There are currently 14 active clinical trials seeking participants for Surgical Site Infection research studies. The states with the highest number of trials for Autism participants are California, Texas, Florida and Ontario.
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
Recruiting
The purpose of the study is to assess the effectiveness of a single dose of preoperative antibiotic in reducing surgical site infections in certain dermatological procedures. Patients will undergo surgical excision or Mohs surgery as is clinically indicated and part of usual care. The study will be a double blinded, placebo-controlled clinical trial. Patients meeting inclusion criteria will be assigned to one of three participant categories: 1) patients undergoing repair with skin flap or graft... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/01/2022
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Surgical Site Infection
Ostomy Primary Closure With 0.1% Betaine/0.1% Polyhexanide Wound Irrigation Compared to Pursestring Closure
Recruiting
The goal of this clinical trial is to compare two types of closure in patients with ostomies that are ready for closure. The main questions it aims to answer are: Surgical site infection rates Patient quality of life Time to wound healing Participants will undergo either complete ostomy wound closure after washing out the wound with Prontosan, or their ostomy wound will be closed using the Pursestring method, where the wound will be left partially open and allowed to heal from the inside out.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/21/2024
Locations: University Medical Center, Las Vegas, Nevada
Conditions: Surgical Site Infection, Wound Surgical, Colorectal Disorders
Reducing Wound Infections Using Bioelectric Wound Dressings
Recruiting
The purpose of this study is to compare the outcomes of using Bioelectric wound dressing on the pre-operative wound site and post operatively and compared it outcomes to the standard of care chlorhexidine skin preparation.
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
03/13/2024
Locations: AdventHealth Celebration, Kissimmee, Florida
Conditions: Surgical Site Infection
Tobramycin Injection to Prevent Infection in Open Fractures
Recruiting
The goal of open extremity fracture (OEF) treatment is to promote fracture healing and restore function while preventing the development of infection. This is achieved through systematic and timely wound debridement and irrigation, fracture stabilization, tetanus prophylaxis, systemic and local antimicrobial therapy, and judicious timing of wound closure based on cleanliness. Early prophylactic systemic antibiotics lower infection rates in open fractures but have limitations of achieving adequat... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
12/12/2023
Locations: University of Kentucky, Lexington, Kentucky +1 locations
Conditions: Wound Infection, Fractures, Open, Surgical Site Infection
Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections
Recruiting
This will be a single-center randomized control trial comparing the efficacy of two different formulations of Chlorhexidine surgical skin preparation in preventing cesarean section wound infections. Participants will be randomized to either 4% Chlorhexidine Gluconate aqueous solution (CHG) or 2% Chlorhexidine with isopropyl alcohol (CHG-IPA) 70% to examine the risk of infectious morbidity in those undergoing cesarean delivery. There will also be a cost-effectiveness analysis of the two preoperat... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
11/27/2023
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Surgical Site Infection, Cesarean Section; Infection
D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)
Recruiting
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), Compared to a SoC Treated Control Arm, in Prevention of Post Abdominal Surgery Incisional Infection.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
10/08/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri +20 locations
Conditions: Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
Zinc Oxide Versus Petrolatum Following Skin Surgery
Recruiting
Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for phot... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/24/2023
Locations: UPMC Dermatology St. Margaret, Pittsburgh, Pennsylvania
Conditions: Surgical Incision, Surgery--Complications, Surgical Wound, Surgical Site Infection, Scar, Hypertrophic Scar
Antibacterial-coated Sutures at Time of Cesarean
Recruiting
Abdominal closure with antibacterial-coated sutures has been shown to reduce wound infections after a number of surgical procedures, but none of the previous trials included cesarean delivery. Our objective is to determine whether use of antibacterial-coated sutures reduces surgical site infection (SSI) after cesarean delivery.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
09/15/2023
Locations: University of Texas Medical Branch in Galveston, Galveston, Texas
Conditions: Surgical Site Infection, Surgical Wound Infection, Cesarean Section; Infection, Cesarean Section Complications
Studying How Outpatient Water affEcts Risks With Drains (SHOWER Study)
Recruiting
This is a prospective randomized, controlled, unblinded, interventional feasibility study to evaluate if showering with post operative drains in place leads to an increase in complications. The patients included in the study will be those undergoing breast reductions and panniculectomies at Geisinger Medical Center. The patients will be randomized post operatively into one of two groups: 1) patients instructed to shower with drains in place, and 2) patients instructed not to shower while they ha... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/31/2023
Locations: Geisinger Health, Danville, Pennsylvania
Conditions: Postoperative Wound Infection, Postoperative Complications, Surgical Site Infection, Drain Site Complication
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Recruiting
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enha... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
08/09/2023
Locations: University of California, Irvine Medical Center, Orange, California +2 locations
Conditions: Surgical Site Infection
Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
Recruiting
Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.
Gender:
All
Ages:
Between 12 months and 19 years
Trial Updated:
04/10/2023
Locations: Boston Children's Hopsital, Boston, Massachusetts
Conditions: Surgical Site Infection
Chlorhexidine and/or Betadine Prep in Pediatric Arm Surgery Following Trauma
Recruiting
There have been numerous studies demonstrating surgical site infections that arise from contamination at time of surgery or by seeding from other sites in the body which arise from organisms normally found on the skin. This has been known to cause complications in spine surgery, shoulder, hip, and knee arthroplasty. While studies have shown that organisms like Cutibacterium persists on the skin despite standard surgical preparation, there have not been studies that examine the organisms found in... Read More
Gender:
All
Ages:
10 years and below
Trial Updated:
03/17/2023
Locations: Geisinger Woodbine, Danville, Pennsylvania
Conditions: Arm Fracture, Surgical Site Infection