There are currently 16 active clinical trials seeking participants for Irritable Bowel Syndrome research studies. The states with the highest number of trials for Irritable Bowel Syndrome participants are Florida, California, Texas and North Carolina.
Fecal Microbiota Transplantation for IBS
NCT05776914
Recruiting
The purpose of this study is to learn the efficacy and safety of fecal microbiota transplantation (FMT) using stool from a donor with low proteolytic activity and containing the bacteria Alistipes putredinis in patients with irritable bowel syndrome (IBS) and high proteolytic activity. Proteolytic activity is the breakdown of proteins into smaller polypeptides or amino acids.
Gender:
FEMALE
Ages:
Between 18 years and 70 years
Trial Updated:
04/09/2025
Locations: Mayo Clinic in Minnesota, Rochester, Minnesota
Conditions: Irritable Bowel Syndrome, Diarrhea
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Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children
NCT03339128
Recruiting
The primary objectives of this study are to explore the therapeutic effect of eluxadoline in treating irritable bowel syndrome with diarrhea (IBS-D) in pediatric participants 6-17 years of age, to evaluate the pharmacokinetics of eluxadoline in pediatric participants with IBS-D, and to evaluate the safety and tolerability of eluxadoline in pediatric participants with IBS-D. Enrollment of 12-17 years old age group is closed, enrollment of the 6-11 years old age group will continue.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
04/09/2025
Locations: HealthStar Research of Hot Springs PLLC /ID# 234609, Hot Springs, Arkansas +45 locations
Conditions: Irritable Bowel Syndrome
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Psyllium in Pediatric IBS
NCT06639984
Recruiting
The goal of this clinical trial is to learn if a fiber (psyllium) can change the way bacteria use fructans (a type of sugar) and whether psyllium can help decrease childhood irritable bowel syndrome (IBS) symptoms when eating fructans. The main questions it aims to answer are: Aim 1: The effect of psyllium at two doses given with a fructan meal on microbial fructan fermentation (intracolonic pH; H2 gas production; gut microbiome composition; fecal short-chain fatty acids, lactate, glycomics).... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
03/31/2025
Locations: Duke University, Durham, North Carolina
Conditions: Irritable Bowel Syndrome
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A Study of Varenicline in the Treatment of Visceral Sensation
NCT06854406
Recruiting
The purpose of this study�is to evaluate the effect of varenicline on rectal sensation, based on ascending method of limits and on graded rapid phasic distensions in participants with non-constipation IBS and chronic abdominal pain.�
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
02/25/2025
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Irritable Bowel Syndrome
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Hydrogen Breath Test an Instrument to Predict Rifaximin-Response in Irritable Bowel Syndrome Predominant Diarrhea
NCT03729271
Recruiting
The purpose of this study is to learn more about how to improve treatment of patients with diarrhea predominant Irritable Bowel Syndrome (IBS-D) symptoms.Included patients will be requested to answer online surveys and will undergo treatment with rifaximin. Hydrogen breath testing and biologic samples collection will also be completed during the study.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
02/03/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Irritable Bowel Syndrome, Irritable Bowel Syndrome With Diarrhea
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GI Alpha-Gal Study
NCT06268717
Recruiting
This is a double-blind, crossover food challenge study using pork with and without α-gal in patients with a clinical diagnosis of gastrointestinal (GI)- α-gal allergy, and to investigate the pathophysiology underlying their symptoms.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/13/2024
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Alpha-Gal Syndrome, Irritable Bowel Syndrome, Diarrhea, Abdominal Pain, Vomiting
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Standardized Yoga & Meditation Program for Stress Reduction for Adolescents With Irritable Bowel Syndrome
NCT05719246
Recruiting
Irritable Bowel Syndrome (IBS) is the most common cause of recurrent abdominal pain in children. IBS is a functional gastrointestinal disorder that is linked to motor and sensory physiology, as well as the central nervous system, that presents as abdominal pain with abnormal defecation patterns. This discomfort leads to emotional stress, decreased quality of life, and anxiety. The study proposes that yoga and mindfulness will decrease anxiety and increase quality of life for patients with IBS. T... Read More
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
10/09/2024
Locations: Cooper University Hospital, Camden, New Jersey
Conditions: Irritable Bowel Syndrome, Anxiety, Quality of Life
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Mechanisms of Gulf War Illness
NCT05972291
Recruiting
Many veterans with Gulf War Illness developed chronic gastrointestinal symptoms during their deployment to the Persian Gulf. The pathophysiologic mechanisms of these chronic gastrointestinal symptoms are not well understood but cause significant morbidity in veterans. Our proposed studies will provide an innovative and novel treatment trial for chronic gastrointestinal symptoms in veterans with Gulf War Illness that were deployed into war zones. Given that there are currently no specific treatme... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
09/27/2024
Locations: Memphis VA Medical Center, Memphis, TN, Memphis, Tennessee
Conditions: Gulf War Illness, Irritable Bowel Syndrome, Gastrointestinal Symptoms
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Mucosal and Microbiota Changes During Acute Campylobacteriosis
NCT03223077
Recruiting
Gastrointestinal (GI) infection with Campylobacter causes inflammation in the bowel and can change bacteria in the gut. Certain individuals with Campylobacter infection are also known to develop chronic bowel problems such as Irritable Bowel Syndrome (IBS). The researchers are doing this study to understand if changes in gut bacteria and gut mucosal lining during an acute infection can help identify individuals who might be at risk for developing problems in the future.
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
07/09/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Irritable Bowel Syndrome
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Comparison of Rimegepant and Placebo for Pain in IBS
NCT06221111
Recruiting
The primary aim of this study is to evaluate the efficacy of rimegepant on abdominal pain scores in participants with non-constipation IBS.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
06/06/2024
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Irritable Bowel Syndrome
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Do Biomarkers Predict Response to a Pediatric Chronic Pain Symptom Management Program?
NCT03823742
Recruiting
The purpose of this study is find out if we can use simple tests (biomarkers) to tell us if a specific child would benefit most from CBT or from the low FODMAPs diet.
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
05/24/2024
Locations: Children's Nutrition Research Center, Houston, Texas +1 locations
Conditions: Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome, Functional Gastrointestinal Disorders, Functional Bowel Disorder, Functional Abdominal Pain, Functional Abdominal Pain Disorders
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Online Social Learning Program for Parents With Irritable Bowel Syndrome: Raising Resilient Children
NCT05730491
Recruiting
The goal of this clinical trial is to test efficacy of the REACH program in parents with irritable bowel syndrome (IBS) and their young children. The main question it aims to answer is: -How can parents with IBS help their young kids develop healthy habits? Participants will be asked to complete online surveys and to use a website. Researchers will compare results from parents who use one of two websites chosen by chance, like flipping a coin. One website focuses on child health and safety beh... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2024
Locations: Seattle Children's Hospital, Seattle, Washington
Conditions: Irritable Bowel Syndrome, Abdominal Pain
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