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Major Depressive Disorder Clinical Trials
A listing of 130 Major Depressive Disorder clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.
13 - 24 of 130
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There are currently 130 active clinical trials seeking participants for Major Depressive Disorder research studies. The states with the highest number of trials for Major Depressive Disorder participants are California, Florida, Texas and New York.
Featured Trial
Paid Clinical Studies Nationwide
Recruiting
Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.
Featured Trial
Chronic Cough Study
Recruiting
Are you tired of living with chronic cough? The ASPIRE Study is now looking to enroll people from all backgrounds to help research potential new treatment options for chronic cough. You are under no obligation to take part and health insurance is not required. Find out more today! We’d love to hear from you.
Conditions:
Chronic Cough
Refractory or Unexplained Chronic Cough
Cough
Asthma
Allergic Asthma
Featured Trial
Studying an Investigational Virus Vaccine
Recruiting
The main objectives of this study are to assess the safety and effectiveness of an investigational vaccine aimed at preventing norovirus, commonly known as the stomach flu. Participants will be randomly assigned to receive either the investigational vaccine or a placebo. Should you express interest, you will be contacted directly by the research site, which will provide further details and answer any questions you may have about study requirements, risks/benefits, and any compensation.
Conditions:
Healthy
Interested in vaccine studies
All Conditions
Preventative Trials
Featured Trial
Depression Clinical Trial
Recruiting
Join us in researching a potential investigational treatment for Depression. Reimbursement for study-related expenses may be available to you.
Qualifying participants:
•Are between 18-65
•Have been experiencing a major depressive episode forat least a month
Qualifying participants:
•Are between 18-65
•Have been experiencing a major depressive episode forat least a month
Conditions:
Depression
Major Depressive Disorder
Depressive Disorder
Depressive Symptoms
Depressive Disorder
Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
Recruiting
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity, this study aims to improve our understanding of how these conditions affect the brain.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Major Depressive Disorder, Bipolar Disorder, Mild Cognitive Impairment
Near Infrared Spectroscopy (NIRS) for Assessment of Depression
Recruiting
Develop a NIRSIT testing protocol that can be administered in the diagnostic setting and reliably distinguishes the symptoms and severity of depression, with the help of repeated measure (up to five visits per subject) comparison of patients being treated for Major Depressive Disorder with control, non-depressed subjects.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: San Francisco Veterans Affairs Medical Center, San Francisco, California
Conditions: Major Depressive Disorder
Open Label Optimization Study
Recruiting
The goal of this observational study is to demonstrate effectiveness in the treatment of Major Depressive Disorder
The primary objective is to assess the effectiveness in the treatment of Major Depressive Disorder using the CGI-I at the end of the treatment
Participants will receive 10 treatments per day for 5 days (M-F) of SAINT®
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: BrainHealth Solutions, Costa Mesa, California +6 locations
Conditions: Major Depressive Disorder
Biomarker-guided rTMS for Treatment Resistant Depression
Recruiting
Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. The investigators are continuing to learn how to optimize outcomes from rTMS treatment. The purpose of this research project is to use brain network connectivity patterns as measured by resting state functional magnetic resonance imaging (fMRI) to confirm a way to optimize the use of rTMS to treat depression. In addition, the study aims to gain a better understanding of how rTMS influences brain networks.
Gender:
ALL
Ages:
Between 22 years and 65 years
Trial Updated:
03/17/2025
Locations: Stanford University, Stanford, California +1 locations
Conditions: Treatment Resistant Depression, Major Depressive Disorder
Concurrent fMRI-guided rTMS and Cognitive Therapy for the Treatment of Major Depressive Episodes
Recruiting
Background:
Repetitive transcranial magnetic stimulation (rTMS) is a treatment for depression. It stimulates the brain. Researchers want to see if using magnetic resonance imaging (MRI) scans helps locate the best area for rTMS in each person. They also want to find other ways to make it more effective.
Objective:
To study the effects of combining MRI- guided transcranial magnetic stimulation (TMS) and talk therapy on the brain in people with depression.
Eligibility:
Adults ages 18-75 with... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Major Depressive Disorder
Efficacy and Safety Study of BHV-7000 Monotherapy in Major Depression
Recruiting
The purpose of this study is to determine the efficacy and safety of BHV-7000 in participants with Major Depressive Disorder (MDD)
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/14/2025
Locations: Reverie Mind, LLC, Chandler, Arizona +67 locations
Conditions: Major Depressive Disorder
GATE-251 or Placebo for the Reduction of Symptoms of Major Depressive Disorder
Recruiting
The goal of this clinical trial is to learn if GATE-251 works to treat depression in adults. It will also learn about the safety of GATE-251. The main questions it aims to answer are:
Does GATE-251 reduce depression scores in participants compared to participants who take a placebo (a look-alike tablet that contains no GATE-251)?
What medical problems are observed in participants who take GATE-251?
Participants will take one tablet of GATE-251 or placebo every week for 6 weeks. Participants w... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
03/13/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +28 locations
Conditions: Major Depressive Disorder
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans with Major Depressive Disorder"
Recruiting
The purpose of this study is to examine the efficacy, safety, and tolerability of CYB003 compared to matching placebo as adjunctive treatment in participants with MDD.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/11/2025
Locations: Noble Clinical Research, Tucson, Arizona +24 locations
Conditions: Major Depressive Disorder
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
Recruiting
Background:
Most drugs that treat mood disorders take a long time to work. Ketamine works within hours. A dose can last for a week or more. Certain receptors in the brain might help ketamine work. A drug that blocks these receptors might affect how it works.
Objective:
To see if the antidepressant response of ketamine is linked to AMPA receptors.
Eligibility:
Adults ages 18-70 with major depression disorder without psychotic features
Design:
Participants will be screened under protocol 01... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/10/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
Recruiting
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms o... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/05/2025
Locations: Florida State University, Tallahassee, Florida
Conditions: Major Depressive Disorder, Anhedonia
Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33
Recruiting
The purpose of this research study is to determine if application of near infrared energy to the forehead can change blood flow in the brains of people with depression. Near infrared energy is like light but is not visible to the human eye.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/05/2025
Locations: Harvard Medical School, Boston, Massachusetts +2 locations
Conditions: Major Depressive Disorder
A Study of the Efficacy and Safety of SP-624 in the Treatment of Adults With Major Depressive Disorder
Recruiting
This is a Phase 2B clinical study evaluating the effectiveness and safety of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/05/2025
Locations: IMA Clinical Research, Phoenix, Arizona +41 locations
Conditions: Major Depressive Disorder
13 - 24 of 130