There are currently 23 active clinical trials seeking participants for Menopause research studies. The states with the highest number of trials for Menopause participants are Florida, California, Texas and Pennsylvania.
Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females
Recruiting
Menopause greatly increases cardiovascular disease risk (CVD). Current exercise guidelines are inadequate to ameliorate this risk and higher intensity exercise may be necessary for cardiovascular benefits in postmenopausal females. Oral nitrate supplementation enhances exercise performance and CVD risk profile in several clinical conditions. The investigators recently reported that 3-days of nitrate supplementation in postmenopausal females enhances acute post-exercise vascular function, in an i... Read More
Gender:
FEMALE
Ages:
Between 45 years and 75 years
Trial Updated:
07/23/2025
Locations: Student Health and Wellness Building - Department of Kinesiology, Charlottesville, Virginia
Conditions: Menopause
Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
Recruiting
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one a... Read More
Gender:
FEMALE
Ages:
Between 35 years and 70 years
Trial Updated:
07/22/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hypertension, Menopause, Premature, Menopause, Blood Pressure
Efficacy of Suvorexant in the Treatment of Insomnia in Midlife Women With Pre-Diabetes
Recruiting
The aim of this study is to determine if suvorexant can help treat the severity of insomnia in midlife women who are pre-diabetic.
Gender:
FEMALE
Ages:
Between 40 years and 65 years
Trial Updated:
07/22/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Insomnia, Diabetes, Menopause
Estrogen Hormone Products
Recruiting
The purpose is to determine if the two estradiol products can deliver similar amounts of estradiol after single and multiple dosing.
Gender:
FEMALE
Ages:
Between 45 years and 65 years
Trial Updated:
06/16/2025
Locations: General Clinical Research Center (GCRC) at the University of Maryland Medical Center, Baltimore, Maryland
Conditions: Menopause
Hot Flashes and Neurovascular Function in Women
Recruiting
Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
05/28/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Hot Flashes, Menopause, Vasomotor System; Labile
The Anabolic Effect of Testosterone on Pelvic Floor Muscles
Recruiting
Stress urinary incontinence is the most common female pelvic floor disorder encountered in clinical practice with significant negative impact on quality of life. The prevalence of urinary incontinence increases with aging, and weakness of the pelvic floor muscles contributes to the development of stress urinary incontinence. Given that androgen receptors are expressed throughout the pelvic floor, the anabolic effects of androgens on pelvic floor muscles may provide a therapeutic option in women... Read More
Gender:
FEMALE
Ages:
60 years and above
Trial Updated:
05/09/2025
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Stress Urinary Incontinence, Menopause
Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function
Recruiting
This is a longitudinal study to determine the influence of the menopause transition on autonomic and vascular function. PI Keller-Ross has published data demonstrating that postmenopausal females have greater sympathetic neural reactivity during a stressor compared with age-matched males and younger females and males. A paucity of literature exists, however, on the role of the menopause transition in autonomic function because the majority of experimental studies on menopause physiology are cros... Read More
Gender:
FEMALE
Ages:
Between 45 years and 55 years
Trial Updated:
05/07/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Menopause
The Cardiovascular Impact of Hot Flushes
Recruiting
The overall objective of this study is to examine the physiological responses that occur during a hot flush in postmenopausal women. The following specific aims will be executed to reach the overall objective of this study. Aim 1: To determine if hot flushes can be reliably induced with a temperature-controlled, water- circulating (TCWC) heating pad. Based on previous research, the investigators hypothesize that hot flushes will be inducible with the TCWC in symptomatic women, but not in asympto... Read More
Gender:
FEMALE
Ages:
Between 40 years and 70 years
Trial Updated:
04/14/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hot Flashes, Menopause
Role of Menopause in Thermoregulation
Recruiting
The frequency and severity of heat waves has increased in the last decades. Older adults (over 65 years) have impaired responses to heat stress making them at increased risk for adverse events. Previous heat waves report that women over 65 experience worse health outcomes than any other age group and age matched men. Aging and reproductive hormones, specifically estrogen, independently alter responses to heat stress. However, the combined effects of low estrogen following menopause and aging on... Read More
Gender:
FEMALE
Ages:
Between 42 years and 64 years
Trial Updated:
04/10/2025
Locations: Noll Laboratory, University Park, Pennsylvania
Conditions: Menopause, Aging
Choline Dose Ranging in Postmenopausal Women
Recruiting
This study will use a randomized placebo-controlled trial to examine smaller doses of choline and whether a signal in the brain is detectable using fMRI. This study will examine if an even smaller doses of choline can show these similar brain activation and connectivity patterns to the 1650 mg dose. This will be a dose ranging study of 550 mg and 1100 mg oral choline compared to placebo.
Gender:
FEMALE
Ages:
Between 50 years and 65 years
Trial Updated:
04/04/2025
Locations: University of Vermont, Burlington, Vermont
Conditions: Menopause
Impact of Cannabinoids on Menopause Symptoms
Recruiting
The purpose of the study is to examine the impact of the hemp-derived minor cannabinoids on symptoms of menopause/perimenopause.
Gender:
FEMALE
Ages:
Between 40 years and 60 years
Trial Updated:
04/01/2025
Locations: Washington State University - Pullman Campus, Pullman, Washington
Conditions: Perimenopause, Menopause
Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training
Recruiting
The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.
Gender:
FEMALE
Ages:
Between 45 years and 60 years
Trial Updated:
03/31/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Menopause, Hot Flashes, Blood Pressure Regulation