There are currently 20 active clinical trials seeking participants for Neuropathic Pain research studies. The states with the highest number of trials for Neuropathic Pain participants are Florida, California, Texas and North Carolina.
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients with Spinal Cord Injury
NCT06438471
Recruiting
The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to spinal cord injury. The main question it aims to answer is whether EC5026 is safe and well tolerated in SCI patients with neuropathic pain. In addition, this trial will also study the effects of EC5026 on pain. Researchers will compare EC5026 to placebo. Participants will be asked to: * Take EC5026 or placebo in a masked fashion, once... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/12/2025
Locations: AU Medical Center, Augusta, Georgia
Conditions: Spinal Cord Injuries, Neuropathic Pain
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Diabetic Neuropathy in Spinal Cord Stimulator Patients
NCT04687215
Recruiting
The objective of this study is to assess the effect Spinal Cord Stimulators have toward improving vascular changes of diabetes mellitus in patients eligible for SCS placement based on their condition of painful diabetic neuropathy; we will evaluate improving their disability and quality of life, improving micro-circulatory changes induced by Diabetes Mellitus (DM), improving macro-circulatory changes induced by DM and improving arterial stiffness of the vessels of the lower extremity.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: University of Chicago Medical Center, Chicago, Illinois
Conditions: Diabetes Mellitus, Neuropathy, Neuropathic Pain, Vascular Diseases, Vascular Stiffness, Microvascular Changes, Pain, Chronic
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Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
NCT06568042
Recruiting
The purpose of this study is to evaluate how safe and how well a treatment works compared to placebo for people with nerve pain that begins in their feet and moves up the leg to just below the knee. Participation may last up to 30 weeks including screening.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2025
Locations: MD First Research - Chandler, Chandler, Arizona +80 locations
Conditions: Neuropathic Pain, Distal Sensory Polyneuropathy
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The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
NCT06414356
Recruiting
This study is aimed to evaluate outpatient ketamine infusion within a military chronic neuropathic pain population and its effect on PTSD. Currently, this is a pilot study with 30 participants. Participants will be randomized to (1) a moderate dose ketamine, (2) moderate dose ketamine +Mg, or (3) a magnesium control group. Participants will complete self-reported pain and PTSD questionnaires throughout the \~24-week study period. The outlined strategy will provide evidence for the utility of ket... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/24/2025
Locations: Brooke Army Medical Center, San Antonio, Texas
Conditions: Neuropathic Pain, PTSD
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Prospective Evaluation of Intrathecal Targeted Drug Delivery for Cancer Associated Pain
NCT05674240
Recruiting
This Registry study will prospectively evaluate the differences in treatment outcomes in terms of pain intensity, pain interference, concomitant medication use, health-related quality of life, opioid adverse effects, and healthcare utilization between targeted drug delivery and conservative medication management only groups.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/23/2024
Locations: Advocate Aurora Health, Oshkosh, Wisconsin
Conditions: Cancer Pain, Chronic Pain, Cancer Associated Pain, Neuropathic Pain
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Insula Neuromodulation for Chronic Neuropathic Pain
NCT05404581
Recruiting
This study will comprehensively investigate the insula as a brain target for neuromodulation to treat chronic neuropathic pain.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/04/2024
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Neuropathic Pain, Chronic Pain
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Empowered Relief for Youth
NCT05998369
Recruiting
The purpose of this pilot study is to examine the feasibility and preliminary efficacy of Empowered Relief for Youth with chronic pain (ER-Y). ER-Y is a single-session pain management class for youth focused on pain science education and teaching self-regulatory skills for pain management based on the evidence-based adult ER class. Feasibility and acceptability of ER-Y will be assessed post-class. Preliminary efficacy will be assessed by administering surveys at baseline, 4-weeks, 8-weeks, and 1... Read More
Gender:
ALL
Ages:
Between 10 years and 18 years
Trial Updated:
11/21/2024
Locations: Stanford University, Palo Alto, California
Conditions: Chronic Pain, Musculoskeletal Pain, Fibromyalgia, Neuropathic Pain, Complex Regional Pain Syndromes, Abdominal Pain
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Novel Stimulation Patterns to Improve the Effectiveness of Spinal Cord Stimulation
NCT05968664
Recruiting
The goal of this study is to compare pain outcomes achieved by spinal cord stimulation (SCS) using time varying stimulation patterns with pain outcomes achieved by current standard of care SCS.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
11/20/2024
Locations: Baylor College of Medicine, Houston, Texas
Conditions: Chronic Pain, Pain, Neuropathic, Neuropathic Pain
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The Study Assessing the Safety and Efficacy of OK-101 Treatment in Subjects With Neuropathic Corneal Pain
NCT06637527
Recruiting
The primary objective of this study, in subjects with Neuropathic Corneal Pain, is to evaluate the efficacy and safety of OK-101 0.05% and 0.1% as compared to placebo instilled 4 times/day in subjects with neuropathic corneal pain, as assessed by visual analogue scale (VAS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/23/2024
Locations: Tufts Medical Center, Boston, Massachusetts
Conditions: Neuropathic Pain
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Utility of Multisensory Body-Representation in Spinal Cord Injury (SCI) With Pain
NCT06010251
Recruiting
The purpose of this study is to investigate the effectiveness of bodily illusions combined with transcranial direct current stimulation (tDCS) on neuropathic pain symptoms and sensory functions in participants with spinal cord injury (SCI) and neuropathic pain.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
10/08/2024
Locations: University of Miami, Miami, Florida
Conditions: Spinal Cord Injuries, Neuropathic Pain
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Virtual Walking Intervention for Neuropathic Pain in Spinal Cord Injury
NCT05005026
Recruiting
The purpose of this study is to determine if playing a virtual reality walking game can help improve neuropathic pain in adults with chronic spinal cord injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: University of Alabama at Birmingham, Birmingham, Alabama +2 locations
Conditions: Spinal Cord Injuries, Neuropathic Pain
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Brain Connectivity Changes With Spinal Cord Stimulation and Treatment of Chronic Pain: A Resting State NIRS/EEG Study
NCT05811312
Recruiting
This study aims to assess how use of spinal cord stimulation for the treatment of chronic pain impacts brain structure and function. The investigators will use a non-invasive neuroimaging technique called resting state Near Infrared Spectroscopy and Electroencephalography (rs-fNIRS/EEG). The investigators will enroll Veterans who are currently receiving care at the Medical Center and who are either long term users of SCS for the treatment of their chronic pain or being evaluated for use of SCS t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/12/2024
Locations: Louis Stokes VA Medical Center, Cleveland, OH, Cleveland, Ohio
Conditions: Neuropathic Pain
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