There are currently 121 active clinical trials seeking participants for Spinal Cord Injuries research studies. The states with the highest number of trials for Spinal Cord Injuries participants are Texas, New York, Florida and Illinois.
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI
Recruiting
The investigators are conducting a research study to try to improve rehabilitation interventions for individuals with spinal cord injury (SCI). In this study, the aim is to determine if temporarily numbing non-paralyzed arm muscles with an over-the-counter numbing cream while exercising paralyzed muscles, can improve the strength, function, and sensation of paralyzed muscles after a spinal cord injury.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
02/12/2025
Locations: University of Texas Rio Grande Valley, Harlingen, Texas
Conditions: Spinal Cord Injuries, Spine Disease, Stroke
Transcutaneous Spinal Cord Stimulation in Children with Incomplete Spinal Cord Injury
Recruiting
Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups. Both groups will receive eight-weeks of individualized gait training. We will measure adverse events, including pain and skin irritation, to determine safety as the primary outcome. Hypothesis 1: Administration of TSCS to children in a clinical setting will be safe based on similar safety outco... Read More
Gender:
ALL
Ages:
Between 3 years and 16 years
Trial Updated:
02/11/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Spinal Cord Injuries
Dosing rTMS for Depression Post-SCI
Recruiting
Depression is a leading cause of disability worldwide and is more commonly seen in individual's post-spinal cord injury (SCI) than in the general population. Depression post-SCI impacts an individuals' quality of life and recovery. It has been reported that among Veterans with an SCI, those without depression live longer than those with depression. Thus, depression must be treated appropriately. Repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, but... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
02/10/2025
Locations: Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston, South Carolina
Conditions: Spinal Cord Injuries, Depression, Depressive Disorder, Major
MyHand-SCI: an Active Hand Orthosis for Spinal Cord Injury
Recruiting
The purpose of this study is to develop and test the hardware and software components of the MyHand-SCI device to assist with hand function for individuals with C6-C7 spinal cord injury.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: Columbia University Irving Medical Center, New York, New York
Conditions: Spinal Cord Injuries, Tetraplegia
Dosing of Overground Robotic Gait Training with Functional Outcomes and Neuroplasticity After Spinal Cord Injury
Recruiting
The DOOR SCI project examines dosing effects of robotic gait training (RGT) and transcranial magnetic stimulation (TMS) initiated during inpatient rehabilitation and continued through early outpatient rehabilitation
Gender:
ALL
Ages:
Between 16 years and 85 years
Trial Updated:
02/04/2025
Locations: Baylor Scott & White Institute for Rehabilitation, Dallas, Texas
Conditions: Spinal Cord Injuries
Augmenting Rehabilitation Outcomes and Functional Neuroplasticity Using Epidural Stimulation of Cervical Spinal Cord
Recruiting
The goal of this study is to investigate the effects of cervical epidural spinal stimulation with upper extremity training. This is an investigational study. The device used for epidural spinal stimulation (ESS) to deliver spinal stimulation is called the CoverEdgeX 32 Surgical Lead system. This device is approved by the Food and Drug Administration (FDA) for the treatment of severe pain and to manage chronic pain when other treatments have not been effective. In this study, the device is consi... Read More
Gender:
ALL
Ages:
Between 22 years and 70 years
Trial Updated:
01/28/2025
Locations: The Methodist Hospital Research Institute, Houston, Texas
Conditions: Spinal Cord Injuries, Cervical Spinal Cord Injury
Telerehabilitation Early After CNS Injury
Recruiting
The goal of this clinical trial is to assess the safety and feasibility of providing extra doses of rehabilitation therapy for persons with a recent stroke, traumatic brain injury (TBI) and/or spinal cord injury (SCI). The therapy treatment targets to improve arm function by introducing telerehabilitation to the bedside of participants during the inpatient rehab admission period. Participants will use a newly developed functional training system (HandyMotion) to access therapy treatment program... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: California Rehabilitation Institute, Los Angeles, California +4 locations
Conditions: Cerebral Stroke, Traumatic Brain Injury, Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation to Promote Walking Recovery After Spinal Cord Injury
Recruiting
The goal of this clinical trial is to investigate the effects of transcutaneous spinal cord stimulation (TSCS) combined with exoskeleton training, as compared to exoskeleton training alone to improve motor function in individuals with incomplete spinal cord injury who are 12 months or less post-injury. Participants will be randomly assigned to a treatment group (exoskeleton training with TSCS, or exoskeleton training without TSCS). Participants in both groups will undergo a baseline evaluation,... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Craig Hospital, Englewood, Colorado
Conditions: Spinal Cord Injuries
BioFLO for Respiratory Recovery in SCI
Recruiting
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (\~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related to... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
12/13/2024
Locations: Brooks Rehabilitation, Jacksonville, Florida
Conditions: Spinal Cord Injuries
Hemodynamic Management Following Acute Traumatic Spinal Cord Injury
Recruiting
The purpose of this study is to assess the effect of various hemodynamic management strategies on functional neurologic outcomes and non-neurologic adverse events in the first 5 days following acute spinal cord injury (SCI). The hemodynamic management strategies assessed include targeting a mean arterial blood pressure (MAP) goal of 85-90 mmHg, targeting a spinal cord perfusion pressure (SCPP) goal of ≥65 mmHg, or targeting normal hemodynamics, which is a MAP goal of ≥65 mmHg.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: The University of Texas Health Science Center at Houston, Houston, Texas
Conditions: Spinal Cord Injuries
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia
Recruiting
The purpose of this study is to obtain preliminary device safety information and demonstrate proof of principle (feasibility) of the ability of people with tetraplegia to control a computer cursor and other assistive devices with their thoughts.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/27/2024
Locations: Stanford University School of Medicine, Stanford, California +1 locations
Conditions: Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked in Syndrome, Muscular Dystrophies
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
Recruiting
The goal of this study is to improve our understanding of speech production, and to translate this into medical devices called intracortical brain-computer interfaces (iBCIs) that will enable people who have lost the ability to speak fluently to communicate via a computer just by trying to speak.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/27/2024
Locations: University of California, Davis, Sacramento, California
Conditions: Anarthria, Dysarthria, Tetraplegia, Spinal Cord Injuries, Amyotrophic Lateral Sclerosis, Brain Stem Infarctions, Locked-in Syndrome, Muscular Dystrophies