There are currently 1888 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC / Norris Comprehensive Cancer Center, Childrens Hospitla Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Acceptance and Commitment Therapy (ACT) for Combating the Effects of Race-Related Stress Among Black Adolescents
NCT05685368
Recruiting
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical... Read More
Gender:
ALL
Ages:
Between 13 years and 21 years
Trial Updated:
11/03/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
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MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial
NCT06060873
Recruiting
This study evaluates the accuracy of blood-based biomarker testing to predict the presence of active testicular cancer.
Gender:
MALE
Ages:
16 years and above
Trial Updated:
11/02/2023
Locations: Los Angeles County-USC Medical Center, Los Angeles, California +1 locations
Conditions: Malignant Testicular Germ Cell Tumor
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VR to Reduce Pain/Anxiety During Painful Procedures
NCT04268901
Recruiting
This study aims to test the effectiveness of virtual reality (VR) as a non-pharmaceutical intervention to reduce pain and anxiety in children undergoing painful procedures in Phlebotomy, Radiology, Infusion, Orthopedics, Gastroenterology, and Immunology, amongst others, at CHLA, as measured by self- and proxy-report. Examples of the painful procedures include IV sticks, cast removals, allergy testing, and anorectal manometries.
Gender:
ALL
Ages:
Between 7 years and 21 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Phlebotomy, Orthopedics, Radiology, Pain, Anxiety, Virtual Reality, Allergy, Gastroenterology
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Caloric Restriction and Activity to Reduce Chemoresistance in B-ALL
NCT05082519
Recruiting
This study is for older children, adolescents, and young adults with B-cell Acute Lymphoblastic Leukemia (B-ALL). Higher amounts of body fat is associated with resistance to chemotherapy in patients with B-ALL. Chemotherapy during the first month causes large gains in body fat in most people, even those who start chemotherapy at a healthy weight. This study is being done to find out if caloric restriction achieved by a personalized nutritional menu and exercise plan during routine chemotherapy... Read More
Gender:
ALL
Ages:
Between 10 years and 25 years
Trial Updated:
10/25/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: B-cell Acute Lymphoblastic Leukemia, Obesity
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A Study of APG-2575 in Combination With Azacitidine in Patients With Acute Myeloid Leukemia (AML)
NCT04964518
Recruiting
This is a Phase Ib/II, open-label, multi-center study evaluating the safety, tolerability, efficacy and PK of APG-2575 in combination with Azacitidine in the patients with AML/MPAL or MDS/CMML. The study consists of dose escalation (Part I) and dose expansion phase (Part II)
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
10/23/2023
Locations: UCLA Medical cetner Division of Hematology, Los Angeles, California
Conditions: AML, Adult
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A Phase 1, Multi-Center, Open-Label, Dose-Escalation, Safety, Pharmacokinetic, and Pharmacodynamic Study of Minnelide™ Capsules Given Alone or in Combination With Protein-Bound Paclitaxel in Patients With Advanced Solid Tumors
NCT03129139
Recruiting
A Phase I, Multicenter, Open-label, Dose-Escalation, Safety, Pharmacokinetic and Pharmacodynamic Study of Minnelide™Capsules given daily for 21 days followed by 7 days off schedule in patients with Advanced Solid Tumors
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/17/2023
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Advanced Cancer, Gastric Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer Metastatic, Colo-rectal Cancer, Solid Tumor, Solid Carcinoma, Solid Carcinoma of Stomach, Cancer of Stomach
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CAN-Stim Compared to SNS in Treatment of Urinary Urgency Incontinence With Wireless Neuromodulation Technology
NCT02577302
Recruiting
This is a prospective, randomized, controlled, multi-center, study in which 150 evaluable subjects will be randomized 1:1 to receive either a Protect CAN-Stim or SNS InterStim® system. Subjects from both groups will immediately start with therapy. The primary endpoint is a ≥ 50% reduction in number of incontinence episodes associated with urgency at the 3-month visit, with additional measurements assessed at 14 days, 1, 6, 9 and 12-months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2023
Locations: Kaiser Permanente, Los Angeles, California
Conditions: Urinary Incontinence, Urge
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Transcutaneous Electrical Acupoint Stimulation (TEAS) for Chronic Constipation
NCT03243955
Recruiting
Transcutaneous electrical acupoint stimulation (TEAS) is an emerging technology for non-invasive neuromodulation that has broad potential implications and warrants further study. The investigators' clinical experience from the University of California, Los Angeles (UCLA) Center for East-West Medicine (CEWM) has also demonstrated that TEAS can be used as an effective self-care tool for patients with chronic illness who do not have the time or resources for frequent acupuncture treatments. Chronic... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Constipation - Functional
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DETERMINE: Detemir vs NPH
NCT05124457
Recruiting
The purpose of the study is to compare rates of neonatal hypoglycemia with maternal NPH vs determir use.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Gestational Diabetes, Diabetes Mellitus, Type 2
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A Phase I First in Human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of WGI-0301 in Patients With Advanced Solid Tumors
NCT05267899
Recruiting
The purpose of this study is to learn about the effects of a study medicine, WGI-0301 to find the best dose for treating solid tumors, and to see how safe and tolerable the study drug is for patients with solid tumors. The study is also done to learn how the study drug is taken up by your body; this is called Pharmacokinetic (PK) studies and how the study drug affects the body; this is called Pharmacodynamics (PD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/25/2023
Locations: Valkyrie Clinical Trials, Los Angeles, California
Conditions: Advanced Solid Tumors
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Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History
NCT05867381
Recruiting
This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Gender:
ALL
Ages:
Between 65 years and 84 years
Trial Updated:
09/22/2023
Locations: Keck School of Medicine, University of Southern California, Los Angeles, California
Conditions: Air Pollution, Atherosclerosis
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The Cedars-Sinai Smidt Heart Institute Takotsubo Registry & Proteomic Study
NCT03910569
Recruiting
The Cedars-Sinai SHI Takotsubo Registry and Proteomic Study is an observational registry that will collect retrospective and prospective demographic, clinical, hemodynamic, laboratory and other diagnostic parameters, therapy and outcome data from individuals who meet the inclusion/exclusion criteria of Takotsubo Registry protocol. Subjects will also be invited to provide a blood sample utilizing a Mitra kit sent to their homes. Researchers from the Barbra Streisand Women's Heart Center will anal... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/06/2023
Locations: Cedars Sinai Medical Center, Los Angeles, California
Conditions: Takotsubo Cardiomyopathy
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