There are currently 68 active clinical trials seeking participants for PTSD research studies. The states with the highest number of trials for PTSD participants are California, Texas, New York and Florida.
Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD
Recruiting
The long-term goal of this study is to reduce suicidal thoughts and behaviors among treatment-seeking individuals who also have posttraumatic stress disorder (PTSD). Prolonged exposure (PE) and crisis response plan (CRP) have demonstrated empirical support for reducing suicide attempts as compared to treatment as usual. However, no studies to date have assessed their effectiveness when used in combination. In light of this knowledge gap, the primary objective of this study will be to test the ef... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/03/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: PTSD, Suicidal Ideation, Suicide, Attempted, Trauma, Psychological
Positive Processes and Transition to Health - Single-Session (PATH-SS)
Recruiting
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are: Does PATH-SS leads to improvements in PTSD and depressio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: PTSD, Depression
Repurposing Low-Dose Clonidine for PTSD in Veterans
Recruiting
Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD symptoms, including daytime, nighttime, and sleep-related behaviors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/14/2025
Locations: Aurora Psychiatric Hospital, Wauwatosa, Wisconsin
Conditions: PTSD, Posttraumatic Stress Disorder, Sleep
Improving Behavioral Health for Caregivers and Children After Pediatric Injury
Recruiting
Pediatric traumatic injury (PTI) is a public health priority, with more than 125,000 children experiencing injuries that require hospitalization each year. These children, and their caregivers, are affected in many ways that may affect quality of life, emotional and behavioral health, physical recovery, family roles and routines, and academic functioning; yet US trauma centers do not adequately address these outcomes and a scalable national model of care for these families is needed. This propos... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2025
Locations: Children's Hospital Los Angeles, Los Angeles, California +3 locations
Conditions: Quality of Life, PTSD, Depression Not Otherwise Specified, Child Externalizing Behavior
Treatments for Insomnia in Veterans With PTSD
Recruiting
This randomized trial will compare a novel treatment, Acceptance of the Behavioral Changes to Treat Insomnia (ABC-I) to Cognitive Behavioral Therapy for Insomnia (CBT-I) among Veterans with comorbid Post-Traumatic Stress Disorder (PTSD) and insomnia disorder. ABC-I combines the behavioral components of CBT-I with components of another behavioral therapy (Acceptance and Commitment Therapy) and has been shown to improve treatment adherence. The study objectives are: 1) to evaluate the benefits of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: VA Greater Los Angeles Healthcare System, Sepulveda, CA, Sepulveda, California
Conditions: Insomnia, PTSD
Non-Inferiority Trial of TrIGR for PTSD
Recruiting
Trauma-related guilt is common and impairing among trauma survivors, particularly among Veterans with posttraumatic stress disorder (PTSD). The investigators' work shows that a brief treatment targeting trauma-related guilt, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt and PTSD and depression symptoms. Whether TrIGR is no less effective than longer, more resource heavy PTSD treatments disseminated by by VA, like cognitive processing therapy (CPT), is the next critical questi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/25/2025
Locations: VA San Diego Healthcare System, San Diego, CA, San Diego, California +1 locations
Conditions: PTSD
Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens
Recruiting
Psychosocial traumatic events during childhood, serve as strong and consistent predictors of substance use problems (SUP) during adolescence and adulthood.PTSD that extends from such trauma often co-occurs with SUP. Despite this well-established link, standard care for adolescents with co-occurring SUP and PTSD for the last several decades has been to treat these problems separately. This compartmentalized approach to treatment creates a burden on teens and families, raises unique challenges to... Read More
Gender:
ALL
Ages:
Between 13 years and 75 years
Trial Updated:
06/25/2025
Locations: CU Medicine Psychiatry - Outpatient Clinic, Aurora, Colorado +1 locations
Conditions: Substance Use Disorders, PTSD
REstoring Mental Health Through COmmUnity-based Psychological Services in New York City
Recruiting
The goal is to improve mental health. The study will evaluate the impact of community-based mental health services. Successful completion of this study will contribute to the National Institute of Mental Health Strategic Plan employing implementation science to maximize the public health impact of research for effectiveness and reach of mental health services in the United States.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/17/2025
Locations: New School, New York, New York
Conditions: Depression, Anxiety, Psychological Distress, PTSD
Evaluating Signs of Safety: A Deaf-Accessible Therapy Toolkit for AUD and Trauma
Recruiting
The U.S. Deaf community - a group of more than one million Americans who communicate using American Sign Language (ASL) - experiences nearly triple the rate of lifetime problem drinking and twice the rate of trauma exposure compared to the general population. Although there are several treatments for alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) in hearing populations, none have been developed for or tested with Deaf clients. To address these barriers, the study team develo... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/13/2025
Locations: University of Massachusetts Medical School, Worcester, Massachusetts
Conditions: PTSD, Alcohol; Use, Problem
MDMA Plus Exposure Therapy for PTSD
Recruiting
Posttraumatic stress disorder (PTSD) is a debilitating disorder. While effective treatments exist, some patients fail to receive the full benefits. Alternative treatment approaches are needed. 3,4-methylenedioxymethamphetamine (MDMA) is a medicine associated with feelings of closeness and love for others, empathy, insightfulness, and feelings of peace or well-being. Recent research combining one or two doses of MDMA with psychotherapy has shown improvements in PTSD symptoms. For the present stu... Read More
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
06/03/2025
Locations: Emory Brain Health Center, Atlanta, Georgia
Conditions: PTSD
PTSD Treatment for Incarcerated Men and Women: WPP
Recruiting
Study examining the psychological response to group Cognitive Processing Therapy (CPT) in incarcerated men and women with Post-traumatic stress disorder (PTSD). The study will be conducted in male and female incarcerated populations and will include 2 groups of individuals for both CPT and waitlist control in both populations (140 participants total).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/29/2025
Locations: Psychiatric Institute and Clinic, Madison, Wisconsin
Conditions: PTSD
Treatment for Antepartum Posttraumatic Stress Disorder/PTSD Study
Recruiting
The majority of women with perinatal posttraumatic stress disorder (PTSD) do not receive mental health treatment despite the documented associations between PTSD and adverse pregnancy outcomes; this is likely due to workforce shortages, lack of data on the effectiveness of existing evidence-based treatment for PTSD in usual care obstetrics settings, and patient-level barriers to engagement such as stigma. The proposed study is a randomized controlled trial, which will examine the effectiveness o... Read More
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
05/28/2025
Locations: Boston Medical Center and remote, Boston, Massachusetts
Conditions: PTSD