The state of California currently has 58 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Los Angeles, San Francisco, San Diego and Sacramento.
Diet and Depression
NCT06252701
Recruiting
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a large percentage of UPF.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
09/30/2024
Locations: University of California, San Francisco, San Francisco, California
Conditions: Depression, Major Depressive Disorder, Weight Gain, Obesity, Metabolic Syndrome
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Aging and Reward System Response to Inflammation and Anxiety Study
NCT05363527
Recruiting
The purpose of this study is to use an experimental inflammatory challenge to examine whether older adults with symptoms of anxiety experience loss of pleasure or loss of motivation when they are exposed to inflammation. Loss of pleasure or loss of motivation will be evaluated using self-report questionnaires, computer tasks, and during a brain scan.
Gender:
ALL
Ages:
Between 60 years and 80 years
Trial Updated:
09/04/2024
Locations: Norman Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, Los Angeles, California
Conditions: Anhedonia, Inflammation, Anxiety, Aging, Depression
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Treating Major Depression With Yoga Mono-therapy
NCT06091527
Recruiting
The goal of this single-center, single-blind, randomized, controlled, parallel group, interventional trial is to evaluate antidepressant efficacy of yoga monotherapy of 12-weeks duration in 180 adults meeting diagnostic criteria for mild-to-moderate major depression at the Zuckerberg San Francisco General Hospital. Researchers will compare the yoga interventions to an education control intervention on holistic healthcare.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: Zuckerberg San Francisco General Hospital, San Francisco, California
Conditions: Depression Mild, Depression Moderate
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Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
NCT06080646
Recruiting
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
07/31/2024
Locations: San Francisco Healthcare System, San Francisco, California
Conditions: Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode, Depressive Symptoms, Anhedonia
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Healthcare Providers as Trusted Messengers to Increase Receipt of Tax Credits Among Low-income Families
NCT05612685
Recruiting
The purpose of this study is to pilot test the feasibility, acceptability, and preliminary efficacy of healthcare provider referrals to a tax filing app within parent-child health programs to test whether such referrals can increase receipt of tax credits among low-income parents. The study will use a single-group, pre/post test design with a sample of approximately 100 women who have a child under 6 years of age. Participants will be recruited from parental-child health programs and clinics in... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/23/2024
Locations: UCLA School of Nursing, Los Angeles, California
Conditions: Depression, Child Development, Stress, Physical Illness, Health Care Utilization
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Accelerated Intermittent Theta-Burst Stimulation (aiTBS) in Treatment-Resistant Depression of Bipolar II Disorder
NCT05849402
Recruiting
The purpose of this study is to investigate the effectiveness of accelerated intermittent theta-burst transcranial magnetic stimulation (aiTBS) in inducing anti-depressant responses in individuals with treatment-resistant depression of bipolar II disorder. This is a double-blind, randomized, sham-controlled trial that targets a single location on the left dorsolateral prefrontal cortex (LDLPFC) using the MagPro rTMS system.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
04/26/2024
Locations: Stanford University, Palo Alto, California
Conditions: Bipolar II Disorder, Most Recent Episode Major Depressive, Current Depressive Episode, Treatment Resistant Depression
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A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis
NCT05865405
Recruiting
The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related symptoms at regular intervals, which is then available to their Neurologist in their electronic medical record. The neurologist is also able to view additional information from their medical record, and receives alerts for changes reported by the pat... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/16/2024
Locations: Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California
Conditions: Multiple Sclerosis, MS, Depression
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The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over
NCT06011681
Recruiting
Mild cognitive impairment (MCI) leading to Alzheimer's disease and related disorders (ADRD) represents a significant health and economic burden of the rapidly expanding senior population. The accurate detection and diagnosis of MCI and its common comorbidity, late-life depression (LLD), is essential for prolonging patient quality of life and developing advancements in research and treatment options. The purpose of the proposed program is to refine Miro Health's A.I. to accurately detect, differe... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/18/2024
Locations: Miro Health, Sacramento, California
Conditions: Depression, Mild Cognitive Impairment
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Acceptance and Commitment Therapy (ACT) for Combating the Effects of Race-Related Stress Among Black Adolescents
NCT05685368
Recruiting
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical... Read More
Gender:
ALL
Ages:
Between 13 years and 21 years
Trial Updated:
11/03/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
Register for Updates
Personalized Need-focused Single Session Intervention
NCT05953779
Recruiting
This is a two-site randomized controlled trial, with two goals. First, the investigators aim to demonstrate that single-session interventions for mild-to-moderate anxiety and depression can generate statistically significant symptom change as a main effect across control and experimental (i.e. personalized) conditions. Second, the investigators hope to establish the additional incremental efficacy of personalization via person-specific intensive longitudinal data collection and analysis.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2023
Locations: University of California, Berkeley, Berkeley, California
Conditions: Depression and/or Anxiety in the Mild-to-moderate Range
Register for Updates