There are currently 20 active clinical trials seeking participants for Preterm Birth research studies. The states with the highest number of trials for Preterm Birth participants are Pennsylvania, Texas, California and Ontario.
Bilateral Infant Stimulation Study
Recruiting
This study will investigate stress that parents of children admitted to the neonatal intensive care unit (NICU) experience. Investigation of a novel intervention of using bilateral alternating stimulation to reduce parental stress and anxiety and increase bonding/attachment in NICU. Evaluate parental stress and feelings of bonding using surveys before and after the intervention. Intervention will be done at neonate's bedside while admitted to the NICU. Vital sign data will be collected as a mark... Read More
Gender:
All
Ages:
All
Trial Updated:
05/01/2024
Locations: Oregon Health and Science University Neonatal Intensive Care Unit, Portland, Oregon
Conditions: Parent-Child Relations, Preterm Birth, Stress Reaction, Hospitalism in Children
The Effect of Sulfasalazine on CRH Levels in Pregnant Women
Recruiting
The goal of this randomized clinical trial is to assess sulfasalazine as a potential treatment to prevent recurrent preterm birth. The main questions it aims to answer are: Does sulfasalazine down regulate corticotropin releasing hormone (CRH) levels in pregnant persons with a prior history of preterm birth? Does sulfasalazine reduce the incidence of recurrent preterm birth in pregnant persons given drug vs. controls? Consenting participants will be randomized to receive sulfasalazine or to a... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/15/2024
Locations: Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey
Conditions: Preterm Birth
Prospective Evaluation of Pathways for Preterm Birth
Recruiting
This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients without a short cervix will be recruited to provide baseline data. Plan to enroll 240 patients identified through our ultrasound unit with goal of 60 patients in each group.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
04/09/2024
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Preterm Birth, Cervix; Pregnancy
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
Recruiting
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies receive some form of mechanical respiratory support to aid breathing. Common to all types of respiratory support is the delivery of a treatment called positive end-expiratory pres... Read More
Gender:
All
Ages:
Between 23 weeks and 28 weeks
Trial Updated:
03/20/2024
Locations: University of Arkansas for Medical Sciences, Little Rock, Arkansas +29 locations
Conditions: Lung Injury, Preterm Birth
Reducing Pregnancy Risks: The Mastery Lifestyle Intervention
Recruiting
This randomized controlled trial will test an intervention called the Mastery Lifestyle Intervention (the MLI) that was developed from data of 1000+pregnant Hispanic women related to risks of preterm birth. The investigators will deliver a psychoeducational intervention that is manualized over 6 group sessions. The investigators will also have a usual care group that receives standard prenatal care. The investigators plan to enroll 221 pregnant women and start the study with them at 14-20 weeks... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
03/12/2024
Locations: Anthony Chavez, MD, Houston, Texas
Conditions: Mental Health Wellness 1, Preterm Birth
Impact of Dietary Sodium Supplementation on Growth & Intestinal Microbiome
Recruiting
The purpose of this project is to determine the direct impact of sodium supplementation in preterm infants and to see the overall improvement of their growth and health status. from this study will help us develop a better treatment for in the future.
Gender:
All
Ages:
Between 25 weeks and 30 weeks
Trial Updated:
03/11/2024
Locations: Children's wisconsin, Milwaukee, Wisconsin
Conditions: Preterm Birth
Blood Warming in Preterm Infants to Decrease Hypothermia
Recruiting
Background/significance: Over 100,000 early preterm infants are born annually in the United States and suffer morbidity and mortality during hospitalization in a neonatal intensive care unit. One such condition is hypothermia. Hypothermia has been defined as a contributor of neonatal morbidity by The World Health Organization. Another acute morbidity is anemia in preterm infants due to the prematurity and frequent laboratory testing. Anemia requires correction with a packed red blood cells (PRBC... Read More
Gender:
All
Ages:
Between 24 weeks and 32 weeks
Trial Updated:
11/27/2023
Locations: Kayla Everhart, Columbia, South Carolina
Conditions: Preterm Birth, Blood Transfusion Complication, Hypothermia
Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients
Recruiting
This is an observational study of pregnant persons in threatened labor. The study device will record electromyography signals, then the signals will be examined to determine who is in true labor and who is in threatened labor. The two goals are: To establish the thresholds for the Contraction Synchronization Index (CSI) and the False Labor Index (FSI) to be used by the Labor Status Monitor to diagnose in-Labor or Not-in-Labor for preterm patients with threatened labor To obtain feedback from su... Read More
Gender:
Female
Ages:
All
Trial Updated:
11/27/2023
Locations: University of Rochester Medical Center, Rochester, New York +1 locations
Conditions: PreTerm Labor, Threatened Preterm Labor, Preterm Birth
Reducing Disparity in Receipt of Mother's Own Milk in Very Low Birth Weight Infants
Recruiting
In the US, the burden of very low birth weight (VLBW; <1500 g) birth is borne disproportionately by black (non-Hispanic black/African American) mothers who are 2.2-2.6 times more likely than nonblack mothers to deliver VLBW infants. This disparity is amplified because black VLBW infants are significantly less likely to receive mother's own milk (MOM) feedings from birth until neonatal intensive care unit (NICU) discharge than nonblack infants, which adds to the lifelong burden of VLBW birth with... Read More
Gender:
All
Ages:
All
Trial Updated:
11/03/2023
Locations: Rush University Medical Center, Chicago, Illinois
Conditions: Pumping, Breast, Milk, Human, Infant, Very Low Birth Weight, Preterm Birth
PAL to Improve Oral Feeding for Infants With Chronic Lung Disease
Recruiting
The purpose of this study is to investigate the effects of the Pacifier Activated Lullaby (PAL) intervention on the transition to oral feeding for preterm infants with chronic lung disease and respiratory distress syndrome that require non-invasive respiratory support at 34 weeks PMA. This study will utilize a clinical trial design. Participants will be randomized into two groups. One group will receive the PAL intervention, the other group serving as a no contact control. Participants will be m... Read More
Gender:
All
Ages:
Between 1 day and 33 weeks
Trial Updated:
10/02/2023
Locations: University of Missouri Healthcare, Columbia, Missouri
Conditions: Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant, Bronchopulmonary Dysplasia, Preterm Birth
Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes
Recruiting
There is a fundamental gap in understanding the maternal and neonatal effects of antenatal corticosteroid (ACS) administration in women with threatened preterm birth (PTB) who have diabetes. Since the initial discovery of ACS for neonatal benefit in 1972, more than 40 randomized controlled trials have been performed evaluating its efficacy. However, none of these trials have included women with T2DM, and there is limited data among women with gestational diabetes. While ACS have been shown to re... Read More
Gender:
All
Ages:
50 years and below
Trial Updated:
10/01/2023
Locations: University of Alabama at Birmingham, Birmingham, Alabama +3 locations
Conditions: Diabetes Mellitus, Type 2, Preterm Birth, Pregnancy, High Risk, Diabetes, Gestational
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
Recruiting
This prospective, randomized, controlled study evaluates the safety and efficacy of a preterm birth (PTB) prevention strategy versus standard of care pregnancy management to reduce the incidence of adverse pregnancy outcomes.
Gender:
Female
Ages:
18 years and above
Trial Updated:
08/24/2023
Locations: UCSD, San Diego, California +18 locations
Conditions: Preterm Labor, Preterm Birth