The state of California currently has 65 active clinical trials seeking participants for Hypertension research studies. These trials are conducted in various cities, including Los Angeles, San Francisco, San Diego and Sacramento.
Mono vs. Dual Therapy for Pediatric Pulmonary Arterial Hypertension
Recruiting
The investigators' central hypothesis is that early combination therapy with two PAH-specific oral therapies that have been shown to be well tolerated in the pediatric population, sildenafil and bosentan, will result in better World Health Organization (WHO) functional class at 12 months after initiation of PAH treatment than therapy with sildenafil alone.
Gender:
All
Ages:
Between 3 months and 18 years
Trial Updated:
10/27/2023
Locations: The Regents of the University of California, San Francisco, San Francisco, California
Conditions: Pediatric Pulmonary Hypertension
Technology-enabled Management Versus Usual Care for Blood Pressure
Recruiting
Two arm parallel randomized clinical trial
Gender:
All
Ages:
Between 30 years and 90 years
Trial Updated:
08/27/2023
Locations: Stanford Health Care, Palo Alto, California
Conditions: Hypertension
Enhancing Mental and Physical Health of Women Veterans
Recruiting
Women Veterans are the fastest growing segment of VA users. This dramatic growth has created challenges for VA to ensure that appropriate services are available to meet women Veterans' needs, and that they will want and be able to use those services. The EMPOWER QUERI 2.0 Program is a cluster randomized type 3 hybrid implementation-effectiveness trial testing two strategies designed to support implementation and sustainment of evidence-based practices for women Veterans in up to 20 VA facilities... Read More
Gender:
All
Ages:
All
Trial Updated:
08/16/2023
Locations: VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles, California
Conditions: Cardiovascular Diseases, Overweight, Obesity, Smoking, Hypertension, Cholesterol, Diabetes Mellitus, Prediabetic State, Pregnancy, Depression, Postpartum, Prevention, Implementation Science, Quality Improvement, Virtual Care
Chronic Thromboembolic Disease Registry
Recruiting
The goal of this patient registry is to learn about the natural history in patients with chronic thromboembolic disease (CTD) and/or chronic thromboembolic pulmonary hypertension (CTEPH). The main question[s] it aims to answer are: Long-term outcome after various types of treatment, including medication, balloon pulmonary angioplasty, and pulmonary endarterectomy Effect of treatment on patient's quality of life and exercise tolerance Participants will be followed longitudinally to assess their... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/14/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Disease
Hypertension in Young Adults Trial
Recruiting
This is a pilot randomized controlled trial which will test the effect of 3 different anti-hypertensive agents and 3 different strategies of engaging young adults in home blood pressure monitoring on blood pressure control, with secondary outcomes focused on quality of life and adverse events.
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
08/10/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Hypertension
A Phase 3 Study to Evaluate the Safety and Tolerability of L606 in Subjects With PAH or PH-ILD
Recruiting
This Phase 3, 2-part, open-label, multicenter study aims to demonstrate the safety and tolerability of L606 in patients with PAH or PH-ILD. The study will determine the short-term and long-term safety and tolerability of L606 in this patient population; also evaluate the steady-state pharmacokinetics (PK) of L606 as compared to Tyvaso, effects on exercise ability, quality of life, and treatment satisfaction with L606.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
08/09/2023
Locations: VA Greater Los Angeles Healthcare, Los Angeles, California
Conditions: Pulmonary Arterial Hypertension, Pulmonary Hypertension Due to Lung Diseases
Novel Index (PIMR) in PAH
Recruiting
The chief regulator of resistance in pulmonary arterial hypertension (PAH) is the small arteries. In the heart, the invasive measurement of the resistance of the small arteries has been shownto be safe, easy, reliable, and prognostic. This study is intended to translate prior work in heart arteries to the PAH space and invasively measure the resistance of the small arteries of the lung (pulmonary index of microcirculatory resistance [PIMR]) and the coronary artery supplying the right ventricle (... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Pulmonary Hypertension
Effect of Electro-Acupuncture on Blood Pressure
Recruiting
Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.
Gender:
All
Ages:
Between 39 years and 85 years
Trial Updated:
06/15/2023
Locations: Susan Samueli Integrative Health Institute, Costa Mesa, California +1 locations
Conditions: Hypertension
Acupuncture Therapy and Hypertension
Recruiting
Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will not be on hypertensive medications. The course last for 8 weeks and the frequency is once a week.
Gender:
All
Ages:
Between 50 years and 75 years
Trial Updated:
06/15/2023
Locations: Susan Samueli Integrative Health Institute, Irvine, California +1 locations
Conditions: Mild to Moderate Hypertension
Secondhand Tobacco Smoke and Cardiovascular Disease
Recruiting
This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secondhand tobacco smoke.
Gender:
All
Ages:
40 years and above
Trial Updated:
05/11/2023
Locations: San Francisco Veterans' Affairs Medical Center, San Francisco, California
Conditions: Cardiovascular Diseases, Hypertension
Mi Propio Camino Intervention RCT for Blood Pressure Medication Adherence
Recruiting
The purpose of this study is to compare the effect of two educational interventions on adherence to blood pressure medications among adults with uncontrolled hypertension.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/03/2023
Locations: Health Policy Research Institute, Irvine, California
Conditions: Hypertension, Medication Adherence
Dietary Sodium Intake and Blood Pressure in Living Kidney Donors
Recruiting
This is a pilot study to determine the feasibility of the study design and examine the main outcome whether low dietary sodium intake is superior to high dietary sodium intake in controlling blood pressure to be within the normotensive range in living kidney donors.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/30/2022
Locations: University of California Irvine Medical Center, Orange, California
Conditions: Hypertension, Living Kidney Donor, Dietary Sodium Intake