There are currently 1889 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC / Norris Comprehensive Cancer Center, Childrens Hospitla Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Esophageal Temperature During PVI Using Q-DOT Micro
NCT06392932
Recruiting
This study will assess how two different ablation strategies, using two different ablation catheters during catheter ablation for paroxysmal atrial fibrillation, affect the temperature of the esophagus during ablation, and the risk of injury to the esophagus.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Cedars-Sinai Smidt Heart Institute, Los Angeles, California
Conditions: Atrial Fibrillation Paroxysmal
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Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer
NCT02280161
Recruiting
This research trial studies germ-line mutations in blood and saliva samples from patients with cancer. Studying samples of blood and saliva from patients with cancer in the laboratory may help doctors learn more about how inherited genetic mutations can affect cancer predisposition (an inherited increase in the risk of developing cancer), their impact on treatment response, and their role in cancer development.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Malignant Neoplasm
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Decoding and Selective Modulation of Human Memory During Awake/Sleep Cycles
NCT05452122
Recruiting
The proposed project seeks to elucidate memory processes and consolidation during sleep by leveraging the unique capability of direct recordings from the human brain at multiple levels of resolution-single neurons, localized neuronal assemblies, intracranial local field potentials-during rich behavioral tasks with real-life narratives and extracting neural features that relate to different aspects of episodic experience. The investigators will further probe causal mechanisms of consolidation by... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
10/03/2024
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Memory, Delayed
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Open Trial of Biofeedback for Respiratory Symptoms
NCT05973513
Recruiting
Biofeedback is a therapeutic paradigm that teaches patients how to gain awareness and control over previously unrecognized sympathetic changes such as body temperature, blood pressure, and heart rate. We propose to use a six session biofeedback protocol that includes heart-rate variability (HRV) biofeedback, respiration/relaxation training, and body temperature control to treat patients with unaddressed respiratory symptoms (e.g. shortness of breath) who are under the care of pulmonologists and... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
10/02/2024
Locations: Natacha Emerson, Los Angeles, California
Conditions: Shortness of Breath/Dyspnea
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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: California Research Institute, Los Angeles, California
Conditions: HER2-positive Advanced Solid Tumor
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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
NCT06129864
Recruiting
The main purpose of this study is to assess the efficacy and safety of volrustomig compared to observation in participants with unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have not progressed after receiving definitive concurrent chemoradiotherapy (cCRT).
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
10/02/2024
Locations: Research Site, Los Angeles, California
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma
Register for Updates
Study to Assess AFM24 in Combination with Atezolizumab in Selected Advanced/Metastatic EGFR-expressing Cancers
NCT05109442
Recruiting
AFM24-102 is a Phase 1/2a open-label, non-randomized, multicenter, dose escalation, and expansion study evaluating AFM24 in combination with atezolizumab in patients with selected EGRF-expressing advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: USC Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Advanced Solid Tumor
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ABC-CT Pre-School Feasibility Study
NCT06413316
Recruiting
This is a multicenter study that aims to determine whether the EEG and ET experiments studied in the ABC-CT Phase 1 and ABC-CT Confirmation studies can be successfully used with 3-5-year-old children and to determine the viability of these measures as potential biomarkers in 3-5-year-old children with ASD. Blood (DNA) samples will be collected from participants with ASD and biological parents for future genomic analyses, and raw, processed, and analyzed data will be shared to create a community... Read More
Gender:
ALL
Ages:
Between 3 years and 5 years
Trial Updated:
10/01/2024
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Autism Spectrum Disorder
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SMR Stemless Reverse Vs SMR Reverse Shoulder System
NCT04697004
Recruiting
The SMR Stemless Reverse is intended for total, primary shoulder joint replacement by reducing pain and restoring shoulder articular mobility function. This is a prospective, multi-center, randomized, controlled trial to demonstrate non-inferiority of the SMR Stemless Reverse to the SMR Reverse Shoulder System. Patients with joint dysfunction who continue to experience significant symptoms despite an appropriate course of non-operative management are eligible. Patients will be considered enroll... Read More
Gender:
ALL
Ages:
22 years and above
Trial Updated:
10/01/2024
Locations: Cedars-Sinai Kerlan-Jobe Institute, Los Angeles, California
Conditions: Arthroplasty, Replacement
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Molecular Genetics Studies of Cancer Patients and Their Relatives
NCT04185935
Recruiting
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
Gender:
ALL
Ages:
All
Trial Updated:
10/01/2024
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Malignant Neoplasm
Register for Updates
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma Cells
NCT06059690
Recruiting
The purpose of this project is to validate a new combined MRI and PET imaging technique as a biomarker or measure of glycolysis in brain tumors. To accomplish this, the investigators propose obtaining image-guided measures of tissue pH and biopsied tissue in tumor areas selected for bulk resection surgery. Investigators will then correlate the imaging measurements with pH, RNA expression, protein expression, and bioenergetics measurements of key glycolytic enzymes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: University of California at Los Angeles, Los Angeles, California
Conditions: Glioblastoma Multiforme, Glycolytic Index, Epidermal Growth Factor Receptor
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Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
NCT06090903
Recruiting
This clinical trial uses a type of imaging scan called magnetic resonance imaging (MRI) to study brain tumor biology in patients with glioblastoma that can be removed by surgery (resectable). Malignant gliomas are the second leading cause of cancer mortality in people under the age of 35 in the United States. Glioblastoma is a type of malignant glioma with very poor patient prognosis. There are currently only about 3 drugs approved by the Food and Drug Administration (FDA) for the treatment of g... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/27/2024
Locations: UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California
Conditions: Glioblastoma, Recurrent Glioblastoma, Resectable Glioblastoma
Register for Updates