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Congenital Heart Disease Clinical Trials
A listing of 32 Congenital Heart Disease clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
1 - 12 of 32
There are currently 32 active clinical trials seeking participants for Congenital Heart Disease research studies. The states with the highest number of trials for Congenital Heart Disease participants are California, Ohio, Massachusetts and New York.
Featured Trial
Paid Clinical Studies Nationwide
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Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
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Conditions:
Overweight
Overweight and Obesity
Obesity
Weight Loss
Morbid Obesity
Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
Recruiting
Background:
In Fontan Associated Liver Disease (FALD), congestion of blood in the liver causes cirrhosis. This condition can cause death. Researchers want to understand what triggers this process and find new treatments for it.
Objective:
To understand how long-term congestion of blood in the liver causes liver scarring that eventually leads to cirrhosis.
Eligibility:
People aged 18 and older who are at risk of developing FALD from the Fontan procedure.
Design:
Participants will be screen... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
07/31/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Congenital Heart Disease
Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis
Recruiting
Newborns with congenital heart disease (CHD) are at increased risk of developing postpartum and postoperative blood clots after cardiac surgery. The molecular mechanisms that are responsible for the clotting profile predisposing children to blood clots in the early stages of life are currently not well described.
The goal of this proposal is to prospectively collect plasma samples from ten (10) neonates with antenatal diagnosis of severe congenital heart disease (CHD) to better understand mecha... Read More
Gender:
ALL
Ages:
Between 1 day and 7 days
Trial Updated:
07/14/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Congenital Heart Disease, Single-ventricle, Thrombosis
Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease
Recruiting
The goal of this clinical trial is to test the safety of lab-grown heart cells made from stem cells in subjects with congenital heart disease. The main questions it aims to answer are:
* Is this product safe to deliver to humans
* Is the conduct of this trial feasible
Participants will be asked to:
* Agree to testing and monitoring before and after product administration
* Receive investigational product
* Agree to lifelong follow-up Researchers will compare subjects from the same pool to see... Read More
Gender:
ALL
Ages:
Between 18 years and 40 years
Trial Updated:
06/23/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Univentricular Heart, Congenital Heart Disease, Heart Failure NYHA Class III, Heart Failure NYHA Class IV
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development
Recruiting
The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to contract with when the heart beats. Investigators will also study the proteins and RNA of these pieces to determine how the newborn heart cells control their force of contraction differently from adult heart cells. Investigat... Read More
Gender:
ALL
Ages:
20 years and below
Trial Updated:
06/11/2025
Locations: Emory University School of Medicine, Atlanta, Georgia
Conditions: Congenital Heart Disease, Tetralogy of Fallot
Fontan Fitness Trial
Recruiting
The goal of this randomized control trial is to learn about physical fitness and exercise habits in children aged 10-17 with the Fontan Circulation through a home-based, digital exercise intervention. The main questions it aims to answer are:
* Does a home-based, digital intervention increase physical activity (PA) in youth with the FC compared to enhanced usual care?
* Does a home-based, digital intervention increase physical fitness in youth with the FC compared to enhanced usual care?
* Do m... Read More
Gender:
ALL
Ages:
Between 10 years and 17 years
Trial Updated:
06/06/2025
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Single-ventricle, Congenital Heart Disease
PDA for Kidneys Study
Recruiting
The goal of this observational study is to gather more information on kidney oxygen levels in babies with a patent ductus arteriosus (PDA), and evaluate the relationships between kidney oxygen levels, PDA status and kidney injury.
Researchers will do this by looking at ultrasound images of the heart, analyzing substances in the urine, and evaluating oxygen levels in the kidneys.
Gender:
ALL
Ages:
Between 1 minute and 7 days
Trial Updated:
05/16/2025
Locations: Meriter Hospital, Inc., Madison, Wisconsin
Conditions: Patent Ductus Arteriosus, Congenital Heart Disease
RAPID: a Comparison Study of a Novel Ultrasound Device of Automated Congenital Heart Imaging
Recruiting
The RAPID ultrasound is a portable imaging device that captures a one point image from the subcostal region of the heart. The device is set on the patient's chest and captures the image in \<1 minute. It uses ultrasound imaging energy that is similar to commercialized devices and safe for patients of all ages and sizes. The device is a non-significant risk and therefore will not require an IDE. Images from RAPID will be taken directly before or after the standard clinical PCU. Images taken fr... Read More
Gender:
ALL
Ages:
1 year and below
Trial Updated:
05/07/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Congenital Heart Disease
Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry
Recruiting
This real-world, international registry aims to evaluate the current experience with sodium-glucose cotransporter 2 inhibitors (SGLT2i) in adult congenital heart disease (ACHD) patients by investigating the prescription patterns, safety, tolerability, and potential beneficial effects on heart failure-related outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/22/2025
Locations: Johns Hopkins University, Baltimore, Maryland +9 locations
Conditions: Adult Congenital Heart Disease, Congenital Heart Disease, Systemic Right Ventricle, Transposition of the Great Arteries, Congenitally Corrected Transposition of the Great Arteries, Fontan, Single Ventricle, Tetralogy of Fallot (TOF)
Improving Congenital Heart Disease Care
Recruiting
The theory-informed digital health intervention, called as "Empower My Congenital Health (EmpowerMyCH)" aims to activate and engage ACHD patients in building confidence toward navigating the adult healthcare system. This tool is built after incorporating the theories of behavior change, gathering inputs from target patients in all stages of its design and implementation. The key features of the tool include a digital medical passport, updated congenital information, community support, and patien... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: University of California, San Francisco, San Francisco, California
Conditions: Congenital Heart Disease, Behavior, Health, Quality of Life, Empowerment, Patient, Activation, Patient
Effect of Fetal Aortic Valvuloplasty on Outcomes
Recruiting
In one of the most severe congenital heart defects, hypoplastic left heart syndrome (HLHS), the left ventricle is underdeveloped and the prognosis is worse than in most other heart defects. The underdevelopment can occur gradually during fetal growth caused by a narrowing of the aortic valve. At some international centers, such fetuses are treated with a balloon dilation of the narrowed valve, but there is no scientifically sound evidence that this treatment is effective.
The aim of this study... Read More
Gender:
ALL
Ages:
Between 23 weeks and 31 weeks
Trial Updated:
03/18/2025
Locations: Fetal Cardiovascular Program, University of California San Francisco, San Francisco, California +12 locations
Conditions: Congenital Heart Disease, Aortic Valve Stenosis, Fetal Cardiac Disorder, Hypoplastic Left Heart Syndrome
Genetics of Congenital Heart Disease
Recruiting
Congenital heart disease (CHD) is the most common type of birth defect but the cause for the majority of cardiac birth defects remains unknown. Numerous epidemiologic studies have demonstrated evidence that genetic factors likely play a contributory, if not causative, role in CHD. While numerous genes have been identified by us and other investigators using traditional genetic approaches, these genes account for a minority of the non-syndromic CHDs. Therefore, we are now utilizing whole genome s... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/10/2025
Locations: Nationwide Children's Hospital, Columbus, Ohio
Conditions: Congenital Heart Disease
A Study of Hemodynamic Cardiopulmonary Exercise for CHD
Recruiting
The purpose of this study is to compare the difference in the ability to detect hemodynamic abnormalities between invasive hemodynamic assessments performed at rest versus exercise, to assess the correlation between invasive and noninvasive (Doppler-derived) rest-exercise hemodynamic indices and to compare the association between indices of disease severity and hemodynamic abnormalities identified at rest versus exercise.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Congenital Heart Disease
1 - 12 of 32