There are currently 51 active clinical trials seeking participants for Insulin Resistance research studies. The states with the highest number of trials for Autism participants are California, New York, Massachusetts and Missouri.
Go Girls! Fitness Support Group Intervention Effectiveness Study
Recruiting
The main purpose of this study is to determine if the Go Girls! program to take place at the Kluge Children's Rehabilitation Center Therapeutic Recreation Gymnasium, intended to introduce girls to a fun, non-threatening environment of exercise with peer support, improves scores on a physical activity enjoyment scale (PACES). Information regarding enjoyment of physical activity before and after the program will allow objective evaluation of whether the program is achieving its mission. Qualitativ... Read More
Gender:
Female
Ages:
Between 10 years and 18 years
Trial Updated:
10/25/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Abnormal Weight Gain, Excess Weight, Insulin Resistance, Premature Adrenarche, Type 2 Diabetes Mellitus
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
Recruiting
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
05/08/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Obesity, Insulin Resistance, Cardiovascular Risk Factor
Intramyocellular Fatty Acid Trafficking in Insulin Resistance States - Effects of Intestinal Delivery of Lipids
Recruiting
Muscle insulin resistance is a hallmark of upper body obesity (UBO) and Type 2 diabetes (T2DM). It is unknown whether muscle free fatty acid (FFA) availability or intramyocellular fatty acid trafficking is responsible for muscle insulin resistance, although it has been shown that raising FFA with Intralipid can cause muscle insulin resistance within 4 hours. The investigators do not understand to what extent the incorporation of FFA into ceramides or diacylglycerols (DG) affect insulin signaling... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
03/21/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Insulin Resistance
Pancreatic Clamp in NAFLD
Recruiting
This is a single-center, prospective, randomized, controlled (crossover) clinical study designed to investigate the specific dose-response impact of insulin infusion rate (IIR) on blood glucose levels during a pancreatic clamp study. The investigators will recruit participants with a history of overweight/obesity and evidence of insulin resistance (i.e., fasting hyperinsulinemia plus prediabetes and/or impaired fasting glucose and/or Homeostasis Model Assessment of Insulin Resistance [HOMA-IR] s... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/15/2024
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Insulin Resistance, Prediabetic State, Hyperinsulinemia, Non-Alcoholic Fatty Liver Disease, Obesity
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Recruiting
Background: - Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: - To examine how specific genes and proteins in blood cells respond to environmental e... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
03/12/2024
Locations: NIEHS Clinical Research Unit (CRU), Research Triangle Park, North Carolina
Conditions: Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance, Cancer
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Recruiting
Background: About 40 percent of adults and 20 percent of adolescents in the U.S. have a body mass index over 30 kg/m2. Being overweight may lead to a state of low-level inflammation. This may cause health problems. Researchers want to see if an anti-inflammatory medicine can help. Objective: To learn if colchicine can improve metabolism in people who have high body weight, increased inflammation, and high insulin in the blood but who have not yet developed high blood sugar. Eligibility: Peo... Read More
Gender:
All
Ages:
Between 12 years and 100 years
Trial Updated:
03/12/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Obesity, Insulin Resistance, Inflammation
Precision Diets for Diabetes Prevention
Recruiting
With this study the investigators want to understand the physiological differences for people developing pre-diabetes and diabetes. The investigators hypothesize that different individuals go through different paths in the development of the disease. By understanding the personal mechanism for developing disease, the investigators will find a personalized approach to prevent that development. The investigators are also hoping to be able to find a biomarker that will pinpoint to the particular de... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Stanford University, Stanford, California
Conditions: Pre Diabetes, Insulin Resistance, Diabetes Mellitus, Type 2
Glycemic Effect of Diazoxide in NAFLD
Recruiting
The goal of this clinical trial is to compare a two-week course of diazoxide (at two different doses) and placebo in people with overweight/obesity and insulin resistance (IR) with, or at high risk for, non-alcoholic fatty liver disease (NAFLD). The main questions it aims to answer are how mitigation of compensatory hyperinsulinemia with diazoxide affects parameters of glucose and lipid metabolism (how people with IR and NAFLD respond to lowering high insulin levels so that the investigators can... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
03/04/2024
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
Recruiting
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
02/21/2024
Locations: University of Missouri, Columbia, Missouri
Conditions: Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction, Obesity
Sleep and IR in Transgender Adolescents
Recruiting
Disordered sleep is a health issue with significant impacts on physical and psychological well-being that has increased in prevalence, but its impact on transgender adolescents has not been fully quantified. While there is found to be an impact of sex steroids on sleep, and sex-dependent differences in the impact of sleep duration and quality on insulin resistance (IR), there is limited available information regarding the impact of Gender Affirming Hormone Therapy (GAHT) for transgender individu... Read More
Gender:
All
Ages:
Between 12 years and 18 years
Trial Updated:
02/16/2024
Locations: Duke University, Durham, North Carolina
Conditions: Sleep Disorder, Insulin Resistance, Gender Dysphoria
Everolimus Aging Study
Recruiting
The objective of this project is to determine if mTORC1 inhibition by 24 weeks of daily (0.5 mg/day) or weekly (5 mg/week) everolimus can safely improve physiological and molecular hallmarks of aging in humans. Participants who are 55-80 years old and insulin resistant or prediabetic will be randomized to treatment and can expect to be on study for up to approximately 38 weeks. Participants aged 18-35 will not receive the intervention and can expect to be on study for up to approximately 8 weeks... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
02/13/2024
Locations: University of Wisconsin-Madison, Madison, Wisconsin
Conditions: Aging, Insulin Resistance
Metabolic Effects of Sleep Extension in People With Obesity
Recruiting
This study is designed to determine the impact of extending sleep duration on glucose metabolism in people with obesity. Half of the participants will be instructed to increase their time-in-bed by one hour (sleep extension) while the other half will be be instructed to maintain their current sleep habits.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/07/2024
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Insulin Resistance, Obesity