There are currently 47 active clinical trials seeking participants for Diabetic Foot Ulcer research studies. The states with the highest number of trials for Diabetic Foot Ulcer participants are California, Florida, Texas and Pennsylvania.
Trial Assessing the Efficacy of Human Placental Membrane Products and Standard of Care Versus Standard of Care Alone in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers
Recruiting
The purpose of this study is to evaluate the efficacy of human placental membrane products and standard of care versus standard of care alone in the management of nonhealing diabetic foot ulcers and venous leg ulcers.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Center for Foot and Ankle Disorders, Philidelphia, Pennsylvania
Conditions: Diabetic Foot, DFU, Diabetic Foot Ulcer, Foot Ulcer, Diabetic, Ulcer Foot, Venous Leg Ulcer, Leg Ulcer, Leg Ulcers Venous, Ulcer
Randomized Evaluation of Nonhealing Diabetic Foot Ulcers With Exclusive Wound Therapy
Recruiting
The goal of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of nonhealing diabetic foot ulcers with multiple CAMPs plus SOC versus matched controls over 12 weeks using a modified platform trial design.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/24/2025
Locations: Serena Group- Monroeville, Monroeville, Pennsylvania
Conditions: Diabetic Foot Ulcer, DFU, Diabetic Foot Ulcer (DFU), Foot Ulcer Due to Type 1 Diabetes Mellitus, Foot Ulcer Due to Type 2 Diabetes Mellitus, Ulcer, Ulcer Foot
Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)
Recruiting
A Phase 2a Multi-Center, Prospective, Randomized, Controlled Study to Evaluate the Safety and Efficacy of Topically Applied PEP-TISSEEL in Subjects with Diabetic Foot Ulcers (DFU)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Professional Education & Research Institute (PERI), Blue Ash, Ohio
Conditions: Diabetic Foot Ulcer
Non-healing Diabetic Foot Ulcers Treated With Standard Care With or Without BR-AM
Recruiting
This trial is a multicenter, randomized, controlled study designed to evaluate the safety and efficacy of BioREtain® Amniotic Membrane (BR-AM) plus standard of care versus standard of care only in the treatment of diabetic foot ulcers. The trial design will control potential variables that may affect the outcome between the treatment group and the control group by standardizing the requirements for debridement, wound dressings, and offloading. Weekly subject visits will help monitor compliance i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/21/2025
Locations: Site 17, Guntersville, Alabama +16 locations
Conditions: Non-infected Diabetic Foot Ulcer, Diabetic Foot, Diabetic Wound, Diabetic Foot Ulcer, Non-ischemic Diabetic Foot Ulcer
Clinical Study Evaluating Symphony™ Versus Standard of Care in the Treatment of Non-Healing Diabetic Foot Ulcers
Recruiting
The study will evaluate the safety and performance of Symphony™ versus Standard of Care (SOC) in the treatment of chronic non-healing diabetic foot ulcers (DFU) after 12 weeks of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/01/2025
Locations: LA Foot and Ankle, Los Angeles, California +10 locations
Conditions: Diabetic Foot, Diabetic Foot Ulcer, Foot Ulcer, Chronic Foot Ulcer
A Modified Platform Trial of Multiple CAMPs for the Management of Diabetic Foot Ulcers and Venous Leg Ulcers
Recruiting
The purpose of this study is to determine how well multiple CAMPs (Cellular, Acellular and Matrix-Like Products) and Standard of Care work when compared to Standard of Care alone in achieving complete closure of hard-to-heal diabetic foot and venous leg ulcers.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/24/2025
Locations: Phase One Clinical Trials, Inc., Bakersfield, California +7 locations
Conditions: Diabetic Foot Ulcer, Venous Leg Ulcer
Evaluating a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers
Recruiting
People with diabetes often experience foot ulcers, which can harm their ability to move, lower their quality of life, and increase the chances of losing a limb. These diabetic foot ulcers (DFUs) commonly come back (recur) even after they've healed, so it's crucial to stop them from returning to avoid toe, foot , or leg amputation. While wearing special shoes to reduce pressure on the feet is essential for healing and preventing DFUs, many people struggle to follow this treatment plan once their... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
06/20/2025
Locations: Rancho Los Amigos National Rehabilitation Center, Downey, California +2 locations
Conditions: Diabetic Foot, Diabetic Foot Ulcer, Foot Ulcer, Diabetic, Foot Wound
Nonhealing Diabetic Foot Ulcers Treated With Standard of Care (SOC) Alone or Standard of Care and Amnion-Intermediate-Chorion (AIC)
Recruiting
The purpose of this study is to determine how well our dHPT (Dehydrated Human Placental Tissue) Product and Standard of Care work when compared to Standard of Care alone in achieving complete closure of diabetic foot.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/18/2025
Locations: 004, Mission Viejo, California +3 locations
Conditions: Diabetic Foot Ulcer
Evaluate Use of Tropocells(R) Autologous Platelet-rich Fibrin (PRF) for Wagner Grade 1 and Grade 2, Mild to Mod Neuroischemic Plantar Diabetic Foot Ulcer Wound Care.
Recruiting
The goal of this investigational study is to evaluate the safety and clinical performance of Tropocells Autologous Platelet-rich Fibrin (PRF) for wound care for both males and females, ages 18-80 years old, with Grade 1 and 2, mild to moderate, neuroischemic diabetic chronic foot ulcers in subjects with Type 1 and Type 2 Diabetes Mellitus. The main question\[s\] it aims to answer \[is/are\]: Measure 1: Wound Closure with Tropocells Autologous PRF System for DFU Measure 2: Safety of Tropocells A... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/10/2025
Locations: WoundCentrics Wound Care & Hyperbarics -Corpus Christi - Shoreline, Corpus Christi, Texas +1 locations
Conditions: Diabetic Foot Ulcer, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM), Neuroischemic Foot Ulcer, Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer), Chronic Wound Care
Exercise Enhances Wound Healing in Patients With Diabetic Foot Ulcers
Recruiting
The overarching purpose of this study is to investigate the impact that exercise, as delivered through a medically supervised, outpatient cardiac rehabilitation program, has on the wound healing process in Type 2 diabetics having foot ulcers classified as being Wound, Ischemia, foot Infection (WIfI) stage 2 or lower. The criterion reference measure of diabetic foot ulcer wound healing is be the time required to reach the maturation phase of the wound healing cascade (wound closure without draina... Read More
Gender:
ALL
Ages:
Between 20 years and 80 years
Trial Updated:
06/02/2025
Locations: UNM Cardiac Rehabilitation Services, Albuquerque, New Mexico
Conditions: Diabetic Foot Ulcer
Mirragen Diabetic Foot Ulcer Study
Recruiting
This study is being done to collect data from treatment of patients who have diabetes with non-healing foot wounds and are being treated with a resorbable and biocompatible borate-based bioactive glass fiber matrix. A borate-based bioactive glass fiber matrix is used to cover the ulcer for wound management. The primary objective of this study is to evaluate the safety and efficacy of the borate-based bioactive glass fiber matrix in the treatment of diabetic foot ulcers in a real-world setting. T... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/21/2025
Locations: UT Health Medical Arts and Research Center, San Antonio, Texas
Conditions: Diabetic Foot Ulcer, Osteomyelitis Chronic
Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome
Recruiting
A Pilot Study to Determine the Impact of the Phoenix Wound Matrix® on the Wound Microbiome in Chronic Diabetic Foot Ulcers
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/19/2025
Locations: PA Foot & Ankle Associates, Northampton, Pennsylvania
Conditions: Diabetic Foot Ulcer