The state of Georgia currently has 16 active clinical trials seeking participants for Depression research studies. These trials are conducted in various cities, including Atlanta, Augusta, Decatur and Savannah.
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of two administrations of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
02/20/2024
Locations: Atlanta Center for Medical Research, Atlanta, Georgia +1 locations
Conditions: Treatment Resistant Depression
A Study to Assess the Efficacy and Safety of REL-1017 as Adjunctive Treatment for Major Depressive Disorder (MDD)
Recruiting
This is an outpatient, 2-arm, Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy and safety of REL-1017 once daily (QD) as an adjunctive treatment of Major Depressive Disorder. Study participants will continue to take their current antidepressant therapy in addition to the study drug or placebo for the duration of the treatment period.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/15/2024
Locations: Relmada Site, Savannah, Georgia
Conditions: Major Depressive Disorder, Depression
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
02/15/2024
Locations: Psych Atlanta, Atlanta, Georgia +1 locations
Conditions: Treatment Resistant Depression
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Recruiting
Bipolar disorder is a severe chronic mood disorder that affects up to 4% of the adult population and 1.8% of the pediatric population in the United States. The treatment of the depressive episodes of bipolar disorder in the pediatric population has not been as widely studied as the treatment of depressive episodes in bipolar disorder in adults, therefore pharmacotherapeutic options are limited. Given the change in disease state and safety demonstrated in adults with depressive episodes associate... Read More
Gender:
All
Ages:
Between 10 years and 17 years
Trial Updated:
02/13/2024
Locations: Atlanta Center for Medical Research /ID# 226480, Atlanta, Georgia +3 locations
Conditions: Depression, Bipolar I Disorder
Inflammation and Depression in People With HIV
Recruiting
The purpose of this 10-week, double-blind, placebo-controlled study is to determine whether inflammation impacts reward and motor neural circuitry to contribute to depressive symptoms like anhedonia and psychomotor slowing in people with Human Immunodeficiency Virus (HIV) and depression. Sixty male and female patients with HIV who have depression, anhedonia and high inflammation and are stable on effective treatment for their HIV will be randomized to receive either the anti-inflammatory drug ba... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/08/2024
Locations: Grady Memorial Hospital, Atlanta, Georgia +1 locations
Conditions: HIV, Depression, Anhedonia
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
Recruiting
The purpose of this study is to learn the environmental and psychological factors that impact suicidality in patients diagnosed with Bipolar Disorder. Additionally, the study aims to identify treatments to reduce the suicidal behavior and improve quality of life through a 6-week group-based intervention program.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
01/29/2024
Locations: Grady Health System, Atlanta, Georgia
Conditions: Depression, Alcoholism, Drug Abuse
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
01/08/2024
Locations: Emory University, Atlanta, Georgia +4 locations
Conditions: Treatment Resistant Depression
Dopaminergic Therapy for Anhedonia - 2
Recruiting
The purpose of this 8-week, double-blind, placebo-controlled, study is to explore new treatment options for people with depression who have high inflammation and anhedonia. Seventy male and female participants with depression, between 25-55 years of age, with higher levels of inflammation and anhedonia will be randomized to receive L-DOPA or matched placebo over 8 weeks. Participants will complete lab tests, medical and psychiatric assessments, motivation and motor tasks, and MRI scans as part o... Read More
Gender:
All
Ages:
Between 25 years and 55 years
Trial Updated:
01/08/2024
Locations: Emory University Hospital, Atlanta, Georgia
Conditions: Anhedonia, Depression
To Improve Depressive Symptoms Using a Web-App
Recruiting
This study is being done to answer a question on whether a Web App-based Lifestyle Physical Activity Promotion Program is effective in improving depressive symptom experience of midlife Korean American women (WPAPP-K).
Gender:
Female
Ages:
Between 40 years and 60 years
Trial Updated:
01/04/2024
Locations: Emory University Hospital, Atlanta, Georgia
Conditions: Depression
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment Resistant Depression
Recruiting
This study will be conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 2b study. Approximately 180 subjects with treatment resistant depression who meet all eligibility criteria will be enrolled.
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/02/2023
Locations: CenExel Atlanta Center for Medical Research, Atlanta, Georgia +2 locations
Conditions: Treatment Resistant Depression
Brain Stimulation and Decision-making
Recruiting
Decision-making is an important process that is frequently shown to be impaired in patients with depression. While a number of preclinical and clinical studies have identified key regions involved in this process, it remains unclear exactly how these regions are influencing choice behavior especially when choices become more challenging. The goal of this project is to understand how these regions, such as the cingulate cortex, impact difficult choice behavior. Specifically, the researchers are i... Read More
Gender:
All
Ages:
Between 18 years and 50 years
Trial Updated:
10/26/2023
Locations: Emory University, Atlanta, Georgia
Conditions: Depression
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
Recruiting
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI). Subjects will be randomized (1:1) to receive CBT (computer-assisted) or TAU alone following esketamine.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
09/18/2023
Locations: Emory University, Atlanta, Georgia
Conditions: Depression and Suicide