There are currently 12 active clinical trials seeking participants for Hemorrhage research studies. The states with the highest number of trials for Autism participants are Texas, Ohio, California and Pennsylvania.
Ascending Dose Study of FrontlineODP™ Spray Dried Plasma
NCT05629338
Recruiting
This study in healthy volunteers is designed to assess the safety of infusing increasing doses of spray dried plasma (FrontlineODP).
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
10/18/2023
Locations: Hoxworth Blood Center, Cincinnati, Ohio +2 locations
Conditions: Coagulopathy, Hemorrhage
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The Effect of Fluids on Aortic VTI During C-section
NCT04330742
Recruiting
Pregnancy is associated with a myriad of physiologic changes, including expansion of blood volume, decrease in oncotic pressure, and increased cardiac output. The obstetric population is associated with intrapartum hemorrhage. Accordingly, it is important to have an accurate method to assess fluid status in intrapartum patients. The use of standard volume assessment tools including arterial lines and central venous catheters is limited given the brevity of obstetric procedures and the morbidity... Read More
Gender:
Female
Ages:
Between 18 years and 35 years
Trial Updated:
04/19/2024
Locations: Ben Taub General Hospital, Houston, Texas
Conditions: Pregnancy Related, Hemorrhage, Fluid Overload, Labor Complication
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The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP)
NCT06291415
Recruiting
This is an open-label, multicenter study to evaluate the safety, tolerability, and efficacy of HMPL-523 in adult subjects with ITP.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/18/2024
Locations: Center for Cancer and Blood Disorders, Bethesda, Maryland +14 locations
Conditions: Immune Thrombocytopenia, Blood Platelet Disorder, Hematologic Diseases, Purpura, Thrombocytopenic, Purpura, Blood Coagulation Disorder, Thrombotic Microangiopathies, Hemorrhagic Disorders, Autoimmune Diseases, Immune System Diseases, Hemorrhage, Pathologic Processes, Skin Manifestations, Thrombocytopenia, Purpura, Thrombocytopenic, Idiopathic, Primary Immune Thrombocytopenia, ITP - Immune Thrombocytopenia
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Bentracimab in Ticagrelor-treated Patients With Uncontrolled Bleeding or Requiring Urgent Surgery or Invasive Procedure
NCT04286438
Recruiting
This is a multi-center, open-label, prospective single-arm study of reversal of the antiplatelet effects of ticagrelor with bentracimab (PB2452) in patients who present with uncontrolled major or life-threatening bleeding or who require urgent surgery or invasive procedure. At least 200 patients will be enrolled from approximately 200 centers in North America, Europe, and Asia-Pacific regions, including mainland China. Patients with reported use of ticagrelor within the prior 3 days who require... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/14/2024
Locations: Providence St. Jude Medical Center, Fullerton, California +84 locations
Conditions: Hemorrhage, Urgent Surgery, Invasive Procedure
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Mixed-reality REBOA Simulator With Virtual Coaching
NCT05062928
Recruiting
Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) is a life-saving emergency procedure that is highly suited for simulation-based training. This study aims to assess the validity of our REBOA simulator with virtual coach (or live quantitative feedback) for mastery learning. The hypotheses are: H0: Virtual coach is non-inferior in REBOA training to an average human instructor. H1: Virtual coach is inferior in REBOA training to an average human instructor. We expect to learn wh... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/06/2024
Locations: University of Florida, Gainesville, Florida
Conditions: Hemorrhage, Simulation Training
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ECMO Hemostatic Transfusions in Children
NCT05796557
Recruiting
Critically ill children supported by extracorporeal membrane oxygenation (ECMO) receive large volumes of prophylactic platelet transfusions to prevent bleeding. However, mounting evidence has demonstrated significant morbidity and mortality associated with these transfusions. The ECmo hemoSTAtic Transfusions In Children (ECSTATIC) pilot trial will test two different platelet transfusion strategies, based on two different platelet counts thresholds, one high (higher platelet transfusion strategy)... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
02/02/2024
Locations: Children's Healthcare of Atlanta - Emory, Atlanta, Georgia +9 locations
Conditions: Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Thromboembolism, Transfusion Adverse Reaction
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BiZact Tonsillectomy in the Pediatric Population
NCT04725305
Recruiting
This study has been designed to evaluate how effective the Bizact tonsillectomy device is in reducing operating time and complications that occur after surgery. This device operates in a different way than the standard device that is used for most tonsillectomies. In 2019, a study was conducted in 186 children and adults using this device in tonsillectomies. Results showed lower blood loss and shortened time in surgery. However, the rate for bleeding as a complication after surgery was the same... Read More
Gender:
All
Ages:
18 years and below
Trial Updated:
10/25/2023
Locations: Texas Children's Hospital, Houston, Texas
Conditions: Tonsillectomy, Tonsillitis Chronic, Hemorrhage, Postoperative Pain, Postoperative Hemorrhage, Surgery--Complications, Otorhinolaryngologic Diseases
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NIRS Monitoring in Premature Infants
NCT02601339
Recruiting
This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) and/or post-hemorrhagic hydrocephalus (PHH) in comparison to newborns with hydrocephalus of a different etiology (VC) and healthy controls (HC). We hypothesize that baseline cerebral metabolic dysfunction... Read More
Gender:
All
Ages:
Between 0 months and 12 months
Trial Updated:
08/09/2023
Locations: Boston Children's Hospital, Boston, Massachusetts +2 locations
Conditions: Hemorrhage, Premature Infants, Newborn, Hydrocephalus
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Consortium for Optimized Integration of Bio-Artificial Blood Components for Adaptive Resuscitation Therapy
NCT05756426
Recruiting
There is need for a whole blood analog for use when banked blood is unavailable or undesirable. In civilian trauma, hemorrhage accounts for ~ 35% of pre-hospital deaths; moreover, ~ 20% of military casualties are in hemorrhagic shock on arrival to field hospitals and an additional 5% require urgent transfusion. A recent review concluded that hemorrhage accounted for ~ 90% of potentially survivable battlefield deaths - lives that could be saved with better hemorrhage control capabilities and imp... Read More
Gender:
All
Ages:
Between 18 years and 88 years
Trial Updated:
08/09/2023
Locations: University of Maryland Baltimore (UMB), Baltimore, Maryland
Conditions: Hemorrhage, Hemodynamic Instability
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Extended Cold Stored Apheresis Platelets in Cardiac Surgery Patients
NCT05220787
Recruiting
This trial is being performed to evaluate the feasibility of the study protocol and to test the efficacy and safety of platelets stored at cold conditions (1-6°C) in 100% plasma for 10-14 days (CSP) in cardiac surgery patients who are actively bleeding and require platelet transfusion.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
07/26/2023
Locations: Swedish Medical Center - Cherry Hill, Seattle, Washington
Conditions: Hemorrhage, Platelets; Defect, Bleeding, Surgical Blood Loss
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MRI of Myocardial Infarction
NCT03531151
Recruiting
Heart failure (HF) is an enormous health burden affecting approximately 5.1 million people in the US and is the cause of 250,000 deaths each year. Approximately 50% of HF is caused by myocardial ischemia and requires immediate restoration of coronary blood flow to the affected myocardium. However, the success of reperfusion is partly limited by intramyocardial hemorrhage, which is the deposition of intravascular material into the myocardium. Hemorrhagic reperfusion injury has high prevalence and... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/17/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Myocardial Infarction, Myocardial Ischemia, Myocardial Injury, Myocardial Fibrosis, Myocardial Reperfusion Injury, Myocardial Edema, Myocardial Necrosis, Heart Failure, Ischemic Heart Disease, Ischemic Cardiomyopathy, Hemorrhage
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CNAP vs IABP in Pregnant Women With Placenta Accreta
NCT04671680
Recruiting
The objective of this study is to investigate a technique to monitor blood pressure in women undergoing cesarean delivery with suspected placenta accreta spectrum. To achieve this objective, the investigators plan to conduct a prospective, observational study with the following aims: Specific Aim 1: Compare concordance between the systolic (SBP), diastolic (DBP), and mean arterial blood pressure (MAP) readings from the continuous non-invasive arterial blood pressure (CNAP) and IABP at several d... Read More
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
09/19/2022
Locations: Beth Israel Deaconess Medical Center, Boston, Massachusetts
Conditions: Placenta Accreta, Blood Pressure, Hemorrhage, Hemorrhage, Postpartum
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