There are currently 2058 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma
Recruiting
The purpose of this research study is to determine the effects bevacizumab (the study drug) combined with Optune (the study device) tumor treatment field therapy has on meningiomas. Bevacizumab is considered investigational because the US Food and Drug Administration (FDA) has not approved its use for the treatment of meningiomas. The study drug is a medication that blocks the growth of new blood vessels. It is thought that the study drug may interfere with the growth of new blood vessels and th... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/25/2022
Locations: USC Brain Tumor Center, Los Angeles, California
Conditions: Anaplastic (Malignant) Meningioma, Atypical Meningioma, Grade II Meningioma, Grade III Meningioma, Recurrent Meningioma, Supratentorial Meningioma
ColoCare Study - Colorectal Cancer Cohort
Recruiting
ColoCare is an international prospective cohort study of stage I-IV colorectal cancer patients (ICD-10 C18-C20).
Gender:
All
Ages:
Between 18 years and 89 years
Trial Updated:
05/22/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Colorectal Cancer
Long Term Safety and Efficacy of Pasireotide s.c. in Patients With Cushing's Disease
Recruiting
This is a non-interventional, multinational, multi-center post-marketing study, to further document the safety and efficacy of pasireotide s.c. administered in routine clinical practice in patients with Cushing's disease. Patients with Cushing's disease and treated with pasireotide s.c. alone and in combination with other therapies will be monitored. For this study, each enrolled patient will be followed up for 3 years after enrollment. Patients who permanently discontinue pasireotide s.c. prior... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/19/2022
Locations: University of Southern California CSOM230B2410 - SC, Los Angeles, California
Conditions: Cushings Disease
TEST-ON - Does iStim Reduce Urinary Urgency?
Recruiting
Overactive bladder (OAB) is a chronic disorder with an overall prevalence in the adult population of over 10%, but that may exceed 40% in elderly groups. Most overactive bladder treatments are aimed at decreasing urgency incontinence episodes. The purpose of this study is to determine whether an at-home transvaginal electrical stimulation (TES) program works to alleviate symptoms of urgency in patients with urinary urgency and frequency without incontinence. This is a cross-over trial. Women >18... Read More
Gender:
Female
Ages:
Between 18 years and 120 years
Trial Updated:
05/16/2022
Locations: UCLA Center for Women's Pelvic Health, Los Angeles, California
Conditions: Overactive Bladder, Urgency-frequency Syndrome, Urinary Frequency More Than Once at Night
MR Imaging and MR Spectroscopy of HIV
Recruiting
The Center for Disease Control and Prevention estimates that 1,148,200 Americans aged 13 years and older are living with HIV infection, including 207,600 (18.1%) who are unaware of their infection. According to pathological data, central nervous system (CNS) involvement is commonly found during the early phase of infection. In vivo proton magnetic resonance spectroscopy studies of HIV-infected humans have demonstrated significant changes of metabolites observed in the brain N-acetylaspartate, cr... Read More
Gender:
All
Ages:
Between 20 years and 65 years
Trial Updated:
05/16/2022
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: HIV Infections
Helping Families Pilot of a Family Resilience Program for Families Experiencing Homelessness
Recruiting
The goal of this study is to pilot an adapted family resilience program among families with a recent history of homelessness in Los Angeles County and to assess for feasibility and acceptability. The investigators have adapted a family resilience program called Families Overcoming Under Stress (FOCUS), a trauma-informed intervention designed for families experiencing trauma, parental substance use, and homelessness. Our primary hypothesis is that the adapted family resilience program will be fea... Read More
Gender:
All
Ages:
8 years and above
Trial Updated:
05/16/2022
Locations: UCLA, Los Angeles, California
Conditions: Family Relationship, Coping Skills
CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry
Recruiting
This multinational, investigator-initiated, retrospective study aims to investigate outcomes of patients, who underwent transcatheter mitral valve implantation (TMVI), in comparison to those screened for TMVI but deemed ineligible, who subsequently underwent interventional mitral valve edge-to-edge repair, mitral valve surgery or medical/conservative therapy.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/16/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, Los Angeles, California
Conditions: Mitral Regurgitation
Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry
Recruiting
Objective: Posttraumatic stress disorder (PTSD) is a prevalent neuropsychiatric disorder in children and is associated with increased neurovascular inflammation, suicidality, adulthood mental health disorder, and major adverse events. Reminder focused positive psychiatry (RFPP) has been shown as well tolerated feasible trauma focused intervention that is associated with improved core PTSD symptoms, decreased severity of reactivity to PTSD trauma reminders, and increased vascular function. This s... Read More
Gender:
All
Ages:
Between 11 years and 15 years
Trial Updated:
05/16/2022
Locations: UCLA, Los Angeles, California
Conditions: Posttraumatic Stress Disorder
Perceptions of LARC Among AYA With Chronic Illness
Recruiting
The investigators aim to perform a qualitative study exploring attitudes and perceived barriers to Long Acting Reversible Contraception (LARC), both implants and IUDs, among adolescent and young adults (AYA) with chronic illness at CHLA. While the literature examining barriers to LARC uptake is growing, its focus has been on older women and women who are not living with chronic illness. There remains a significant gap in the understanding of: What adolescents and young adults from ethnically di... Read More
Gender:
Female
Ages:
Between 16 years and 21 years
Trial Updated:
05/02/2022
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Chronic Conditions, Multiple
International REgistry of COnservative or Radical Treatment of Localized Kidney Tumors
Recruiting
Partial nephrectomy (PN) is the standard treatment for localized renal masses and should be preferred in clinical T1 (<7 cm tumor diameter) renal tumors over radical nephrectomy (RN) whenever technically feasible. Nonetheless, indications, approaches, techniques for PN, and correct reporting of outcomes, are still a matter of great debate within the urology community. Concurrently, case-report series suggested that alternative strategies for the treatment of localized renal tumors (ablation tech... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/02/2022
Locations: Institute of Urology, University of Southern California., Los Angeles, California
Conditions: Kidney Cancer
Study of TBX-3400 in Patients With Stage III and IV Melanoma Resistant or Refractory to Immune Checkpoint Inhibitors
Recruiting
This is a study of transfusion of TBX-3400 in patients with stage III and IV melanoma resistant or refractory to Immune Checkpoint Inhibitors. The patient's own blood cells are exposed to a protein that has been shown in the laboratory to result in anti-tumor activity. The study hypothesis is that TBX-3400 cells will enhance anti-tumor activity and improve the body's immune response.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2022
Locations: The Angeles Clinic and Research Institute, Los Angeles, California
Conditions: Stage III Melanoma, Stage IV Melanoma
The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
Recruiting
Sudden cardiac death (SCD) remains a major cause of mortality within developed nations despite aggressive efforts to reduce its societal burden. Despite extensive clinical and genetic investigations, a subgroup of cardiac arrests remain unexplained, highlighting the potential contribution of additional cardiac conditions that may not be identified with contemporary diagnostic algorithms. The EPS ARREST study aims to evaluate the role of invasive electrophysiology study within this patient popula... Read More
Gender:
All
Ages:
All
Trial Updated:
04/29/2022
Locations: UCLA Medical Center, Los Angeles, California
Conditions: Sudden Cardiac Death