There are currently 54 active clinical trials seeking participants for Insulin Resistance research studies. The states with the highest number of trials for Autism participants are California, New York, Massachusetts and Missouri.
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
NCT06007404
Recruiting
This research study collects health-related information and blood samples to better understand how body composition, lifestyle habits, and diet influence meta-inflammatory monocytes (MiMos) in adolescents. The hypothesis of this study is that adolescents at risk for metabolic disease have enhanced MiMo related activities leading to insulin resistance.
Gender:
All
Ages:
Between 14 years and 18 years
Trial Updated:
09/11/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Type 2 Diabetes, Insulin Resistance, Obesity, Metabolic Disease, PreDiabetes
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Effects of Hepatic Ultrasound on Metabolic Homeostasis
NCT04622683
Recruiting
The purpose of this study is to define the effect of ultrasound exposure of the liver in the region of the porta hepatis on glucose homeostasis and insulin resistance in healthy subjects.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
08/22/2023
Locations: Yale-New Haven Hospital, New Haven, Connecticut
Conditions: Healthy, Insulin Resistance
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Reversal of Lipid-Induced Insulin Resistance
NCT02193295
Recruiting
The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
08/21/2023
Locations: Yale Center for Clinical Investigation HRU, New Haven, Connecticut
Conditions: Insulin Resistance, NAFLD
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Precision Nutrition and Metabolic Function
NCT04131166
Recruiting
The purposes of this study are: 1) to determine the mechanisms responsible for the development of cardiometabolic complications in some, but not all people with obesity; 2) determine the best dietary approach for cardiometabolic health; and 3) understand why some people have a stable metabolic phenotype over time whereas cardiometabolic health improves or worsens in others.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
08/04/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Obesity, Insulin Resistance
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Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health
NCT02706262
Recruiting
The purpose of this research study is to 1) understand how some, but not all people with obesity develop obesity related conditions such as type 2 diabetes and cardiovascular disease, and 2) compare the effects of 3 popular weight loss diets (Mediterranean, low-carbohydrate, or a very-low-fat plant-based diet) in people with obesity.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
08/04/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Obesity, Insulin Resistance
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Small Extracellular Vesicles and Insulin Action
NCT05933707
Recruiting
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop obesity-related conditions; 2) assess the effect of small extracellular vesicles (sEVs also called exosomes), obtained from human participants, on metabolic function in cultured cells and in mice.
Gender:
All
Ages:
Between 25 years and 55 years
Trial Updated:
07/06/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
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Exercise Effects on Adipose Tissue Structure and Function
NCT04812314
Recruiting
Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the wei... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
06/15/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain
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Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
NCT05543083
Recruiting
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group, or a combination of cognitive-behavioral therapy and exercise training groups, decreases stress, improves mood, increases physical activity and physical fitness, and decreases insulin resistance among teenagers at risk for diabetes.
Gender:
Female
Ages:
Between 12 years and 17 years
Trial Updated:
06/15/2023
Locations: Children's Hospital Colorado, Aurora, Colorado +1 locations
Conditions: Insulin Resistance, Depression, Depressive Disorder, Mood Disorders, Mental Disorder in Adolescence, Hyperinsulinism, Glucose Metabolism Disorders, Metabolic Disease
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The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
NCT05912348
Recruiting
The goal of this clinical trial is to learn about the alterations insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men. The main questions it aims to answer are: Does the addition of excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance in fit young men? Does the addition of excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates... Read More
Gender:
Male
Ages:
Between 18 years and 26 years
Trial Updated:
06/12/2023
Locations: University of New Hampshire Cardiometabolic Research Laboratory, Durham, New Hampshire
Conditions: Insulin Resistance, Impaired Glucose Tolerance, Obesity, Metabolic Disturbance
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ENAC Blockade and Arterial Stiffness
NCT03837626
Recruiting
To determine whether treatment with the ENaC inhibitor, amiloride, improves endothelial function and arterial stiffness in obese insulin resistant subjects in a randomized placebo-controlled trial examining pre and postmenopausal women and age-matched men.
Gender:
All
Ages:
Between 30 years and 70 years
Trial Updated:
05/30/2023
Locations: University of Missouri Hospital and Clinics, Columbia, Missouri
Conditions: Overweight and Obesity, Insulin Resistance
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Effects of Obesity and Intensity of Exercise on Ghrelin Levels
NCT04581980
Recruiting
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
05/08/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Obesity, Insulin Resistance, Cardiovascular Risk Factor
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Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
NCT03318094
Recruiting
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake. The investigators will test the hypothesis that removal of sympathetic vasoconstriction can result in improvement in insulin-mediated vasodilation and subsequently sensitivity to insulin-mediated glucose uptake.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/27/2023
Locations: Autonomic Dysfunction Center, Nashville, Tennessee
Conditions: Insulin Resistance, Healthy, Obesity
Register for Updates