There are currently 51 active clinical trials seeking participants for Surgery research studies. The states with the highest number of trials for Surgery participants are California, Ontario, Guangdong and Ohio.
NO During CPB in Neonates to Reduce Risk of AKI
Recruiting
Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize tha... Read More
Gender:
ALL
Ages:
Between 1 day and 31 days
Trial Updated:
07/21/2025
Locations: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
Conditions: AKI, CHD - Congenital Heart Disease, Surgery
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
Recruiting
This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline mental health and poor physical function, improves satisfaction at 1-year (when compared to standard of care).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
05/14/2025
Locations: Cleveland Clinic Foundation, Cleveland, Ohio
Conditions: Knee Osteoarthritis, Knee Arthropathy, Surgery
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Recruiting
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when comp... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2025
Locations: University of Michigan, Ann Arbor, Michigan +7 locations
Conditions: Surgery, Pain, Postoperative
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Recruiting
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2025
Locations: University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas +19 locations
Conditions: Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia, Surgery, Quality of Life, Pain, Postoperative, Anesthesia Morbidity
Intervention to Improve Utilization of Extended Venous Thromboembolism Prophylaxis After Cancer Surgery
Recruiting
While blood clots after major cancer surgery are common and harmful to patients, the medications to decrease blood clot risk are seldom used after patients leave the hospital despite the recommendation of multiple professional medical societies. The reason why these medications are seldom prescribed is not well understood. The main questions this study aims to answer are: * Does surgeon education paired with an electronic medical record based decision support tool improve the guideline concorda... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/28/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Venous Thromboembolism, Pulmonary Embolism, Deep Vein Thrombosis, Cancer, Surgery
Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
Recruiting
The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the development of postoperative complications. The investigators propose to replace this complex regimen with a single administration of intraocular antibiotic and subconjunctival steroid at the time of surgery. This pilot study will obtain the preliminary data required to eventual... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/18/2025
Locations: Zuckerberg San Francisco General Hospital and Trauma Center (ZSFG), San Francisco, California
Conditions: Cataract, Surgery, Compliance, Patient, Compliance, Medication, Satisfaction, Patient
Music Interventions During Wide-Awake Hand Surgery
Recruiting
The purpose of this study is to examine if patients have a lower anxiety level during wide awake hand surgery while listening to their choice of music vs standardized relaxation music. Patients who are planning to undergo wide awake (local anesthetic only hand surgery) and agree to participate will be randomized to either a music intervention where they listen to their choice of music genre or standardized relaxation music during their time in the operating room. 170 participants will be enrolle... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/07/2025
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Anxiety, Surgery
Post-Discharge Risk-Based Management in Patients Undergoing High-Risk Elective Major Cancer Operations (PRS II)
Recruiting
This is a randomized trial of intensified post-discharge surveillance (Intervention Arm) versus standard post-discharge surveillance (Control Arm).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/02/2025
Locations: Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania
Conditions: Surgery, Cancer
Collecting Outcomes and Managing Pain After Surgery
Recruiting
The primary aim of this study is to measure pain and psychosocial patient reported outcomes, objective functionality, and actual daily at home opioid usage in orthopedic patients. The study's goal following the data collection is to predict which patients are at high risk for chronic opioid use.
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
06/24/2025
Locations: Duke Orthopaedics, Durham, North Carolina
Conditions: Surgery
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
Recruiting
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2025
Locations: University of California, San Diego, La Jolla, California
Conditions: Acute Postoperative Pain, Surgery
Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination
Recruiting
The primary objective is to evaluate the difference in outcomes for mail-in vs. in-home disposal methods for leftover prescription opioids after discharge from surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/10/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Surgery, Analgesics, Opioids
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Recruiting
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful. This study intends to characterize perioperative fasting practices and their potential effects on clinical outcomes through possible effects on patient well-being (anxiety, hunger, thirst), physiology (hypovolemia, hypotension), perioperative aspiration, etc. We hypothesized that in addition to known adverse effects o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
06/06/2025
Locations: Mass General Brigham, Boston, Massachusetts
Conditions: Anesthesia, Sedation, Monitored Anesthesia Care, Procedure, Surgery, Day, Surgery, Surgery Scheduled, Fasting Before Operation, Aspiration; Gastric Contents, Anesthesia