There are currently 27 active clinical trials seeking participants for Polycystic Ovary Syndrome research studies. The states with the highest number of trials for Polycystic Ovary Syndrome participants are Virginia, Pennsylvania, Heilongjiang and California.
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists
Recruiting
Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if BAT helps the body burn energy. Objective: To learn more about how BAT works to burn energy. Eligibility: People ages 18-40 with a body mass index between 18 and 40 Design: Participants will be screened with: Medical history Physical exam Blood, urine, and heart tests Dietitian interview Participants will have... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
08/21/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Polycystic Ovary Syndrome
The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System
Recruiting
A Prospective, Multicenter, Randomized, Pivotal Study of the May Health System in Transvaginal Ablation of Ovarian Tissue under Ultrasound Guidance in Women with Infertility due to Polycystic Ovary Syndrome
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
08/04/2025
Locations: UCSF Center for Reproductive Health, San Francisco, California +15 locations
Conditions: Polycystic Ovary Syndrome, Infertility, Female
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
07/30/2025
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome
Recruiting
The purpose of this study is to determine if estradiol augmentation of luteinizing hormone (LH) secretion secretion (primary endpoint) and follicle-stimulating hormone (FSH) secretion (secondary endpoint) is reduced in adult women with polycystic ovary syndrome.
Gender:
FEMALE
Ages:
Between 18 years and 30 years
Trial Updated:
07/30/2025
Locations: University of Virginia Clinical Research Unit, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?
Recruiting
The purpose of this study is to determine if, in mid- to late pubertal girls with hyperandrogenism (HA), androgen-receptor blockade (spironolactone) alone normalizes sleep-wake luteinizing hormone (LH) pulse frequency (primary endpoint) and overall LH and follicle-stimulating hormone secretion (secondary endpoints).
Gender:
FEMALE
Ages:
Between 10 years and 17 years
Trial Updated:
07/30/2025
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Hyperandrogenism, Polycystic Ovary Syndrome, Puberty
Dampening the Reproductive Axis With Continuous Kisspeptin
Recruiting
The goal of this study is to assess response to kisspeptin as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals with polycystic ovarian syndrome (PCOS).
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
07/22/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Reproductive Disorder, PCOS, Polycystic Ovary Syndrome
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Recruiting
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, wellness programs and similar resources that are more available in urban areas. Although pharmaceutical therapies have continued to show therapeutic advancements, the rates of disease onset and death from c... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
07/21/2025
Locations: West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia
Conditions: Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension, Coronary Heart Disease, Heart Failure, Depression, Anxiety, Type II Diabetes, Metabolic Syndrome
Combined Oral Contraceptive Pill and Resistance Starch
Recruiting
This study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of placebo to explore if resistant starch improves cardiometabolic parameters or impacts gut dysbiosis compared to placebo.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
06/11/2025
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Metabolic Syndrome, Polycystic Ovary Syndrome
Does Vaginal Delivery of Combined Hormonal Contraception Affect the Risk of Metabolic Syndrome in Overweight/obese Women with PCOS
Recruiting
A prospective study to determine the metabolic effects of the contraceptive vaginal ring among overweight and obese women with polycystic ovary syndrome (PCOS). We will recruit a total of 40 participants and study use of the vaginal ring over a 4-month period.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
12/03/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Polycystic Ovary Syndrome
Inositol Supplementation to Treat PCOS (INSUPP-PCOS)
Recruiting
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
12/03/2024
Locations: Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania +1 locations
Conditions: Polycystic Ovary Syndrome, Anovulation, Hyperandrogenism, Insulin Resistance, Glucose Intolerance, Metabolic Complication
Myo-Inositol for Infertility in PCOS
Recruiting
This will be a prospective, double-blind randomized clinical trial of letrozole and placebo versus letrozole and inositols for up to 5 treatment cycles of ovulation induction or until pregnancy is achieved. All participants and members of the research team will be blinded to the treatment arms. Placebo and inositol supplement will be packaged to appear the same, tested, and packaged by a commercial supply company. The inositols will be a 40:1 blend of myo-inositol and D-chiro inositol.
Gender:
ALL
Ages:
Between 18 years and 36 years
Trial Updated:
09/13/2024
Locations: OUHSC Reproductive Medicine Clinic, Oklahoma City, Oklahoma
Conditions: Polycystic Ovary Syndrome
Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis
Recruiting
The study aims to investigate the relationship between fasting insulin and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) across various demographic factors, including age, sex, race/ethnicity, BMI, and polycystic ovary syndrome (PCOS) diagnosis. By analyzing these variables, the study seeks to identify potential variations in insulin levels, which could provide valuable insights into the impact of different factors on metabolic health and the development of insulin-related conditi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2024
Locations: Lilli Health, Houston, Texas
Conditions: Insulin Resistance, Polycystic Ovary Syndrome, Hyperinsulinism, Obesity, Metabolic Syndrome