There are currently 140 active clinical trials seeking participants for Major Depressive Disorder research studies. The states with the highest number of trials for Major Depressive Disorder participants are California, Florida, Texas and New York.
Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults
Recruiting
This project aims to explore the feasibility and effects of a symptom-specific, brain-circuit-based, home-based neuromodulation therapy for addressing mood and memory symptoms in older adults with major depressive disorder (MDD) in the context of dementia.
Gender:
All
Ages:
55 years and above
Trial Updated:
07/27/2023
Locations: Hinda and Arthur Marcus Institute for Aging Research, Boston, Massachusetts
Conditions: Major Depressive Disorder, Alzheimer Disease, Dementia, Nervous System Diseases, Memory Disorders, Depressive Disorder
The Role of Social Determinants in Cardiovascular Health and Vascular Function
Recruiting
This study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities. We hypothesize that individuals of a lower social economic position and those struggling with depression are at greater risk of cardiovascular disease.
Gender:
All
Ages:
18 years and above
Trial Updated:
07/25/2023
Locations: Baylor Scott & White Family Health Center at Juanita J. Craft Recreation Center, Dallas, Texas
Conditions: Social Determinants of Health, Major Depressive Disorder, Cardiovascular Diseases
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
Recruiting
The investigators are conducting this study to learn more about the cognitive and attentional processes among individuals with three types of repetitive negative thinking (RNT): mental rituals (as seen in obsessive compulsive disorder, OCD), worries (as seen in generalized anxiety disorder, GAD), and ruminations (as seen in major depressive disorder, MDD). Specifically, the investigators are studying whether psychological treatment can help people with RNT who have trouble stopping unwanted thou... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
07/11/2023
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation
Recruiting
In the treatment of Major Depressive Disorder (MDD), total sleep deprivation can produce rapid but short-lasting improvements in mood. In order to develop a new generation of treatments with rapid and sustained efficacy, a better understanding of the mechanism of action is urgently needed. One candidate mechanism is the modulation of synaptic strength mediated by glutamatergic activity as sleep deprivation has been suggested to increase synaptic strength. Although determining how sleep deprivati... Read More
Gender:
All
Ages:
Between 25 years and 50 years
Trial Updated:
07/10/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Major Depressive Disorder
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of up to Two Doses of Psilocybin for the Treatment of Major Depressive Disorder in Adults With Cancer
Recruiting
This is a Phase 2, single-center study to explore the efficacy, safety, and tolerability of up to two 25-mg doses of psilocybin administered at an interval of 9 to 10 weeks in patients with MDD and cancer. This two-part study will administer a fixed dose (25 mg) of psilocybin in a double-blind, randomized, placebo-controlled portion (Dosing Session 1) and subsequently allow rollover into an open-label portion (Dosing Session 2; fixed dose of psilocybin, 25 mg) for patients who do not achieve rem... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/07/2023
Locations: Sunstone Medical, PC, Rockville, Maryland
Conditions: Cancer, Major Depressive Disorder
Cellular Aging and Neurobiology of Depression Study
Recruiting
We are conducting an eight week longitudinal study to learn if blood levels of certain naturally occurring compounds and genetic markers differ between patients with depression and healthy adults who are not depressed, and if any such differences relate to memory performance, mood, and neurobiology. We are also interested in how the gut microbiome is affected by antidepressant treatment. We will do this by comparing the unmedicated depressed patients with matched healthy controls at baseline an... Read More
Gender:
All
Ages:
Between 21 years and 60 years
Trial Updated:
06/30/2023
Locations: University of California San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)
Recruiting
This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan. The trial will be the first fully powered randomized trial of treatment for any psychiatric disorder following perinatal loss.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
06/26/2023
Locations: Anywhere in the entire state of Michigan (treatment is virtual), Flint, Michigan
Conditions: Major Depressive Disorder
Appalachian Mind Health Initiative
Recruiting
We propose to carry out a treatment experiment in which we evaluate the extent to which randomizing primary care clinicians have access to remote internet-based Cognitive Behavior Therapy (eCBT) in rural West Virginia (WV) and Kentucky (KY) will help improve treatment of patients with Major Depressive Disorder (MDD). WV and KY are two of the most rural states in America and mental health treatment resources are low; especially in rural parts of the state.
Gender:
All
Ages:
18 years and above
Trial Updated:
06/07/2023
Locations: University of Lousiville Health, Louisville, Kentucky +6 locations
Conditions: Major Depressive Disorder
University of Iowa Interventional Psychiatry Service Patient Registry
Recruiting
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD). These treatments include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), racemic ketamine infusion and intranasal esketamine insufflation. The investigators will obtain various indicators, or biomarkers, of a depressed individuals' state before, during, and/or after these treatments. Such biomarkers... Read More
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
05/08/2023
Locations: University of Iowa Health Care, Iowa City, Iowa
Conditions: Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder, Bipolar Disorder, Bipolar Depression, Obsessive-Compulsive Disorder
Closed-Loop Deep Brain Stimulation for Major Depression
Recruiting
Neurons are specialized types of cells that are responsible for carrying out the functions of the brain. Neurons communicate with electrical signals. In diseases such as major depression this electrical communication can go awry. One way to change brain function is using electrical stimulation to help alter the communication between groups of neurons in the brain. The purpose of this study is to test a personalized approach to brain stimulation as an intervention for depression. The study resea... Read More
Gender:
All
Ages:
Between 22 years and 70 years
Trial Updated:
04/27/2023
Locations: University of California, San Francisco, San Francisco, California
Conditions: Major Depressive Disorder
Tracking Response to Antidepressants in Advance of Investigational Trials
Recruiting
TRAIT is an open-label observational study to evaluate treatment response to selective-serotonin reuptake inhibitors (SSRIs) and selective-norepinephrine reuptake inhibitors (SNRIs) among individuals meeting criteria for Major Depressive Disorder (MDD) and seeking enrollment in investigational trials.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/23/2023
Locations: Adams Clinical, Watertown, Massachusetts
Conditions: Major Depressive Disorder
Peripheral Neuroimmune Mechanisms of Hyperthermia
Recruiting
The goal of this study is to examine how whole-body hyperthermia affects the thermoinflammatory profile, which includes the combined immune and heat shock response, in patients with depression and whether these changes correlate with decreased depression in individuals with Major Depressive Disorder.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/08/2023
Locations: Massachusetts General Hospital Depression Clinical & Research Program, Boston, Massachusetts
Conditions: Hyperthermia, Major Depressive Disorder, Inflammation