There are currently 8 active clinical trials seeking participants for ARDS research studies. The states with the highest number of trials for Autism participants are Ontario, California, Texas and Jiangsu.
Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
Recruiting
To evaluate the safety and efficacy of intravenous (IV) administration of bone marrow mesenchymal stem cell derived extracellular vesicles (EVs), ExoFlo, versus placebo for the treatment of hospitalized patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
02/09/2024
Locations: Direct Biologics Investigational Site, Chandler, Arizona +30 locations
Conditions: Acute Respiratory Distress Syndrome, ARDS
MICU Recovery Clinic
Recruiting
Summary: Emerging data demonstrate long-term morbidity and mortality in those who survive critical illness. However, there is no data regarding long-term follow-up for ICU survivors. The investigators have begun the implementation of an ICU recovery clinic. Rationale: ICU survivors are at high risk for functional, cognitive and psychiatric impairments. However, methods to mitigate these impairments and improve recovery are lacking. Special follow-up clinics for survivors of critical illness ha... Read More
Gender:
All
Ages:
All
Trial Updated:
10/31/2023
Locations: Wake Forest Baptist Medical Center, Winston-Salem, North Carolina
Conditions: Critical Illness, Sepsis, Respiratory Failure, ARDS
Clinical Decision Support Tool in PARDS Pilot Study
Recruiting
Previous clinical trials in adults with acute respiratory distress syndrome (ARDS) have demonstrated that ventilator management choices can improve Intensive Care Unit (ICU) mortality and shorten time on mechanical ventilation. This study seeks to scale an established Clinical Decision Support (CDS) tool to facilitate dissemination and implementation of evidence-based research in mechanical ventilation of infants and children with pediatric ARDS (PARDS). This will be accomplished by using CDS t... Read More
Gender:
All
Ages:
Between 1 month and 18 years
Trial Updated:
10/30/2023
Locations: Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois +7 locations
Conditions: Ventilation Therapy; Complications, Ventilator-Induced Lung Injury, Ards
Generating Evidence in ECMO Ventilation Strategies
Recruiting
The goal of this pilot clinical trial is to test if ICU level ventilator protocols are appropriate interventions to study differences in ventilator strategies for patients with acute respiratory failure supported by VV-ECMO. The main questions it aims to answer are: will clinicians closely follow different ICU ventilator protocols will different ICU ventilator protocols change the way that patients are treated. Participants will be assigned to one of two ventilator protocols based on the month... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/11/2023
Locations: Duke University Medical Center, Durham, North Carolina
Conditions: ARDS, Acute Respiratory Failure
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With COVID-19
Recruiting
COVID-19 patients who develop severe disease often develop acute respiratory distress syndrome (ARDS) as a result of a dysregulated immune response. This in turn stimulates a pro-inflammatory cascade ("cytokine storm") as well as emergency myelopoiesis. This proinflammatory cascade is activated when viral-mediated cell damage occurs in the lungs, resulting in the release of damage-signaling alarmin molecules such as S100A8/A9 (Calprotectin), HMGB1, Resistin, and oxidized phospholipids. These da... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/28/2023
Locations: UCSF Fresno, Fresno, California +19 locations
Conditions: COVID-19, ARDS
Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)
Recruiting
This is a multicenter randomized controlled clinical trial with an adaptive design assessing the efficacy of setting the ventilator based on measurements of respiratory mechanics (recruitability and effort) to reduce Day 60 mortality in patients with acute respiratory distress syndrome (ARDS). The CAVIARDS study is also a basket trial; a basket trial design examines a single intervention in multiple disease populations. CAVIARDS consists of an identical 2-arm mechanical ventilation protocol imp... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/27/2022
Locations: New York University Grossman School of Medicine, New York, New York +30 locations
Conditions: ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
Recruiting
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of patient with COVID-19. Primary aims include the development of ARDS, refractory hypoxemia, acute cardiac injury, pulmonary embolism, pneumothorax or death. Secondary aims include potential change in CT and plain film utilization given the use of POCUS, as well as emerge... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/22/2022
Locations: UCLA-Ronald Reagan, Los Angeles, California +3 locations
Conditions: Lung Injury, ARDS, Acute Cardiac Event, Covid19, Ultrasound, Hypoxemia, Acute Respiratory Distress Syndrome
Critical Care Results of SARS-CoV-2 ARDS by Dapsone and Standard COVID-19 Treatment
Recruiting
Abstract Background: Clinicians in pulmonary critical care medicine and critical care medicine considered dapsone administration to treat SARS-CoV-2 inflammasome. Dapsone is useful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3). Objective: To study the targeting of NLRP3 itself or up-/downstream factors of the NLRP3 inflammasome by dapsone must be responsible for its observed preventive effects, functioning as a competitor. Methods: Patients who were... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
06/07/2021
Locations: Hunt Regional Medical Center, Greenville, Texas
Conditions: SARS-CoV-2, Hypoxia, ARDS