoria East Hospital-Alberts Cellular Therapy ( Site 1101), Centurion, Gauteng

Wits Clinical Research ( Site 1102), Johannesburg, Gauteng

Groote Schuur Hospital-Clinical Haematology ( Site 1100), Cape Town, Western Cape

Haemalife ( Site 1105), Kuilsriver, Western Cape

Constantiaberg Haematology ( Site 1106), Plumstead, Western Cape

Institut Català d'Oncologia - L'Hospitalet-Haematology Department ( Site 1207), L'Hospitalet Del Llobregat, Barcelona

HOSPITAL CLÍNIC DE BARCELONA ( Site 1202), Barcelona, Cataluna

HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 1208), Majadahonda, Madrid, Comunidad De

HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID ( Site 1209), Pozuelo de Alarcon, Madrid

hospital universitario de canarias ( Site 1205), La Laguna, Santa Cruz De Tenerife

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1206), Barcelona, Not set

Hospital Universitario de Salamanca - Complejo Asistencial U-Servicio de Hematologia ( Site 1201), Salamanca, Not set

Karolinska Universitetssjukhuset Solna ( Site 1302), Stockholm, Stockholms Lan

Chang Gung Memorial Hospital at Kaohsiung-Division of Hematology and Oncology ( Site 1702), Kaohsiung, Not set

National Cheng Kung University Hospital ( Site 1700), Tainan, Not set

National Taiwan University Hospital ( Site 1701), Taipei, Not set

Chang Gung Medical Foundation-Linkou Branch ( Site 1703), Taoyuan, Not set

Maharaj Nakorn Chiang Mai Hospital ( Site 1800), Muang, Chiang Mai

Chulalongkorn University ( Site 1802), Bangkok, Krung Thep Maha Nakhon

Faculty of Medicine Siriraj Hospital-Division of Hematology, Department of Medicine ( Site 1801), Bangkok, Krung Thep Maha Nakhon

Naresuan University Hospital ( Site 1804), Muang, Phitsanulok

Songklanagarind hospital ( Site 1803), HatYai, Songkhla

Ankara Universitesi Tip Fakultesi Hastanesi-hematology ( Site 1401), Ankara, Not set

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1407), Ankara, Not set

Antalya Egitim ve Arastırma Hastanesi ( Site 1409), Antalya, Not set

Trakya University-Balkan Onkoloji Hastanesi ( Site 1403), Edirne, Not set

Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 1408), Istanbul, Not set

Ege Universitesi Hastanesi ( Site 1404), İzmir, Not set

Ondokuz Mays Üniversitesi ( Site 1410), Samsun, Not set

Southmead Hospital ( Site 3010), Bristol, Bristol, City Of

St Bartholomew's Hospital-Centre for Experimental Cancer Medicine ( Site 3006), London, London, City Of

The Churchill Hospital ( Site 3007), Oxford, Oxfordshire

GenesisCare - Cambridge ( Site 3001), Newmarket, Suffolk

GenesisCare - Windsor ( Site 3002), Windsor, Windsor And Maidenhead

Barnet Hospital ( Site 3005), Barnet, Not set

St James's University Hospital ( Site 3004), Leeds, Not set

City Hospital, Nottingham University Hospitals NHS Trust ( Site 3003), Nottingham, Not set

Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma

Learn More ›

Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets

NCT05618028

Recruiting

B-cell malignancies are a group of cancers of B lymphocytes, a type of white blood cell responsible for fighting infections. The purpose of this study is to assess safety, tolerability, pharmacokinetics and preliminary efficacy of ABBV-525 as a monotherapy. ABBV-525 is an investigational drug being developed for the treatment of B-Cell Malignancies. Study doctors put the participants in groups called treatment arms. Participants will receive ABBV-525 at different doses. Approximately 100 adult... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/14/2025

Locations: University of California Los Angeles /ID# 246357, Los Angeles, California +31 locations

University of California Los Angeles /ID# 246357, Los Angeles, California

Yale University School of Medicine /ID# 259081, New Haven, Connecticut

Mount Sinai Medical Center-Miami Beach /ID# 248251, Miami Beach, Florida

Fort Wayne Medical Oncology and Hematology, Inc /ID# 250113, Fort Wayne, Indiana

Indiana University Melvin and Bren Simon Comprehensive Cancer Center /ID# 259872, Indianapolis, Indiana

Tulane Cancer Center Clinic /ID# 249586, New Orleans, Louisiana

START Midwest /ID# 252359, Grand Rapids, Michigan

Memorial Sloan Kettering Cancer Center-Koch Center /ID# 245459, New York, New York

Levine Cancer Institute /ID# 246363, Charlotte, North Carolina

University Of Cincinnati Medical Center /ID# 262288, Cincinnati, Ohio

University of Texas MD Anderson Cancer Center /ID# 245463, Houston, Texas

University of Utah Health Hospital /ID# 259924, Salt Lake City, Utah

Northwest Medical Specialties - Tacoma /ID# 260376, Tacoma, Washington

Monash University /ID# 246366, Clayton, Victoria

The Alfred Hospital /ID# 248592, Melbourne, Victoria

UZ Gent /ID# 246462, Gent, Oost-Vlaanderen

Universitair Ziekenhuis Leuven /ID# 246461, Leuven, Vlaams-Brabant

CHRU Lille - Hopital Claude Huriez /ID# 252054, Lille, Nord

IUCT Oncopole /ID# 259409, Toulouse Cedex 9, Occitanie

Charite Universitaetsklinikum Berlin - Campus Virchow /ID# 252062, Berlin, Not set

Shamir Medical Center /ID# 257711, Beer Ya'akov, HaMerkaz

The Chaim Sheba Medical Center /ID# 251442, Ramat Gan, Tel-Aviv

Hadassah Medical Center-Hebrew University /ID# 251441, Jerusalem, Yerushalayim

Rabin Medical Center /ID# 257665, Petah Tikva, Not set

Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 246537, L'Hospitalet de Llobregat, Barcelona

Hospital Universitario Vall d'Hebron /ID# 245475, Barcelona, Not set

Hospital Clinic de Barcelona /ID# 246543, Barcelona, Not set

Hospital Universitario Ramon y Cajal /ID# 246540, Madrid, Not set

Hospital Universitario 12 de Octubre /ID# 246538, Madrid, Not set

Leeds Teaching Hospitals NHS Trust /ID# 245470, Leeds, West Yorkshire

The Royal Marsden NHS Foundation Trust /ID# 250324, London, Not set

The Christie Hospital /ID# 250325, Manchester, Not set

Conditions: Diffuse Large B-Cell Lymphoma, Chronic Lymphocytic Leukemia, B Cell Malignancies, Non-Hodgkin's Lymphoma

Learn More ›

A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia

NCT06637501

Recruiting

The purpose of this study is to support the registration plan of sonrotoclax plus zanubrutinib treatment in participants with previously untreated CLL. This study is designed to assess the contribution of sonrotoclax to the efficacy outcome of the combination of zanubrutinib and sonrotoclax.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

04/10/2025

Locations: University of Miami, Miami, Florida +37 locations

University of Miami, Miami, Florida

Cleveland Clinic Florida, Weston, Florida

Northwest Georgia Oncology Centers Marietta, Marietta, Georgia

Illinois Cancer Specialists (Niles) Usor, Niles, Illinois

University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland

Nebraska Cancer Specialists (Satellite Site), Omaha, Nebraska

Nebraska Cancer Specialists, Omaha, Nebraska

University of Nebraska Medical Center, Omaha, Nebraska

Summit Medical Group, Florham Park, New Jersey

New York Cancer and Blood Specialists, Shirley, New York

Oncology Associates of Oregon Willamette Valley Cancer Center, Eugene, Oregon

Texas Oncology Dfw, Dallas, Texas

Texas Oncology Tyler, Tyler, Texas

Utah Cancer Specialists, Salt Lake City, Utah

Northwest Cancer Specialist, Pc(Us Oncology Research), Vancouver, Washington

Centro de Pesquisas Oncologicas Cepon, Florianopolis, Not set

Hospital de Clinicas de Porto Alegre, Porto AlegreRS, Not set

Instituto Dor de Pesquisa E Ensino Sao Paulo, Sao Paulo, Not set

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, Sao Paulo, Not set

Fujian Medical University Union Hospital, Fuzhou, Fujian

Henan Cancer Hospital, Zhengzhou, Henan

The First Peoples Hospital of Changzhou, Changzhou, Jiangsu

Jiangsu Province Hospital, Nanjing, Jiangsu

Rui Jin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai

The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang

Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia, Brescia, Not set

Aou Careggi, Servizio Sanitario Toscana, Firenze, Not set

Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco, Modena, Not set

Aoor Villa Sofia Cervello, Palermo, Not set

Pratia Onkologia Katowice, Katowice, Not set

Pratia McM Krakow, Krakow, Not set

Uniwersytecki Szpital Kliniczny Nr W Lublinie, Lublin, Not set

Uniwersytecki Szpital Kliniczny Hematology, Wrocaw, Not set

Hospital Clinic de Barcelona, Barcelona, Not set

Hospital de Cabuenes, Gijon, Not set

Clinica Universidad de Navarra, Madrid, Not set

Hospital Universitario Fundacion Jimenez Diaz, Madrid, Not set

Clinica Universidad de Navarra Pamplona, Pamplona, Not set

Conditions: Chronic Lymphocytic Leukemia

Learn More ›

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