There are currently 29 active clinical trials seeking participants for Trauma research studies. The states with the highest number of trials for Trauma participants are California, Texas, Ontario and Florida.
REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam
Recruiting
The purpose of this study is to demonstrate safety, effectiveness and benefit-risk profile of ResQFoam for the inhospital treatment of exsanguinating, intraabdominal haemorrhage due to trauma in patients where emergent laparotomy is required.
Gender:
ALL
Ages:
15 years and above
Trial Updated:
07/01/2024
Locations: University of Cincinnati, Cincinnati, Ohio
Conditions: Hemorrhagic Shock, Trauma, Exsanguinating Hemorrhage, Shock; Traumatic
Onyx™ Liquid Embolic IDE Clinical Study
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of Onyx™ LES in the treatment of subjects with active arterial bleeding in the peripheral vasculature outside of the heart and brain.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
05/28/2025
Locations: UCHealth University of Colorado Hospital, Aurora, Colorado +1 locations
Conditions: Peripheral Arterial Hemorrhage, Trauma, GI Bleed, Ulcer, Hemorrhage
Brief Intervention for Chronic Pain and History of Stressful Experiences
Recruiting
The goal of this study is to understand whether a brief, three session program can be helpful in reducing symptoms related to both chronic pain and stressful experiences/trauma.
Gender:
ALL
Ages:
21 years and above
Trial Updated:
05/13/2025
Locations: Brigham and Women's Hospital, Chestnut Hill, Massachusetts
Conditions: Chronic Pain, Trauma, Adverse Childhood Experiences
Mg OSTEOCRETE Post-Treatment Outcomes
Recruiting
Mg OSTEOCRETE is a bone substitute used to fill a defect in bone caused by excision of a tumor, orthopaedic hardware that has become loosened, or a trauma-related condition. The aim of this study is to determine the amount of time it takes for bone to heal after treatment with Mg OSTEOCRETE, and to better understand the efficacy of this treatment through clinical and patient-reported outcomes.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Cancer of Bone, Trauma, Aseptic Loosening of Orthopaedic Hardware
PRESERVE & CONNECT: Impact Study of the BPC
Recruiting
The PRESERVE \& CONNECT project is a multi-site randomized control trial of the Breakthrough Parenting Curriculum: Navigating Trauma Across Generations (BPC) in rural and racially and ethnically diverse communities in Vermont and Connecticut.
Gender:
ALL
Ages:
All
Trial Updated:
04/14/2025
Locations: University of Connecticut, Hartford, Connecticut +1 locations
Conditions: Child Maltreatment, Trauma
The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
Recruiting
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
01/24/2025
Locations: UF Academic Research Building, Gainesville, Florida +2 locations
Conditions: Trauma Injury, Trauma, Critical Illness, Microbiome, Chronic Anemia, Acute Blood Loss Anemia
CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial
Recruiting
The CAlcium and VAsopressin following Injury Early Resuscitation (CAVALIER) Trial is a proposed 4 year, double-blind, mutli-center, prehospital and early in hospital phase randomized trial designed to determine the efficacy and safety of prehospital calcium and early in hospital vasopressin in patients at risk of hemorrhagic shock.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/08/2025
Locations: Allegheny Health Network, Pittsburgh, Pennsylvania +1 locations
Conditions: Trauma, Hemorrhage
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
Recruiting
An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control. However, given the harmful side effect profile and opioid epidemic in the United States, it is advantageous to use alternate forms of analgesia. Multimodal pain control captures the effectiveness of different analgesic modalities and maximizes analgesia while minimizing side effects. The theory... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/05/2024
Locations: Henry Ford Hospital System, Detroit, Michigan
Conditions: Opioid Use, Fractures, Bone, Trauma
Women Focused Encounters for Resilience Independence Strength and Eudaimonia
Recruiting
The goal of this combination Type 1 hybrid and observational study is to evaluate the impact of a peer delivered intervention of acceptance and comittment therapy(ACT) + exercise + social support to address the substance (ab)use, violence, and AIDS/HIV (SAVA) to improve medication adherence for women living with HIV (WLWH). This intervention will be implemented by community based organizations that focus on WLWH across four counties. The main question it aims to answer are: * Will peer provisio... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/03/2024
Locations: UC San Diego AntiViral Research Center (AVRC), San Diego, California
Conditions: HIV Infections, Substance Use, Trauma, Medication Adherence
Suction Versus Water Seal for Initial Treatment of Traumatic Pneumothorax Trial
Recruiting
The goal of this clinical trial is to compare the effect of placing chest tubes to water seal versus suction initially, in patients with traumatic pneumothoraces, on overall chest tube duration. The main question it aims to answer is: * Does placing chest tubes to water seal initially results in a shorter chest tube duration, without an increase in complications? Alternating each month, patients' chest tubes will either be placed to water seal or to suction initially. All other management dec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/27/2024
Locations: Vanderbilt University Medical Center, Nashville, Tennessee
Conditions: Pneumothorax, Trauma
Magnesium Infusion for Pain Management in Critically Ill Trauma Patients
Recruiting
Magnesium is a naturally occurring mineral that is important for your body and brain. Magnesium sulfate (study drug) is a medication containing magnesium that is commonly used to improve low blood levels of magnesium. Magnesium sulfate has also proven to be successful in managing pain before and after surgery. However, this drug has primarily been used for pain control in patients undergoing surgery. Patients in the ICU with injuries also need good pain control. Using magnesium may assist in dec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/21/2024
Locations: UC Davis Health, Sacramento, California
Conditions: Trauma, Acute Pain
A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients
Recruiting
Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and H1b. experiential avoidance, depression, regrets, and increases in patients' value-concordant care (secondary outcomes) at T1-T4. Hypothesis 2. Qualitative data will provide insights not captured by quantitative data. Hypothesis 3. Reductions in experiential avoidance wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/20/2024
Locations: University of Miami, Miami, Florida +2 locations
Conditions: Grief, Trauma, Psychotherapy, Critical Care