Huntington's Disease Clinical Trials

A listing of 4 Huntington's Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 4 active clinical trials seeking participants for Huntington's Disease research studies. The states with the highest number of trials for Huntington's Disease participants are California, New York, Ohio and Ontario.

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Conditions:

High Blood Pressure

High Blood Pressure (& [Essential Hypertension])

High Blood Pressure (Hypertension).

Hypertension

Essential Hypertension

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Conditions:

Weight Loss

Morbid Obesity

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Featured Trial

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Recruiting

Earn $325 - $475 in electronic payment card compensation for your time and effort by participating in a clinical study to develop a blood test that may one day help screen for colon cancer. Take a quick quiz to see if you qualify.

Conditions:

Healthy

Healthy Volunteers

Healthy Subjects

Healthy Volunteer

Healthy Participants

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Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's Disease

NCT04120493

Recruiting

This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a Phase 1/2, multicenter, first-in-human (FIH) study. The first three cohorts of the study have completed enrollment, including the randomized, double-blind, sham-controlled cohorts. Cohort 4 is open-label. Cohort 4 participants will receive high dose AMT-130.

Gender:

ALL

Ages:

Between 25 years and 65 years

Trial Updated:

08/11/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama +13 locations

Conditions: Huntington's Disease

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HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

NCT02855476

Recruiting

HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.

Gender:

ALL

Ages:

Between 11 years and 75 years

Trial Updated:

05/27/2025

Locations: Cenexel, Englewood, Colorado +38 locations

Cenexel, Englewood, Colorado

Georgetown University, Washington, District of Columbia

John Hopkins University, Baltimore, Maryland

Wake Forest University, Winston-Salem, North Carolina

Vanderbilt University Medical Center, Nashville, Tennessee

University of Texas Health Science Center, Houston, Texas

University of British Columbia, The Centre for Huntingtons Disease, Vancouver, British Columbia

The Ottawa Hospital, Ottawa, Ontario

North York General Hospital, Toronto, Ontario

Centre for Movement Disorders, Toronto, Ontario

Centre Hospitalier Universitaire d'Angers, Angers, Not set

Le Centre Hospitalier Universitaire de Bordeaux, Bordeaux, Not set

University Hospital Ulm, Ulm, Baden-Württemberg

Dresden University, Dresden, Saxony

St Josef And Elisabeth Hospital, Bochum, Not set

University Hospital of Erlangen, Erlangen, Not set

George Huntington Institute, Münster, Not set

Kbo-Isar-Amper-Klinikum Taufkirchen (Vils), Taufkirchen, Not set

Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Not set

Lega Italiana Ricera Huntington, Rome, Not set

The University of Auckland, Grafton, Auckland

NZ Brain Research Institute, Christchurch, Canterbury

Institute of Psychiatry and Neurology, Warsaw, Not set

Cruces University Hospital, Bilbao, Biscay

Hospital de Sant Pau, Barcelona, Not set

Ramón y Cajal Universitary Hospital, Madrid, Not set

Royal Devon & Exeter NHS Foundation Trust, Exeter, Devon

Glasgow Clinical Research Facility, Glasgow, Scotland

Birmingham Huntingtons Disease Clinic, Birmingham, West Midlands

North Bristol NHS Trust, Bristol, Not set

Cambridge University Hospitals NHS Foundation Trust, Cambridge, Not set

Cardiff University, Cardiff, Not set

Fife Health Board - Whyteman's Brae Hospital, Kirkcaldy, Not set

Leeds Teaching Hospital Trust, Leeds, Not set

The Walton Centre NHS Foundation Trust, Liverpool, Not set

University College London Hospitals NHS Foundation Trust, London, Not set

St George's University Of London, London, Not set

Oxford University Hospitals NHS Foundation Trust, Oxford, Not set

University Hospitals Plymouth NHS Trust, Plymouth, Not set

Conditions: Huntington's Disease

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Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease

NCT01860339

Recruiting

Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT). This disease has classically been conceptualized as a neurodegenerative disease. However, recent evidence suggests that abnormal brain development may play an important role in the etiology of HD. Huntingtin (HTT)is expressed during development and through life. In animal studies, the HTT gene has been shown to be vital for brain development. This suggests that a mutant form of HTT (gene-expanded or CAG repeats of 40 and above) would affect normal brain development. In addition, studies in adults who are gene-expanded for HD, but have not yet manifested the illness, (pre-HD subjects) have significant changes in the structure of their brain, even up to 20 years before onset of clinical diagnosis. How far back these changes are evident is unknown. One possibility is that these brain changes are present throughout life, due to changes in brain development,though initially associated with only subtle functional abnormalities. In an effort to better understand the developmental aspects of this brain disease, the current study proposes to evaluate brain structure and function in children, adolescents, and young adults (ages 6-30) who are at risk for developing HD - those who have a parent or grandparent with HD. Brain structure will be evaluating using Magnetic Resonance Imaging (MRI) with quantitative measures of the entire brain, cerebral cortex, as well as white matter integrity via Diffusion Tensor Imaging. Brain function will be assessed by cognitive tests, behavioral assessment, and physical and neurologic evaluation. Subjects that are gene-expanded (GE) will be compared to subjects who are gene non-expanded (GNE). Changes in brain structure and/or function in the GE group compared to the GNE group would lend support to the notion that this disease has an important developmental component. Read Less

Gender:

ALL

Ages:

Between 6 years and 30 years

Trial Updated:

11/21/2024

Locations: University of California Davis, Sacramento, California +5 locations

Conditions: Huntington's Disease

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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

NCT01574053

Recruiting

Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More

Gender:

ALL

Ages:

18 years and above

Trial Updated:

02/26/2024

Locations: University of Alabama, Birmingham, Alabama +182 locations

University of Alabama, Birmingham, Alabama

St. Joseph's Hospital and Medical Center, Phoenix, Arizona

University of California - Irvine Medical Center, Irvine, California

Loma Linda Medical Center, Loma Linda, California

University of California - Los Angeles, Los Angeles, California

University of California - Davis, Sacramento, California

University of California - San Diego, San Diego, California

University of California - San Francisco, San Francisco, California

Cenexel Rocky Mountain Clinical Research, LLC, Englewood, Colorado

University of Connecticut, Farmington, Connecticut

Georgetown University, Washington, District of Columbia

University of Florida Board of Trustees, Gainesville, Florida

University of Miami, Miami, Florida

University of South Florida, HDSA Center of Excellence at USF, Tampa, Florida

Emory University, Wesley Woods Health Center, Atlanta, Georgia

Georgia Health Sciences University, Augusta, Georgia

Northwestern University, Chicago, Illinois

University of Chicago, Chicago, Illinois

Rush University Medical Center, Chicago, Illinois

University of Illinois College of Medicine at Rockford, Rockford, Illinois

Indiana University, Indianapolis, Indiana

University of Iowa, Iowa City, Iowa

University of Kansas Medical Center, Kansas City, Kansas

Hereditary Neurological Disease Center, Wichita, Kansas

University of Louisville, Louisville, Kentucky

University of Maryland School of Medicine, Baltimore, Maryland

Johns Hopkins University, Baltimore, Maryland

Boston University Medical Center, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Boston, Massachusetts

University of Michigan, Ann Arbor, Michigan

Wayne State University, Detroit, Michigan

Hennepin County Medical Center, Minneapolis, Minnesota

Washington University in St. Louis, Saint Louis, Missouri

University of Nebraska Medical Center, Omaha, Nebraska

Cleveland Clinic - Las Vegas, Las Vegas, Nevada

Cooper University Hospital, Camden, New Jersey

Rutgers, the State University of New Jersey, New Brunswick, New Jersey

Albany Medical College, Albany, New York

Columbia University, New York, New York

University of Rochester, Rochester, New York

Duke University, Durham, North Carolina

Wake Forest School of Medicine, Winston-Salem, North Carolina

Sanford Health, Fargo, North Dakota

University of Cincinatti, Cincinnati, Ohio

Cleveland Clinic, Cleveland, Ohio

The Ohio State University, Columbus, Ohio

Oregon Health and Science University, Portland, Oregon

University of Pennsylvania, Philadelphia, Pennsylvania

University of Pittsburgh, Pittsburgh, Pennsylvania

University of South Carolina, Columbia, South Carolina

University of Tennessee Health Science Center, Memphis, Tennessee

Vanderbilt University Medical Center, Nashville, Tennessee

Baylor College of Medicine, Houston, Texas

University of Texas Health Science Center, Houston, Texas

University of Utah, Salt Lake City, Utah

University of Vermont, Burlington, Vermont

University of Virginia, Charlottesville, Virginia

Virginia Commonwealth University Parkinson's and Movement Disorders Center, Henrico, Virginia

Virginia Commonwealth University, Richmond, Virginia

Booth Gardner Parkinson's Care Center (Evergreen Health), Kirkland, Washington

University of Washington Medical Center, Seattle, Washington

University of Wisconsin - Madison, Madison, Wisconsin

Instituto de Neurociencias Buenos Aires (INEBA), Buenos Aires, Not set

Westmead Hospital, Westmead, New South Wales

Monash University, Melbourne, Victoria

The Neurosciences Unit - North Metropolitan Hospital, Perth, Western Australia

University of Melbourne, Royal Melbourne Hospital, Parkville, Not set

Universitatsklinik Innsbruck, Innsbruck, Not set

University Hospitals Leuven, Leuven, Vlaams-Brabant

Bruxelles - Erasme, Bruxelles, Not set

Institut de Pathologie et de Génétique (IPG), Charleroi, Not set

Hôpital du Beau Vallon ASBL, Saint-Servais, Not set

University of Calgary, Movement Disorders Program, Calgary, Alberta

University of Alberta (Glenrose), Edmonton, Alberta

University of Alberta Hospital in Edmonton, Edmonton, Alberta

University of British Columbia, Vancouver, British Columbia

Nova Scotia Health Authority, Halifax, Nova Scotia

Centre for Movement Disorders, Markham, Ontario

The Ottawa Hospital, Ottawa, Ontario

North York General Hospital, Toronto, Ontario

CHUM Hospital of Notre Dame, Montreal, Quebec

CETRAM, Santiago, Not set

Universidad de Antioquia, Grupo de Neurociencias, Medellín, Antioquia

Servicios Médicos MS, Clínica de Marly, Bogotá, Cundinamarca

University Hospital of Aarhus, Aarhus, Not set

University Hospital of Copenhagen, Copenhagen, Not set

University Hospital of Odense, Odense, Not set

Hôpitaux Universitaires de Strasbourg Hôpital de Hautepierre-Service de Neurologie, Strasbourg, Alsace Lorraine

CHU Amiens-Picardie, Amiens, Not set

CHU Angers, Centre de Référence Maladies Neurogénétiques, Angers, Not set

Bordeaux - Huntington Disease competencies center, Bordeaux, Not set

CHU Gabriel-Montpied, Clermont-Ferrand, Not set

Hôpital Henri Mondor, Centre d'Investigation Clinique, Créteil, Not set

Lille-Amiens - Huntington Disease Constituent site, LILLE Cedex, Not set

Hôpital La Timone, Marseille, Not set

CHU Montpellier, Montpellier, Not set

Institut du Cerveau et de la Moelle Epinière, Paris, Not set

Hôpital Purpan, Centre d'Investigation Clinique, Toulouse, Not set

University Hospital Aachen, Aachen, Not set

University of Berlin, Berlin, Not set

St. Josef und St. Elisabeth Hospital, Bochum, Not set

University Hospital Carl Gustav Carus Dresden, Dresden, Not set

University Hospital Erlangen, Erlangen, Not set

University Medical Center Freiburg, Freiburg, Not set

Paracelsus Elena Klinik Kassel, Kassel, Not set

University Hospital Schleswig-Holstein, Lübeck, Not set

University Hospital Giessen and Marburg, Marburg, Not set

Technical University of Munich, Munich, Not set

George-Huntington-Institut GmbH, Münster, Not set

kbo-Isar-Amper-Klinikum Taufkirchen (Vils), Taufkirchen, Not set

University Hopsital of Ulm, Ulm, Not set

University Hospital of Wuerzburg, Würzburg, Not set

Beaumont Hospital, Dublin 9, Republic Of Ireland

Fondazione IRCCS Istituto Neurologico Carlo Besta - Genetics, Milan, MI

Bari Policlinico General Hospital, Bari, Not set

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Not set

Università degli Studi di Genova (DINOGMI), Genoa, Not set

Fondazione IRCCS Istituto Neurologico Carlo Besta - Neurology, Milan, Not set

University of Naples, Napoli, Not set

Università Cattolica del Sacro Cuore, Rome, Not set

Lega Italiana Ricerca Huntington (LIRH), Rome, Not set

Azienda Ospedaliera Sant'Andrea, Rome, Not set

University Medical Center Groningen, Groningen, Not set

Leiden University Medical Centre, Leiden, Not set

Clinical Trial Center Maastricht B.V., Maastricht, Not set

Auckland City Hospital, Auckland, Not set

New Zealand Brain Research Institute at University of Otago, Christchurch, Not set

Wellington Hospital, Wellington, Not set

Copernicus Podmiotem Leczniczym sp. z o.o., Gdansk, Not set

Krakowska Akademia Neurologii Sp. z o.o, Katowice, Not set

Krakow - Krakowska Akademia Neurologii, Kraków, Not set

Solumed Centrum Medyczne, Poznan, Not set

Medical University of Warsaw, Warsaw, Not set

Institute of Psychiatry and Neurology, Warsaw, Warsaw, Not set

Hospital Prof Doutor Fernando Fonseca, Amadora, Not set

Hospital Universitário de Coimbra, Coimbra, Not set

Central Lisbon Hospital, Lisbon, Not set

Hospital de Santa Maria / Instituto de Medicina Molecular, Lisbon, Not set

Hospital Universitário de São João, Porto, Not set

Hospital Infanta Cristina, Badajoz, Badajoz, Not set

Hospital de Cruces, Barakaldo, Not set

Hospital Universitari de Bellvitge, Barcelona,, Not set

Hospital de la Santa Creu i Sant Pau, Barcelona, Not set

Hospital Mare de Déu de la Mercè, Barcelona, Not set

Fundacion Clinic per a La Recerca Biomèdica, Barcelona, Not set

Hospital Universitario de Burgos, Burgos, Not set

Hospital Universitario Ramón y Cajal, Madrid, Not set

Fundación Jiménez Díaz, Madrid, Not set

Hospital Son Espases, Palma De Mallorca, Not set

Complejo Hospitalario de Navarra, Pamplona, Not set

Fundacion Hospital Universitario La Fe, Valencia, Not set

Siloah AG, Gümligen, Not set

University Hospital Zurich, Zürich, Not set

Royal Devon and Exeter NHS Foundation Trust, Exeter, Devon

Leicestershire Partnership, Narborough, Leicestershire

North Bristol NHS Trust, Bristol, UK

Fife Health Board, Kirkcaldy, UK

Betsi Cadwaladr University Health Board, Wrexham, UK

University of Aberdeen, Aberdeen, Not set

Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, Not set

University of Cambridge, Cambridge, Not set

Cardiff University, Cardiff, Not set

Tayside Health Board, Dundee, Not set

Lothian Health Board, Edinburgh, Not set

Greater Glasgow Health Board, Glasgow, Not set

Ayrshire Central Hospital, Kilmarnock, Not set

NHS Forth Valley, Larbert, Not set

Leeds Teaching Hospitals, Leeds, Not set

The Walton Centre, Liverpool, Not set

Guy's and St. Thomas's NHS Foundation Trust, London, Not set

St. George's Hospital, London, Not set

University College of London, London, Not set

Central Manchester University Hospitals NHS Foundation Trust, Manchester, Not set

Northumberland, Tyne & Wear NHS Foundation Trust of St. Nicholas Hospital, Newcastle-upon-Tyne, Not set

St. Andrews Healthcare, Northampton, Not set

Oxford Radcliffe Hospitals, Oxford, Not set

Plymouth Hospitals NHS Trust, Plymouth, Not set

Poole Hospital, Poole, Not set

Royal Berkshire NHS Foundation Trust, Reading, Not set

Sheffield Children's NHS Foundation Trust, Sheffield, Not set

University Hospital Southampton, Southampton, Not set

North Staffordshire Combined Healthcare NHS Trust, Stoke-on-Trent, Not set

Avon and Wiltshire Mental Health Partnership, Swindon, Not set

Conditions: Huntington's Disease

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