There are currently 18 active clinical trials seeking participants for Congestive Heart Failure research studies. The states with the highest number of trials for Autism participants are California, Ohio, New York and Texas.
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction
Recruiting
It is believed that targeted SERCA2a enzyme replacement in HFrEF patients will correct defective intracellular Ca2+ hemostasis, resulting in improved cardiac contractile function and energetics which will, in turn, translate to improved clinical outcomes. Additionally, it is hypothesized that correcting SERCA2a dysfunction will also improve coronary blood flow through correction of the impaired endothelium-dependent nitric oxide-mediated vasodilatation observed in heart failure.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
03/24/2024
Locations: San Diego Cardiac Center, San Diego, California +4 locations
Conditions: Congestive Heart Failure, Heart Failure, Systolic, Heart Failure, HFrEF - Heart Failure With Reduced Ejection Fraction
Social Risk Score, Clinical Decision Support Tool and Closed Loop Referral for Social Risk Screen and Referral
Recruiting
The overarching goal of this project is to leverage health information technology (HIT) to integrate available digital information on social needs to improve care for racial and ethnic minorities and socially disadvantaged populations with chronic diseases. In the previous phases of this project the investigators developed a social risk score to identify social needs among medically under-served patients with special emphasis on application among African American patients with low income and ch... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/19/2024
Locations: Johns Hopkins GreenSpring Station, Baltimore, Maryland +4 locations
Conditions: Chronic Disease, Diabetes Mellitus, Hypertension, Congestive Heart Failure
SyncAV Post-Market Trial
Recruiting
The SyncAV Post-Market Trial is a prospective, randomized, multi-center trial performed to determine if cardiac resynchronization therapy (CRT) devices programmed with SyncAV ON improve long-term CRT response compared to devices programmed with conventional CRT through evaluation of changes in left ventricular (LV) reverse remodeling.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2024
Locations: Heart Center Research, LLC., Huntsville, Alabama +118 locations
Conditions: Congestive Heart Failure
SVC Occlusion in Subjects With Acute Decompensated Heart Failure
Recruiting
Safety and performance evaluation of the preCARDIA System for patients with ADHF.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
02/05/2024
Locations: Colorado Heart & Vascular, Lakewood, Colorado +16 locations
Conditions: Acute Decompensated Heart Failure, Acute Heart Failure, Congestive Heart Failure, Heart Diseases
Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF
Recruiting
Sensorum Health (Sensorum) is conducting a pilot study to determine if Sensorum's proprietary passive sensor network can be used to identify signals of early health decompensation in subjects prior to a hospitalization for chronic disease exacerbation or other ambulatory care sensitive conditions. Successful early detection would provide a window of opportunity to intervene outside of the acute setting in future interventional studies.
Gender:
All
Ages:
55 years and above
Trial Updated:
01/12/2024
Locations: Weill Cornell Medicine, New York, New York
Conditions: CHF, Congestive Heart Failure
Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects With Non-Ischemic NYHA Class III Heart Failure
Recruiting
This is a Phase 2 adaptive, double-blinded, placebo-controlled, randomized, multi-center trial study to evaluate the safety and efficacy of a single dose of AB-1002, administered via antegrade intracoronary artery infusion, in males and females age >18 years with non-ischemic cardiomyopathy and NYHA Class III symptoms of HF. Subjects will be randomized into one of three treatment groups in a 1:1:1
Gender:
All
Ages:
18 years and above
Trial Updated:
01/09/2024
Locations: Minneapolis Heart Institute, Minneapolis, Minnesota +2 locations
Conditions: Congestive Heart Failure
Baroreflex Activation Therapy in Left Ventricular Assist Device Patients Study
Recruiting
This study will involve LVAD patients who have already received a clinically-indicated BAT (BAROSTIM) device. After recovery from LVAD implant, we will investigate the effects of BAT in a double-blind cross-over study design.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/05/2024
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Congestive Heart Failure
Circulating Markers for Ischemic Heart Disease
Recruiting
The purpose of this research is to determine if two proteins in the blood are increased during acute myocardial infarction and whether their levels are higher in those who develop heart failure than those who do not. These two proteins are produced and potentially released when the heart muscle is damaged. They may then be released into the blood and be detected by standard method in the research laboratory. At this time, detection of an increase in these proteins in the blood is not known to be... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
12/02/2023
Locations: University of Connecticut Health Center, Farmington, Connecticut
Conditions: Myocardial Infarction, Ischemia, Congestive Heart Failure
Stress and Congestive Heart Failure
Recruiting
The purpose of this study is to investigate whether acute stress can precipitate congestive heart failure (CHF) exacerbation in patients with CHF.
Gender:
All
Ages:
18 years and above
Trial Updated:
10/12/2023
Locations: St. Francis Hospital, Hartford, Connecticut +1 locations
Conditions: Congestive Heart Failure
Leveraging Home Health Aides to Improve Outcomes in Heart Failure
Recruiting
The purpose of the study is to determine the effectiveness of an intervention among home health aides caring for adults admitted to home care with a primary diagnosis of heart failure at VNS Health Partners in Care (home care agency). The study will examine the interventions' effect on home health aides' heart failure knowledge and confidence caring for adults with heart failure, as well as on the client's overall health (visits to the emergency department and hospital readmissions).
Gender:
All
Ages:
18 years and above
Trial Updated:
10/06/2023
Locations: VNS Health Partners in Care, New York, New York
Conditions: Heart Failure, Congestive Heart Failure
Advance Care Planning in the Emergency Department
Recruiting
This is a two-armed, parallel-design, pre-/post-intervention assessment study. The investigators will conduct a randomized controlled trial for ED GOAL on a cohort of 120 older adults with serious illness to collect patient-centered outcomes and determine preliminary efficacy on increasing advance care planning engagement (self-reported and/or in the electronic medical record) one month after leaving the emergency department. The investigators will also conduct qualitative interviews with partic... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
06/20/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Congestive Heart Failure, Metastatic Cancer, Chronic Kidney Disease Requiring Chronic Dialysis, Chronic Obstructive Pulmonary Disease
Evaluation of Home-based Sensor System to Detect Health Decompensation in Elderly Patients With History of CHF or COPD
Recruiting
Sensorum Health (Sensorum) is conducting a pilot study to determine if Sensorum's proprietary passive sensor network can be used to identify signals of early health decompensation in subjects prior to a hospitalization for chronic disease exacerbation or other ambulatory care sensitive conditions. Successful early detection would provide a window of opportunity to intervene outside of the acute setting in future interventional studies.
Gender:
All
Ages:
65 years and above
Trial Updated:
05/09/2023
Locations: Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, New Jersey
Conditions: COPD, Chronic Obstructive Pulmonary Disease, COPD Exacerbation, CHF, Congestive Heart Failure