Pimavanserin and Aggression and Social Cognition.
Recruiting
The investigators are studying how certain drugs can reduce anger outbursts in people with anger problems. In this study the investigators seek to determine if a single 34 mg (two 17 mg tablets) oral dose of the 5-HT2a receptor blocker, pimavanserin, will reduce aggressive responding in individuals with impulsive aggression (Intermittent Explosive Disorder: IED) on a laboratory task that assesses aggression (Taylor Aggression Paradigm: TAP). We will also be examining how this drug impacts hostil... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
03/26/2025
Locations: The Ohio State University College of Medicine, Columbus, Ohio
Conditions: Intermittent Explosive Disorder
Effect of Nitrous Oxide on Aggression.
Recruiting
The goal of this experimental medicine clinical trial is to test the hypothesis that nitrous oxide inhalation will result in a change in neurocircuit function in healthy controls and in individuals with impulsive aggressive tendencies. The main question aims to answer are: Does Nitrous Oxide normalize brain circuit function in impulsively aggressive individuals 24 hours after inhalation. Participants will undergo a 60 minute inhalation session with 50% Nitrous Oxide (or room air at another sessi... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
03/26/2025
Locations: Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Intermittent Explosive Disorder
Neural Correlates During Alcohol Intoxication
Recruiting
Alcohol intoxication is responsible for a large proportion of violent crime/assault and personal injury in our society. While a number of variables have been associated with alcohol-related aggression, high trait aggression and impaired executive function have been identified as key factors. Both Alcohol Use Disorder (AUD) and Impulsive Aggression behavior (AGG) are related to impaired social-emotional information processing (SEIP) whereby social threat cues, especially ones that are ambiguous i... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
03/26/2025
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Alcohol Use Disorder, Intermittent Explosive Disorder
Adaptix RCT Evaluating Adaptix™ Versus PEEK Cages
Recruiting
The purpose of this randomized controlled trial is to assess and compare radiographic and clinical outcomes in patients who are to undergo combined interbody/posterolateral lumbar fusion procedures, supplemented with pedicle screw instrumentation, using one of the following interbody cages; the Medtronic Adaptix™ cage with roughened micro and nano-textured titanium surfaces or the CAPSTONE® poly-ether-ether-ketone cage.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: The Ohio State University Wexner Medical Center Neurological Surgery, Columbus, Ohio
Conditions: Spinal Canal Stenosis, Spondylolisthesis, Osteophyte, Bony Growth Formation, Degenerative Disc Disease
Addiction Potential of Very Low Nicotine Filtered Little Cigars
Recruiting
The goal of this clinical trial is to learn how reducing the nicotine content in filtered little cigars can affect the the use of these cigars and lung health in current adult filtered little cigar users. The main question\[s\] it aims to answer are: Are puffing behaviors, appeal/satisfaction, craving suppression, pharmacokinetic effects, and demand similar between the regular cigars smoked by participants, normal nicotine study cigars and very low nicotine study cigars? Are health effects and... Read More
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
03/25/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Smoking (Tobacco) Addiction
The Ohio State University (OSU) SCREEN Community Program
Recruiting
This clinical trial develops and tests how well a multi-level intervention (MLI), The Ohio State University (OSU) SCREEN Community Program, works to increase screening and follow-up for breast, cervical and colorectal (CRC) cancer among low-income and un/underinsured female residents in three counties in Central Ohio. In Ohio, incidence and mortality rates for breast, cervical and CRC are higher than or similar to the national average; in addition, underserved populations - minority, rural and l... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/25/2025
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Breast Carcinoma, Cervical Carcinoma, Colorectal Carcinoma
Motor-voice Assessment in Infants (MAMI)
Recruiting
The goal of this observational study is to discover features of normal and disordered motor-voice profiles that are biobehavioral markers of physical disability in infants.. The main questions it aims to answer are: Identify voice factors among infants with newborn-detectable risk. Identify association between individual characteristics (Gestational age at birth, global function, motor-function) and voice factors. Examine unique features of voice production that are present in infants with hig... Read More
Gender:
ALL
Ages:
10 days and below
Trial Updated:
03/25/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Cerebral Palsy Infantile, Pre-Term, Motor Delay, Neurodevelopmental Disorders, Autism Spectrum Disorder
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
Recruiting
The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Alzheimer's Disease, Lewy Body Dementia, Parkinson's Disease
Clinical and Radiological Outcomes of Posterior Cervical Fusion Supplemented With Interfacet Spacers
Recruiting
This is a prospective study to assess fusion rates and cervical sagittal parameters following posterior cervical arthrodesis procedures supplemented with CIS. Data will be collected from medical records for up to 730 days after surgery. Data to be collected will be demographic, preoperative clinical information, surgical details, and radiographic information. Patients will also undergo a non-standard of care CT scan 2 years after surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/25/2025
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Cervical Fusion
Evaluation of GeoHAI Implementation
Recruiting
Geographic Information Systems (GIS) and spatial analysis have become important tools in public health informatics but have rarely been applied to the hospital setting. In this study we apply these tools to address the challenge of Hospital Acquired Infections (HAIs) by building, implementing, and evaluating a new computer application which incorporates mapping and geographic data to assist hospital epidemiologists in identifying HAI clusters and assessing transmission risk. We expect that incor... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: The Ohio State University, Columbus, Ohio
Conditions: Clostridioides Difficile Infection, Healthcare Associated Infection
Donor Immune Cells (TGFbi NK Cells) and Isatuximab for the Treatment of Relapsed or Refractory Multiple Myeloma
Recruiting
This phase I trial tests the side effects and best dose of TGFbi natural killer (NK) cells (TiNK) when given together with isatuximab for the treatment of patients with multiple myeloma that has come back after a period of improvement (relapsed) or that has not responded to treatment (refractory). NK cells are a type of white blood cell that are known to spontaneously attack cancer cells. TiNK are NK cells made in a laboratory to have a higher response to tumor cells. A monoclonal antibody is a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Ohio State University Comprehensive Cancer Center, Columbus, Ohio
Conditions: Recurrent Multiple Myeloma, Refractory Multiple Myeloma
The Effects of Post-Operative Interventions on Surgical Site Occurrences in AWR
Recruiting
Randomized controlled trial to compare SSO's in abdominal wall reconstruction patients using Prevena, Prineo, and traditional incisional dressings.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/24/2025
Locations: Department of Plastic Surgery, Columbus, Ohio
Conditions: Abdomen Hernia