There are currently 35 active clinical trials seeking participants for Ischemic Stroke research studies. The states with the highest number of trials for Ischemic Stroke participants are California, Florida, New York and Ohio.
Treatment of Acute Ischemic Stroke (ReMEDy2 Trial)
Recruiting
This is a Phase 2/3 study evaluating the safety and efficacy of DM199 (rinvecalinase alfa) in treating participants with moderate stroke severity, who present within 24 hours of Acute Ischemic Stroke (AIS) onset due to small and medium vessel occlusions. This study focuses on participants with limited treatment options. Participants who have or will receive mechanical thrombectomy (MT) are not eligible for participation. Additionally, participants who have received fibrinolytics are excluded unl... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/14/2025
Locations: Gulf Health Hospitals d/b/a Thomas Hospital, Fairhope, Alabama +30 locations
Conditions: Acute Stroke, Ischemic Stroke, Stroke
Sleep for Stroke Management and Recovery Trial
Recruiting
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/04/2025
Locations: University of Alabama Hospital, Birmingham, Alabama +111 locations
Conditions: Ischemic Stroke, Sleep Apnea, Sleep Apnea, Obstructive, Stroke, CPAP, Telemedicine, Home Sleep Apnea Test, Randomized Clinical Trial, Multicenter Trial
CTSN Embolic Protection Trial
Recruiting
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
03/03/2025
Locations: CHI St. Vincent Heart Institute, North Little Rock, Arkansas +27 locations
Conditions: Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease, Coronary Artery Disease
OsciPulse D-dimer Pilot Trial
Recruiting
Pilot, randomized, non-blinded clinical trial to generate preliminary data to evaluate the impact of the OsciPulse system on serum d-dimer levels compared to standard of care intermittent compression therapy for DVT prophylaxis in patients admitted in the neuro ICU or intermediate neurological care unit with acute ischemic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/24/2025
Locations: HUP Neurology Dept. of Stroke and Neurocritical Care- University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Ischemic Stroke
StrokeNet Thrombectomy Endovascular Platform
Recruiting
STEP is a Randomized, Multifactorial, Adaptive Platform trial that seeks to optimize the care of patients with acute ischemic stroke (AIS) due to large (LVO) or medium vessel occlusions (MVO).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: Boston Medical Center, Boston, Massachusetts +1 locations
Conditions: Ischemic Stroke
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Recruiting
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Ischemic Stroke, Hypertension, Hyperlipidemias, Diabetes
Left Atrial Appendage Exclusion for Prophylactic Stroke Reduction Trial
Recruiting
This trial is a prospective, randomized, multicenter, multinational, blinded, superiority trial. The objective of this trial is to evaluate the effectiveness of left atrial appendage exclusion (LAAE) for the prevention of ischemic stroke or systemic arterial embolism in subjects undergoing cardiac surgery who have risk factors for atrial fibrillation and ischemic stroke.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: Heart Center Research / Huntsville Hospital, Huntsville, Alabama +114 locations
Conditions: Ischemic Stroke, Systemic Embolism
Verapamil for Neuroprotection in Stroke
Recruiting
The purpose of this research study is to test an experimental procedure called intra-arterial delivery of verapamil in patients diagnosed with acute ischemic stroke. This study investigates the safety of intra-arterial delivery of verapamil, a drug used to treat vasospasm (spasm of a blood vessel), and how it affects recovery from stroke. Recruitment is limited to patients that have received mechanical thrombectomy as standard of care.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/15/2025
Locations: AtlantiCare Regional Medical Center, Atlantic City, New Jersey +2 locations
Conditions: Ischemic Stroke
EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment
Recruiting
This is a multicenter study that will be conducted at approximately 20 centers and up to 30 centers, if the sample size will be increased following interim assessment. The Q Therapeutic System (BQ 3.0) is a wearable medical device that produces and delivers non-invasive, extremely-low-intensity and low-frequency, frequency-tuned electromagnetic fields in order to stimulate neuronal networks with the aim of reducing disability and promoting neurorecovery. The Q Therapeutic System (BQ 3.0) is in... Read More
Gender:
ALL
Ages:
Between 22 years and 80 years
Trial Updated:
01/08/2025
Locations: Rancho Research Institute, Downey, California +13 locations
Conditions: Ischemic Stroke
K01 Impacts of Lingual Endurance Exercise
Recruiting
Swallowing impairments (dysphagia) frequently occur after stroke and have devastating consequences on overall health and quality of life, and long-term deficits in swallow function also increase risk of morbidity (e.g. depression) and mortality (i.e. aspiration pneumonia). As such, rehabilitation of swallow function to improve safety and efficiency of swallowing is essential in this population. This study aims to: 1) Provide preliminary data to evaluate the effect of a novel lingual endurance ex... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Dysphagia, Dysphagia, Oropharyngeal, Ischemic Stroke
NOninVasive Intracranial PrEssure from Transcranial DoppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
Recruiting
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University. In this study, the investigators will primarily use the monitor mode of the Transcranial Doppler (TCD, non-invasive FDA approved device) to record cerebral blood flow velocity (CBFV) signals from the Middle Cerebral Artery and Internal Carotid Artery. TCD data and intracranial pressure (ICP... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: UC Davis, Davis, California +3 locations
Conditions: Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Hemorrhage, Liver Failure, Ischemic Stroke
The Recovery in Stroke Using PAP Study
Recruiting
The proposed study is a randomized controlled trial among an anicipated 180 participants with acute ischemic stroke and mod/severe OSA diagnosed by ambulatory polysomnography (PSG) comparing PAP treatment with usual care concerning the primary outcome of functional recovery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: Yale University, New Haven, Connecticut
Conditions: Ischemic Stroke, Obstructive Sleep Apnea