There are currently 2047 clinical trials in Los Angeles, California looking for participants to engage in research studies. Trials are conducted at various facilities, including Cedars-Sinai Medical Center, USC Norris Comprehensive Cancer Center, Children's Hospital Los Angeles and University of California Los Angeles. Whether you're a healthy volunteer looking to participate in paid medical research or seeking trials related to a specific condition, the city provides a diverse range of opportunities near you.
MeSenteric SpAring Versus High Ligation Ileocolic Resection for the Prevention of REcurrent Crohn's DiseaSe (SPARES)
NCT04578392
Recruiting
Study description - Patients will be randomized according to post-operative recurrence risk to either a high ligation of ileocolic artery or mesenteric sparing ileocolic resection for terminal ileal Crohn's disease. The primary endpoint 6-month endoscopic recurrence. Endpoints - Primary endpoint; 6 months Secondary endpoints at 1 and 5 years post ileocecal resection Study population - Adult Crohn's disease patients with medically refractory terminal ileal Crohn's disease undergoing a primary i... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/01/2022
Locations: Cedars-Sinai Hospital System, Los Angeles, California
Conditions: Crohn Disease
Register for Updates
Digitally-Captured Step Counts for Evaluating Performance Status in Advanced Cancer Patients
NCT03757182
Recruiting
The purpose of this study is to examine the relationships between objectively measured physical activity and provider-assessed and patient-reported functional outcomes in patients with advanced cancer. Findings from this study will help us better understand how change in daily physical activity, as measured using the wearable activity monitor, is related to change in a patient's functional status and clinical condition.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/30/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cancer, Cancer, Metastatic, Neoplasms
Register for Updates
Capsule Endoscopy for Severe Hematochezia
NCT03616041
Recruiting
Patients with severe hematochezia (bright red blood per rectum) may have a bleeding source proximal to the colon. Visualization of the entire gastrointestinal tract using a second-generation colon capsule endoscopy system could improve diagnostic yields and form the basis for a new approach to early diagnosis that could change guidelines and practice management in these patients. The hypothesis of this study is that urgent colon capsule endoscopy will have higher rates of lesion localization and... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/21/2022
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California +1 locations
Conditions: Hematochezia
Register for Updates
Standard Endoscopic Hemostasis Versus OVESCO Severe Non-variceal UGI Hemorrhage
NCT03065465
Recruiting
The primary specific aim is to perform a randomized controlled trial (RCT) to compare 30 day rebleed rates and other clinical outcomes of patients with severe, non-variceal upper GI hemorrhage (NVUGIH) - ulcers and Dieulafoy's lesions who are randomized as initial treatment with the new large over-the-scope-clip device for endoscopic hemostasis versus standard endoscopic hemostasis.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
03/21/2022
Locations: VA Greater Los Angeles Healthcare System, Los Angeles, California +1 locations
Conditions: Upper Gastrointestinal Hemorrhage
Register for Updates
Non Exudative AMD Imaged With SS-OCT- Extension
NCT04469140
Recruiting
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: University of California Los Angeles Doheny Eye Institute, Los Angeles, California
Conditions: Dry Macular Degeneration
Register for Updates
Calibration of MR and PET-MR Imaging Protocols at RIC
NCT02249520
Recruiting
This is a protocol to facilitate on-site calibration of the technical aspects of the Siemens Biograph mMR (molecular MR) Positron Emission Tomography-Magnetic Resonance (PET-MR) scanner and the 3T Siemens Vida MR scanner at the Cedars-Sinai Medical Center (CSMC) Biomedical Imaging Research Institute (BIRI) Research Imaging Core after scanner installation. The mMR is a FDA-approved standard clinical device (non-experimental) and will be used in accordance with clearance and approval from the FDA.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/07/2022
Locations: Cedars-Sinai Medical Center, Los Angeles, California
Conditions: Cancer, Coronary Artery Disease
Register for Updates
Validation of Ejection Fraction and Cardiac Output Using Biostrap Wristband
NCT05279066
Recruiting
In this study, the investigators will compare the accuracy of the Biostrap wristband, a wearable device with a clinical-grade Photoplethysmography (PPG) sensor, to measure ejection fraction and cardiac output in patients undergoing a cardiac ultrasound and pulmonary arterial catheterization, respectively.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/03/2022
Locations: Ronald Reagan UCLA Medical Center, Los Angeles, California
Conditions: Heart Failure
Register for Updates
NOVOCART®3D for Treatment of Articular Cartilage of the Knee
NCT01957722
Recruiting
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/01/2022
Locations: UCLA, Los Angeles, California
Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
Register for Updates
External Pharyngeal Exerciser for Dysphagia
NCT05267314
Recruiting
Pharyngeal muscle weakness and dysphagia is common in individuals post-stroke or with Parkinson's disease and in individuals with head/neck cancer who have undergone surgery and/or radiation therapy. Therapeutic options for these patients are limited. This pilot study is intended to assess the feasibility, safety, and efficacy of the External Pharyngeal Exerciser (EPE) on patients with pharyngeal dysphagia receiving swallow therapy. Feasibility will be assessed by patient acceptance and practice... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2022
Locations: Anisa Shaker, Los Angeles, California
Conditions: Pharyngeal Dysphagia, Dysphagia, Oral Pharyngeal Dysphagia
Register for Updates
Innovative Liver Elasticity, Attenuation, and Dispersion Ultrasound Study
NCT04012242
Recruiting
The objective of this study is: (1) to investigate the correlation of ultrasound parameters (SW speed, Dispersion slope, Attenuation value, Normalized Local Variance, Liver / Kidney Intensity Ratio) with the pathological parameters (fibrosis, intralobular inflammation, ballooning degeneration and steatosis); (2) to evaluate the diagnostic performance of SW speed for liver fibrosis, Dispersion slope for intralobular inflammation and Attenuation value for steatosis by comparison with the tissue di... Read More
Gender:
All
Ages:
20 years and above
Trial Updated:
02/06/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Nonalcoholic Steatohepatitis, Ultrasound, Elastography
Register for Updates
Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment
NCT05171972
Recruiting
In this study the investigators wish to test the hypothesis that the repertoire of solutes secreted by leukocytes isolated from patients with relapsing-remitting forms of Multiple Sclerosis (MS) following 6 months of treatment with Ofatumumab (Kesimpta®) will be less toxic to mouse-derived oligodendrocyte lineage cells, grown in a dish, than solutes secreted by the same leukocyte populations prior to treatment with Ofatumumab.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/03/2022
Locations: University of Southern California, Los Angeles, California
Conditions: Relapsing Remitting Multiple Sclerosis
Register for Updates
Study of TBX-3400 in Subjects With Solid Malignant Tumors Resistant or Refractory to Standard Therapies
NCT04640246
Recruiting
This is a study of treatment with TBX-3400 in subjects with solid malignant tumors that are resistant or refractory to standard therapies. The subject's own blood cells are exposed to a protein that has been shown in the laboratory to result in anti-tumor activity. The study hypothesis is that TBX-3400 cells will enhance anti-tumor activity and improve the body's immune response to the tumor.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/01/2022
Locations: The Angeles Clinic and Research Institute, Los Angeles, California
Conditions: Cancer, Tumor, Solid, Refractory Cancer
Register for Updates