There are currently 2033 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
A Phase 1/2 Study of BA3071 as Monotherapy and in Combination With a PD-1 Blocking Antibody in Patients With Advanced Solid Tumors
NCT05180799
Recruiting
The objective of this study is to assess safety and efficacy of BA3071 in solid tumors
Gender:
All
Ages:
18 years and above
Trial Updated:
12/08/2023
Locations: The Angeles Clinic and Research Institute, Los Angeles, California +1 locations
Conditions: Solid Tumor, Adult, NSCLC, Urothelial Carcinoma, Gastric Cancer, Small Cell Lung Cancer, Hepatocellular Carcinoma, Cervical Carcinoma, Melanoma, Renal Cell Carcinoma, Carcinoma
Register for Updates
First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer
NCT05156866
Recruiting
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-2-307-ADC in patients with advanced cancer
Gender:
All
Ages:
18 years and above
Trial Updated:
12/08/2023
Locations: UCLA - JCCC Clinical Research Unit, Los Angeles, California
Conditions: Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
Register for Updates
iMmune SignAtures and Clinical outComes in AP
NCT05878236
Recruiting
The MoSAIC study is a prospective, observational study designed to develop an early prediction tool for severe acute pancreatitis (SAP) and define a distinct immunologic profile compared to moderate acute pancreatitis (MAP). The aims are to validate a new multi-cytokine panel for early prediction of SAP and to identify the specific immune cells that correspond with cytokine signatures in early acute pancreatitis to characterize the immune pathways driving the development of SAP. Participants wil... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
12/07/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Acute Pancreatitis
Register for Updates
Stem Cell Therapy for Limbal Stem Cell Deficiency
NCT03957954
Recruiting
This phase I study will collect preliminary information on the activity and safety of cLSC. We will investigate the ability to manufacture and transplant cLSC onto the cornea successfully at the time of surgery (feasibility), and have cLSC begin to populate the ocular surface (efficacy) without serious adverse events (safety).
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: University of California, Los Angeles, California
Conditions: Limbal Stem-cell Deficiency
Register for Updates
Exercise for Brain Regeneration in Epilepsy
NCT05179083
Recruiting
Nearly 100 million Americans are affected by neurological disorders with an overall cost above $765 billion for the more prevalent conditions. Given this significant burden, effective treatments to prevent dementia and new disease modifying therapies are urgently needed. Regeneration of lost neurons with new ones (i.e., neurogenesis) is compromised at early stages of dementia and in part correlates with cognitive impairment in Alzheimer's disease. Boosting the neurogenesis delays the cognitive... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2023
Locations: University of Southern California Department of Neurosurgery, Los Angeles, California
Conditions: Temporal Lobe Epilepsy
Register for Updates
Prostate Resection After Microwave Ablation (PRAMA)
NCT06128525
Recruiting
This phase I trial tests the safety of magnetic resonance imaging (MRI)/ ultrasound (US) fusion guided transperineal targeted microwave ablation (TMA) before a radical prostatectomy (RP) and how well it works in treating patients with prostate cancer. Prostate cancer is the second most common cancer in men and most will never become aggressive. Despite this, most men choose to undergo treatment which may include surgery. Removing the prostate gland and sometimes the lymph nodes (radical prostate... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: USC / Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Prostate Carcinoma
Register for Updates
International CDKL5 Clinical Research Network
NCT05558371
Recruiting
Pathogenic variants in the Cyclin-dependent kinase like 5 (CDKL5) gene cause CDKL5 deficiency disorder (CDD, MIM 300672, 105830), a severe developmental and epileptic encephalopathy associated with cognitive and motor impairments and cortical visual impairment. While capability for disease modifying therapies is accelerating, there is a critical barrier for clinical trial readiness that may result in failure of these therapies, not due to lack of efficacy but due to lack of validated outcome mea... Read More
Gender:
All
Ages:
Between 1 month and 100 years
Trial Updated:
12/05/2023
Locations: University of California Los Angeles/UCLA Mattel Children's Hospital, Los Angeles, California
Conditions: CDKL5, CDKL5 Deficiency Disorder, CDD
Register for Updates
Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT03850574
Recruiting
A Phase 1/2, Open-label, Multicenter, Dose Escalation and Expansion Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Tuspetinib (HM43239) in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML)
Gender:
All
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: USC/Norris Comprehensive Cancer Center, Los Angeles, California
Conditions: Relapsed or Refractory Acute Myeloid Leukemia
Register for Updates
Brain Imaging Biomarkers for Response to Spinal Cord Stimulation in Patients With Chronic Low Back Pain
NCT04658628
Recruiting
In this protocol, "Brain imaging biomarkers for response to Spinal Cord Stimulation in patients with chronic low back pain," the investigators plan to perform brain mapping studies in 42 patients who are undergoing spinal cord stimulation (SCS) for chronic low back pain (CLBP) as part of the participants normal clinical care during a 2-year period. This imagining study is completed for research purposes. There is no standard of care imaging for the participants. This study requires two visits in... Read More
Gender:
All
Ages:
21 years and above
Trial Updated:
12/05/2023
Locations: University of California Los Angeles, Los Angeles, California
Conditions: Chronic Low-back Pain
Register for Updates
Contrast Enhanced Ultrasound Medical Imaging for Identifying Breast Masses
NCT06171607
Recruiting
This clinical trial investigates the role of contrast enhanced ultrasound (CEUS) in identifying cystic breast masses as benign or malignant. Ultrasound is a diagnostic imaging test that uses sound waves to make pictures of the body without using radiation (x-rays). Ultrasounds are widely used to diagnose many diseases in the body. This trial may help researchers learn if using CEUS will help in determining whether or not an ultrasound guided biopsy is necessary.
Gender:
Female
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California +1 locations
Conditions: Breast Carcinoma
Register for Updates
Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System
NCT04555161
Recruiting
This prospective study is a multi-center early feasibility study assessing the safety and performance of the Aria CV Pulmonary Hypertension System in patients with pulmonary hypertension and right heart dysfunction.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/04/2023
Locations: University of California-Los Angeles, Los Angeles, California
Conditions: Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
Register for Updates
Simplified IMmunosuppressive Protocol Utilizing Low Dose EnvarsusXR
NCT04773392
Recruiting
The purpose of this study is to determine if the combination of once-daily tacrolimus extended-release (EnvarsusXR) and Azathioprine is non inferior with respect to the composite outcome of acute rejection, graft and patient survival as compared to a combination of twice-daily immediate release tacrolimus and mycophenolate mofetil/mycophenolic acid.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
12/04/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Kidney Transplantation, Kidney Transplant Rejection
Register for Updates