There are currently 19 active clinical trials seeking participants for Preterm Birth research studies. The states with the highest number of trials for Autism participants are Pennsylvania, Texas, California and Ontario.
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
Recruiting
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies receive some form of mechanical respiratory support to aid breathing. Common to all types of respiratory support is the delivery of a treatment called positive end-expiratory pres... Read More
Gender:
All
Ages:
Between 23 weeks and 28 weeks
Trial Updated:
03/20/2024
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +29 locations
Conditions: Lung Injury, Preterm Birth
Reducing Pregnancy Risks: The Mastery Lifestyle Intervention
Recruiting
This randomized controlled trial will test an intervention called the Mastery Lifestyle Intervention (the MLI) that was developed from data of 1000+pregnant Hispanic women related to risks of preterm birth. The investigators will deliver a psychoeducational intervention that is manualized over 6 group sessions. The investigators will also have a usual care group that receives standard prenatal care. The investigators plan to enroll 221 pregnant women and start the study with them at 14-20 weeks... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
03/12/2024
Locations: Anthony Chavez, MD, Houston, Texas
Conditions: Mental Health Wellness 1, Preterm Birth
Impact of Dietary Sodium Supplementation on Growth & Intestinal Microbiome
Recruiting
The purpose of this project is to determine the direct impact of sodium supplementation in preterm infants and to see the overall improvement of their growth and health status. from this study will help us develop a better treatment for in the future.
Gender:
All
Ages:
Between 25 weeks and 30 weeks
Trial Updated:
03/11/2024
Locations: Children's wisconsin, Milwaukee, Wisconsin
Conditions: Preterm Birth
Blood Warming in Preterm Infants to Decrease Hypothermia
Recruiting
Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia. Hypothermia has been defined as a contributor of neonatal morbidity by The World Health Organization. Another acute morbidity is anemia in preterm infants due to the prematurity and frequent laboratory testing. Anemia requires correction with a packed red blood cells (PRBC... Read More
Gender:
All
Ages:
Between 24 weeks and 32 weeks
Trial Updated:
11/27/2023
Locations: Kayla Everhart, Columbia, South Carolina
Conditions: Preterm Birth, Blood Transfusion Complication, Hypothermia
Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients
Recruiting
This is an observational study of pregnant persons in threatened labor. The study device will record electromyography signals, then the signals will be examined to determine who is in true labor and who is in threatened labor. The two goals are: To establish the thresholds for the Contraction Synchronization Index (CSI) and the False Labor Index (FSI) to be used by the Labor Status Monitor to diagnose in-Labor or Not-in-Labor for preterm patients with threatened labor To obtain feedback from su... Read More
Gender:
Female
Ages:
All
Trial Updated:
11/27/2023
Locations: University of Rochester Medical Center, Rochester, New York +1 locations
Conditions: PreTerm Labor, Threatened Preterm Labor, Preterm Birth
Reducing Disparity in Receipt of Mother's Own Milk in Very Low Birth Weight Infants
Recruiting
In the US, the burden of very low birth weight (VLBW; <1500 g) birth is borne disproportionately by black (non-Hispanic black/African American) mothers who are 2.2-2.6 times more likely than nonblack mothers to deliver VLBW infants. This disparity is amplified because black VLBW infants are significantly less likely to receive mother's own milk (MOM) feedings from birth until neonatal intensive care unit (NICU) discharge than nonblack infants, which adds to the lifelong burden of VLBW birth with... Read More
Gender:
All
Ages:
All
Trial Updated:
11/03/2023
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Pumping, Breast, Milk, Human, Infant, Very Low Birth Weight, Preterm Birth
PAL to Improve Oral Feeding for Infants With Chronic Lung Disease
Recruiting
The purpose of this study is to investigate the effects of the Pacifier Activated Lullaby (PAL) intervention on the transition to oral feeding for preterm infants with chronic lung disease and respiratory distress syndrome that require non-invasive respiratory support at 34 weeks PMA. This study will utilize a clinical trial design. Participants will be randomized into two groups. One group will receive the PAL intervention, the other group serving as a no contact control. Participants will be m... Read More
Gender:
All
Ages:
Between 1 day and 33 weeks
Trial Updated:
10/02/2023
Locations: University of Missouri Healthcare, Columbia, Missouri
Conditions: Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia, Preterm Birth
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
Recruiting
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes. Since the initial discovery of ACS for neonatal benefit in 1972, more than 40 randomized controlled trials have been performed evaluating its efficacy. However, none of these trials have included women with T2DM, and there is limited data among women with gestational diabetes. While ACS have been shown to re... Read More
Gender:
All
Ages:
50 years and below
Trial Updated:
10/01/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama +3 locations
Conditions: Diabetes Mellitus, Type 2, Preterm Birth, Pregnancy, High Risk, Diabetes, Gestational
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
Recruiting
This prospective, randomized, controlled study evaluates the safety and efficacy of a preterm birth (PTB) prevention strategy versus standard of care pregnancy management to reduce the incidence of adverse pregnancy outcomes.
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/24/2023
Locations: UCSD, San Diego, California +18 locations
Conditions: Preterm Labor, Preterm Birth
Health and Wellness After Preterm Birth
Recruiting
This study continues an adaptation of the behavioral intervention Care Coordination After Preterm Birth (CCAPB). This is a pragmatic pilot randomized controlled feasibility trial of CCAPB with baseline and post-intervention assessments.
Gender:
Female
Ages:
Between 14 years and 45 years
Trial Updated:
08/03/2023
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Preterm Birth, Health Care Utilization, Tobacco Use, Contraceptive Usage, Depression, Weight, Birth
Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development
Recruiting
This study is a randomized trial comparing 2 methods of human milk fortification for preterm infants in the neonatal intensive care unit (NICU). All participating infants will receive a human milk diet comprising maternal and/or donor milk plus multi-component and modular fortifiers. In one group (control), the milk will be fortified according to routine standard of care. In the other group (intervention), the fortification will be individually targeted based on the results of point-of-care huma... Read More
Gender:
All
Ages:
Between 1 day and 21 days
Trial Updated:
06/27/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Preterm Birth, Breast Milk Expression, Nutrition Disorder, Infant, Brain Development Abnormality, Neurodevelopmental Disorders
Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial
Recruiting
Azithromycin is an antibiotic that is effective against bacteria that been associated with preterm birth (PTB). The purpose of this study is to evaluate if the addition of azithromycin prior to exam indicated cerclage prolongs gestation. A cerclage is a suture placed in the cervix to prolong gestation.
Gender:
Female
Ages:
Between 18 years and 80 years
Trial Updated:
06/23/2023
Locations: Northwestern University, Chicago, Illinois +1 locations
Conditions: Preterm Birth, Obstetric Labor, Premature, Obstetric Labor Complications, Pregnancy Complications, Physiological Effects of Drugs, Uterine Cervical Incompetence, Anti-Bacterial Agents, Azithromycin, Cefazolin